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Entry version 97 (07 Oct 2020)
Sequence version 1 (25 Jul 2006)
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Protein
Submitted name:

DIAPH2 protein

Gene

DIAPH2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DIAPH2 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DIAPH2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
Q17R91

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q17R91

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 471GBD/FH3InterPro annotationAdd BLAST374
Domaini635 – 1035FH2InterPro annotationAdd BLAST401
Domaini1058 – 1088DADInterPro annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni543 – 601DisorderedSequence analysisAdd BLAST59
Regioni1018 – 1055DisorderedSequence analysisAdd BLAST38
Regioni1078 – 1103DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili210 – 237Sequence analysisAdd BLAST28
Coiled coili388 – 415Sequence analysisAdd BLAST28
Coiled coili916 – 936Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 43PolyampholyteSequence analysisAdd BLAST15
Compositional biasi556 – 601Pro-richSequence analysisAdd BLAST46

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family. Diaphanous subfamily.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR014767, DAD_dom
IPR027644, DIAPH2
IPR010465, Drf_DAD
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd

The PANTHER Classification System

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PANTHERi
PTHR45691:SF3, PTHR45691:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06345, Drf_DAD, 1 hit
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51231, DAD, 1 hit
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17R91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQPGAAASG AGGGSEEPGG GRSNKRSAGN RAANEEETKN KPKLNIQIKT
60 70 80 90 100
LADDVRDRIT SFRKSTVKKE KPLIQHPIDS QVAMSEFPAA QPLYDERSLN
110 120 130 140 150
LSEKEVLDLF EKMMEDMNLN EEKKAPLRNK DFTTKREMVV QYISATAKSI
160 170 180 190 200
VGSKVTGGLK NSKHECTLSS QEYVHELRSG ISDEKLLNCL ESLRVSLTSN
210 220 230 240 250
PVSWVNNFGH EGLGLLLDEL EKLLDKKQQE NIDKKNQYKL IQCLKAFMNN
260 270 280 290 300
KFGLQRILGD ERSLLLLARA IDPKQPNMMT EIVKILSAIC IVGEENILDK
310 320 330 340 350
LLGAITTAAE RNNRERFSPI VEGLENQEAL QLQVACMQFI NALVTSPYEL
360 370 380 390 400
DFRIHLRNEF LRSGLKTMLP DLKEKENDEL DIQLKVFDEN KEDDLTELSH
410 420 430 440 450
RLNDIRAEMD DMNEVYHLLY NMLKDTAAEN YFLSILQHFL LIRNDYYIRP
460 470 480 490 500
QYYKIIEECV SQIVLHCSGM DPDFKYRQRL DIDLTHLIDS CVNKAKVEES
510 520 530 540 550
EQKAAEFSKK FDEEFTARQE AQAELQKRDE KIKELEAEIQ QLRTQAQVLS
560 570 580 590 600
SSSGIPGPPA APPLPGVGPP PPPPAPPLPG GAPLPPPPPP LPGMMGIPPP
610 620 630 640 650
PPPPLLFGGP PPPPPLGGVP PPPGISLNLP YGMKQKKMYK PEVSMKRINW
660 670 680 690 700
SKIEPTELSE NCFWLRVKED KFENPDLFAK LALNFATQIK VQKNAEALEE
710 720 730 740 750
KKTGPTKKKV KELRILDPKT AQNLSIFLGS YRMPYEDIRN VILEVNEDML
760 770 780 790 800
SEALIQNLVK HLPEQKILNE LAELKNEYDD LCEPEQFGVV MSSVKMLQPR
810 820 830 840 850
LSSILFKLTF EEHINNIKPS IIAVTLACEE LKKSESFNRL LELVLLVGNY
860 870 880 890 900
MNSGSRNAQS LGFKINFLCK IRDTKSADQK TTLLHFIADI CEEKYRDILK
910 920 930 940 950
FPEELEHVES ASKVSAQILK SNLASMEQQI VHLERDIKKF PQAENQHDKF
960 970 980 990 1000
VEKMTSFTKT AREQYEKLST MHNNMMKLYE NLGEYFIFDS KTVSIEEFFG
1010 1020 1030 1040 1050
DLNNFRTLFL EAVRENNKRR EMEEKTRRAK LAKEKAEQEK LERQKKKKQL
1060 1070 1080 1090 1100
IDINKEGDET GVMDNLLEAL QSGAAFRDRR KRIPRNPVVN HPCATRANPR

SAT
Length:1,103
Mass (Da):125,512
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36BF6C7E4CC53306
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC117414 mRNA Translation: AAI17415.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117414 mRNA Translation: AAI17415.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiQ17R91

Proteomic databases

PeptideAtlasiQ17R91

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DIAPH2, human

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR014767, DAD_dom
IPR027644, DIAPH2
IPR010465, Drf_DAD
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
PANTHERiPTHR45691:SF3, PTHR45691:SF3, 1 hit
PfamiView protein in Pfam
PF06345, Drf_DAD, 1 hit
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit
SMARTiView protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231, DAD, 1 hit
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ17R91_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17R91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: October 7, 2020
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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