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Protein

Protein FAM187B

Gene

FAM187B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM187B
Alternative name(s):
Transmembrane protein 162
Gene namesi
Name:FAM187B
Synonyms:TMEM162
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000177558.3
HGNCiHGNC:26366 FAM187B
neXtProtiNX_Q17R55

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 335ExtracellularSequence analysisAdd BLAST318
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 369CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177558
PharmGKBiPA164719910

Polymorphism and mutation databases

BioMutaiFAM187B
DMDMi145566967

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028462618 – 369Protein FAM187BAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ17R55
PeptideAtlasiQ17R55
PRIDEiQ17R55
ProteomicsDBi61135

PTM databases

iPTMnetiQ17R55
PhosphoSitePlusiQ17R55

Expressioni

Gene expression databases

BgeeiENSG00000177558
CleanExiHS_FAM187B
GenevisibleiQ17R55 HS

Interactioni

Protein-protein interaction databases

BioGridi127118, 13 interactors
STRINGi9606.ENSP00000323355

Structurei

3D structure databases

ProteinModelPortaliQ17R55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM187 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUE Eukaryota
ENOG410XNRD LUCA
GeneTreeiENSGT00530000063991
HOGENOMiHOG000112462
HOVERGENiHBG072209
InParanoidiQ17R55
OMAiSGAHWYY
OrthoDBiEOG091G0LQO
PhylomeDBiQ17R55
TreeFamiTF332178

Family and domain databases

InterProiView protein in InterPro
IPR039311 FAM187A/B
IPR036179 Ig-like_dom_sf
PANTHERiPTHR32178 PTHR32178, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17R55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPMLWLLLH FAAPALGFYF SISCPSGKQC QQALLSGNDI LLYCNSSGAH
60 70 80 90 100
WYYLFTQGKK GRLTSLTNIS NMEIMPEGSL LIKDPLPSQT GLYHCWNKNG
110 120 130 140 150
RQVVQYEIDF QDVTTLHITH KDLGQRPLQN ETLHLGSKQL IFTWWEPWQD
160 170 180 190 200
CNRCEEPGEC KRLGYRYIEE PLEEAMPCWL YLGEVLVWSS RLRPELQVEA
210 220 230 240 250
CHVQCTNNTQ LRVDYVIFDN FRLDEKTEFV WLDCPLGSMY RPVNWRANDT
260 270 280 290 300
PLTWESQLSG QDFTTFLDPS TGGRQLQVFQ PAVYKCFVQQ ELVAQFKPAA
310 320 330 340 350
SLETLEAQWR ENDAQWREAR KALRGRADSV LKGLKLVLLV VTVLALLGAL
360
LKCIHPSPGR RSTQVLVVK
Length:369
Mass (Da):42,387
Last modified:April 17, 2007 - v2
Checksum:i1EAD9CAC56D13E70
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0317903P → S1 PublicationCorresponds to variant dbSNP:rs34873156Ensembl.1
Natural variantiVAR_031791160C → R1 PublicationCorresponds to variant dbSNP:rs565791Ensembl.1
Natural variantiVAR_031792216V → I. Corresponds to variant dbSNP:rs564117Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098526 mRNA Translation: BAC05322.1
BC117457 mRNA Translation: AAI17458.1
BC117459 mRNA Translation: AAI17460.1
CCDSiCCDS12448.1
RefSeqiNP_689694.1, NM_152481.1
UniGeneiHs.128069

Genome annotation databases

EnsembliENST00000324675; ENSP00000323355; ENSG00000177558
GeneIDi148109
KEGGihsa:148109
UCSCiuc002nyk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF187B_HUMAN
AccessioniPrimary (citable) accession number: Q17R55
Secondary accession number(s): Q8N7G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: July 18, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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