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Entry version 102 (17 Jun 2020)
Sequence version 2 (17 Apr 2007)
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Protein

Protein FAM187B

Gene

FAM187B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM187B
Alternative name(s):
Transmembrane protein 162
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM187B
Synonyms:TMEM162
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000177558.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26366 FAM187B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q17R55

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 335ExtracellularSequence analysisAdd BLAST318
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 369CytoplasmicSequence analysisAdd BLAST13

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000177558

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164719910

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q17R55 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM187B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145566967

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028462618 – 369Protein FAM187BAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q17R55

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17R55

PeptideAtlas

More...
PeptideAtlasi
Q17R55

PRoteomics IDEntifications database

More...
PRIDEi
Q17R55

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61135

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q17R55

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q17R55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177558 Expressed in right testis and 36 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q17R55 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177558 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127118, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q17R55, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323355

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q17R55 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM187 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVUE Eukaryota
ENOG410XNRD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063991

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_054403_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17R55

Identification of Orthologs from Complete Genome Data

More...
OMAi
EACHVQC

Database of Orthologous Groups

More...
OrthoDBi
1290951at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17R55

TreeFam database of animal gene trees

More...
TreeFami
TF332178

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039311 FAM187A/B
IPR036179 Ig-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR32178 PTHR32178, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q17R55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPMLWLLLH FAAPALGFYF SISCPSGKQC QQALLSGNDI LLYCNSSGAH
60 70 80 90 100
WYYLFTQGKK GRLTSLTNIS NMEIMPEGSL LIKDPLPSQT GLYHCWNKNG
110 120 130 140 150
RQVVQYEIDF QDVTTLHITH KDLGQRPLQN ETLHLGSKQL IFTWWEPWQD
160 170 180 190 200
CNRCEEPGEC KRLGYRYIEE PLEEAMPCWL YLGEVLVWSS RLRPELQVEA
210 220 230 240 250
CHVQCTNNTQ LRVDYVIFDN FRLDEKTEFV WLDCPLGSMY RPVNWRANDT
260 270 280 290 300
PLTWESQLSG QDFTTFLDPS TGGRQLQVFQ PAVYKCFVQQ ELVAQFKPAA
310 320 330 340 350
SLETLEAQWR ENDAQWREAR KALRGRADSV LKGLKLVLLV VTVLALLGAL
360
LKCIHPSPGR RSTQVLVVK
Length:369
Mass (Da):42,387
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EAD9CAC56D13E70
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0317903P → S1 PublicationCorresponds to variant dbSNP:rs34873156Ensembl.1
Natural variantiVAR_031791160C → R1 PublicationCorresponds to variant dbSNP:rs565791Ensembl.1
Natural variantiVAR_031792216V → I. Corresponds to variant dbSNP:rs564117Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK098526 mRNA Translation: BAC05322.1
BC117457 mRNA Translation: AAI17458.1
BC117459 mRNA Translation: AAI17460.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12448.1

NCBI Reference Sequences

More...
RefSeqi
NP_689694.1, NM_152481.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324675; ENSP00000323355; ENSG00000177558

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
148109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:148109

UCSC genome browser

More...
UCSCi
uc002nyk.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098526 mRNA Translation: BAC05322.1
BC117457 mRNA Translation: AAI17458.1
BC117459 mRNA Translation: AAI17460.1
CCDSiCCDS12448.1
RefSeqiNP_689694.1, NM_152481.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127118, 13 interactors
IntActiQ17R55, 10 interactors
STRINGi9606.ENSP00000323355

PTM databases

iPTMnetiQ17R55
PhosphoSitePlusiQ17R55

Polymorphism and mutation databases

BioMutaiFAM187B
DMDMi145566967

Proteomic databases

MassIVEiQ17R55
PaxDbiQ17R55
PeptideAtlasiQ17R55
PRIDEiQ17R55
ProteomicsDBi61135

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3047 39 antibodies

The DNASU plasmid repository

More...
DNASUi
148109

Genome annotation databases

EnsembliENST00000324675; ENSP00000323355; ENSG00000177558
GeneIDi148109
KEGGihsa:148109
UCSCiuc002nyk.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
148109
EuPathDBiHostDB:ENSG00000177558.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM187B
HGNCiHGNC:26366 FAM187B
HPAiENSG00000177558 Tissue enriched (testis)
neXtProtiNX_Q17R55
OpenTargetsiENSG00000177558
PharmGKBiPA164719910

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVUE Eukaryota
ENOG410XNRD LUCA
GeneTreeiENSGT00530000063991
HOGENOMiCLU_054403_0_0_1
InParanoidiQ17R55
OMAiEACHVQC
OrthoDBi1290951at2759
PhylomeDBiQ17R55
TreeFamiTF332178

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
148109 2 hits in 780 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
148109
PharosiQ17R55 Tdark

Protein Ontology

More...
PROi
PR:Q17R55
RNActiQ17R55 protein

Gene expression databases

BgeeiENSG00000177558 Expressed in right testis and 36 other tissues
GenevisibleiQ17R55 HS

Family and domain databases

InterProiView protein in InterPro
IPR039311 FAM187A/B
IPR036179 Ig-like_dom_sf
PANTHERiPTHR32178 PTHR32178, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF187B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17R55
Secondary accession number(s): Q8N7G6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 17, 2020
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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