UniProtKB - Q17R14 (MYO1D_BOVIN)
Unconventional myosin-Id
MYO1D
Functioni
Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity).
Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity).
Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity).
By similarityCaution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 102 – 109 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- calcium-dependent protein binding Source: UniProtKB
- calmodulin binding Source: UniProtKB
- microfilament motor activity Source: UniProtKB
GO - Biological processi
- cellular localization Source: UniProtKB
- early endosome to recycling endosome transport Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Biological process | Protein transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Unconventional myosin-Id |
Gene namesi | Name:MYO1D |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Endosome
- Early endosome By similarity
Other locations
- Perikaryon By similarity
- dendrite By similarity
- cell cortex By similarity
Note: Colocalizes with the actin cytoskeleton in the cell cortex close to the apical cell membrane. Colocalizes with cytoplasmic puncta that are reminiscent of transport vesicles.By similarity
Cytoskeleton
- myosin complex Source: UniProtKB
Cytosol
- cytosol Source: GOC
Endoplasmic reticulum
- smooth endoplasmic reticulum Source: UniProtKB
Endosome
- early endosome Source: UniProtKB-SubCell
- endosome Source: UniProtKB
Plasma Membrane
- axolemma Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB
Other locations
- apical dendrite Source: UniProtKB
- axon Source: UniProtKB
- brush border Source: UniProtKB
- cell cortex Source: UniProtKB-SubCell
- cytoplasmic vesicle Source: UniProtKB
- myelin sheath Source: UniProtKB
- neuron projection Source: UniProtKB
- neuronal cell body Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Cytoplasm, EndosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000274173 | 2 – 1006 | Unconventional myosin-IdAdd BLAST | 1005 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 200 | PhosphoserineBy similarity | 1 | |
Modified residuei | 536 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q17R14 |
PRIDEi | Q17R14 |
Interactioni
Subunit structurei
Interacts (via the two IQ motifs) with calmodulin. Binds an additional calmodulin chain via a third, C-terminal region.
Interacts with F-actin.
By similarityGO - Molecular functioni
- actin filament binding Source: UniProtKB
- calcium-dependent protein binding Source: UniProtKB
- calmodulin binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000020634 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 695 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 687 | |
Domaini | 699 – 719 | IQ 1PROSITE-ProRule annotationAdd BLAST | 21 | |
Domaini | 721 – 741 | IQ 2PROSITE-ProRule annotationAdd BLAST | 21 | |
Domaini | 812 – 1005 | TH1PROSITE-ProRule annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 572 – 594 | Actin-bindingPROSITE-ProRule annotationAdd BLAST | 23 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0164, Eukaryota |
InParanoidi | Q17R14 |
OrthoDBi | 122881at2759 |
Family and domain databases
CDDi | cd01378, MYSc_Myo1, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR010926, Myosin_TH1 IPR036072, MYSc_Myo1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00612, IQ, 1 hit PF00063, Myosin_head, 1 hit PF06017, Myosin_TH1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51757, TH1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN
60 70 80 90 100
PYKSLNIYGR DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIVI
110 120 130 140 150
SGESGAGKTE ASKYIMQYIA AITNPSQRAE IERVKNMLLK SNCVLEAFGN
160 170 180 190 200
AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS
210 220 230 240 250
FHSFYQLLQG GSDQMLRSLH LQKSLSSYSY IHVGAQLKSS INDAAEFKVV
260 270 280 290 300
ADAMKVIGFK PEEIQTAYKI LAAILHLGNL KFVVDGDTTL IEDGKLVSII
310 320 330 340 350
AELLSTKTDM VEKALLYRTV ATGRDVIDKQ HTEQEASYGR DAFAKAIYER
360 370 380 390 400
LFCWIVSRIN DIIAVKNSDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI
410 420 430 440 450
NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK
460 470 480 490 500
GIIAILDDAC MNVGKVTDEM FLEALNSKLG KHGHFSSRKL CASDKILEFD
510 520 530 540 550
RDFRIRHYAG DVVYSVVGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG
560 570 580 590 600
KLSITEVTRR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDMKSPQI
610 620 630 640 650
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH
660 670 680 690 700
DLPSDKEAVK KLVEYCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLVR
710 720 730 740 750
IVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGI
760 770 780 790 800
KTMRDYGKHV QWPTPPKVLH RFEEVLQAVF NRWRASQLIK TIPASDLPQV
810 820 830 840 850
RAKVAAVEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR
860 870 880 890 900
KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
910 920 930 940 950
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV
960 970 980 990 1000
NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI
LSVPGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118080 mRNA Translation: AAI18081.1 |
RefSeqi | NP_001069306.1, NM_001075838.2 |
Genome annotation databases
GeneIDi | 522967 |
KEGGi | bta:522967 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118080 mRNA Translation: AAI18081.1 |
RefSeqi | NP_001069306.1, NM_001075838.2 |
3D structure databases
AlphaFoldDBi | Q17R14 |
SMRi | Q17R14 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000020634 |
Proteomic databases
PaxDbi | Q17R14 |
PRIDEi | Q17R14 |
Genome annotation databases
GeneIDi | 522967 |
KEGGi | bta:522967 |
Organism-specific databases
CTDi | 4642 |
Phylogenomic databases
eggNOGi | KOG0164, Eukaryota |
InParanoidi | Q17R14 |
OrthoDBi | 122881at2759 |
Family and domain databases
CDDi | cd01378, MYSc_Myo1, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR010926, Myosin_TH1 IPR036072, MYSc_Myo1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00612, IQ, 1 hit PF00063, Myosin_head, 1 hit PF06017, Myosin_TH1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51757, TH1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYO1D_BOVIN | |
Accessioni | Q17R14Primary (citable) accession number: Q17R14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | July 25, 2006 | |
Last modified: | May 25, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families