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Entry version 76 (29 Sep 2021)
Sequence version 1 (25 Jul 2006)
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Protein

Tetratricopeptide repeat protein 27

Gene

TTC27

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 27
Short name:
TPR repeat protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSBTAG00000033010

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:36466, TTC27

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002950951 – 847Tetratricopeptide repeat protein 27Add BLAST847

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q17QZ7

PRoteomics IDEntifications database

More...
PRIDEi
Q17QZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17QZ7, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000044110

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17QZ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati457 – 490TPR 1Add BLAST34
Repeati496 – 529TPR 2Add BLAST34
Repeati531 – 564TPR 3Add BLAST34
Repeati565 – 598TPR 4Add BLAST34
Repeati600 – 632TPR 5Add BLAST33
Repeati633 – 666TPR 6Add BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC27 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1128, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044929

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17QZ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFESWNN

Database of Orthologous Groups

More...
OrthoDBi
1039489at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR044244, TTC27/Emw1

The PANTHER Classification System

More...
PANTHERi
PTHR16193, PTHR16193, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 4 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17QZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGVMWTPEL AVLRGFPTQA ERQQWKQEGV ASLESGSFLQ LLLEGNYKAI
60 70 80 90 100
LLNSLTQSIL NSATITEEKI DSYLEKQIVT FLDDSAELDK IRRQQKILLL
110 120 130 140 150
GVSSLQLFVQ SNWTGPLVDL HPQDFLPSVL FQQFSEIKAL DAFLLSLLVL
160 170 180 190 200
DGESIYSLTT KPILLLLARI ILVNIRHKLT AIQSLPWWTL RCVNIHQQLL
210 220 230 240 250
EERSPQLFAL AEDCIDQVMK LEDLFVDDSG QCLAVQFHLE CAYIFLYYYE
260 270 280 290 300
YKKAKDQFSI AKDICRLQIG LTGALGKRTR FQENYVAQLI LDVRREGTVF
310 320 330 340 350
SNCEFTPAPT PQEYLTKNLE LNDDTVLNEI KLADCEQFQM PDLCAEELAV
360 370 380 390 400
ILGICTDFQK NNPVHKLTEE ELLAFTSCLL SQPKFWAIQT SALILRTKLE
410 420 430 440 450
RGSTRRVERA MRQTQALADQ FEDKTASVLE RLKIFYCCQV PPHWAVQRQL
460 470 480 490 500
AGLLFELGCT NSALQIFEKL EMWEDVVICY ERAGQHGKAE EILRQELEKK
510 520 530 540 550
ETPSLYCLLG DVLRDHSYYD QAWELSRHRS ARAQRSKGLL HLRSREFKEC
560 570 580 590 600
VECFERSLKI NPMQLGVWFS LGCAYLALED YGGSARAFQR CVTLEPDNAE
610 620 630 640 650
AWNNLSTSYI RLKQKVKAFR TLQEALKCNY EHWQIWENYI LTSTDVGEFS
660 670 680 690 700
EAIKAYHRLL DLRDKYKDTQ VLKILVRAVM DGMADRSGDV ATGLRGKLQE
710 720 730 740 750
LFGRVTSRVT NDGEIWRLYA QVYGNGQSDK PDENEKAFQY LSKAYKCDTQ
760 770 780 790 800
SSCWEKNITS FKEVVQRALG LAHVAIKCSK NKSSPQEAIQ VLSSVRLNLR
810 820 830 840
GLLSKAKQLF TDAASGEIAR ELADEIAAMD TLVTELQDLS NQFRNQY
Length:847
Mass (Da):96,953
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC8237B5EA391EE1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC118098 mRNA Translation: AAI18099.1

NCBI Reference Sequences

More...
RefSeqi
NP_001069330.1, NM_001075862.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000046862; ENSBTAP00000044110; ENSBTAG00000033010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
524908

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:524908

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118098 mRNA Translation: AAI18099.1
RefSeqiNP_001069330.1, NM_001075862.1

3D structure databases

SMRiQ17QZ7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044110

Proteomic databases

PaxDbiQ17QZ7
PRIDEiQ17QZ7

Genome annotation databases

EnsembliENSBTAT00000046862; ENSBTAP00000044110; ENSBTAG00000033010
GeneIDi524908
KEGGibta:524908

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55622
VEuPathDBiHostDB:ENSBTAG00000033010
VGNCiVGNC:36466, TTC27

Phylogenomic databases

eggNOGiKOG1128, Eukaryota
GeneTreeiENSGT00500000044929
InParanoidiQ17QZ7
OMAiGFESWNN
OrthoDBi1039489at2759

Gene expression databases

ExpressionAtlasiQ17QZ7, baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR044244, TTC27/Emw1
PANTHERiPTHR16193, PTHR16193, 1 hit
PfamiView protein in Pfam
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 4 hits
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005, TPR, 4 hits
PS50293, TPR_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC27_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17QZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 25, 2006
Last modified: September 29, 2021
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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