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Protein

Spliceosome-associated protein CWC27 homolog

Gene

CWC27

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.By similarity

Caution

Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Spliceosome-associated protein CWC27 homologCurated
Alternative name(s):
Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homologBy similarity
Short name:
PPIase CWC27By similarity
Gene namesi
Name:CWC27By similarity
Synonyms:SDCCAG10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003136462 – 473Spliceosome-associated protein CWC27 homologAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei347PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ17QX9
PRIDEiQ17QX9

Interactioni

Subunit structurei

Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000040

Structurei

3D structure databases

ProteinModelPortaliQ17QX9
SMRiQ17QX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 166PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili206 – 230Sequence analysisAdd BLAST25
Coiled coili311 – 378Sequence analysisAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi252 – 254Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0885 Eukaryota
COG0652 LUCA
HOGENOMiHOG000161443
HOVERGENiHBG097993
InParanoidiQ17QX9
KOiK12737

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17QX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD
60 70 80 90 100
NTIFHRVVPG FIVQGGDPTG TGTGGESIYG VPFKDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGPHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLTEVDID
160 170 180 190 200
DEERPRNSHK IRSCEVLFNP FDDIIPREIK KPKKEKPEEE VKKLKPKGTK
210 220 230 240 250
NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP HLSSVPAVES
260 270 280 290 300
ERGDAAEDSD DDGEYEGAEH DEYVDGDEKN QMRERIAKKL KKDTSENVKR
310 320 330 340 350
AGEGEVEKKP VSRSEELRKE ARQLKRELLA AKQKKAENSA IQAEKRSEEE
360 370 380 390 400
EAAPDGAVAE YRREKQKYEA LRKQQAKTGT SREDQTLALL NQFKSKLTQA
410 420 430 440 450
IAETPENDIS ETEVEDDEGW MSHVLQFEDK SRKVKDASMQ DSDTFEIYDP
460 470
RNPVNKRRRE ESKKLMREKK ERR
Length:473
Mass (Da):54,063
Last modified:July 25, 2006 - v1
Checksum:i4D2E11C916CB9214
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118124 mRNA Translation: AAI18125.1
RefSeqiNP_001068628.1, NM_001075160.2
UniGeneiBt.37259

Genome annotation databases

GeneIDi504397
KEGGibta:504397

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118124 mRNA Translation: AAI18125.1
RefSeqiNP_001068628.1, NM_001075160.2
UniGeneiBt.37259

3D structure databases

ProteinModelPortaliQ17QX9
SMRiQ17QX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000040

Proteomic databases

PaxDbiQ17QX9
PRIDEiQ17QX9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi504397
KEGGibta:504397

Organism-specific databases

CTDi10283

Phylogenomic databases

eggNOGiKOG0885 Eukaryota
COG0652 LUCA
HOGENOMiHOG000161443
HOVERGENiHBG097993
InParanoidiQ17QX9
KOiK12737

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCWC27_BOVIN
AccessioniPrimary (citable) accession number: Q17QX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: July 18, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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