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Protein

Ragulator complex protein LAMTOR3

Gene

LAMTOR3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-1632852 Macroautophagy
R-BTA-165159 mTOR signalling
R-BTA-166208 mTORC1-mediated signalling
R-BTA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-BTA-5628897 TP53 Regulates Metabolic Genes
R-BTA-5674135 MAP2K and MAPK activation
R-BTA-6798695 Neutrophil degranulation
R-BTA-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR3
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
Gene namesi
Name:LAMTOR3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:30781 LAMTOR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003561601 – 124Ragulator complex protein LAMTOR3Add BLAST124

Proteomic databases

PaxDbiQ17QQ1
PRIDEiQ17QQ1

Expressioni

Gene expression databases

BgeeiENSBTAG00000007923

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR2; the interaction is direct. Interacts with MAP2K1/MEK1 and MAPK2 (By similarity). Interacts with MORG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044998

Structurei

3D structure databases

ProteinModelPortaliQ17QQ1
SMRiQ17QQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMTOR3 family.Curated

Phylogenomic databases

eggNOGiENOG410IWYZ Eukaryota
ENOG4111KCU LUCA
GeneTreeiENSGT00390000013159
HOVERGENiHBG052480
InParanoidiQ17QQ1
KOiK04370
OMAiYQVIQMN
OrthoDBiEOG091G0TYL
TreeFamiTF324889

Family and domain databases

InterProiView protein in InterPro
IPR015019 LAMTOR3
PANTHERiPTHR13378 PTHR13378, 1 hit
PfamiView protein in Pfam
PF08923 MAPKK1_Int, 1 hit
SMARTiView protein in SMART
SM01278 MAPKK1_Int, 1 hit

Sequencei

Sequence statusi: Complete.

Q17QQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDNA PEHALRPGFL
60 70 80 90 100
STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSNANT
110 120
GLIVSLEKEL APLFEELRQV VEVS
Length:124
Mass (Da):13,650
Last modified:July 25, 2006 - v1
Checksum:i0A5196D390153D13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118239 mRNA Translation: AAI18240.1
RefSeqiNP_001069450.1, NM_001075982.1
UniGeneiBt.58709

Genome annotation databases

EnsembliENSBTAT00000047833; ENSBTAP00000044998; ENSBTAG00000007923
GeneIDi533155
KEGGibta:533155

Entry informationi

Entry nameiLTOR3_BOVIN
AccessioniPrimary (citable) accession number: Q17QQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 25, 2006
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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