UniProtKB - Q17QJ7 (P5CR2_BOVIN)
Pyrroline-5-carboxylate reductase 2
PYCR2
Functioni
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP+. Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity).
Involved in cellular response to oxidative stress (By similarity).
By similarityCatalytic activityi
: L-proline biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde. This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 34 | NADP; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 56 | NADPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 6 – 11 | NADPBy similarity | 6 | |
Nucleotide bindingi | 69 – 72 | NADPBy similarity | 4 | |
Nucleotide bindingi | 95 – 97 | NADPBy similarity | 3 |
GO - Molecular functioni
- pyrroline-5-carboxylate reductase activity Source: GO_Central
GO - Biological processi
- cellular response to oxidative stress Source: UniProtKB
- L-proline biosynthetic process Source: GO_Central
- proline biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Amino-acid biosynthesis, Proline biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
Reactomei | R-BTA-8964539, Glutamate and glutamine metabolism |
UniPathwayi | UPA00098;UER00361 |
Names & Taxonomyi
Protein namesi | Recommended name: Pyrroline-5-carboxylate reductase 2 (EC:1.5.1.2)Short name: P5C reductase 2 Short name: P5CR 2 |
Gene namesi | Name:PYCR2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000005835 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Mitochondrion
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000270819 | 2 – 320 | Pyrroline-5-carboxylate reductase 2Add BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q17QJ7 |
PeptideAtlasi | Q17QJ7 |
PRIDEi | Q17QJ7 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000005835, Expressed in retina and 95 other tissues |
ExpressionAtlasi | Q17QJ7, baseline |
Interactioni
Subunit structurei
Homodecamer; composed of 5 homodimers.
Interacts with LTO1.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000000047 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 298 – 320 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3124, Eukaryota |
GeneTreei | ENSGT00950000183044 |
HOGENOMi | CLU_042344_3_0_1 |
InParanoidi | Q17QJ7 |
OMAi | EQICTPK |
OrthoDBi | 952695at2759 |
Family and domain databases
HAMAPi | MF_01925, P5C_reductase, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR036291, NAD(P)-bd_dom_sf IPR028939, P5C_Rdtase_cat_N IPR029036, P5CR_dimer IPR000304, Pyrroline-COOH_reductase |
PANTHERi | PTHR11645, PTHR11645, 1 hit |
Pfami | View protein in Pfam PF03807, F420_oxidored, 1 hit PF14748, P5CR_dimer, 1 hit |
PIRSFi | PIRSF000193, Pyrrol-5-carb_rd, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00112, proC, 1 hit |
PROSITEi | View protein in PROSITE PS00521, P5CR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSVGFIGAGQ LACALARGFT AAGILSAHKI IASSPEMDLP TVSALRKMGV
60 70 80 90 100
NLTRSNKETV RHSDVLFLAV KPHIIPFILD EIGADVQARH IVVSCAAGVT
110 120 130 140 150
ISSVEKKLMA FQPAPKVIRC MTNTPVLVRE GATVYATGTH ALVEDGQLLE
160 170 180 190 200
QLMSSVGFCT EVEEDLIDAV TGLSGSGPAY AFMALDALAD GGVKMGLPRR
210 220 230 240 250
LAVRLGAQAL LGAAKMLLDS EQHPGQLKDN VCSPGGATIH ALHFLESGGF
260 270 280 290 300
RSLLINAVEA SCIRTRELQS MADQEKISPA ALKKTLLDRV KLESPTVTTL
310 320
TPTSSGKLLT RSPVPGGKKD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LVY3 | A0A3Q1LVY3_BOVIN | Pyrroline-5-carboxylate reductase | PYCR2 | 323 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118324 mRNA Translation: AAI18325.1 |
RefSeqi | NP_001068649.1, NM_001075181.1 |
Genome annotation databases
Ensembli | ENSBTAT00000000047; ENSBTAP00000000047; ENSBTAG00000005835 |
GeneIDi | 504987 |
KEGGi | bta:504987 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118324 mRNA Translation: AAI18325.1 |
RefSeqi | NP_001068649.1, NM_001075181.1 |
3D structure databases
SMRi | Q17QJ7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000000047 |
Proteomic databases
PaxDbi | Q17QJ7 |
PeptideAtlasi | Q17QJ7 |
PRIDEi | Q17QJ7 |
Genome annotation databases
Ensembli | ENSBTAT00000000047; ENSBTAP00000000047; ENSBTAG00000005835 |
GeneIDi | 504987 |
KEGGi | bta:504987 |
Organism-specific databases
CTDi | 29920 |
VEuPathDBi | HostDB:ENSBTAG00000005835 |
Phylogenomic databases
eggNOGi | KOG3124, Eukaryota |
GeneTreei | ENSGT00950000183044 |
HOGENOMi | CLU_042344_3_0_1 |
InParanoidi | Q17QJ7 |
OMAi | EQICTPK |
OrthoDBi | 952695at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00098;UER00361 |
Reactomei | R-BTA-8964539, Glutamate and glutamine metabolism |
Gene expression databases
Bgeei | ENSBTAG00000005835, Expressed in retina and 95 other tissues |
ExpressionAtlasi | Q17QJ7, baseline |
Family and domain databases
HAMAPi | MF_01925, P5C_reductase, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR036291, NAD(P)-bd_dom_sf IPR028939, P5C_Rdtase_cat_N IPR029036, P5CR_dimer IPR000304, Pyrroline-COOH_reductase |
PANTHERi | PTHR11645, PTHR11645, 1 hit |
Pfami | View protein in Pfam PF03807, F420_oxidored, 1 hit PF14748, P5CR_dimer, 1 hit |
PIRSFi | PIRSF000193, Pyrrol-5-carb_rd, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00112, proC, 1 hit |
PROSITEi | View protein in PROSITE PS00521, P5CR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P5CR2_BOVIN | |
Accessioni | Q17QJ7Primary (citable) accession number: Q17QJ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | July 25, 2006 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families