UniProtKB - Q17QJ5 (TSN5_BOVIN)
Protein
Tetraspanin-5
Gene
TSPAN5
Organism
Bos taurus (Bovine)
Status
Functioni
Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44.By similarity
GO - Molecular functioni
- enzyme binding Source: Ensembl
GO - Biological processi
- positive regulation of Notch signaling pathway Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
- protein maturation Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Tetraspanin-5Short name: Tspan-5 |
Gene namesi | Name:TSPAN5 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:36440 TSPAN5 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 39 – 61 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 83 – 92 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 114 – 232 | ExtracellularSequence analysisAdd BLAST | 119 | |
Transmembranei | 233 – 253 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 254 – 268 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287713 | 1 – 268 | Tetraspanin-5Add BLAST | 268 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 49 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q17QJ5 |
PRIDEi | Q17QJ5 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000012343 Expressed in 9 organ(s), highest expression level in prefrontal cortex |
Interactioni
Subunit structurei
Interacts with ADAM10.
1 PublicationGO - Molecular functioni
- enzyme binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016375 |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882 Eukaryota ENOG4111IRY LUCA |
GeneTreei | ENSGT00940000161376 |
HOGENOMi | HOG000230652 |
InParanoidi | Q17QJ5 |
KOi | K17345 |
OMAi | IRAKSDS |
OrthoDBi | 1180379at2759 |
TreeFami | TF313002 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335 Tetraspanin, 1 hit |
PIRSFi | PIRSF002419 Tetraspanin, 1 hit |
PRINTSi | PR00259 TMFOUR |
SUPFAMi | SSF48652 SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421 TM4_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q17QJ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG IAFLGIGLWA WNEKGVLSNI
60 70 80 90 100
SSITDLGGFD PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI
110 120 130 140 150
IFFLELTAGV LAFVFKDWIK DQLYFFINNN IRAYRDDIDL QNLIDFTQEY
160 170 180 190 200
WQCCGAFGAD DWNLNIYFNC TDSNASRERC GVPFSCCTKD PAEDVINTQC
210 220 230 240 250
GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF IGIALLQIFG
260
ICLAQNLVSD IEAVRASW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MUG3 | A0A3Q1MUG3_BOVIN | Tetraspanin | TSPAN5 | 253 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118327 mRNA Translation: AAI18328.1 |
RefSeqi | NP_001069587.1, NM_001076119.1 |
Genome annotation databases
Ensembli | ENSBTAT00000016375; ENSBTAP00000016375; ENSBTAG00000012343 |
GeneIDi | 538668 |
KEGGi | bta:538668 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118327 mRNA Translation: AAI18328.1 |
RefSeqi | NP_001069587.1, NM_001076119.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016375 |
Proteomic databases
PaxDbi | Q17QJ5 |
PRIDEi | Q17QJ5 |
Genome annotation databases
Ensembli | ENSBTAT00000016375; ENSBTAP00000016375; ENSBTAG00000012343 |
GeneIDi | 538668 |
KEGGi | bta:538668 |
Organism-specific databases
CTDi | 10098 |
VGNCi | VGNC:36440 TSPAN5 |
Phylogenomic databases
eggNOGi | KOG3882 Eukaryota ENOG4111IRY LUCA |
GeneTreei | ENSGT00940000161376 |
HOGENOMi | HOG000230652 |
InParanoidi | Q17QJ5 |
KOi | K17345 |
OMAi | IRAKSDS |
OrthoDBi | 1180379at2759 |
TreeFami | TF313002 |
Gene expression databases
Bgeei | ENSBTAG00000012343 Expressed in 9 organ(s), highest expression level in prefrontal cortex |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335 Tetraspanin, 1 hit |
PIRSFi | PIRSF002419 Tetraspanin, 1 hit |
PRINTSi | PR00259 TMFOUR |
SUPFAMi | SSF48652 SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421 TM4_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSN5_BOVIN | |
Accessioni | Q17QJ5Primary (citable) accession number: Q17QJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | July 25, 2006 | |
Last modified: | October 16, 2019 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families