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Protein

Rho-related GTP-binding protein RhoV

Gene

Rhov

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.By similarity

Cofactori

Mg2+By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45GTPBy similarity8
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi143 – 146GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoV
Gene namesi
Name:RhovBy similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264371 – 236Rho-related GTP-binding protein RhoVAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1
Lipidationi234S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ17QI8
PRIDEiQ17QI8

Interactioni

Subunit structurei

Interacts with PAK2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021672

Structurei

3D structure databases

ProteinModelPortaliQ17QI8
SMRiQ17QI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.By similarity

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ17QI8
KOiK07866

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Q17QI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPRELSEAE SSPLRSPTPP PGRGSASPEL GIKCVLVGDG AVGKSSLIVS
60 70 80 90 100
YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DLDRLRSLCY
110 120 130 140 150
PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD
160 170 180 190 200
VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS
210 220 230
AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
Length:236
Mass (Da):25,971
Last modified:July 25, 2006 - v1
Checksum:i3E30E35DCC0856A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118335 mRNA Translation: AAI18336.1
RefSeqiNP_001069567.1, NM_001076099.1
UniGeneiBt.61724

Genome annotation databases

GeneIDi538143
KEGGibta:538143

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118335 mRNA Translation: AAI18336.1
RefSeqiNP_001069567.1, NM_001076099.1
UniGeneiBt.61724

3D structure databases

ProteinModelPortaliQ17QI8
SMRiQ17QI8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021672

Proteomic databases

PaxDbiQ17QI8
PRIDEiQ17QI8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi538143
KEGGibta:538143

Organism-specific databases

CTDi171177

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ17QI8
KOiK07866

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHOV_BOVIN
AccessioniPrimary (citable) accession number: Q17QI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 25, 2006
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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