UniProtKB - Q17QI5 (VAMP7_BOVIN)
Vesicle-associated membrane protein 7
VAMP7
Functioni
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity).
By similarityGO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- calcium-ion regulated exocytosis Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- endosome to lysosome transport Source: UniProtKB
- eosinophil degranulation Source: UniProtKB
- exocytosis Source: GO_Central
- neutrophil degranulation Source: UniProtKB
- phagocytosis, engulfment Source: UniProtKB
- protein transport Source: UniProtKB-KW
- vesicle fusion Source: UniProtKB
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle-associated membrane protein 7Short name: VAMP-7 Alternative name(s): Synaptobrevin-like protein 1 |
Gene namesi | Name:VAMP7 Synonyms:SYBL1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Endosome
- Late endosome membrane By similarity; Single-pass type IV membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type IV membrane protein By similarity
Lysosome
- Lysosome membrane By similarity; Single-pass type IV membrane protein By similarity
Golgi apparatus
- trans-Golgi network membrane By similarity; Single-pass type IV membrane protein By similarity
Other locations
- secretory vesicle membrane By similarity; Single-pass type IV membrane protein By similarity
- phagosome membrane By similarity; Single-pass type IV membrane protein By similarity
- synaptosome By similarity
Note: In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Endosome
- late endosome membrane Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- neuron projection Source: UniProtKB
- phagocytic vesicle Source: UniProtKB
- phagocytic vesicle membrane Source: UniProtKB-SubCell
- SNARE complex Source: UniProtKB
- synapse Source: UniProtKB-SubCell
- transport vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 188 | CytoplasmicSequence analysisAdd BLAST | 187 | |
Transmembranei | 189 – 209 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 220 | VesicularSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Synapse, SynaptosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000284056 | 2 – 220 | Vesicle-associated membrane protein 7Add BLAST | 219 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 167 | PhosphoserineBy similarity | 1 | |
Modified residuei | 168 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinInteractioni
Subunit structurei
Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis.
Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. May interact with STX17 (By similarity).
Interacts with PICALM (By similarity).
Interacts with RAB21 (By similarity).
By similarityGO - Molecular functioni
- SNARE binding Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 110 | LonginPROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 125 – 185 | v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | Q17QI5 |
OrthoDBi | 1211929at2759 |
Family and domain databases
CDDi | cd14824, Longin, 1 hit |
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR010908, Longin_dom IPR001388, Synaptobrevin IPR042855, V_SNARE_CC |
Pfami | View protein in Pfam PF13774, Longin, 1 hit PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
SMARTi | View protein in SMART SM01270, Longin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS50859, LONGIN, 1 hit PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY
60 70 80 90 100
LFHYICQDRI VYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY
110 120 130 140 150
AMNSEFSSVL AAQLKHHSEN KGLDKVMETQ AQVDELKGIM VRNIDLVAQR
160 170 180 190 200
GERLELLIDK TENLVDSSVT FKTTSRNLAR AMCMKNLKLT IIIIIISVVF
210 220
IYIIVSPLCG GFTWPNCVKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118341 mRNA Translation: AAI18342.1 |
RefSeqi | NP_001069770.1, NM_001076302.1 |
Genome annotation databases
GeneIDi | 613984 |
KEGGi | bta:613984 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118341 mRNA Translation: AAI18342.1 |
RefSeqi | NP_001069770.1, NM_001076302.1 |
3D structure databases
AlphaFoldDBi | Q17QI5 |
BMRBi | Q17QI5 |
SMRi | Q17QI5 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 613984 |
KEGGi | bta:613984 |
Organism-specific databases
CTDi | 6845 |
Phylogenomic databases
InParanoidi | Q17QI5 |
OrthoDBi | 1211929at2759 |
Family and domain databases
CDDi | cd14824, Longin, 1 hit |
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR010908, Longin_dom IPR001388, Synaptobrevin IPR042855, V_SNARE_CC |
Pfami | View protein in Pfam PF13774, Longin, 1 hit PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
SMARTi | View protein in SMART SM01270, Longin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS50859, LONGIN, 1 hit PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VAMP7_BOVIN | |
Accessioni | Q17QI5Primary (citable) accession number: Q17QI5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | July 25, 2006 | |
Last modified: | May 25, 2022 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families