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Protein
Submitted name:

MAP2K2 protein

Gene

MAP2K2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-112411 MAPK1 (ERK2) activation
R-BTA-445144 Signal transduction by L1
R-BTA-5673000 RAF activation
R-BTA-5674135 MAP2K and MAPK activation
R-BTA-5674499 Negative feedback regulation of MAPK pathway

Names & Taxonomyi

Protein namesi
Submitted name:
MAP2K2 proteinImported
Gene namesi
Name:MAP2K2Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:55215 MAP2K2

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSBTAG00000024450 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011377

Structurei

3D structure databases

SMRiQ17QH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 369Protein kinaseInterPro annotationAdd BLAST298

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 57Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0581 Eukaryota
ENOG410XQ5A LUCA
GeneTreeiENSGT00760000119199
HOGENOMiHOG000234206
HOVERGENiHBG108518
KOiK04369
OMAiIAGWVCK
OrthoDBiEOG091G0DEC
TreeFamiTF105137

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q17QH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARRKPVLP ALTINPAIAE GPSPTSEGAS EAHLVDLQKK LEELELDEQQ
60 70 80 90 100
KKRLEAFLTQ KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR
110 120 130 140 150
KLIHLEIKPA IRNQIIRELQ VLHECNSPYI VGFYGAFYSD GEISICMEHM
160 170 180 190 200
DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG LAYLREKHQI MHRDVKPSNI
210 220 230 240 250
LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ GTHYSVQSDI
260 270 280 290 300
WSMGLSLVEL SIGRYPIPPP DAKELEAIFG RPMVDGAEGE PPSISPRPRP
310 320 330 340 350
PGRPISGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTQ DFQEFVNKCL
360 370 380 390 400
IKNPAERADL KMLMNHTFIK RSEVEEVDFA GWLCKTLRLN QPSTPTRTAV
Length:400
Mass (Da):44,502
Last modified:July 25, 2006 - v1
Checksum:iFF7CDABD0A943BD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02019622 Genomic DNA No translation available.
DAAA02019623 Genomic DNA No translation available.
BC118362 mRNA Translation: AAI18363.1
RefSeqiNP_001033160.2, NM_001038071.2
UniGeneiBt.8367

Genome annotation databases

EnsembliENSBTAT00000011377; ENSBTAP00000011377; ENSBTAG00000024450
GeneIDi510434
KEGGibta:510434

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02019622 Genomic DNA No translation available.
DAAA02019623 Genomic DNA No translation available.
BC118362 mRNA Translation: AAI18363.1
RefSeqiNP_001033160.2, NM_001038071.2
UniGeneiBt.8367

3D structure databases

SMRiQ17QH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011377

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011377; ENSBTAP00000011377; ENSBTAG00000024450
GeneIDi510434
KEGGibta:510434

Organism-specific databases

CTDi5605
VGNCiVGNC:55215 MAP2K2

Phylogenomic databases

eggNOGiKOG0581 Eukaryota
ENOG410XQ5A LUCA
GeneTreeiENSGT00760000119199
HOGENOMiHOG000234206
HOVERGENiHBG108518
KOiK04369
OMAiIAGWVCK
OrthoDBiEOG091G0DEC
TreeFamiTF105137

Enzyme and pathway databases

ReactomeiR-BTA-112411 MAPK1 (ERK2) activation
R-BTA-445144 Signal transduction by L1
R-BTA-5673000 RAF activation
R-BTA-5674135 MAP2K and MAPK activation
R-BTA-5674499 Negative feedback regulation of MAPK pathway

Gene expression databases

BgeeiENSBTAG00000024450 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ17QH2_BOVIN
AccessioniPrimary (citable) accession number: Q17QH2
Secondary accession number(s): F1MYR6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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