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Protein

Histone H2A

Gene

H2AFX

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-171306 Packaging Of Telomere Ends
R-BTA-201722 Formation of the beta-catenin:TCF transactivating complex
R-BTA-212300 PRC2 methylates histones and DNA
R-BTA-2299718 Condensation of Prophase Chromosomes
R-BTA-2559580 Oxidative Stress Induced Senescence
R-BTA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-BTA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-BTA-3214858 RMTs methylate histone arginines
R-BTA-427359 SIRT1 negatively regulates rRNA expression
R-BTA-427413 NoRC negatively regulates rRNA expression
R-BTA-5250924 B-WICH complex positively regulates rRNA expression
R-BTA-5578749 Transcriptional regulation by small RNAs
R-BTA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-BTA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-BTA-5693571 Nonhomologous End-Joining (NHEJ)
R-BTA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-BTA-69473 G2/M DNA damage checkpoint
R-BTA-73728 RNA Polymerase I Promoter Opening
R-BTA-73777 RNA Polymerase I Chain Elongation
R-BTA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-BTA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:H2AFXImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSBTAG00000038047

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000050955

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 89HistoneInterPro annotationAdd BLAST85
Domaini92 – 123Histone_H2A_CInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOGENOMiHOG000234652
HOVERGENiHBG009342
KOiK11251
OMAiVIVECAC
OrthoDBiEOG091G0XGD
TreeFamiTF300137

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Q17QG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV
60 70 80 90 100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG
110 120 130 140
VTIAQGGVLP NIQAVLLPKK TSATVGPKAP AGGKKATQAS QEY
Length:143
Mass (Da):15,129
Last modified:July 25, 2006 - v1
Checksum:iD4683775D43CC3A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02040492 Genomic DNA No translation available.
BC118370 mRNA Translation: AAI18371.1
RefSeqiNP_001073248.1, NM_001079780.2
UniGeneiBt.10510

Genome annotation databases

EnsembliENSBTAT00000055530; ENSBTAP00000050955; ENSBTAG00000038047
GeneIDi531733
KEGGibta:531733

Similar proteinsi

Entry informationi

Entry nameiQ17QG8_BOVIN
AccessioniPrimary (citable) accession number: Q17QG8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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