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Entry version 96 (12 Aug 2020)
Sequence version 1 (25 Jul 2006)
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Protein

Sodium/hydrogen exchanger

Gene

AAEL001503

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiportUniRule annotation, Ion transport, Sodium transportUniRule annotationARBA annotation, Transport
LigandSodium

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.36.1.10, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AAEL001503Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7159.AAEL001503-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1966, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005912_4_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q17L17

Identification of Orthologs from Complete Genome Data

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OMAi
ESVCTPD

Database of Orthologous Groups

More...
OrthoDBi
389547at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17L17

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR004709, NaH_exchanger

The PANTHER Classification System

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PANTHERi
PTHR10110, PTHR10110, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084, NAHEXCHNGR

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840, b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17L17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAHSLQQEV NLSRRACRIP KWPLSGAQQE EENDEEVLEE QLLNGANQSP
60 70 80 90 100
ASEVAAFRLG PVHSENSPGG IDEDPLSFRN RRMHDGRMGS VVDFSCDLVA
110 120 130 140 150
RVFLLVKALV MGVLRFDLTS PKRASSSSSS SSSYGSQFSK NLVKWCTWAI
160 170 180 190 200
VLSVLLANHG GFVLARPKNG VVTADGVDAA SVASGQWELL TPQPVSSDGA
210 220 230 240 250
VGGQISGSLS SVKQQDDQSH GGELGDASHG EGHEVERYPV AQVEFSRVET
260 270 280 290 300
PFVIGVWILS ASIAKIGFHM TPKLSKIFPE SCLLIVVGVI IGVLLRYATN
310 320 330 340 350
LHVSPLTPNT FFFYMLPPII LDAGYFMPNR MFFDNIGTIL LMAVIGTIFN
360 370 380 390 400
IATIGVSLWA CGLTGIFGVD LPFLHVFLFS SLISAVDPVA VLAVFEEIHV
410 420 430 440 450
NEVLYIVVFG ESLLNDAVTV VMYHMFESYN EIGASNIQVV DIVSGVASFF
460 470 480 490 500
VVALGGTIIG VIWGFLTGLV TRFTDHVRVI EPIFIFVMAY LAYLNAEIFH
510 520 530 540 550
MSGILAITFC GITMKNYVEQ NVSHKSHTTI KYALKMLSSS AETIIFMFLG
560 570 580 590 600
VATVNNRHIW NTWFVILTIV FCSVFRIIGV LILSAMANRF RIHKLSKVDQ
610 620 630 640 650
FVMSYGGLRG AVAFALVLLV STDHIPLQPM FVTTTIAVIY FTVFLQGITI
660 670 680 690 700
KPLVRVLNVK RANKRKPTMN ERIHERFMDH TMAGIEDIVG KTGNYNIRDK
710 720 730 740 750
FKRFDNRFIR PYLIKNLQGP EPKILETYSK LTMRDAMDYM RRNPSTIGQM
760 770 780 790 800
SGTESMSALF RNYTGVFGGS PSFSNLENST RNLDMQELDY NPSKKDLTDA
810 820 830 840 850
RIHHLLSVEL KPYRRTRRLS YSRHAVDDRD LSTQVNYKMQ MNIRRMISEK
860 870 880 890 900
KHKRSKRGKD GKTQNHVSFP ELPQNGSAKQ FANDYINEVL HEDNEDEDKL
910 920 930 940 950
PTAAGDDWDG GGLTFTAKSS LDEKSEQPKS DKRMSKDLRD LEAAENRVTT
960 970 980 990 1000
PTAIEAVLPW KRVDEDDENG AIKQNEFPSW ASNKEYLAYN SPSATFLGGL
1010 1020 1030 1040 1050
TQPKQAKSVI GLFRRESSGS GGIVIGGVTD SEASTPVTAT TPIGRAKKDK
1060 1070 1080 1090 1100
RSASIAGYIT FPGSSDAGDD PLGVSRAVVS HANAFPVTAS HRRNNRRGSL
1110 1120 1130 1140 1150
LELSGEAIPE ENYSKSLPDR DKHGPRRGPT LIKASGTPKP ARNSKSNNPQ
1160 1170
TTALLSSSST DSEEEEEEDK DCADEQHPI
Length:1,179
Mass (Da):130,187
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i155CC6710E1F8293
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH477219 Genomic DNA Translation: EAT47410.1

NCBI Reference Sequences

More...
RefSeqi
XP_001653402.1, XM_001653352.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477219 Genomic DNA Translation: EAT47410.1
RefSeqiXP_001653402.1, XM_001653352.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7159.AAEL001503-PA

Protein family/group databases

TCDBi2.A.36.1.10, the monovalent cation:proton antiporter-1 (cpa1) family

Phylogenomic databases

eggNOGiKOG1966, Eukaryota
HOGENOMiCLU_005912_4_0_1
InParanoidiQ17L17
OMAiESVCTPD
OrthoDBi389547at2759
PhylomeDBiQ17L17

Family and domain databases

InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR004709, NaH_exchanger
PANTHERiPTHR10110, PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PRINTSiPR01084, NAHEXCHNGR
TIGRFAMsiTIGR00840, b_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ17L17_AEDAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17L17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: August 12, 2020
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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