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Entry version 109 (16 Oct 2019)
Sequence version 1 (25 Jul 2006)
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Protein
Submitted name:

AAEL004942-PB

Gene

AAEL004942

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AAEL004942-PBImported
Submitted name:
HelicaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AAEL004942Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008820 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7159.AAEL004942-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini70 – 105QLQInterPro annotationAdd BLAST36
Domaini343 – 415HSAInterPro annotationAdd BLAST73
Domaini618 – 783Helicase ATP-bindingInterPro annotationAdd BLAST166
Domaini935 – 1096Helicase C-terminalInterPro annotationAdd BLAST162
Domaini1275 – 1345BromoInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni96 – 231DisorderedSequence analysisAdd BLAST136
Regioni452 – 479DisorderedSequence analysisAdd BLAST28
Regioni532 – 559DisorderedSequence analysisAdd BLAST28
Regioni1212 – 1253DisorderedSequence analysisAdd BLAST42
Regioni1395 – 1455DisorderedSequence analysisAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili330 – 350Sequence analysisAdd BLAST21
Coiled coili391 – 416Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 33Pro-richSequence analysisAdd BLAST33
Compositional biasi96 – 111PolarSequence analysisAdd BLAST16
Compositional biasi112 – 178Pro-richSequence analysisAdd BLAST67
Compositional biasi184 – 210PolarSequence analysisAdd BLAST27
Compositional biasi544 – 559PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1231 – 1245PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1395 – 1410PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1414 – 1430PolarSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0386 Eukaryota
COG0553 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000172363

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17BI8

Identification of Orthologs from Complete Genome Data

More...
OMAi
TALNIKF

Database of Orthologous Groups

More...
OrthoDBi
685477at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17BI8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
2.20.28.130, 1 hit
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR014978 Gln-Leu-Gln_QLQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR030088 SMARCA2
IPR029295 SnAC
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

The PANTHER Classification System

More...
PANTHERi
PTHR10799:SF541 PTHR10799:SF541, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07533 BRK, 1 hit
PF00439 Bromodomain, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF08880 QLQ, 1 hit
PF14619 SnAC, 1 hit
PF00176 SNF2_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00592 BRK, 1 hit
SM00297 BROMO, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SM00951 QLQ, 1 hit
SM01314 SnAC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160481 SSF160481, 1 hit
SSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS51666 QLQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q17BI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPGGPPGPG PNMGGPGGPN MMPGGPPPPP GQENLNALQR AIDSMEEKGL
60 70 80 90 100
QEDPRYSQLL ALRATSKQQN LNASQLHQLR GQIMAYRLLA RHQPISKQLA
110 120 130 140 150
SQIQAQRSDG TPPQCPTPPA SPYPGGPQGG PSPQPGMQQQ QPPQPGPPQG
160 170 180 190 200
PQQGPPGVPP GKVGPPEPGK PATGGMPPSQ SPMPGMTMGG QQPSHQQQMG
210 220 230 240 250
PGQPQRPSSQ GPAGAGPRPA AQAPAVQPIQ KQNRVTTVAK PVGLDPIIIL
260 270 280 290 300
QERENRMAAR IALRMEELSN LPAVMPEDLR IQAQIELRAL RVLNFQRQLR
310 320 330 340 350
SEIVQCTRRD TTLETAVNVK AYKRTKRQGL REARATEKLE KQQKLEAERK
360 370 380 390 400
RRQKHQEFLA LVLQHGKDFK EYHRNNVAKL GRLNKAIMNY HANAEREQKK
410 420 430 440 450
EQERIEKERM RRLMAEDEEG YRKLIDQKKD KRLAFLLSQT DEYIGNLTEM
460 470 480 490 500
VKQHKVDQKK KKDDEEQRKR RKKRMVLESG DIQHLDTDCE AHDCRVTVVE
510 520 530 540 550
TSSGKTIAGD DAPFLRDLYN WLQIHPGWEY VISDDEDDDD DEDSDEKKKK
560 570 580 590 600
KVEDDLSDEN KTKEVIQKAK VEDDEYKTEE QTYYSIAHTV HEKVTEQASI
610 620 630 640 650
LVNGKLKEYQ IKGLEWLVSL FNNNLNGILA DEMGLGKTIQ TIALVTYLME
660 670 680 690 700
KKKNNGPYLI IVPLSTLSNW VLEFEKWAPA VGVVAYKGSP AGRRAVQNQM
710 720 730 740 750
KATKFNVLLT TYEYVIKDKA VLAKISWKYM IIDEGHRMKN HHCKLTQVLN
760 770 780 790 800
THYIAPHRLL LTGTPLQNKL PELWALLNFL LPSIFKSVST FEQWFNAPFA
810 820 830 840 850
TTGEKVELNE EETILIIRRL HKVLRPFLLR RLKKEVESQL PDKVEYIVKC
860 870 880 890 900
DMSGLQRVLY KHMQSKGVLL TDGSEKGNKG KGGAKALMNT IVQLRKLCNH
910 920 930 940 950
PFMFQHIEEK YCDHIGGHGT VSGPDLYRAS GKFELLDRIL PKLKASGHRV
960 970 980 990 1000
LLFCQMTQCM TIIEDYLSWR GFGYLRLDGT TKAEERGDLL KKFNCKNSEY
1010 1020 1030 1040 1050
FVFLLSTRAG GLGLNLQTAD TVVIFDSDWN PHQDLQAQDR AHRIGQRNEV
1060 1070 1080 1090 1100
RVLRLMTVNS VEERILAAAR YKLNMDEKVI QAGMFDQKST GSERQQFLQS
1110 1120 1130 1140 1150
ILHQDEMDEE EENEVPDDEM INLMISRNDD ELELFKKMDA ERKAEEVKPR
1160 1170 1180 1190 1200
LIDESELPDW LVKEEEEVDR WDYEEDNSIL GRGSRQRKEV DYTDSLTEKE
1210 1220 1230 1240 1250
WLKAIDDGAD FDEELEEEER EKKRKGRKRK SRREDSDDES VISTVTKRRK
1260 1270 1280 1290 1300
GTTAPKVKKQ MKKVIDAVIK YTDQDGRVLS EPFMRLPSRR DLPDYYEVIK
1310 1320 1330 1340 1350
RPIDIKKIVT RIEEAKYADF PDLEKDFFQL CQNAQIYNEE ASLIYEDSLE
1360 1370 1380 1390 1400
LQQIFTTSKQ KILEAADEED SDDDGNYDCI PNSWQIVENA SHLPIADDDN
1410 1420 1430 1440 1450
SDEESGSVKM KLKISKAGTS SSSSMSASKP KGTPGRRKRS QKKYTISDDD

DDDMD
Length:1,455
Mass (Da):165,783
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CE948AF5521654C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q17BI9Q17BI9_AEDAE
AAEL004942-PA
AAEL004942
1,433Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH477321 Genomic DNA Translation: EAT43622.1

NCBI Reference Sequences

More...
RefSeqi
XP_001650090.1, XM_001650040.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AAEL004942-RA; AAEL004942-PA; AAEL004942

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
AAEL004942-RA; AAEL004942-PA; AAEL004942

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477321 Genomic DNA Translation: EAT43622.1
RefSeqiXP_001650090.1, XM_001650040.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7159.AAEL004942-PA

Genome annotation databases

EnsemblMetazoaiAAEL004942-RA; AAEL004942-PA; AAEL004942
VectorBaseiAAEL004942-RA; AAEL004942-PA; AAEL004942

Phylogenomic databases

eggNOGiKOG0386 Eukaryota
COG0553 LUCA
HOGENOMiHOG000172363
InParanoidiQ17BI8
OMAiTALNIKF
OrthoDBi685477at2759
PhylomeDBiQ17BI8

Family and domain databases

Gene3Di1.20.920.10, 1 hit
2.20.28.130, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR014978 Gln-Leu-Gln_QLQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR030088 SMARCA2
IPR029295 SnAC
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR10799:SF541 PTHR10799:SF541, 1 hit
PfamiView protein in Pfam
PF07533 BRK, 1 hit
PF00439 Bromodomain, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF08880 QLQ, 1 hit
PF14619 SnAC, 1 hit
PF00176 SNF2_N, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00592 BRK, 1 hit
SM00297 BROMO, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SM00951 QLQ, 1 hit
SM01314 SnAC, 1 hit
SUPFAMiSSF160481 SSF160481, 1 hit
SSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS51666 QLQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ17BI8_AEDAE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17BI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: October 16, 2019
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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