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Entry version 121 (07 Apr 2021)
Sequence version 3 (01 Dec 2001)
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Protein

High-energy light unresponsive protein 1

Gene

lite-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior (PubMed:18687026, PubMed:20436480, PubMed:27863243). Directly senses and absorbs both UV-A and UV-B light with very high efficiency (PubMed:27863243). Absorption of UV-B but not UV-A light shows resistance to photobleaching (PubMed:27863243). In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation (PubMed:27863243). Might have a role in response to white light exposure (PubMed:29500338).4 Publications

Caution

Was initially thought to play a role in the gustatory response (PubMed:18687026). However, it was later shown that it acts as a photoreceptor for short wavelength (UV) light (PubMed:27863243).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Transducer
Biological processSensory transduction
LigandChromophore

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.69.3.5, the heteromeric odorant receptor channel (horc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High-energy light unresponsive protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lite-1Imported
Synonyms:gur-2Imported
ORF Names:C14F11.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
C14F11.3 ; CE29579 ; WBGene00001803 ; lite-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 67Cytoplasmic1 PublicationAdd BLAST67
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei68 – 88Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini89 – 114Extracellular1 PublicationAdd BLAST26
Transmembranei115 – 135Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini136 – 164Cytoplasmic1 PublicationAdd BLAST29
Transmembranei165 – 185Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini186 – 211Extracellular1 PublicationAdd BLAST26
Transmembranei212 – 232Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini233 – 290Cytoplasmic1 PublicationAdd BLAST58
Transmembranei291 – 311Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini312 – 324Extracellular1 PublicationAdd BLAST13
Transmembranei325 – 345Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini346 – 402Cytoplasmic1 PublicationAdd BLAST57
Transmembranei403 – 423Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini424 – 439Extracellular1 PublicationAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit no response to blue-violet light but respond to physical stimulation.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi77W → A: Nearly abolished photoreceptor activity. 1 Publication1
Mutagenesisi226S → F in xu10; loss of phototaxis behavior due to impaired photoreceptor activity. 2 Publications1
Mutagenesisi328W → A: Nearly abolished photoreceptor activity. 1 Publication1
Mutagenesisi332A → V in xu8; loss of phototaxis behavior due to impaired photoreceptor activity. 2 Publications1
Mutagenesisi401R → H in xu7; loss of phototaxis behavior. Loss of phototransduction in ASJ neurons. Slightly reduces lifespan under constant white light exposure as compared to wild-type. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003527771 – 439High-energy light unresponsive protein 1Add BLAST439

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17990

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the AVG and PVT neurons of the tail.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001803, Expressed in multi-cellular organism and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C14F11.3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In contrast to other members of the family, adopts a reversed membrane topology.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TFJI, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_625900_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17990

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFHEERD

Database of Orthologous Groups

More...
OrthoDBi
776225at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013604, 7TM_chemorcpt

The PANTHER Classification System

More...
PANTHERi
PTHR21143, PTHR21143, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08395, 7tm_7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17990-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPPSSHSNI FHSTFKHTVK ETMANAKKTM IAKILSSRNK WAICDRTLYP
60 70 80 90 100
IYYLLLILGL NQSIRPNNSL LFRIYSWLVF CLLLFTTLRK FNQVGVRPNG
110 120 130 140 150
TRENLQEFFA NPRSMITLCN ALIMLSGLLA SLQLYTLGAK RLKPLKILCQ
160 170 180 190 200
FSLNVRTKQA ERRQFMINTF LAVFSGLLAL TMAATYAMSK WGYILYIVGT
210 220 230 240 250
PNLDTETIFC VLLDSYALFV SRAAISALAI LFYQHCSVIR RSIKHLINEM
260 270 280 290 300
VPAEQDECPL PESSLQKIHD CQISYQRIFN GKAVIEEYYS FVLFYSYGVC
310 320 330 340 350
IPIFCFLMFV GMSAQSICWS EVVSIVIWIV NAILVLLLFS LPAFMINEDG
360 370 380 390 400
DRLVASSFRM YHETFHEERD LTVLSQMTFF TFQIHSTKLT LSACNYFYMD
410 420 430
RSILLSLFSA ILTYFLILWE FDIKNNQSLQ NIANHTIHT
Length:439
Mass (Da):50,554
Last modified:December 1, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92D68C2A67572914
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD64541.1
AF387605 mRNA Translation: AAK70488.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T15490

NCBI Reference Sequences

More...
RefSeqi
NP_509043.3, NM_076642.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C14F11.3.1; C14F11.3.1; WBGene00001803

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C14F11.3

UCSC genome browser

More...
UCSCi
C14F11.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

A taste of light - Issue 194 of August 2017

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD64541.1
AF387605 mRNA Translation: AAK70488.1
PIRiT15490
RefSeqiNP_509043.3, NM_076642.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C14F11.3

Protein family/group databases

TCDBi1.A.69.3.5, the heteromeric odorant receptor channel (horc) family

Proteomic databases

PaxDbiQ17990

Genome annotation databases

EnsemblMetazoaiC14F11.3.1; C14F11.3.1; WBGene00001803
GeneIDi180894
KEGGicel:CELE_C14F11.3
UCSCiC14F11.3, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180894
WormBaseiC14F11.3 ; CE29579 ; WBGene00001803 ; lite-1

Phylogenomic databases

eggNOGiENOG502TFJI, Eukaryota
GeneTreeiENSGT00940000166130
HOGENOMiCLU_625900_0_0_1
InParanoidiQ17990
OMAiTFHEERD
OrthoDBi776225at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q17990

Gene expression databases

BgeeiWBGene00001803, Expressed in multi-cellular organism and 3 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR013604, 7TM_chemorcpt
PANTHERiPTHR21143, PTHR21143, 1 hit
PfamiView protein in Pfam
PF08395, 7tm_7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLITE1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17990
Secondary accession number(s): Q963E8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 1, 2001
Last modified: April 7, 2021
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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