Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 115 (05 Jun 2019)
Sequence version 3 (03 Sep 2014)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Piezo-type mechanosensitive ion channel component

Gene

pezo-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelUniRule annotation
Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.75.1.8 the mechanical nociceptor, piezo (piezo) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel componentUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pezo-1Imported
ORF Names:C10C5.1Imported, CELE_C10C5.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C10C5.1a ; CE49845 ; WBGene00007505 ; pezo-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 45HelicalUniRule annotationAdd BLAST26
Transmembranei57 – 81HelicalUniRule annotationAdd BLAST25
Transmembranei122 – 143HelicalUniRule annotationAdd BLAST22
Transmembranei175 – 199HelicalUniRule annotationAdd BLAST25
Transmembranei211 – 229HelicalUniRule annotationAdd BLAST19
Transmembranei241 – 264HelicalUniRule annotationAdd BLAST24
Transmembranei307 – 325HelicalUniRule annotationAdd BLAST19
Transmembranei452 – 471HelicalUniRule annotationAdd BLAST20
Transmembranei477 – 497HelicalUniRule annotationAdd BLAST21
Transmembranei504 – 525HelicalUniRule annotationAdd BLAST22
Transmembranei549 – 571HelicalUniRule annotationAdd BLAST23
Transmembranei625 – 646HelicalUniRule annotationAdd BLAST22
Transmembranei652 – 669HelicalUniRule annotationAdd BLAST18
Transmembranei681 – 701HelicalUniRule annotationAdd BLAST21
Transmembranei738 – 756HelicalUniRule annotationAdd BLAST19
Transmembranei817 – 838HelicalUniRule annotationAdd BLAST22
Transmembranei844 – 859HelicalUniRule annotationAdd BLAST16
Transmembranei866 – 885HelicalUniRule annotationAdd BLAST20
Transmembranei928 – 949HelicalUniRule annotationAdd BLAST22
Transmembranei1039 – 1060HelicalUniRule annotationAdd BLAST22
Transmembranei1101 – 1120HelicalUniRule annotationAdd BLAST20
Transmembranei1161 – 1180HelicalUniRule annotationAdd BLAST20
Transmembranei1186 – 1205HelicalUniRule annotationAdd BLAST20
Transmembranei1226 – 1248HelicalUniRule annotationAdd BLAST23
Transmembranei1615 – 1639HelicalUniRule annotationAdd BLAST25
Transmembranei1651 – 1674HelicalUniRule annotationAdd BLAST24
Transmembranei1705 – 1723HelicalUniRule annotationAdd BLAST19
Transmembranei1827 – 1846HelicalUniRule annotationAdd BLAST20
Transmembranei1866 – 1888HelicalUniRule annotationAdd BLAST23
Transmembranei1897 – 1915HelicalUniRule annotationAdd BLAST19
Transmembranei2039 – 2063HelicalUniRule annotationAdd BLAST25
Transmembranei2347 – 2368HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q17897

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17897 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17897

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1240 – 1455PIEZOInterPro annotationAdd BLAST216
Domaini1978 – 2431Piezo_RRas_bdgInterPro annotationAdd BLAST454

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni389 – 417DisorderedSequence analysisAdd BLAST29
Regioni764 – 794DisorderedSequence analysisAdd BLAST31
Regioni1459 – 1498DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1344 – 1364Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi771 – 794PolarSequence analysisAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIEZO (TC 1.A.75) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1893 Eukaryota
ENOG410YVF6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166986

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000022123

Database of Orthologous Groups

More...
OrthoDBi
13738at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13167 PTHR13167, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

Q17897-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVPPLLKSC VVKLLLPAAL LAAAIIRPSF LSIGYVLLAL VSAVLPPIRK
60 70 80 90 100
SLALPKLVGT FVIITFLFCL AVALGVGSYQ ISEQVVHKND RTYICNRSDT
110 120 130 140 150
TLFRSIGLVR FHPTGTFEST RAFLPEIIAT SAALLTIIIV MFLSHRDEQL
160 170 180 190 200
DVVGDVVTVR SESGREQRRQ RKLAAIMWSA IGNSLRRLTN FVLFLFTAYV
210 220 230 240 250
GIVKPSLSNS IYFLAFLFIS TWWSTYTPLR HGVYNQIKKF LIFYSALHFL
260 270 280 290 300
VLYTYQIPIV HHSWLPTGSF LPRLFGLTVL MDSSCPEWWK FPFVAPDFND
310 320 330 340 350
DDLIMKWPLY ANPIVVLVFF YLTVAQYKFT RNGSREYIDD NEYGSSVHEE
360 370 380 390 400
RFVSAGTVET NVDDVGQLIS ISESTASAPS GRGRGNTLLL SNASSSANDD
410 420 430 440 450
EQGRARSRSP LRNGEEQGSI PLRKVTSQVV DRNKLSNIFN TPGDKESAAS
460 470 480 490 500
KGMIAVMTFV IFHSYSIALT AMMTWALLYH SIFGLILLIL TCILWIFRDT
510 520 530 540 550
RKSSFAMAPI ILMYIEFLLI LQYFLSMDIH AEIGDPAWMN FVGIEWTTLP
560 570 580 590 600
VHAVIILCVQ TLLTLPVFLL LRLARREKFY ESLSDYERQR RINSYGTFGA
610 620 630 640 650
SKTGAGGVAV AKDPKSRKFA AFVEYLSNKV SVYFIFVVSV VLLVVSTCFA
660 670 680 690 700
PNFYNILFFA LWALNLIYLK FSFRLYRGLA YAFWLTLTFY TSIVIIALYI
710 720 730 740 750
YQFPGVSQWI IRNTSLSQEW LNAIGLVDFR AIGESGALFL QLLAPIALFV
760 770 780 790 800
VTMLQLKFFH GPWSRATSPR RAENDPPTST TEAAAVASTS GTQGRAHAAG
810 820 830 840 850
DTLVKKLHKL ANQTIELLWR FFEVHISKIV FVIIAIFIAN NINALYIPLV
860 870 880 890 900
ILLSLAICLP SAADGIFSLF MCAYLFLVAL SKMIYQLDIV PELSQIDRGV
910 920 930 940 950
GADNCSHGNI SMPEWFGLKK EVEGTEPIYM LFGVIVSIIA LAFQSIVIYR
960 970 980 990 1000
QRHYRASLGL PESMRAKVFP DFHHSHFDRS LKNAIQFLID YGFYKFGLEI
1010 1020 1030 1040 1050
TMIAIGIDIF NRMDALAAIQ CFWLVLFALN KRVFVRRIWV FYVIYMAILY
1060 1070 1080 1090 1100
PLQFFSYVGL PPDSCIEYPW SYWIPSYSDD ARFNLSYLLN LSIYGVNWPS
1110 1120 1130 1140 1150
AYLIGDFFVL LLASCQLAVF RREGEDNDSI YNDGNFVIKP ENPQYDFIDT
1160 1170 1180 1190 1200
KKSYVDYFKS FVFHYGHWIT LMSTLAAGIA GTSLFALGYI IFTLTMLWSG
1210 1220 1230 1240 1250
NNLYVMNSTL RSFEHTLKRW NALLGYTLFT ITMKVCLQIF GCVFLSWFDQ
1260 1270 1280 1290 1300
SGGWGKTLCI VRQLFSITCV NNECHVLKEL EDFSKACAVE TKEGNIGFDV
1310 1320 1330 1340 1350
IALSFLVFQI RIFHSWYFQH CMVEYRSEVI LANRGAVLKN QLIEKEMKEQ
1360 1370 1380 1390 1400
NEQQKAKFND IRRRTEAIRE RYQKQIERGA AERDFEPVTY GHAKRAGDYY
1410 1420 1430 1440 1450
MFKYDPENDD LVEPVDSFVP EVDPKATAYD RLDPGQIMYA ATAHDLDLAK
1460 1470 1480 1490 1500
TVQQVKKGDT IKDPDSRALI AVSEPEARKP GGTEETDGDE DEDNKDSKVE
1510 1520 1530 1540 1550
STAKFIQKMI ASALDLCSVT LNKLCREHRY VGFVLSKEKQ KLKSGHSESL
1560 1570 1580 1590 1600
SNTSRKLTDI RSAVDLPSLQ LVQSANDVEK METAVSVDWQ QKSSATRLLN
1610 1620 1630 1640 1650
AVVNCIGAHT DILCYFFAIM TQVMTGGLIT LPLPLMSLFW GNLSNPRPSK
1660 1670 1680 1690 1700
FFWVTMITYT ECVIVIKFVC QFAFMPYNSI TWRTEHQMDP MSLDKLFGVS
1710 1720 1730 1740 1750
QRDSFALWDI VLLFSLFFHR YMLRKLGLWK DANLTDTFTL KEEPRSASGS
1760 1770 1780 1790 1800
DTGSPKKIAQ EPKVVVTQSD TLEGTSGGEI VIPSDPNAVS NMEELDCEPP
1810 1820 1830 1840 1850
IPEKQSGPIG RFIHQLFHPK FRYIRDLYPI MFGIDVICFL IMTFGYSAFG
1860 1870 1880 1890 1900
EGGSGNVLDD VKASRIPVTL VVMLVGMTLA IIIDRALYLR KSVVGKLIYQ
1910 1920 1930 1940 1950
VLMIAFLHIW VFLVLPNMTR RSAISNHVAQ ALYVIKSCYF LVSAWQIRNG
1960 1970 1980 1990 2000
YPELCIGNLL THSYGMTNMI AFKVFMNIPF LFELRTAIDW TWTDTSMPLF
2010 2020 2030 2040 2050
DFFNMENFYA HIFNIKCARQ FEAAYPAPRG IPKGKLVKYM MGFPIIIGVV
2060 2070 2080 2090 2100
IFIFSPLLLW SLLNQIGTIS MPEKVTLRIS IEGYPPLYEM EAQGSNHDNA
2110 2120 2130 2140 2150
ELGMIKPDQL ASLNQALTDS YTTRDTNSIL RSRMSVSYLK GYTYEDILIV
2160 2170 2180 2190 2200
RFRPESEIYW PISQDSRNAM IDKLSRNTSV NFEVSLEFTR PYDPNENAAL
2210 2220 2230 2240 2250
KHSKSWLVPI SLDMTIRAKI QSALRGDPGH PILIPQSIPA FIQVPNQGEL
2260 2270 2280 2290 2300
TLPTSIGNTI INDGNPRINT TGMEKSDEAR AWFDSLTLNL EQGKSQNEKM
2310 2320 2330 2340 2350
WIATSEHPGD QNAKLWIKTA NTTYSGRPYL QVVGFIDRAF PSFLAKVFKG
2360 2370 2380 2390 2400
GVIAVYLSVI LVVGRGLVRG IFTTSPSTVM FTELPNADHL LKICLDIYLV
2410 2420 2430
REAKDFMLEQ DLFAKLIFLF RSPATLIEWT RMSKKKQE
Length:2,438
Mass (Da):276,345
Last modified:September 3, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C6FD22DBA4C4657
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D0VWN8D0VWN8_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C6KRJ3C6KRJ3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,400Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061ACU2A0A061ACU2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,442Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9G2S3H9G2S3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AJB7A0A061AJB7_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,404Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9G2S2H9G2S2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AE33A0A061AE33_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AL01A0A061AL01_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,686Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O01260O01260_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,704Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9WRT3B9WRT3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,730Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92444.3

NCBI Reference Sequences

More...
RefSeqi
NP_001255389.2, NM_001268460.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C10C5.1a; C10C5.1a; WBGene00007505

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
182492

UCSC genome browser

More...
UCSCi
C10C5.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92444.3
RefSeqiNP_001255389.2, NM_001268460.2

3D structure databases

SMRiQ17897
ModBaseiSearch...

Protein family/group databases

TCDBi1.A.75.1.8 the mechanical nociceptor, piezo (piezo) family

Proteomic databases

EPDiQ17897

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC10C5.1a; C10C5.1a; WBGene00007505
GeneIDi182492
UCSCiC10C5.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
182492
WormBaseiC10C5.1a ; CE49845 ; WBGene00007505 ; pezo-1

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00940000166986
HOGENOMiHOG000022123
OrthoDBi13738at2759

Gene expression databases

BgeeiWBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiQ17897 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ17897_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17897
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: September 3, 2014
Last modified: June 5, 2019
This is version 115 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again