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Entry version 166 (26 Feb 2020)
Sequence version 2 (11 Jul 2012)
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Protein

Serine protease svh-1

Gene

svh-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease which ensures proper pharyngeal pumping during larval growth by regulating the levels of extracellular matrix component fbl-1 (PubMed:25464847). Independently of its enzymatic activity and probably by acting as a ligand for tyrosine-protein kinase receptor svh-2, involved in axon regeneration after injury by promoting the generation of productive and stable growth cones (PubMed:22388962, PubMed:25464847). May play a role in gonad development (PubMed:25464847).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei755Charge relay systemPROSITE-ProRule annotation1 Publication1
Active sitei803Charge relay systemPROSITE-ProRule annotation1
Active sitei898Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.B69

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine protease svh-1Curated (EC:3.4.21.-PROSITE-ProRule annotation)
Alternative name(s):
HGF/MSP/plasminogen-like protein svh-11 Publication
Suppressor of vhp-1 deletion lethality protein svh-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:svh-1Imported
ORF Names:C07G1.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C07G1.1 ; CE47478 ; WBGene00006620 ; svh-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2 – 17Missing : Probably prevents secretion. Impaired axon regeneration following injury. Impaired larval growth. 2 PublicationsAdd BLAST16
Mutagenesisi755H → A in h755a: Impaired larval growth. No defect in axon regeneration following injury. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044858728 – 951Serine protease svh-1Sequence analysisAdd BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi241N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi320 ↔ 333PROSITE-ProRule annotation
Disulfide bondi327 ↔ 346PROSITE-ProRule annotation
Glycosylationi329N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi340 ↔ 355PROSITE-ProRule annotation
Disulfide bondi387 ↔ 410PROSITE-ProRule annotation
Disulfide bondi391 ↔ 398PROSITE-ProRule annotation
Disulfide bondi461 ↔ 571PROSITE-ProRule annotation
Glycosylationi464N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi474 ↔ 584PROSITE-ProRule annotation
Glycosylationi536N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi544N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi545 ↔ 561PROSITE-ProRule annotation
Disulfide bondi558 ↔ 571PROSITE-ProRule annotation
Disulfide bondi566 ↔ 584PROSITE-ProRule annotation
Disulfide bondi578 ↔ 593PROSITE-ProRule annotation
Glycosylationi602N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi622 ↔ 681PROSITE-ProRule annotation
Disulfide bondi635 ↔ 693PROSITE-ProRule annotation
Glycosylationi650N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi661 ↔ 673PROSITE-ProRule annotation
Disulfide bondi740 ↔ 756PROSITE-ProRule annotation
Glycosylationi776N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi838 ↔ 904PROSITE-ProRule annotation
Disulfide bondi867 ↔ 883PROSITE-ProRule annotation
Glycosylationi869N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi894 ↔ 923PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17800

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in ADL sensory neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006620 Expressed in multi-cellular organism and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C07G1.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini234 – 304KringlePROSITE-ProRule annotationAdd BLAST71
Domaini319 – 356LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini355 – 435PANPROSITE-ProRule annotationAdd BLAST81
Domaini433 – 585SRCR 1PROSITE-ProRule annotationAdd BLAST153
Domaini557 – 594LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST38
Domaini598 – 694SRCR 2PROSITE-ProRule annotationAdd BLAST97
Domaini713 – 947Peptidase S1PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Kringle domain is dispensable for larval growth and axon regeneration after injury.1 Publication
The PAN domain is required to maintain gonad structure and thus fertility. Dispensable for larval growth.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000172378

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_315286_0_0_1

KEGG Orthology (KO)

More...
KOi
K23489

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQCDYEV

Database of Orthologous Groups

More...
OrthoDBi
158600at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00108 KR, 1 hit
cd00112 LDLa, 2 hits
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.20.10, 1 hit
3.10.100.10, 1 hit
3.10.250.10, 1 hit
4.10.400.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000001 Kringle
IPR013806 Kringle-like
IPR038178 Kringle_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00051 Kringle, 1 hit
PF00057 Ldl_recept_a, 1 hit
PF00089 Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00130 KR, 1 hit
SM00192 LDLa, 2 hits
SM00473 PAN_AP, 1 hit
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF56436 SSF56436, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 2 hits
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 2 hits
PS50948 PAN, 1 hit
PS50287 SRCR_2, 2 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q17800-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYIVIVTMRT ILFFGIFFIF IFQCAKCIEL KIFEDLLEVR SQSGLFFPLC
60 70 80 90 100
SKSFHQKYGE QACASISSTF LSYSTVSLQQ YTYSVGCTTS VCFTFLSSFC
110 120 130 140 150
KTGVKVFCSP SLCASGTLQI GSKCLSISTV PVQGYSEANY YCNPATLISS
160 170 180 190 200
LKPTEIESIR DTILPTFADT RLFLTSGLRQ GATWKWGNGD TVEQEVTGTG
210 220 230 240 250
RCLALQAGNL VAIDCDSEAY VFCESGRECI ARDKEYSGTA NRTSDGKMCL
260 270 280 290 300
MWNDPTVLFR RERDLEILNH NFCRFVNDAD GKKSATPVCY TKPNELSQCY
310 320 330 340 350
IPPCPESFND VVPIESGDSC PIGSISCDNG SKCISEKFQC DYEVDCNDGS
360 370 380 390 400
DEHNCEDYLQ YYELIGAYRL ADNIIEVWTF IPHVQGCARK CRESLLMCEA
410 420 430 440 450
FSYEPKSQTC LLTDTSQTFS SLARKITSLY YRRRFSTKDV EFQVENKVLY
460 470 480 490 500
ATKSAKKGHV CDDNYSREKL SSICRVLGFG DPIYTVESHQ SESSLGPLQP
510 520 530 540 550
TTLHPTNPSF DSPSSVSQMR RTSPSATLAP RLPAWNLSCL REPNCTSTVI
560 570 580 590 600
STCEPIRCSH CQQAACGDGS CIRFDQLCNG QIDCQSGEDE DYCRANSFRL
610 620 630 640 650
TNGSDTSGYL EVLFRSRWEP ICADHLNGKI SNSICDAMRL GEHGFILSTN
660 670 680 690 700
ATISSGYNVN CDVDCSIRRS SSCTRHARIS CISQNGMSSA SQCGLRYVEV
710 720 730 740 750
NARDAAKSRI ARVVGGFETV PGAFPWTAAL RNKATKAHHC GASILDKTHL
760 770 780 790 800
ITAAHCFEED ERVSSYEVVV GDWDNNQTDG NEQIFYLQRI HFYPLYKDIF
810 820 830 840 850
SHDIAILEIP YPGIEFNEYA QPICLPSKDF VYTPGRQCVV SGWGSMGLRY
860 870 880 890 900
AERLQAALIP IINRFDCVNS SQIYSSMSRS AFCAGYLEGG IDSCQGDSGG
910 920 930 940 950
PFACRREDGA FVLAGVISWG DGCAQKKQPG IYTMVAPYLS WISAIINGQP

V
Length:951
Mass (Da):105,383
Last modified:July 11, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DA09F6600B7AC45
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB693146 mRNA Translation: BAL45941.1
BX284604 Genomic DNA Translation: CCD61391.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T15451

NCBI Reference Sequences

More...
RefSeqi
NP_501379.2, NM_068978.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C07G1.1.1; C07G1.1.1; WBGene00006620

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
182375

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C07G1.1

UCSC genome browser

More...
UCSCi
C07G1.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB693146 mRNA Translation: BAL45941.1
BX284604 Genomic DNA Translation: CCD61391.2
PIRiT15451
RefSeqiNP_501379.2, NM_068978.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C07G1.1

Protein family/group databases

MEROPSiS01.B69

Proteomic databases

PaxDbiQ17800

Genome annotation databases

EnsemblMetazoaiC07G1.1.1; C07G1.1.1; WBGene00006620
GeneIDi182375
KEGGicel:CELE_C07G1.1
UCSCiC07G1.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
182375
WormBaseiC07G1.1 ; CE47478 ; WBGene00006620 ; svh-1

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000172378
HOGENOMiCLU_315286_0_0_1
KOiK23489
OMAiFQCDYEV
OrthoDBi158600at2759

Gene expression databases

BgeeiWBGene00006620 Expressed in multi-cellular organism and 2 other tissues

Family and domain databases

CDDicd00108 KR, 1 hit
cd00112 LDLa, 2 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 1 hit
3.10.100.10, 1 hit
3.10.250.10, 1 hit
4.10.400.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000001 Kringle
IPR013806 Kringle-like
IPR038178 Kringle_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00051 Kringle, 1 hit
PF00057 Ldl_recept_a, 1 hit
PF00089 Trypsin, 1 hit
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00130 KR, 1 hit
SM00192 LDLa, 2 hits
SM00473 PAN_AP, 1 hit
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF56436 SSF56436, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 2 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 2 hits
PS50948 PAN, 1 hit
PS50287 SRCR_2, 2 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVH1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17800
Secondary accession number(s): H1AGA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2019
Last sequence update: July 11, 2012
Last modified: February 26, 2020
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. Peptidase families
    Classification of peptidase families and list of entries
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