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Entry version 130 (08 May 2019)
Sequence version 2 (02 Oct 2007)
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Protein

Septin and tuftelin-interacting protein 1 homolog

Gene

stip-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in pre-mRNA splicing (By similarity). Required for embryonic development and survival.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Septin and tuftelin-interacting protein 1 homolog
Short name:
STIP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:stip-1
Synonyms:stip
ORF Names:C07E3.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C07E3.1a ; CE41502 ; WBGene00007412 ; stip-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003422831 – 830Septin and tuftelin-interacting protein 1 homologAdd BLAST830

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q17784

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17784

PeptideAtlas

More...
PeptideAtlasi
Q17784

PRoteomics IDEntifications database

More...
PRIDEi
Q17784

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in muscle cells from body, pharynx and vulva, in neurons from head and tail, in pharyngeal gland and in tail hypodermal cells.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in oocyte, embryo, larval stage 1 to 4, and in adult.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007412 Expressed in 5 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17784 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex (By similarity). Can assemble into large rod-like polymers.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
39919, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-25481N

Protein interaction database and analysis system

More...
IntActi
Q17784, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C07E3.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17784

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini153 – 199G-patchPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 49Poly-Asp7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFP11/STIP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2184 Eukaryota
ENOG410XP4Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230471

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17784

KEGG Orthology (KO)

More...
KOi
K13103

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWEWHEL

Database of Orthologous Groups

More...
OrthoDBi
1238995at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17784

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000467 G_patch_dom
IPR022783 GCFC_dom
IPR024933 STIP
IPR022159 STIP/TFIP11_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01585 G-patch, 1 hit
PF07842 GCFC, 1 hit
PF12457 TIP_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017706 TFIP11, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00443 G_patch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50174 G_PATCH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q17784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDDDGRESF EINDMDLEYA MNPGGRRRFQ NKDQATYGVF APDSDDDDDE
60 70 80 90 100
QGTSRGPYKK RSKISAPMSF VSGGIQQGNK IDKDDPASLN LNLGGEKKPK
110 120 130 140 150
EDDEGSIQID FDKRTKKAPK QNGAQVFAGM RSSANHGAAD INQFGSWMRG
160 170 180 190 200
DGNSNKIMKM MQAMGYKPGE GLGAQGQGIV EPVQAQLRKG RGAVGAYGKE
210 220 230 240 250
STATGPKFGE SAADAQKRMA QEGTSSRPTN DDQEKSGLKI KGSWKKSQTV
260 270 280 290 300
KTKYRTIEDV MEEGMSASRP ASHQQSQQYS NIKVIDMTGK QQKIYSGYDS
310 320 330 340 350
FSMKTRSEYD TVDDEERTVF DVPELIHNLN LLVDLTEEGI RRSNQQLISL
360 370 380 390 400
KDQTTALEYD LQQVQKSLGT EEQEAQHIKD VYELIDGFSS NRSPSMEECQ
410 420 430 440 450
ELFRRLRSEF PHEYELYSLE TVAIPTVLPL IQKYFVAWKP LEDKNYGCEL
460 470 480 490 500
ISTWRDILDD SKNGRKMTFG HNKTKGDEIR AYDRIIWEGI LPSIRRACLQ
510 520 530 540 550
WDPSTQMHEM IELVEQWIPL LSAWITENIL EQLVVPKIAE RVNQWDPMTD
560 570 580 590 600
EIPIHEWLVP WLVLLGDRIQ TVMPPIRQKL SKALKLWDPM DRSALETLRP
610 620 630 640 650
WQNVWSAATF SAFIAQNIVP KLGVALDTME LNPTMNPEYP EWTACMEWLE
660 670 680 690 700
FTHPDAIANI VTKYFFPRFY NCLCLWLDSP GVDYNEVKRW YGSWKARIPQ
710 720 730 740 750
VLVNYPTVNE NLRRSMIAIG RSLQGEKVGG LQATPIAPMA PPPPMAPHFT
760 770 780 790 800
QAAPVQKLSL KEIIEYTAGK NGFTYHPQKD RYKDGRQVFW FGALSIYLDS
810 820 830
EMVYVMDPIE FVWRPSGLNE LIQMAQGAQG
Length:830
Mass (Da):94,313
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC374A3301F6FF380
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9U3R2Q9U3R2_CAEEL
TIP_N domain-containing protein
stip-1 C07E3.1, CELE_C07E3.1
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ342049 mRNA Translation: ABC69941.1
Z49908 Genomic DNA Translation: CAA90093.2

NCBI Reference Sequences

More...
RefSeqi
NP_496226.2, NM_063825.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C07E3.1a.1; C07E3.1a.1; WBGene00007412
C07E3.1a.2; C07E3.1a.2; WBGene00007412

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C07E3.1

UCSC genome browser

More...
UCSCi
C07E3.1a c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ342049 mRNA Translation: ABC69941.1
Z49908 Genomic DNA Translation: CAA90093.2
RefSeqiNP_496226.2, NM_063825.4

3D structure databases

SMRiQ17784
ModBaseiSearch...

Protein-protein interaction databases

BioGridi39919, 2 interactors
DIPiDIP-25481N
IntActiQ17784, 2 interactors
STRINGi6239.C07E3.1a

Proteomic databases

EPDiQ17784
PaxDbiQ17784
PeptideAtlasiQ17784
PRIDEiQ17784

Genome annotation databases

EnsemblMetazoaiC07E3.1a.1; C07E3.1a.1; WBGene00007412
C07E3.1a.2; C07E3.1a.2; WBGene00007412
GeneIDi174600
KEGGicel:CELE_C07E3.1
UCSCiC07E3.1a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174600
WormBaseiC07E3.1a ; CE41502 ; WBGene00007412 ; stip-1

Phylogenomic databases

eggNOGiKOG2184 Eukaryota
ENOG410XP4Y LUCA
GeneTreeiENSGT00390000012739
HOGENOMiHOG000230471
InParanoidiQ17784
KOiK13103
OMAiVWEWHEL
OrthoDBi1238995at2759
PhylomeDBiQ17784

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q17784

Gene expression databases

BgeeiWBGene00007412 Expressed in 5 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiQ17784 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR022783 GCFC_dom
IPR024933 STIP
IPR022159 STIP/TFIP11_N
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF07842 GCFC, 1 hit
PF12457 TIP_N, 1 hit
PIRSFiPIRSF017706 TFIP11, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFP11_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17784
Secondary accession number(s): A1XDB6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 2, 2007
Last modified: May 8, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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