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Entry version 142 (26 Feb 2020)
Sequence version 1 (01 Nov 1997)
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Protein

Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2

Gene

rpb-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-112382 Formation of RNA Pol II elongation complex
R-CEL-113418 Formation of the Early Elongation Complex
R-CEL-5578749 Transcriptional regulation by small RNAs
R-CEL-674695 RNA Polymerase II Pre-transcription Events
R-CEL-6781823 Formation of TC-NER Pre-Incision Complex
R-CEL-6782135 Dual incision in TC-NER
R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-CEL-6803529 FGFR2 alternative splicing
R-CEL-6807505 RNA polymerase II transcribes snRNA genes
R-CEL-72086 mRNA Capping
R-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-72165 mRNA Splicing - Minor Pathway
R-CEL-73762 RNA Polymerase I Transcription Initiation
R-CEL-73772 RNA Polymerase I Promoter Escape
R-CEL-73776 RNA Polymerase II Promoter Escape
R-CEL-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-CEL-75953 RNA Polymerase II Transcription Initiation
R-CEL-75955 RNA Polymerase II Transcription Elongation
R-CEL-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-CEL-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-CEL-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2
Short name:
RNA polymerases I, II, and III subunit ABC2
Alternative name(s):
RPB6 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpb-6
ORF Names:C06A1.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C06A1.5 ; CE02117 ; WBGene00007355 ; rpb-6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001338041 – 137Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2Add BLAST137

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q17684

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17684

PeptideAtlas

More...
PeptideAtlasi
Q17684

PRoteomics IDEntifications database

More...
PRIDEi
Q17684

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007355 Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
39944, 22 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C06A1.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17684

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3405 Eukaryota
COG1758 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010415

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_112527_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17684

KEGG Orthology (KO)

More...
KOi
K03014

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTTPFMT

Database of Orthologous Groups

More...
OrthoDBi
1488436at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17684

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.940.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00192 RNApol_arch_K, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020708 DNA-dir_RNA_polK_14-18kDa_CS
IPR018247 EF_Hand_1_Ca_BS
IPR006110 Pol_omega/K/RPB6
IPR012293 RNAP_RPB6_omega
IPR028363 RPB6
IPR036161 RPB6/omega-like_sf
IPR006111 RpoK/Rpb6

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01192 RNA_pol_Rpb6, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF500154 RPB6, 1 hit
PIRSF000778 RpoK/RPB6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63562 SSF63562, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01111 RNA_POL_K_14KD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17684-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEDDYQDM DNDDFVDDNE MEDVIEEDPQ RPDNEDEDDD NVDENFELFD
60 70 80 90 100
QGKAVPTSEH VTTPFMTKYE RARVLGTRAL QIAMGAPVMV ELEGETDPLE
110 120 130
IARKELKQRR IPIIVRRYLP DGSYEDWPTD QLQLADW
Length:137
Mass (Da):15,983
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB98B5EF719373CBC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49886 Genomic DNA Translation: CAA90053.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18973

NCBI Reference Sequences

More...
RefSeqi
NP_496278.1, NM_063877.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C06A1.5.1; C06A1.5.1; WBGene00007355

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C06A1.5

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49886 Genomic DNA Translation: CAA90053.1
PIRiT18973
RefSeqiNP_496278.1, NM_063877.3

3D structure databases

SMRiQ17684
ModBaseiSearch...

Protein-protein interaction databases

BioGridi39944, 22 interactors
STRINGi6239.C06A1.5

Proteomic databases

EPDiQ17684
PaxDbiQ17684
PeptideAtlasiQ17684
PRIDEiQ17684

Genome annotation databases

EnsemblMetazoaiC06A1.5.1; C06A1.5.1; WBGene00007355
GeneIDi174630
KEGGicel:CELE_C06A1.5

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174630
WormBaseiC06A1.5 ; CE02117 ; WBGene00007355 ; rpb-6

Phylogenomic databases

eggNOGiKOG3405 Eukaryota
COG1758 LUCA
GeneTreeiENSGT00390000010415
HOGENOMiCLU_112527_0_1_1
InParanoidiQ17684
KOiK03014
OMAiVTTPFMT
OrthoDBi1488436at2759
PhylomeDBiQ17684

Enzyme and pathway databases

ReactomeiR-CEL-112382 Formation of RNA Pol II elongation complex
R-CEL-113418 Formation of the Early Elongation Complex
R-CEL-5578749 Transcriptional regulation by small RNAs
R-CEL-674695 RNA Polymerase II Pre-transcription Events
R-CEL-6781823 Formation of TC-NER Pre-Incision Complex
R-CEL-6782135 Dual incision in TC-NER
R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-CEL-6803529 FGFR2 alternative splicing
R-CEL-6807505 RNA polymerase II transcribes snRNA genes
R-CEL-72086 mRNA Capping
R-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-72165 mRNA Splicing - Minor Pathway
R-CEL-73762 RNA Polymerase I Transcription Initiation
R-CEL-73772 RNA Polymerase I Promoter Escape
R-CEL-73776 RNA Polymerase II Promoter Escape
R-CEL-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-CEL-75953 RNA Polymerase II Transcription Initiation
R-CEL-75955 RNA Polymerase II Transcription Elongation
R-CEL-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-CEL-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-CEL-9018519 Estrogen-dependent gene expression

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q17684

Gene expression databases

BgeeiWBGene00007355 Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di3.90.940.10, 1 hit
HAMAPiMF_00192 RNApol_arch_K, 1 hit
InterProiView protein in InterPro
IPR020708 DNA-dir_RNA_polK_14-18kDa_CS
IPR018247 EF_Hand_1_Ca_BS
IPR006110 Pol_omega/K/RPB6
IPR012293 RNAP_RPB6_omega
IPR028363 RPB6
IPR036161 RPB6/omega-like_sf
IPR006111 RpoK/Rpb6
PfamiView protein in Pfam
PF01192 RNA_pol_Rpb6, 1 hit
PIRSFiPIRSF500154 RPB6, 1 hit
PIRSF000778 RpoK/RPB6, 1 hit
SUPFAMiSSF63562 SSF63562, 1 hit
PROSITEiView protein in PROSITE
PS01111 RNA_POL_K_14KD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPAB2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17684
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 26, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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