UniProtKB - Q17684 (RPAB2_CAEEL)
Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2
rpb-6
Functioni
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
By similarityGO - Molecular functioni
- DNA binding Source: InterPro
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- developmental process Source: UniProtKB
- reproduction Source: UniProtKB
- transcription, DNA-templated Source: InterPro
Keywordsi
Biological process | Transcription |
Enzyme and pathway databases
Reactomei | R-CEL-112382, Formation of RNA Pol II elongation complex R-CEL-113418, Formation of the Early Elongation Complex R-CEL-5578749, Transcriptional regulation by small RNAs R-CEL-674695, RNA Polymerase II Pre-transcription Events R-CEL-6781823, Formation of TC-NER Pre-Incision Complex R-CEL-6782135, Dual incision in TC-NER R-CEL-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-CEL-6796648, TP53 Regulates Transcription of DNA Repair Genes R-CEL-6803529, FGFR2 alternative splicing R-CEL-6807505, RNA polymerase II transcribes snRNA genes R-CEL-72086, mRNA Capping R-CEL-72163, mRNA Splicing - Major Pathway R-CEL-72165, mRNA Splicing - Minor Pathway R-CEL-73762, RNA Polymerase I Transcription Initiation R-CEL-73772, RNA Polymerase I Promoter Escape R-CEL-73776, RNA Polymerase II Promoter Escape R-CEL-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-CEL-75953, RNA Polymerase II Transcription Initiation R-CEL-75955, RNA Polymerase II Transcription Elongation R-CEL-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-CEL-77075, RNA Pol II CTD phosphorylation and interaction with CE R-CEL-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2Short name: RNA polymerases I, II, and III subunit ABC2 Alternative name(s): RPB6 homolog |
Gene namesi | Name:rpb-6 ORF Names:C06A1.5 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | C06A1.5 ; CE02117 ; WBGene00007355 ; rpb-6 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- RNA polymerase I complex Source: GO_Central
- RNA polymerase II, core complex Source: GO_Central
- RNA polymerase III complex Source: GO_Central
Keywords - Cellular componenti
DNA-directed RNA polymerase, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000133804 | 1 – 137 | Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2Add BLAST | 137 |
Proteomic databases
EPDi | Q17684 |
PaxDbi | Q17684 |
PeptideAtlasi | Q17684 |
Expressioni
Gene expression databases
Bgeei | WBGene00007355, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Subunit structurei
Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
By similarityProtein-protein interaction databases
BioGRIDi | 39944, 22 interactors |
STRINGi | 6239.C06A1.5 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3405, Eukaryota |
GeneTreei | ENSGT00390000010415 |
HOGENOMi | CLU_112527_0_1_1 |
InParanoidi | Q17684 |
OMAi | YQDMDND |
OrthoDBi | 1488436at2759 |
PhylomeDBi | Q17684 |
Family and domain databases
Gene3Di | 3.90.940.10, 1 hit |
HAMAPi | MF_00192, RNApol_arch_Rpo6, 1 hit |
InterProi | View protein in InterPro IPR020708, DNA-dir_RNA_polK_14-18kDa_CS IPR018247, EF_Hand_1_Ca_BS IPR006110, Pol_omega/K/RPB6 IPR028363, RPB6 IPR036161, RPB6/omega-like_sf IPR006111, RpoK/Rpb6 |
Pfami | View protein in Pfam PF01192, RNA_pol_Rpb6, 1 hit |
PIRSFi | PIRSF500154, RPB6, 1 hit PIRSF000778, RpoK/RPB6, 1 hit |
SUPFAMi | SSF63562, SSF63562, 1 hit |
PROSITEi | View protein in PROSITE PS01111, RNA_POL_K_14KD, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MADEDDYQDM DNDDFVDDNE MEDVIEEDPQ RPDNEDEDDD NVDENFELFD
60 70 80 90 100
QGKAVPTSEH VTTPFMTKYE RARVLGTRAL QIAMGAPVMV ELEGETDPLE
110 120 130
IARKELKQRR IPIIVRRYLP DGSYEDWPTD QLQLADW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49886 Genomic DNA Translation: CAA90053.1 |
PIRi | T18973 |
RefSeqi | NP_496278.1, NM_063877.3 |
Genome annotation databases
EnsemblMetazoai | C06A1.5.1; C06A1.5.1; WBGene00007355 |
GeneIDi | 174630 |
KEGGi | cel:CELE_C06A1.5 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49886 Genomic DNA Translation: CAA90053.1 |
PIRi | T18973 |
RefSeqi | NP_496278.1, NM_063877.3 |
3D structure databases
SMRi | Q17684 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 39944, 22 interactors |
STRINGi | 6239.C06A1.5 |
Proteomic databases
EPDi | Q17684 |
PaxDbi | Q17684 |
PeptideAtlasi | Q17684 |
Genome annotation databases
EnsemblMetazoai | C06A1.5.1; C06A1.5.1; WBGene00007355 |
GeneIDi | 174630 |
KEGGi | cel:CELE_C06A1.5 |
Organism-specific databases
CTDi | 174630 |
WormBasei | C06A1.5 ; CE02117 ; WBGene00007355 ; rpb-6 |
Phylogenomic databases
eggNOGi | KOG3405, Eukaryota |
GeneTreei | ENSGT00390000010415 |
HOGENOMi | CLU_112527_0_1_1 |
InParanoidi | Q17684 |
OMAi | YQDMDND |
OrthoDBi | 1488436at2759 |
PhylomeDBi | Q17684 |
Enzyme and pathway databases
Reactomei | R-CEL-112382, Formation of RNA Pol II elongation complex R-CEL-113418, Formation of the Early Elongation Complex R-CEL-5578749, Transcriptional regulation by small RNAs R-CEL-674695, RNA Polymerase II Pre-transcription Events R-CEL-6781823, Formation of TC-NER Pre-Incision Complex R-CEL-6782135, Dual incision in TC-NER R-CEL-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-CEL-6796648, TP53 Regulates Transcription of DNA Repair Genes R-CEL-6803529, FGFR2 alternative splicing R-CEL-6807505, RNA polymerase II transcribes snRNA genes R-CEL-72086, mRNA Capping R-CEL-72163, mRNA Splicing - Major Pathway R-CEL-72165, mRNA Splicing - Minor Pathway R-CEL-73762, RNA Polymerase I Transcription Initiation R-CEL-73772, RNA Polymerase I Promoter Escape R-CEL-73776, RNA Polymerase II Promoter Escape R-CEL-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-CEL-75953, RNA Polymerase II Transcription Initiation R-CEL-75955, RNA Polymerase II Transcription Elongation R-CEL-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-CEL-77075, RNA Pol II CTD phosphorylation and interaction with CE R-CEL-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
PROi | PR:Q17684 |
Gene expression databases
Bgeei | WBGene00007355, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
Gene3Di | 3.90.940.10, 1 hit |
HAMAPi | MF_00192, RNApol_arch_Rpo6, 1 hit |
InterProi | View protein in InterPro IPR020708, DNA-dir_RNA_polK_14-18kDa_CS IPR018247, EF_Hand_1_Ca_BS IPR006110, Pol_omega/K/RPB6 IPR028363, RPB6 IPR036161, RPB6/omega-like_sf IPR006111, RpoK/Rpb6 |
Pfami | View protein in Pfam PF01192, RNA_pol_Rpb6, 1 hit |
PIRSFi | PIRSF500154, RPB6, 1 hit PIRSF000778, RpoK/RPB6, 1 hit |
SUPFAMi | SSF63562, SSF63562, 1 hit |
PROSITEi | View protein in PROSITE PS01111, RNA_POL_K_14KD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RPAB2_CAEEL | |
Accessioni | Q17684Primary (citable) accession number: Q17684 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families