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Entry version 124 (26 Feb 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Nuclear pore complex protein 14

Gene

npp-14

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity). Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-159227 Transport of the SLBP independent Mature mRNA
R-CEL-159230 Transport of the SLBP Dependant Mature mRNA
R-CEL-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins
R-CEL-3232142 SUMOylation of ubiquitinylation proteins
R-CEL-3301854 Nuclear Pore Complex (NPC) Disassembly
R-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-4085377 SUMOylation of SUMOylation proteins
R-CEL-4551638 SUMOylation of chromatin organization proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein 14Imported
Alternative name(s):
Nuclear pore complex protein Nup214Curated
Nucleoporin npp-14Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:npp-14Imported
ORF Names:C03D6.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
C03D6.4 ; CE05198 ; WBGene00003800 ; npp-14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes no visible phenotype (PubMed:12937276). Simultaneous knockdown of npp-2 results in embryonic lethality (PubMed:12937276). RNAi-mediated knockdown in a ced-1 (e1735) and ced-3 (n718) double mutant background partially restores embryonic cell apoptosis (PubMed:27723735).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004401641 – 1390Nuclear pore complex protein 14CuratedAdd BLAST1390

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q17602

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17602

PeptideAtlas

More...
PeptideAtlasi
Q17602

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003800 Expressed in material anatomical entity and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with caspase ced-3 (via propeptide); the interaction tethers ced-3 to the nuclear membrane and prevents its autoprocessing in absence of ced-4.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C03D6.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17602

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1073 – 10741Curated2
Repeati1091 – 10922Curated2
Repeati1111 – 11123Curated2
Repeati1122 – 11234Curated2
Repeati1125 – 11265Curated2
Repeati1163 – 11646Curated2
Repeati1166 – 11677Curated2
Repeati1178 – 11798Curated2
Repeati1244 – 12459Curated2
Repeati1283 – 128410Curated2
Repeati1289 – 129011Curated2
Repeati1295 – 129612Curated2
Repeati1300 – 130113Curated2
Repeati1315 – 131614Curated2
Repeati1344 – 134515Curated2
Repeati1357 – 135816Curated2
Repeati1372 – 137317Curated2

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1073 – 137317 X 2 AA repeats of F-GCuratedAdd BLAST301

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3630 Eukaryota
ENOG410YBVS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165854

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_253002_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17602

KEGG Orthology (KO)

More...
KOi
K14317

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCGCWSP

Database of Orthologous Groups

More...
OrthoDBi
302566at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026054 Nucleoporin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23193 PTHR23193, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17602-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNEDVAEDV SQVTDFHFHT CRKFRLFSSK SDGYSQNEIN IRNRVATSSQ
60 70 80 90 100
LGVTFVTVNS NQLSCFHTKS LLGYKITREN MNVEVTDLPI KTIRLHGVVL
110 120 130 140 150
INDMGVNSDG TVLGVLHTKN NDVSVDVFDI KKICTSSSIE PFKPLCTTRV
160 170 180 190 200
GTEQINQGSC LEWNPAFPDT FAASSTDRSI LVAKINVQSP ANQKLVGIGK
210 220 230 240 250
FGAVTTAISW SPKGKQLTIG DSLGKIVQLK PELEVVRSQH GPENKPNYGR
260 270 280 290 300
ITGLCWLATT EWLVSLENGT DQDAYLMRCK KDKPTEWIQF HELSYSSSKW
310 320 330 340 350
PLPPQLFPAT QLLVDWNVVI VGNSKTSEIS TVGKRDDWQT WVPVEGESIY
360 370 380 390 400
LPTTSSGKDT VPIGVAVDRS MTDEVLLNPD GSQRHRPSPL VLCLTNDGIL
410 420 430 440 450
TAHHIISTFA AHIPCQMSSQ NLAINDLKKL QFDSQKPISA PPSDQTPVTK
460 470 480 490 500
PSTVFGQKPE AETLKSSLVG SPSSVQTPKP SSSLFNPKSI ASNIETSQLT
510 520 530 540 550
ESKPSTPAAP SSQPKIASTP KSEAIPKISD KTLEHKKAEL IATKKQVLIE
560 570 580 590 600
RMDKINDSMA GAKDATMKLS FAVGKVKTTI MECADVVRAS LGDSKEVMDE
610 620 630 640 650
LKNLILSIER MSDRTQHTVK EMDFEIDEKM ELVAGVEDGN QVLEKLRNMS
660 670 680 690 700
ETEKLMRFNK LETAADLLNG KYEECSDLIK KLRMSLSEKE SLRKQAILSP
710 720 730 740 750
LRLSSNLNQL RSGSETELAL KVMRNVSKII MDTREQIQRT ELEFVRFQRD
760 770 780 790 800
VKFQNFKKGK ENLNFTQPLE MSSLDGDAPQ GKSLTDAESI KVRQALVNQI
810 820 830 840 850
QKRGIVKTRN VIVESYKKSE NSAAMKNDLL DTSNLSNAIL KLSMTPRRVM
860 870 880 890 900
PSSSLFSASP STPSTKSDAA TQADEPPIVK TVVVTVESPA KPIASAPAVS
910 920 930 940 950
SPLIKLNTTT ATTTMTTPKV TVPKEEANKT QDQKPIISTP ASSSIFSSGS
960 970 980 990 1000
LFGTKTQTPL VSKEESTLTT GVPSLINSSL SISPQEIEKA SSKVETLNKT
1010 1020 1030 1040 1050
EEVKDEKSEN EVTPDLKSEE PKSLETKVKE EPKPAVQTPV KEEETGSNIQ
1060 1070 1080 1090 1100
KTPSFSFNST TTPKSTSSTS SIFGGGLKTQ TPSSSNSTNI FGARTTTTAT
1110 1120 1130 1140 1150
PTPASNTSSI FGGGSKAASS PFGSFGQAGC QPAKTSNPAT STASVTFSFN
1160 1170 1180 1190 1200
TGATSASAKP AGFGSFGAGA SAKPSSVFGG SVTAPTVPNV DDGMEDDSMA
1210 1220 1230 1240 1250
NGGGSGGFMS GLGNARTSNT SGGNNPFAPK TSTGTSASSS SWLFGGGGNQ
1260 1270 1280 1290 1300
QQQQQQKPSF SFNTAGSSAQ QASAPATGTS SVFGGAPKFG SQPAFGAKPF
1310 1320 1330 1340 1350
GGGANAGLSK NASIFGGATS STTNNPATGG FAQFASGQKT SSLFGGGATP
1360 1370 1380 1390
QTNTSIFGGG ANTTPAPTSS VFGGGASANA NKPTSFTSWR
Length:1,390
Mass (Da):147,968
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FD1DB4D3B7E43D3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA99763.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18883

NCBI Reference Sequences

More...
RefSeqi
NP_492568.1, NM_060167.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C03D6.4.1; C03D6.4.1; WBGene00003800

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172813

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C03D6.4

UCSC genome browser

More...
UCSCi
C03D6.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA99763.1
PIRiT18883
RefSeqiNP_492568.1, NM_060167.6

3D structure databases

SMRiQ17602
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.C03D6.4

Proteomic databases

EPDiQ17602
PaxDbiQ17602
PeptideAtlasiQ17602

Genome annotation databases

EnsemblMetazoaiC03D6.4.1; C03D6.4.1; WBGene00003800
GeneIDi172813
KEGGicel:CELE_C03D6.4
UCSCiC03D6.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172813
WormBaseiC03D6.4 ; CE05198 ; WBGene00003800 ; npp-14

Phylogenomic databases

eggNOGiKOG3630 Eukaryota
ENOG410YBVS LUCA
GeneTreeiENSGT00940000165854
HOGENOMiCLU_253002_0_0_1
InParanoidiQ17602
KOiK14317
OMAiKCGCWSP
OrthoDBi302566at2759

Enzyme and pathway databases

ReactomeiR-CEL-159227 Transport of the SLBP independent Mature mRNA
R-CEL-159230 Transport of the SLBP Dependant Mature mRNA
R-CEL-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins
R-CEL-3232142 SUMOylation of ubiquitinylation proteins
R-CEL-3301854 Nuclear Pore Complex (NPC) Disassembly
R-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-4085377 SUMOylation of SUMOylation proteins
R-CEL-4551638 SUMOylation of chromatin organization proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q17602

Gene expression databases

BgeeiWBGene00003800 Expressed in material anatomical entity and 4 other tissues

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR026054 Nucleoporin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR23193 PTHR23193, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU214_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17602
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: November 1, 1996
Last modified: February 26, 2020
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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