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Protein

E3 ubiquitin-protein ligase rpm-1

Gene

rpm-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1 (PubMed:10839353, PubMed:15707898). Negatively regulates a p38 MAP kinase pathway composed of dlk-1, mkk-4, and pmk-3 that functions presynaptically to regulate synaptic architecture (PubMed:15707898). Has a role during synaptogenesis; regulates neuronal morphology, specifically presynaptic differentiation. May regulate the spatial arrangement of presynaptic terminals or restrict their development (PubMed:10839354, PubMed:15208641, PubMed:15707898, PubMed:21968191). By targeting both dlk-1 and mlk-1 for degradation, may negatively regulate mlk-1/mek-1/kgb-1 and dlk-1/mkk-4/pmk-3 pathways which are involved in axon regeneration after injury (PubMed:21670305). Regulates axon termination in PLM and ALM neurons (PubMed:21968191). May play a role in the formation of muscle connections between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).By similarity7 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3517Zinc 1By similarity1
Metal bindingi3520Zinc 1By similarity1
Metal bindingi3535Zinc 2By similarity1
Metal bindingi3537Zinc 2By similarity1
Metal bindingi3540Zinc 1By similarity1
Metal bindingi3543Zinc 1By similarity1
Metal bindingi3564Zinc 2By similarity1
Metal bindingi3567Zinc 2By similarity1
Metal bindingi3633Zinc 3By similarity1
Metal bindingi3636Zinc 3By similarity1
Active sitei3647By similarity1
Metal bindingi3663Zinc 3By similarity1
Metal bindingi3666Zinc 3By similarity1
Metal bindingi3675Zinc 4By similarity1
Metal bindingi3678Zinc 4By similarity1
Metal bindingi3687Zinc 5By similarity1
Metal bindingi3690Zinc 5By similarity1
Metal bindingi3691Zinc 6By similarity1
Active sitei3698By similarity1
Sitei3699Important for catalysisBy similarity1
Sitei3704Important for catalysisBy similarity1
Metal bindingi3705Zinc 5By similarity1
Metal bindingi3708Zinc 5By similarity1
Sitei3712Important for catalysisBy similarity1
Metal bindingi3726Zinc 6By similarity1
Metal bindingi3740Zinc 6By similarity1
Metal bindingi3746Zinc 6By similarity1
Metal bindingi3757Zinc 4By similarity1
Metal bindingi3760Zinc 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3331 – 3379B box-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri3517 – 3568RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52

GO - Molecular functioni

  • mitogen-activated protein kinase kinase kinase binding Source: WormBase
  • protein phosphatase binding Source: WormBase
  • ubiquitin protein ligase activity Source: WormBase
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ17551
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase rpm-11 Publication (EC:2.3.2.-By similarity)
Alternative name(s):
Pam/highwire/rpm-1 protein
Regulator of presynaptic morphology protein 11 Publication
Synapse defective protein 31 Publication
Gene namesi
Name:rpm-11 PublicationImported
Synonyms:syd-31 Publication
ORF Names:C01B7.6Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC01B7.6 ; CE06730 ; WBGene00004457 ; rpm-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Disruption phenotypei

In mutants, mechanosensory neurons fail to accumulate tagged vesicles, retract synaptic branches and ectopically extend axons (PubMed:10839354). Some motor neurons branch and overgrow, others show altered synaptic organization (PubMed:10839354). Fewer body wall muscle connections to target motor neurons (PubMed:27123983).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2084V → A: Does not bind rae-1; when associated with A-2087 and A-2088. 1 Publication1
Mutagenesisi2087I → A: Does not bind rae-1; when associated with A-2084 and A-2088. 1 Publication1
Mutagenesisi2088R → A: Does not bind rae-1; and when associated with A-2084 and A-2087. 1 Publication1
Mutagenesisi3597R → C in ky346; total number of the synaptic vesicle GFP puncta is reduced. Overextension of ALM neuron axon which terminates with a hook. PLM neuron axon terminates with a hook. Severe loss of synaptic branch formation in PLM neuron. 2 Publications1
Mutagenesisi3675C → Y in ju44; total number of the synaptic vesicle GFP puncta is reduced. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559701 – 3766E3 ubiquitin-protein ligase rpm-1Add BLAST3766

Proteomic databases

EPDiQ17551
PaxDbiQ17551
PeptideAtlasiQ17551
PRIDEiQ17551

PTM databases

iPTMnetiQ17551

Expressioni

Tissue specificityi

Expression is seen in the pharynx, coelomocytes and distal tip cell. Most abundant expression is in axons of the nerve ring neuropil. Expression is not seen in body wall muscle, hypodermis or intestine.2 Publications

Developmental stagei

First expressed in comma stage embryos and persists through to adulthood.1 Publication

Gene expression databases

BgeeiWBGene00004457 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Interactioni

Subunit structurei

Interacts with rae-1 (PubMed:22357847). Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 (PubMed:15208641).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Rae1Q3SWS82EBI-6920110,EBI-6920222From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-958 SCF-rpm-1 ubiquitin ligase complex
IntActiQ17551, 2 interactors
STRINGi6239.C01B7.6

Structurei

3D structure databases

ProteinModelPortaliQ17551
SMRiQ17551
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati631 – 682RCC1 1Sequence analysisAdd BLAST52
Repeati725 – 784RCC1 2Sequence analysisAdd BLAST60
Repeati785 – 836RCC1 3Sequence analysisAdd BLAST52
Repeati838 – 892RCC1 4Sequence analysisAdd BLAST55
Domaini2870 – 3046DOCPROSITE-ProRule annotationAdd BLAST177

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1056 – 1205PHR domain 1By similarityAdd BLAST150
Regioni1503 – 1655PHR domain 2By similarityAdd BLAST153
Regioni3628 – 3764Tandem cysteine domainBy similarityAdd BLAST137

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi683 – 725Cys-richSequence analysisAdd BLAST43
Compositional biasi2508 – 2538Gly-richSequence analysisAdd BLAST31

Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).By similarity
The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration.By similarity

Sequence similaritiesi

Belongs to the RING-Cys relay (RCR) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3331 – 3379B box-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri3517 – 3568RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1428 Eukaryota
ENOG410XP1T LUCA
GeneTreeiENSGT00920000149071
HOGENOMiHOG000016145
InParanoidiQ17551
KOiK10693
OMAiEMSMHHP
OrthoDBiEOG091G0018
PhylomeDBiQ17551

Family and domain databases

Gene3Di2.130.10.30, 2 hits
2.60.120.260, 1 hit
2.60.120.820, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR008979 Galactose-bd-like_sf
IPR012983 PHR
IPR038648 PHR_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF03256 ANAPC10, 1 hit
PF08005 PHR, 2 hits
PF00415 RCC1, 1 hit
PF00643 zf-B_box, 1 hit
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS51284 DOC, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q17551-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFFLREIDG ERVCSTSTET SIPEDRKSAR RLRKLLYKCA ENTCKPDILR
60 70 80 90 100
VPAHCGKLDK EEEKSKTPLD QQQQINFHDI LNSKFVVGPP SPFALVAIAK
110 120 130 140 150
SILARFGNPE EVSEKEDGSE EEAGTSGADE EGKQYKNTDQ LVGASLTCIF
160 170 180 190 200
EVLEQLSRRD AELCVQALES LLSLIQSMPI DCLQSENRLS MSAMMHVLKT
210 220 230 240 250
LREDACPSVS SKATSCLVAL SVACGEPEHL GSTIRSLICM KKNIRMSADS
260 270 280 290 300
TYDMIQMPEN LRKLLLKVRR KALGGDNTAN SPPNWAMVDV HEHSVASSFS
310 320 330 340 350
LPSLPDSSPS SDTPDDDNRI HSTMACDGTF LYILNYVGLY KLGTGLNETI
360 370 380 390 400
SGKLYAANQS LQSSKNVQMY LCNGSLYLRR NYSSCISVID TDSLLDIGEV
410 420 430 440 450
ILPPSCVQHA LFTDGTYFYS ATLIANSTLS TIQLNDSFSP SNEPSSRRSH
460 470 480 490 500
RLTDVKFTIQ GDLQVPHQLP EFLPANLHPQ TVDLHFTREM AFIQARSGKV
510 520 530 540 550
YYAGNGTRFG LFETGNNWME LCLPEPIVQI SVGIDTIMFR SGAGHGWIAS
560 570 580 590 600
VDDKKRNGRL RRLVPSNRRK IVHVCASGHV YGYVSENGKI FMGGLHTMRV
610 620 630 640 650
NVSSQMLNGL DNVMISSLAL GKSHGVAVTR NGHLFTWGLN NMNQCGRVES
660 670 680 690 700
TSTTSSPRHS GRQEYQICPI GEHTWLTDTP SVCAQCGLCS ARGVACGRVP
710 720 730 740 750
RPKGTMCHCG VGESTCLRCG LCRPCGEVTE PAQPGRAQHV QFSSTAAPQR
760 770 780 790 800
STLHPSRVIL SQGPHDVKVS SVSCGNFHTV LLASDRRVFT FGSNCHGQLG
810 820 830 840 850
VGDTLSKNTP QQVILPSDTV IVQVAAGSNH TILRANDGSV FTFGAFGKGQ
860 870 880 890 900
LARPAGEKAG WNAIPEKVSG FGPGFNAFAG WIGADGDSSI IHSHTALLSS
910 920 930 940 950
DNILKAQIVA NKTNIFIFPR EVGKDYIVIR RKLNVFEHHA SDYKCWYTSW
960 970 980 990 1000
ATDPKYDMLW YYNSAEMEIK GYDIFKKSEK SVGDAFDSLT FLAGAEFAVQ
1010 1020 1030 1040 1050
VYDSPAYATS MSLGMQLLSA TFSANVINLS EFWKEKHGER EQDHEKTIMD
1060 1070 1080 1090 1100
GYSVANRFDG TGGGWGYSAN SVEAIQFKVS KEIRLVGVGL YGGRGEYISK
1110 1120 1130 1140 1150
LKLYRQIGTE ADELYVEQIT ETDETVYDCG AHETATLLFS QPIVIQPNHW
1160 1170 1180 1190 1200
HVVSAKISGP SSDCGANGKR HVECDGVTFQ FRKSAVSNNG TDVDVGQIPE
1210 1220 1230 1240 1250
LYYQIVGGSE SRDESDSNKQ LSISRDMSNL FSPAALKNVT AEGIGNLLIL
1260 1270 1280 1290 1300
LEWALQRVQI DEDTNNQVEG SAENQWSQER AGFVAILSMK LISRFVRTVY
1310 1320 1330 1340 1350
KEKGCHDEPG IDFANKLVNL HSMLLEFFFS TDMTGYENRP LIKKEEKVVE
1360 1370 1380 1390 1400
EGYTLMKCVS EAVKLFISLS HCFMGSRSLM NAHLIAVMNK GNHEALILTS
1410 1420 1430 1440 1450
AIIGSLAKIE RFAHQLLCST TTTERFPMLS SLLLKHFNCE KETLASLTSF
1460 1470 1480 1490 1500
PNILRFLYDQ TFMRNAYENT SSLAEAILVK VSRDLAIPTD DTLMGPVVHQ
1510 1520 1530 1540 1550
TSSRFRRRSA QPTWDMSDGC ADAIAFRVDS EGIKLHGFGI YLPTEPDRRN
1560 1570 1580 1590 1600
FVGEIMMLSP DSSEKWTCLL RVTAEMSSEE KEVGIVRFPE YVLLSPGVTY
1610 1620 1630 1640 1650
AVKVNMMKNT KTFCGEGGVT QVHLLNGARL FFSGCSMSQN GTTVQRGQLP
1660 1670 1680 1690 1700
YLIYSILDQS NSLQIKQETI YDTFTLLLRL MANKIGAAIT EGGALPACCQ
1710 1720 1730 1740 1750
HLMSHINPHV MVYMERFPDK ALEMMSTMEQ LIPMVSNLNG VERVFHSYDS
1760 1770 1780 1790 1800
DDSGCDTPYS GIVTTVVESQ HPYKPNTSSS MVLLFEEADY ICVRFSPDCQ
1810 1820 1830 1840 1850
TAQFDDQLTI YLKIDEHSYM PIERCYGSEW PSYPMILPGN CLMFVLDASS
1860 1870 1880 1890 1900
AVEGATSEQM FGYHVTVTGY LVGYNDSTMR LEQDLVWLSA NACRIMTQLP
1910 1920 1930 1940 1950
INPSNIEHLS TAEDDTRHLF EKHGSLLKKG LSLSHSPTLS ELCTKGQPPP
1960 1970 1980 1990 2000
AQSADLQFLR EFLSGHTSTS AGFLAKWLPT GSVVDASKCQ LSLSHDDLIV
2010 2020 2030 2040 2050
GKAVTLKLLC KDQYDREVDC PKLQVEVFAS LGHRNPSSTI HQNLHIGNLP
2060 2070 2080 2090 2100
SSLLIHQNPF QPIIVNHTRY MNIAAMPAYA NYSVEEIRLG FMIEELVKDR
2110 2120 2130 2140 2150
VPLKSSDSSL FSGTWTPTTA GKYRIECKVD GSDISHTYTV EVTERPHRAG
2160 2170 2180 2190 2200
KGTITKPSGS RRGAQMTVAR TVSIPFSSDF SGIRMRLGTT LASTSVGVIP
2210 2220 2230 2240 2250
RGALVEFIEE MDNDDGKWIR LTDETALLYG CNQGVGQVWC LAYHRPLQRE
2260 2270 2280 2290 2300
LIPLKADTDR EKAVKLRRKE IEKESNGSKH HSVSIDAKET YILSPNDVLQ
2310 2320 2330 2340 2350
VYSTPAPHSM IDGEKIIGPC DLMSSGWLAN RHGVWIKLTG VEKYVLQKND
2360 2370 2380 2390 2400
PSSETSLSFS TNGNDEEDLE RPIERKKTRL PNALTPSVAD CIRAVFAAFV
2410 2420 2430 2440 2450
WHEHLVKDLM AAAAYLRFHQ NLHNIWQSCE IPSCTNAPAA LQPIVKIWRE
2460 2470 2480 2490 2500
ICEVVETSVE QHLIMPPVSN KAMRAETVKP PSRSGGCELC DANITVPLTV
2510 2520 2530 2540 2550
HLRMAHPGCG GDCLGYGYNS NGKFTTGWSG ECGAGGRGQS PWYLLCNTCR
2560 2570 2580 2590 2600
SQYLKKTPAG HHQERTRRWR EFRFSTSASD ARPEVIIRQN AMFLLDLNSR
2610 2620 2630 2640 2650
LQTESNSSST ATSGWTINLF PTHLSTPSTM PRSQQKRLDV PPNNSVHQNS
2660 2670 2680 2690 2700
YMKLGYSSDP GPKVNVIMSP PNQGADQSAS LNRPGPSAIN EPAEVLQSPS
2710 2720 2730 2740 2750
AALRTLFSNT NPSTSALLKR PVLAFCVEHH DLKRIKSACV QSVRRAVAFS
2760 2770 2780 2790 2800
HAFRVWNWLL RMVSSEYSVS DIILQYLTTL TSYNRLAEYM FSAKKNSNIL
2810 2820 2830 2840 2850
PHPWRLCFLA GPIAADMVTQ LHAFLHTVSI ILQSAGVDGR LKSLCFKSWT
2860 2870 2880 2890 2900
LQLTAQEQDL LILTCNILGT VGGILSDTSI LDSDNRFVKE MKDITKFADI
2910 2920 2930 2940 2950
TASSRQAMVI CLTDESGETF WESGEEDKNR SRSLSVQLDE SAHGEILSLF
2960 2970 2980 2990 3000
IDNARDEGYR ISSIAFKAIL EDGRRKDLTS LTLESAYCGW LKCCIKDISH
3010 3020 3030 3040 3050
IQIQFKGPNP ASRIRQLMIL GYPAKTTGTP RLAPSTSHHL FFSDTQRDAF
3060 3070 3080 3090 3100
ALFQAISSQA FCGELSEDDT LRERVIDLLF SRVQLYPLQN YVYTQVVQAM
3110 3120 3130 3140 3150
EKEVELLCDK SKRNYSYCCG LMSLLVRICD SRGNMDSFGQ RNSVLTSITQ
3160 3170 3180 3190 3200
LLIFSPVVVQ RQCLNSLECI FASFTPSNVE VPKIIRNLLV VVGKVIQLQV
3210 3220 3230 3240 3250
RDKAAHTVVT VHLCSSVLNA PQNWRVDKSI DMDIGRQTAV LVENLCNGTY
3260 3270 3280 3290 3300
TPEWSNATKC ELANCLLSLI QMPESVSYTE TLSTGGKSKA VAVVSSKRFW
3310 3320 3330 3340 3350
TAISSLSLIK DKSWLELSER WKTVQDEEDQ EPVLLCENHD DGHTVAQVFC
3360 3370 3380 3390 3400
VDCDVALCKE CFTVMHLHKK NRNHGVKNLV QSSTQHDINI HQGCARMKFL
3410 3420 3430 3440 3450
NFLILFHGEA LNGMVEVAAD TLFPTSTSSI QPAMQSSSAF LGIHPMTCRF
3460 3470 3480 3490 3500
CGNNVPVEDQ SLDGTCTHED CVNYAKTACQ VMHTCNHFCG GIRNEEECLP
3510 3520 3530 3540 3550
CMTCKREDAA QDGDDVCVIC FTERLGAAPC IRLGCGHMFH FHCVRMILER
3560 3570 3580 3590 3600
RWNGPRIVFR FMQCPLCIQP IEHSGLQDLI EPLKTIRQEV VDKAKMRLEY
3610 3620 3630 3640 3650
DGLLTTPALT DPRSEFYNQP EEYALDRYMY VLCHKCKKAY FGGESRCQAA
3660 3670 3680 3690 3700
LDSSQFNPEE LLCGGCSDTS GVQVCPRHGV EYLEYKCRFC CSIAVYFCFG
3710 3720 3730 3740 3750
TTHFCAPCHD DFQRLMSLPK HLLPTCPVGP RSTPMEEQTC PLKMKHPPTG
3760
DEFAMGCGIC RNISTF
Length:3,766
Mass (Da):418,058
Last modified:November 1, 1996 - v1
Checksum:iEAB59E816C5BBF4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080217 Genomic DNA Translation: CCD62087.1
PIRiT29165
RefSeqiNP_505267.1, NM_072866.3
UniGeneiCel.2746

Genome annotation databases

EnsemblMetazoaiC01B7.6; C01B7.6; WBGene00004457
GeneIDi179259
KEGGicel:CELE_C01B7.6
UCSCiC01B7.6 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080217 Genomic DNA Translation: CCD62087.1
PIRiT29165
RefSeqiNP_505267.1, NM_072866.3
UniGeneiCel.2746

3D structure databases

ProteinModelPortaliQ17551
SMRiQ17551
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-958 SCF-rpm-1 ubiquitin ligase complex
IntActiQ17551, 2 interactors
STRINGi6239.C01B7.6

PTM databases

iPTMnetiQ17551

Proteomic databases

EPDiQ17551
PaxDbiQ17551
PeptideAtlasiQ17551
PRIDEiQ17551

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC01B7.6; C01B7.6; WBGene00004457
GeneIDi179259
KEGGicel:CELE_C01B7.6
UCSCiC01B7.6 c. elegans

Organism-specific databases

CTDi179259
WormBaseiC01B7.6 ; CE06730 ; WBGene00004457 ; rpm-1

Phylogenomic databases

eggNOGiKOG1428 Eukaryota
ENOG410XP1T LUCA
GeneTreeiENSGT00920000149071
HOGENOMiHOG000016145
InParanoidiQ17551
KOiK10693
OMAiEMSMHHP
OrthoDBiEOG091G0018
PhylomeDBiQ17551

Enzyme and pathway databases

UniPathwayi
UPA00143

SignaLinkiQ17551

Miscellaneous databases

PROiPR:Q17551

Gene expression databases

BgeeiWBGene00004457 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

Gene3Di2.130.10.30, 2 hits
2.60.120.260, 1 hit
2.60.120.820, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR008979 Galactose-bd-like_sf
IPR012983 PHR
IPR038648 PHR_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF03256 ANAPC10, 1 hit
PF08005 PHR, 2 hits
PF00415 RCC1, 1 hit
PF00643 zf-B_box, 1 hit
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS51284 DOC, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPM1_CAEEL
AccessioniPrimary (citable) accession number: Q17551
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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