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Protein

Putative cuticle collagen 145

Gene

col-145

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cuticle collagen 145
Gene namesi
Name:col-145
ORF Names:B0222.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0222.7 ; CE48016 ; WBGene00000718 ; col-145

Subcellular locationi

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000030786731 – 294Putative cuticle collagen 145Add BLAST264

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ17459
PeptideAtlasiQ17459

Expressioni

Gene expression databases

BgeeiWBGene00000718 Expressed in 3 organ(s), highest expression level in material anatomical entity

Interactioni

Subunit structurei

Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.By similarity

Protein-protein interaction databases

BioGridi44335, 1 interactor
DIPiDIP-24575N
STRINGi6239.B0222.7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 276Collagen-likeSequence analysisAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 127Triple-helical regionAdd BLAST26
Regioni148 – 277Triple-helical regionAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 285Pro-richAdd BLAST190
Compositional biasi104 – 275Gly-richAdd BLAST172

Sequence similaritiesi

Belongs to the cuticular collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00800000124346
HOGENOMiHOG000085656
InParanoidiQ17459
OMAiSKCIECP
OrthoDBiEOG091G0UC1

Family and domain databases

InterProiView protein in InterPro
IPR002486 Col_cuticle_N
PfamiView protein in Pfam
PF01484 Col_cuticle_N, 1 hit
SMARTiView protein in SMART
SM01088 Col_cuticle_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17459-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKILVTFST GAASIAVLAV LFTVPSLYNT INEVHDQVLD GVSVFRVETD
60 70 80 90 100
SAWTEMMDIQ ITVTPPTKPR VNPFNSVFRQ KRQTFSGLPA WCQCEPTKPT
110 120 130 140 150
CPPGPPGPPG QPGAPGTPGA PGPKGDDNTA TFAPLTCAPV SQDCVKCPQG
160 170 180 190 200
PAGPAGPSGP AGPAGPDGQP GFPGQRGNDG FPGAPGAPGD NGQPGTPGQD
210 220 230 240 250
GFPGQPGADG QRGSGAPGAP GAPGNAGPAG PAGQDGFPGQ DGAPGPAGPA
260 270 280 290
GQDGFPGNAG SDGQPGAPGG PGLPGNDAAY CACPPRSAVF LSRH
Length:294
Mass (Da):28,744
Last modified:September 18, 2013 - v2
Checksum:iB7111C687D66D8B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080127 Genomic DNA Translation: CCD61420.2
PIRiT29838
RefSeqiNP_505375.2, NM_072974.4

Genome annotation databases

EnsemblMetazoaiB0222.7; B0222.7; WBGene00000718
GeneIDi179297
KEGGicel:CELE_B0222.7
UCSCiB0222.7 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080127 Genomic DNA Translation: CCD61420.2
PIRiT29838
RefSeqiNP_505375.2, NM_072974.4

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44335, 1 interactor
DIPiDIP-24575N
STRINGi6239.B0222.7

Proteomic databases

PaxDbiQ17459
PeptideAtlasiQ17459

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0222.7; B0222.7; WBGene00000718
GeneIDi179297
KEGGicel:CELE_B0222.7
UCSCiB0222.7 c. elegans

Organism-specific databases

CTDi179297
WormBaseiB0222.7 ; CE48016 ; WBGene00000718 ; col-145

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00800000124346
HOGENOMiHOG000085656
InParanoidiQ17459
OMAiSKCIECP
OrthoDBiEOG091G0UC1

Miscellaneous databases

PROiPR:Q17459

Gene expression databases

BgeeiWBGene00000718 Expressed in 3 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR002486 Col_cuticle_N
PfamiView protein in Pfam
PF01484 Col_cuticle_N, 1 hit
SMARTiView protein in SMART
SM01088 Col_cuticle_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO145_CAEEL
AccessioniPrimary (citable) accession number: Q17459
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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