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Entry version 136 (17 Jun 2020)
Sequence version 2 (05 Jul 2004)
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Protein

Aminopeptidase-like protein AC3.5

Gene

AC3.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although strongly related to the peptidase M1 family, it lacks the conserved active metal binding Glu and His in positions 496 and 499, which are replaced by a Arg and Ala residues respectively, suggesting that it has no activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-CEL-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aminopeptidase-like protein AC3.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AC3.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
AC3.5a ; CE36372 ; WBGene00007071

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei78 – 98Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini99 – 1090LumenalSequence analysisAdd BLAST992

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002485221 – 1090Aminopeptidase-like protein AC3.5Add BLAST1090

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi115N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi123N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi710N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi723N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi789N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi894N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi919N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi964N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi993N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q17405

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17405

PRoteomics IDEntifications database

More...
PRIDEi
Q17405

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q17405

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007071 Expressed in multi-cellular organism and 3 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17405 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q17405, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.AC3.5a.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17405

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1046 Eukaryota
COG0308 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17405

Identification of Orthologs from Complete Genome Data

More...
OMAi
GTEADWT

Database of Orthologous Groups

More...
OrthoDBi
110058at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17405

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09601 M1_APN-Q_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042097 Aminopeptidase_N-like_N
IPR024571 ERAP1-like_C_dom
IPR034016 M1_APN-typ
IPR014782 Peptidase_M1_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11838 ERAP1_C, 1 hit
PF01433 Peptidase_M1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63737 SSF63737, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q17405-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDVDLGKDR TQLIDFVYAN GNGSASNLNN RNNIPLSEKA AKEPLQTQPQ
60 70 80 90 100
EAPPAPKPKV QKQKPPVKPK KRIACSPGSA ICLFLLAVAA IIFAAFLGHY
110 120 130 140 150
LTKQNYEMMQ FKSANESMTT CKNFTRSHKK HQDIVNEEDA DENASIKQPT
160 170 180 190 200
KEELALPKNV QPVWYDVSLS PKVGGNGTMG LAHVKLNIEE PTNKIVLNAK
210 220 230 240 250
DIEFTRNLEK IQLSKEVTKR AKKSVDSGTN STSEMPEGSG EEAMATTATT
260 270 280 290 300
TTTESTTPVS SFVDTGIKVT NIEFDENLEK VTLTLDQELK KGSTVVLKIP
310 320 330 340 350
FTSKVSNNNG LKEYKYKNSE GKEQSMFTTQ PSYSYLRHVF PSFDQEAFKA
360 370 380 390 400
PAAITLMHSK GSIVVANTGV KTKDDGDAQT STLNKVLDPD FVIGDLVASE
410 420 430 440 450
VNTTSGITIR IWTRPEVKHS TEQSLDYANQ AIDAMEHILQ SRLESKSLDI
460 470 480 490 500
VAVPGFQTGN RVSPSFIVLP EEDILYNEQS NDINQKTRIA RMISNRIAAQ
510 520 530 540 550
WFGGITNPEE FGTFWLNEAL PRFLEVEALE KILDINSDDL WTYEMEKILE
560 570 580 590 600
RDATATSQPL RVKNVFSSAD IAEIDHEFIG KKGAAVLRMI QKSVGVNVFN
610 620 630 640 650
KAIRSFVSSY RSAYPYDDGL WKSFEKALGG KLKGWNNEPL DVAKFVNTWV
660 670 680 690 700
DQIGFPLVSV EKLDDETVEL SQERFKNDHK TKEQFKFRNA KYWFNWEVPL
710 720 730 740 750
FLKSSGPVGN VSWLHEAFRL PLNTSDSIYL NTDSNGVYRV NYEEKRWNDI
760 770 780 790 800
AKQLEKSHGK LSERTRARLI SDVFALANSG ALPFETALNV TSYLPMETAT
810 820 830 840 850
VPWLIATRIF KKLTERLEGA PIQDKLNSFI YQKIHKKFEE ISSSPGEASS
860 870 880 890 900
NYLKNRLYAN LLDLMAIVKP EKSNEKLNEL FVEGFLAPCQ FSGNFSSDCS
910 920 930 940 950
EVPGDLREKV YCNGVEFGND TVFETVRELA EKEVDGAEKD LLQNSLACFR
960 970 980 990 1000
DPRALRRLIL DNLNSTSTVT LLLRKMNSRP VGKEIATNWI IDNWSTVLKK
1010 1020 1030 1040 1050
KFKNDPETLN AIADAGIILD NEREKSMIET FMEHHHKSTH GIESLDKKIE
1060 1070 1080 1090
EATTDIYWRK QKINELNDYL DGKMKGPAKD DEMESSEEQE
Length:1,090
Mass (Da):122,720
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DA27398EA21681A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9G2W1H9G2W1_CAEEL
Aminopeptidase
AC3.5, CELE_AC3.5
983Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z71177 Genomic DNA Translation: CAA94872.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T18597

NCBI Reference Sequences

More...
RefSeqi
NP_001256214.1, NM_001269285.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AC3.5a.1; AC3.5a.1; WBGene00007071
AC3.5a.2; AC3.5a.2; WBGene00007071

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_AC3.5

UCSC genome browser

More...
UCSCi
AC3.5.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71177 Genomic DNA Translation: CAA94872.2
PIRiT18597
RefSeqiNP_001256214.1, NM_001269285.1

3D structure databases

SMRiQ17405
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ17405, 1 interactor
STRINGi6239.AC3.5a.2

PTM databases

iPTMnetiQ17405

Proteomic databases

EPDiQ17405
PaxDbiQ17405
PRIDEiQ17405

Genome annotation databases

EnsemblMetazoaiAC3.5a.1; AC3.5a.1; WBGene00007071
AC3.5a.2; AC3.5a.2; WBGene00007071
GeneIDi179447
KEGGicel:CELE_AC3.5
UCSCiAC3.5.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179447
WormBaseiAC3.5a ; CE36372 ; WBGene00007071

Phylogenomic databases

eggNOGiKOG1046 Eukaryota
COG0308 LUCA
InParanoidiQ17405
OMAiGTEADWT
OrthoDBi110058at2759
PhylomeDBiQ17405

Enzyme and pathway databases

ReactomeiR-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-CEL-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q17405

Gene expression databases

BgeeiWBGene00007071 Expressed in multi-cellular organism and 3 other tissues
ExpressionAtlasiQ17405 differential

Family and domain databases

CDDicd09601 M1_APN-Q_like, 1 hit
InterProiView protein in InterPro
IPR042097 Aminopeptidase_N-like_N
IPR024571 ERAP1-like_C_dom
IPR034016 M1_APN-typ
IPR014782 Peptidase_M1_dom
PfamiView protein in Pfam
PF11838 ERAP1_C, 1 hit
PF01433 Peptidase_M1, 1 hit
SUPFAMiSSF63737 SSF63737, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYQ02_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17405
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. Peptidase families
    Classification of peptidase families and list of entries
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