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Protein

Cullin-1

Gene

cul-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-187577 SCF(Skp2)-mediated degradation of p27/p21
R-CEL-195253 Degradation of beta-catenin by the destruction complex
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69231 Cyclin D associated events in G1
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8951664 Neddylation
R-CEL-917937 Iron uptake and transport
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Cullin-1
Short name:
CUL-1
Alternative name(s):
Abnormal cell lineage protein 19
Gene namesi
Name:cul-1
Synonyms:lin-19
ORF Names:D2045.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiD2045.6 ; CE29089 ; WBGene00000836 ; cul-1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197801 – 780Cullin-1Add BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki724Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)By similarity

Post-translational modificationi

Neddylated; which enhances the ubiquitination activity of SCF.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ17389
PaxDbiQ17389
PeptideAtlasiQ17389
PRIDEiQ17389

Expressioni

Tissue specificityi

Ubiquitous.

Developmental stagei

Highest levels in embryos and lower levels in larvae and adults.

Gene expression databases

BgeeiWBGene00000836 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 (PubMed:15208641). Interacts with Skp1-related proteins skr-1, skr-2, skr-3, skr-4, skr-7, skr-8, skr-9 and skr-10 (PubMed:11864566).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi41658, 8 interactors
ComplexPortaliCPX-958 SCF-rpm-1 ubiquitin ligase complex
STRINGi6239.D2045.6

Structurei

3D structure databases

ProteinModelPortaliQ17389
SMRiQ17389
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2166 Eukaryota
COG5647 LUCA
GeneTreeiENSGT00760000119212
HOGENOMiHOG000176713
InParanoidiQ17389
KOiK03347
OMAiTTHKHIE
OrthoDBiEOG091G02WR
PhylomeDBiQ17389

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016157 Cullin_CS
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR019559 Cullin_neddylation_domain
IPR016159 Cullin_repeat-like_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00888 Cullin, 1 hit
PF10557 Cullin_Nedd8, 1 hit
SMARTiView protein in SMART
SM00182 CULLIN, 1 hit
SM00884 Cullin_Nedd8, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF74788 SSF74788, 1 hit
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256 CULLIN_1, 1 hit
PS50069 CULLIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q17389-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNSEPRRMT CDSEVVWKKL QDGLDVAYRR ENMAPKDYMT LYTSVYDYCT
60 70 80 90 100
SITLSTSRRD GEDGRAESST PARTAGADFV GHEMYQRVEE YVKAYVIAVC
110 120 130 140 150
EKGAELSGED LLKYYTTEWE NFRISSKVMD GIFAYLNRHW IRRELDEGHE
160 170 180 190 200
NIYMVYTLAL VVWKRNLFND LKDKVIDAML ELIRSERTGS MINSRYISGV
210 220 230 240 250
VECLVELGVD DSETDAKKDA ETKKLAVYKE FFEVKFLEAT RGFYTQEAAN
260 270 280 290 300
FLSNGGNVTD YMIKVETRLN QEDDRCQLYL NSSTKTPLAT CCESVLISNQ
310 320 330 340 350
LDFLQRHFGG LLVDKRDDDL SRMFKLCDRV PNGLDELRKS LENHIAKEGH
360 370 380 390 400
QALERVAMEA ATDAKLYVKT LLEVHERYQS LVNRSFKNEP GFMQSLDKAA
410 420 430 440 450
TSFINNNAVT KRAPPQAQLT KSAELLARYC DQLLRKSSKM PDEAELEELQ
460 470 480 490 500
TKIMVVFKYI DDKDVFSKFY TKMFSKRLIS ELSASDEAEA NFITKLKSMC
510 520 530 540 550
GYEYTARLSK MVNDTQVSKD LTADFKEKKA DMLGQKSVEF NVLVLSSGSW
560 570 580 590 600
PTFPTTPITL PQQLSKTIEI FGQFYNEKFN GRRLTWVYSQ SRGEITSTAF
610 620 630 640 650
PKKYVFTATT AQMCTMLLFN EQDSYTVEQI AAATKMDEKS APAIVGSLIK
660 670 680 690 700
NLVLKADTEL QKEDEVPMTA TVSLNKAYMN KKVRVDLSKF TMKQDAVRDT
710 720 730 740 750
ENVQKNVEED RKSVISACIV RIMKTRKRVQ HQQLMTEVIT QLSGRFKPKV
760 770 780
EMIKRCIGSL IEKEYMLRTE GQKDLYEYLA
Length:780
Mass (Da):89,527
Last modified:November 1, 1997 - v1
Checksum:i38A5C2EE0A7CC881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58083 mRNA Translation: AAC47120.1
Z35639 Genomic DNA Translation: CAA84695.2
PIRiT20365
RefSeqiNP_499309.1, NM_066908.4
UniGeneiCel.6661

Genome annotation databases

EnsemblMetazoaiD2045.6; D2045.6; WBGene00000836
GeneIDi176466
KEGGicel:CELE_D2045.6
UCSCiD2045.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCUL1_CAEEL
AccessioniPrimary (citable) accession number: Q17389
Secondary accession number(s): Q18985
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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