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Protein

Alpha-glucosidase

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts sucrose in nectar to glucose and fructose.

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei223NucleophileBy similarity1
Active sitei286Proton donorBy similarity1
Sitei348Transition state stabilizerBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKiQ17058

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Maltase
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4406

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000000145218 – 567Alpha-glucosidaseAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi507N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ17058
PRIDEiQ17058

Expressioni

Tissue specificityi

Expressed specifically in the hypopharyngeal glands of the forager (worker) honeybee.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi7460.GB19017-PA

Chemistry databases

BindingDBiQ17058

Structurei

3D structure databases

ProteinModelPortaliQ17058
SMRiQ17058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0471 Eukaryota
COG0366 LUCA
HOGENOMiHOG000220640
InParanoidiQ17058
KOiK01187
OMAiRDWYWWR
PhylomeDBiQ17058

Family and domain databases

InterProiView protein in InterPro
IPR006047 Glyco_hydro_13_cat_dom
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVIVFCLM ALSIVDAAWK PLPENLKEDL IVYQVYPRSF KDSNGDGIGD
60 70 80 90 100
IEGIKEKLDH FLEMGVDMFW LSPIYPSPMV DFGYDISNYT DVHPIFGTIS
110 120 130 140 150
DLDNLVSAAH EKGLKIILDF VPNHTSDQHE WFQLSLKNIE PYNNYYIWHP
160 170 180 190 200
GKIVNGKRVP PTNWVGVFGG SAWSWREERQ AYYLHQFAPE QPDLNYYNPV
210 220 230 240 250
VLDDMQNVLR FWLRRGFDGF RVDALPYICE DMRFLDEPLS GETNDPNKTE
260 270 280 290 300
YTLKIYTHDI PETYNVVRKF RDVLDEFPQP KHMLIEAYTN LSMTMKYYDY
310 320 330 340 350
GADFPFNFAF IKNVSRDSNS SDFKKLVDNW MTYMPPSGIP NWVPGNHDQL
360 370 380 390 400
RLVSRFGEEK ARMITTMSLL LPGVAVNYYG DEIGMSDTYI SWEDTQDPQG
410 420 430 440 450
CGAGKENYQT MSRDPARTPF QWDDSVSAGF SSSSNTWLRV NENYKTVNLA
460 470 480 490 500
AEKKDKNSFF NMFKKFASLK KSPYFKEANL NTRMLNDNVF AFSRETEDNG
510 520 530 540 550
SLYAILNFSN EEQIVDLKAF NNVPKKLNMF YNNFNSDIKS ISNNEQVKVS
560
ALGFFILISQ DAKFGNF
Length:567
Mass (Da):65,565
Last modified:November 1, 1996 - v1
Checksum:iA14D88DD657C99C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79208 mRNA Translation: BAA11466.1
PIRiJC4714
RefSeqiNP_001011608.1, NM_001011608.1
XP_006560868.1, XM_006560805.2
XP_006560869.1, XM_006560806.2
XP_006560870.1, XM_006560807.2
XP_016767968.1, XM_016912479.1
XP_016767969.1, XM_016912480.1
XP_016767971.1, XM_016912482.1
UniGeneiAme.1213

Genome annotation databases

GeneIDi406131
KEGGiame:406131

Similar proteinsi

Entry informationi

Entry nameiMAL1_APIME
AccessioniPrimary (citable) accession number: Q17058
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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