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Entry version 125 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Myosin heavy chain

Gene
N/A
Organism
Argopecten irradians (Bay scallop) (Aequipecten irradians)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi176 – 183ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin heavy chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArgopecten irradians (Bay scallop) (Aequipecten irradians)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31199 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaBivalviaAutobranchiaPteriomorphiaPectinidaPectinoideaPectinidaeArgopecten

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q17042

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17042

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q17042

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 79Myosin N-terminal SH3-likeInterPro annotationAdd BLAST51
Domaini83 – 778Myosin motorInterPro annotationAdd BLAST696

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni656 – 678Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni1044 – 1065DisorderedSequence analysisAdd BLAST22
Regioni1190 – 1228DisorderedSequence analysisAdd BLAST39
Regioni1260 – 1335DisorderedSequence analysisAdd BLAST76
Regioni1347 – 1366DisorderedSequence analysisAdd BLAST20
Regioni1902 – 1951DisorderedSequence analysisAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1383 – 1445Sequence analysisAdd BLAST63
Coiled coili1453 – 1480Sequence analysisAdd BLAST28
Coiled coili1488 – 1515Sequence analysisAdd BLAST28
Coiled coili1523 – 1596Sequence analysisAdd BLAST74
Coiled coili1608 – 1803Sequence analysisAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1209 – 1227Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1260 – 1285Polar residuesSequence analysisAdd BLAST26
Compositional biasi1286 – 1302Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1309 – 1335Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1902 – 1918Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1919 – 1941Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR027401, Myosin_IQ_contain_sf
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063, Myosin_head, 1 hit
PF02736, Myosin_N, 1 hit
PF01576, Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 1 hit
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17042-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIDFSDPDF QYLAVDRKKL MKEQTAAFDG KKNCWVPDEK EGFASAEIQS
60 70 80 90 100
SKGDEITVKI VADSSTRTVK KDDIQSMNPP KFEKLEDMAN MTYLNEASVL
110 120 130 140 150
YNLRSRYTSG LIYTYSGLFC IAVNPYRRLP IYTDSVIAKY RGKRKTEIPP
160 170 180 190 200
HLFSVADNAY QNMVTDRENQ SCLITGESGA GKTESTKKVI MYFARVAANL
210 220 230 240 250
YKQKQEEPTT THARASNLED QIIEANPVLE AFGNAKTVRN NNSSRFGKFI
260 270 280 290 300
RIHFGPTGKI AGADIETYLL EKSRVTYQQS AERNYHIFYQ ICSNAIPELN
310 320 330 340 350
DVMLVTPDSG LYSFINQGCL TVDNIDDVEE FKLCDEAFDI LGFTKEEKQS
360 370 380 390 400
MFKCTASILH MGEMKFKQRP REEQAESDGT AEAEKVAFLC GINAGDLLKA
410 420 430 440 450
LLKPKVKVGT EMVTKGQNMN QVVNSVGALA KSLYDRMFNW LVRRVNKTLD
460 470 480 490 500
TKAKRNYYIG VLDIAGFEIF DFNSFEQLCI NYTNERLQQF FNHHMFILEQ
510 520 530 540 550
EEYKKEGIAW EFIDFGMDLQ MCIDLIEKPM GILSILEEEC MFPKADDKSF
560 570 580 590 600
QDKLYQNHMG KNRMFTKPGK PTRPNQGPAH FELHHYAGNV PYSITGWLEK
610 620 630 640 650
NKDPINENVV ALLGASKEPL VAELFKAPEE PAGGGKKKKG KSSAFQTISA
660 670 680 690 700
VHRESLNKLM KNLYSTHPHF VRCIIPNELK QPGLVDAELV LHQLQCNGVL
710 720 730 740 750
EGIRICRKGF PSRLIYSEFK QRYSILAPNA IPQGFVDGKT VSEKILAGLQ
760 770 780 790 800
MDPAEYRLGT TKVFFKAGVL GNLEEMRDER LSKIISMFQA HIRGYLIRKA
810 820 830 840 850
YKKLQDQRIG LSVIQRNIRK WLVLRNWQWW KLYSKVKPLL SIARQEEEMK
860 870 880 890 900
EQLKQMDKMK EDLAKTERIK KELEEQNVTL LEQKNDLFLQ LQTLEDSMGD
910 920 930 940 950
QEERVEKLIM QKADFESQIK ELEERLLDEE DAAADLEGIK KKMEADNANL
960 970 980 990 1000
KKDIGDLENT LQKAEQDKAH KDNQISTLQG EISQQDEHIG KLNKEKKALE
1010 1020 1030 1040 1050
EANKKTSDSL QAEEDKCNHL NKLKAKLEQA LDELEDNLER EKKVRGDVEK
1060 1070 1080 1090 1100
AKRKVEQDLK STQENVEDLE RVKRELEENV RRKEAEISSL NSKLEDEQNL
1110 1120 1130 1140 1150
VSQLQRKIKE LQARIEELEE ELEAERNARA KVEKQRAELN RELEELGERL
1160 1170 1180 1190 1200
DEAGGATSAQ IELNKKREAE LLKIRRDLEE ASLQHEAQIS ALRKKHQDAA
1210 1220 1230 1240 1250
NEMADQVDQL QKVKSKSEKE KQQLRSEVED LQAQIQHISK NKGCSEKVMK
1260 1270 1280 1290 1300
QFESQMSDLN ARLEDSQRSI NELQSQKSRL QAENSDLTRQ LEDAEHRVSV
1310 1320 1330 1340 1350
LSKEKSQLSS QLEDARRSLE EETRARSKLQ NEVRNMHADM DAIREQLEEE
1360 1370 1380 1390 1400
QESKSDVQRQ LSKANNEIQQ WRSKFESEGA NRTEELEDQK RKLLGKLSEA
1410 1420 1430 1440 1450
EQTTEAANAK CSALEKAKSR LQQELEDMSI EVDRANASVN QMEKKQRAFD
1460 1470 1480 1490 1500
KTTAEWQAKV NSLQSELENS QKESRGYSAE LYRIKASIEE YQDSIGALRR
1510 1520 1530 1540 1550
ENKNLADEIH DLTDQLSEGG RSTHELDKAR RRLEMEKEEL QAALEEAEGA
1560 1570 1580 1590 1600
LEQEEAKVMR AQLEIATVRN EIDKRIQEKE EEFDNTRRNH QRALESMQAS
1610 1620 1630 1640 1650
LEAEAKGKAD AMRIKKKLEQ DINELEVALD ASNRGKAEME KTVKRYQQQI
1660 1670 1680 1690 1700
REMQTSIEEE QRQRDEARES YNMAERRCTL MSGEVEELRA ALEQAERARK
1710 1720 1730 1740 1750
ASDNELADAN DRVNELTSQV SSVQGQKRKL EGDINAMQTD LDEMHGELKG
1760 1770 1780 1790 1800
ADERCKKAMA DAARLADELR AEQDHSNQVE KVRKNLESQV KEFQIRLDEA
1810 1820 1830 1840 1850
EASSLKGGKK MIQKLESRVH ELEAELDNEQ RRHAETQKNM RKADRRLKEL
1860 1870 1880 1890 1900
AFQADEDRKN QERLQELIDK LNAKIKTFKR QVEEAEEIAA INLAKYRKAQ
1910 1920 1930 1940 1950
HELEEAEERA DTADSTLQKF RAKSRSSVSV QRSSVSVSAS NAAHVAHHHV

E
Length:1,951
Mass (Da):224,254
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FDC3D7D691C1410
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09782 mRNA Translation: AAC46490.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09782 mRNA Translation: AAC46490.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NKNX-ray2.50A/B/C/D838-890[»]
SMRiQ17042
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiQ17042

Miscellaneous databases

EvolutionaryTraceiQ17042

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR027401, Myosin_IQ_contain_sf
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PF02736, Myosin_N, 1 hit
PF01576, Myosin_tail_1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00015, IQ, 1 hit
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ17042_ARGIR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17042
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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