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Protein

Chymotrypsin-2

Gene

CHYM2

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Charge relay systemBy similarity1
Active sitei119Charge relay systemBy similarity1
Sitei206Required for specificityBy similarity1
Active sitei212Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processDigestion

Protein family/group databases

MEROPSiS01.166

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-2 (EC:3.4.21.1)
Alternative name(s):
AnChym2
Gene namesi
Name:CHYM2
ORF Names:AGAP006711
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 2L, Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002765618 – 32Activation peptideSequence analysisAdd BLAST15
ChainiPRO_000002765733 – 258Chymotrypsin-2Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Disulfide bondi182 ↔ 198PROSITE-ProRule annotation
Disulfide bondi208 ↔ 232PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ17025

Expressioni

Tissue specificityi

After blood feeding, expression is induced in the midgut epithelium, followed by secretion into the midgut lumen.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP006711-PA

Structurei

3D structure databases

ProteinModelPortaliQ17025
SMRiQ17025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 255Peptidase S1PROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
InParanoidiQ17025
OMAiIAHEECR
OrthoDBiEOG091G0DF7
PhylomeDBiQ17025

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRKVFAVVS VLLVVSAAKV TKLVLDDHYV NRVVGGEVAK NGSAPYQVSL
60 70 80 90 100
QVPGWGHNCG GSLLNNRWVL TAAHCLVGYE PSDLMVLVGT NSLKEGGELL
110 120 130 140 150
KVDKLLYHSR YNRPQFHNDI GLMRLEQPVQ FSELVQSVEY LEKAVPVNAT
160 170 180 190 200
VRLTGWGRTS TNGNVPTLLQ SLNVVTLSNE DCKAKMGNPK NVDLGHVCTL
210 220 230 240 250
TKAGEGACNG DSGGPLVYEG KLVGVVNFGV PCGRGFPDGF ARVSYYHEWV

RTTMANNS
Length:258
Mass (Da):27,928
Last modified:May 16, 2006 - v3
Checksum:i8C82E91B5C790EB8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21T → P in CAA79326 (PubMed:11453997).Curated1
Sequence conflicti21T → P in CAA83567 (PubMed:11453997).Curated1
Sequence conflicti28H → N in CAA79326 (PubMed:11453997).Curated1
Sequence conflicti28H → N in CAA83567 (PubMed:11453997).Curated1
Sequence conflicti37E → V in CAA79326 (PubMed:11453997).Curated1
Sequence conflicti37E → V in CAA83567 (PubMed:11453997).Curated1
Sequence conflicti42G → C in CAA79326 (PubMed:11453997).Curated1
Sequence conflicti42G → C in CAA83567 (PubMed:11453997).Curated1
Sequence conflicti66N → D in CAA79326 (PubMed:11453997).Curated1
Sequence conflicti66N → D in CAA83567 (PubMed:11453997).Curated1
Sequence conflicti166P → R in CAA79326 (PubMed:11453997).Curated1
Sequence conflicti190K → E in CAA79326 (PubMed:11453997).Curated1
Sequence conflicti190K → E in CAA83567 (PubMed:11453997).Curated1
Sequence conflicti194 – 196LGH → FPD in CAA79326 (PubMed:11453997).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18888 mRNA Translation: CAA79326.1
Z32645 Genomic DNA Translation: CAA83567.1
AAAB01008807 Genomic DNA Translation: EAA04684.3
PIRiS44184
RefSeqiXP_309032.2, XM_309032.3

Genome annotation databases

EnsemblMetazoaiAGAP006711-RA; AGAP006711-PA; AGAP006711
GeneIDi1270347
KEGGiaga:AgaP_AGAP006711
VectorBaseiAGAP006711-RA; AGAP006711-PA; AGAP006711

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18888 mRNA Translation: CAA79326.1
Z32645 Genomic DNA Translation: CAA83567.1
AAAB01008807 Genomic DNA Translation: EAA04684.3
PIRiS44184
RefSeqiXP_309032.2, XM_309032.3

3D structure databases

ProteinModelPortaliQ17025
SMRiQ17025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP006711-PA

Protein family/group databases

MEROPSiS01.166

Proteomic databases

PaxDbiQ17025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP006711-RA; AGAP006711-PA; AGAP006711
GeneIDi1270347
KEGGiaga:AgaP_AGAP006711
VectorBaseiAGAP006711-RA; AGAP006711-PA; AGAP006711

Organism-specific databases

CTDi1270347

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
InParanoidiQ17025
OMAiIAHEECR
OrthoDBiEOG091G0DF7
PhylomeDBiQ17025

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTR2_ANOGA
AccessioniPrimary (citable) accession number: Q17025
Secondary accession number(s): Q17026, Q7PT16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2006
Last modified: July 5, 2017
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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