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Entry version 87 (02 Jun 2021)
Sequence version 1 (25 Jul 2006)
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Protein

Dynein axonemal assembly factor 1 homolog

Gene

AAEL010772

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cilium-specific protein required for cilia structures.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein axonemal assembly factor 1 homolog
Alternative name(s):
Leucine-rich repeat-containing protein 50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AAEL010772
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008820 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:AAEL010772

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003639341 – 1107Dynein axonemal assembly factor 1 homologAdd BLAST1107

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q16RY9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7159.AAEL010772-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 56LRR 1Add BLAST23
Repeati57 – 78LRR 2Add BLAST22
Repeati79 – 100LRR 3Add BLAST22
Repeati101 – 122LRR 4Add BLAST22
Repeati125 – 146LRR 5Add BLAST22
Repeati150 – 171LRR 6Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 223LRRCTAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni258 – 281DisorderedSequence analysisAdd BLAST24
Regioni428 – 487DisorderedSequence analysisAdd BLAST60
Regioni500 – 608DisorderedSequence analysisAdd BLAST109
Regioni780 – 810DisorderedSequence analysisAdd BLAST31
Regioni834 – 855DisorderedSequence analysisAdd BLAST22
Regioni1070 – 1107DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi473 – 487Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi500 – 518Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi521 – 535Polar residuesSequence analysisAdd BLAST15
Compositional biasi544 – 561Polar residuesSequence analysisAdd BLAST18
Compositional biasi579 – 597Polar residuesSequence analysisAdd BLAST19
Compositional biasi1070 – 1101Basic and acidic residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNAAF1 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQFE, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_282320_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16RY9

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANIMEDY

Database of Orthologous Groups

More...
OrthoDBi
184223at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16RY9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027734, DNAAF1
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45973:SF19, PTHR45973:SF19, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q16RY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRECVEESF GPKKMTKKSI VDSCKKNKLY ITPHLNDILY LNYSGYNAIE
60 70 80 90 100
SLEEYVGLKC LWLECNAISE IKGLEYQTEL KCLYLQNNLI TKIENLDSCK
110 120 130 140 150
QLDTLNLSHN HITRIENCGH DILPVLNTLN LSHNYLKTAD NLDHLRHCNF
160 170 180 190 200
VSVLDLSHNR IEDIAIVKIL GGMKELRVLT MTGNPVVNEI PSYRKTLILE
210 220 230 240 250
CKNLTYLDTR PVFDRDRACA EAWKRGGYEE ERKELLRWKK EEQRKIRRSI
260 270 280 290 300
NATLRMRHRG DGEPELLKTS SDEEDEDKAS KCGKDMSSML EINQKTNEQA
310 320 330 340 350
WAEVEKMFCT TPSATGSSGI FQRFATNRGG GADGDGEVIE TSEEDIEATI
360 370 380 390 400
EDIKAVSPKK LIEEISSDSD GAKENYDCKP DEVIAKPCSE KLIEEIVIET
410 420 430 440 450
AECDSGPSSP EYHEALDKPI ENIVNLTNES PLTSPSFDTE PRTLIEEIEP
460 470 480 490 500
TDVEEEQQIE EQPAPKPLSK NMEKVMSTEK EDDTLNVLIE NNEEISITME
510 520 530 540 550
SKDGELISKV ESRPPSTECK KYKIVSTNDV DNSESEPTDI TNEDQEYRSS
560 570 580 590 600
SVSVTSSTDS SDSEDLFDKI VPNKHPKLAT NYRQDSTTST DSENEVSPSK
610 620 630 640 650
PPIKLEKEKS IAECIDEYKK FFKAAKILES DPEDESSTKM ARPHTAKAKR
660 670 680 690 700
TEPIIYEGVL RNMERNSNES KIAEARTEAK ESKEKVIDRL IEQQNLVDMN
710 720 730 740 750
LEEQNISIGG QEHDFNEYRL EAFRKDQEKL QCLIDRVTAQ KDLYNAHIDQ
760 770 780 790 800
IHNQLANIME DYDQIGLKLK KVDDFLENIK EEPKAPETPS IESEEEIPEE
810 820 830 840 850
LEVHSSEHEQ EIVENDNLAQ QIIEKIISQS VKTSSEDLKS NFDDSSESSD
860 870 880 890 900
SAEEDFMDSI RPDHNLLEIL TSPKPIPILD PELIPNVDNE FQRDPVYRKF
910 920 930 940 950
IEIQEEIDKL TEDELYDIVT EATGEFSEEA HVEHCLNTQV DQYWKQYDDI
960 970 980 990 1000
EEFRKNINLD SHPIIQKFRQ FIRCHCENKY PGEVDSTIDN LDKACRKLER
1010 1020 1030 1040 1050
RLSNQLFDEY LELSRKMSVA TIGGESSANE IELIEVDEEE NDVEDVVKKI
1060 1070 1080 1090 1100
TAWVEEQVQN EIAELNEERA AHAGEVMQDT EDVESKPVEI DGTKEETVDS

ELADNCD
Length:1,107
Mass (Da):126,556
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i113F398DE3556929
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH477692 Genomic DNA Translation: EAT37220.1

NCBI Reference Sequences

More...
RefSeqi
XP_001654892.1, XM_001654842.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AAEL010772-RA; AAEL010772-PA; AAEL010772

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5573861

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aag:5573861

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477692 Genomic DNA Translation: EAT37220.1
RefSeqiXP_001654892.1, XM_001654842.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7159.AAEL010772-PA

Proteomic databases

PRIDEiQ16RY9

Genome annotation databases

EnsemblMetazoaiAAEL010772-RA; AAEL010772-PA; AAEL010772
GeneIDi5573861
KEGGiaag:5573861

Organism-specific databases

VEuPathDBiVectorBase:AAEL010772

Phylogenomic databases

eggNOGiENOG502QQFE, Eukaryota
HOGENOMiCLU_282320_0_0_1
InParanoidiQ16RY9
OMAiANIMEDY
OrthoDBi184223at2759
PhylomeDBiQ16RY9

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR027734, DNAAF1
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
PANTHERiPTHR45973:SF19, PTHR45973:SF19, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAAF1_AEDAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16RY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 25, 2006
Last modified: June 2, 2021
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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