UniProtKB - Q16890 (TPD53_HUMAN)
Protein
Tumor protein D53
Gene
TPD52L1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- G2/M transition of mitotic cell cycle Source: UniProtKB
- positive regulation of apoptotic signaling pathway Source: UniProtKB
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of MAP kinase activity Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q16890 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor protein D53Short name: hD53 Alternative name(s): Tumor protein D52-like 1 |
Gene namesi | Name:TPD52L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000111907.20 |
HGNCi | HGNC:12006, TPD52L1 |
MIMi | 604069, gene |
neXtProti | NX_Q16890 |
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7164 |
OpenTargetsi | ENSG00000111907 |
PharmGKBi | PA36687 |
Miscellaneous databases
Pharosi | Q16890, Tbio |
Polymorphism and mutation databases
BioMutai | TPD52L1 |
DMDMi | 12585368 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185741 | 1 – 204 | Tumor protein D53Add BLAST | 204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 122 | PhosphoserineCombined sources | 1 | |
Modified residuei | 131 | PhosphoserineCombined sources | 1 | |
Modified residuei | 133 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 146 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 149 | PhosphoserineCombined sources | 1 | |
Modified residuei | 174 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q16890 |
jPOSTi | Q16890 |
MassIVEi | Q16890 |
MaxQBi | Q16890 |
PaxDbi | Q16890 |
PeptideAtlasi | Q16890 |
PRIDEi | Q16890 |
ProteomicsDBi | 28063 61125 [Q16890-1] 61126 [Q16890-2] 61127 [Q16890-3] 61128 [Q16890-4] |
TopDownProteomicsi | Q16890-3 [Q16890-3] |
PTM databases
iPTMneti | Q16890 |
PhosphoSitePlusi | Q16890 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111907, Expressed in parotid gland and 233 other tissues |
ExpressionAtlasi | Q16890, baseline and differential |
Genevisiblei | Q16890, HS |
Organism-specific databases
HPAi | ENSG00000111907, Tissue enhanced (adrenal gland, salivary gland) |
Interactioni
Subunit structurei
Forms a homodimer or heterodimer with other members of the family.
Binary interactionsi
Hide detailsQ16890
With | #Exp. | IntAct |
---|---|---|
TPD52 [P55327] | 3 | EBI-717470,EBI-782581 |
itself | 4 | EBI-717470,EBI-717470 |
Tpd52 [Q62393] from Mus musculus. | 3 | EBI-717470,EBI-782591 |
Isoform 2 [Q16890-2]
With | #Exp. | IntAct |
---|---|---|
PBX3 [Q96AL5] | 3 | EBI-18777952,EBI-741171 |
TPD52 - isoform 2 [P55327-2] | 3 | EBI-18777952,EBI-12124194 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113017, 23 interactors |
IntActi | Q16890, 16 interactors |
MINTi | Q16890 |
STRINGi | 9606.ENSP00000434142 |
Miscellaneous databases
RNActi | Q16890, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 22 – 73 | Sequence analysisAdd BLAST | 52 |
Sequence similaritiesi
Belongs to the TPD52 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4010, Eukaryota |
GeneTreei | ENSGT00940000159202 |
HOGENOMi | CLU_080743_0_0_1 |
InParanoidi | Q16890 |
PhylomeDBi | Q16890 |
TreeFami | TF317562 |
Family and domain databases
InterProi | View protein in InterPro IPR007327, TPD52 |
PANTHERi | PTHR19307, PTHR19307, 1 hit |
Pfami | View protein in Pfam PF04201, TPD52, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q16890-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI
60 70 80 90 100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH
110 120 130 140 150
ETLSHAGQKA TAAFSNVGTA ISKKFGDMSY SIRHSISMPA MRNSPTFKSF
160 170 180 190 200
EERVETTVTS LKTKVGGTNP NGGSFEEVLS STAHASAQSL AGGSRRTKEE
ELQC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PNK6 | E9PNK6_HUMAN | Tumor protein D53 | TPD52L1 | 166 | Annotation score: | ||
J3KNE7 | J3KNE7_HUMAN | Tumor protein D53 | TPD52L1 | 209 | Annotation score: | ||
E9PNQ9 | E9PNQ9_HUMAN | Tumor protein D53 | TPD52L1 | 92 | Annotation score: | ||
E9PPQ1 | E9PPQ1_HUMAN | Tumor protein D53 | TPD52L1 | 191 | Annotation score: |
Sequence cautioni
The sequence AAC98475 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 74 | N → T in BAF84576 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 107 | G → E in BAF84561 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034568 | 62 | R → K. Corresponds to variant dbSNP:rs6905231Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036751 | 1 – 29 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_036752 | 129 – 131 | SYS → RRK in isoform 3 and isoform 4. 3 Publications | 3 | |
Alternative sequenceiVSP_036753 | 132 – 204 | Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 73 | |
Alternative sequenceiVSP_036754 | 143 – 144 | NS → RK in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_036755 | 145 – 204 | Missing in isoform 2. 1 PublicationAdd BLAST | 60 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U44427 mRNA Translation: AAB40894.1 U44428 mRNA Translation: AAB40895.1 AF004427 mRNA Translation: AAC98475.1 Different initiation. AF208012 mRNA Translation: AAG49634.1 AK291866 mRNA Translation: BAF84555.1 AK291872 mRNA Translation: BAF84561.1 AK291887 mRNA Translation: BAF84576.1 AL121938 Genomic DNA No translation available. AL136128 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48142.1 BC002375 mRNA Translation: AAH02375.1 |
CCDSi | CCDS34527.1 [Q16890-2] CCDS34528.1 [Q16890-3] CCDS43502.1 [Q16890-5] CCDS5130.1 [Q16890-1] CCDS75514.1 [Q16890-4] |
RefSeqi | NP_001003395.1, NM_001003395.2 [Q16890-5] NP_001003396.1, NM_001003396.2 [Q16890-2] NP_001003397.1, NM_001003397.2 [Q16890-3] NP_003278.1, NM_003287.3 [Q16890-1] XP_005267179.1, XM_005267122.2 [Q16890-5] XP_016866729.1, XM_017011240.1 [Q16890-4] |
Genome annotation databases
Ensembli | ENST00000368388; ENSP00000357373; ENSG00000111907 [Q16890-3] ENST00000368402; ENSP00000357387; ENSG00000111907 [Q16890-2] ENST00000392482; ENSP00000376273; ENSG00000111907 [Q16890-4] ENST00000524679; ENSP00000432787; ENSG00000111907 [Q16890-4] ENST00000532429; ENSP00000435447; ENSG00000111907 [Q16890-5] ENST00000534000; ENSP00000434142; ENSG00000111907 [Q16890-1] ENST00000534199; ENSP00000432590; ENSG00000111907 [Q16890-4] |
GeneIDi | 7164 |
KEGGi | hsa:7164 |
UCSCi | uc003pzu.2, human [Q16890-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U44427 mRNA Translation: AAB40894.1 U44428 mRNA Translation: AAB40895.1 AF004427 mRNA Translation: AAC98475.1 Different initiation. AF208012 mRNA Translation: AAG49634.1 AK291866 mRNA Translation: BAF84555.1 AK291872 mRNA Translation: BAF84561.1 AK291887 mRNA Translation: BAF84576.1 AL121938 Genomic DNA No translation available. AL136128 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48142.1 BC002375 mRNA Translation: AAH02375.1 |
CCDSi | CCDS34527.1 [Q16890-2] CCDS34528.1 [Q16890-3] CCDS43502.1 [Q16890-5] CCDS5130.1 [Q16890-1] CCDS75514.1 [Q16890-4] |
RefSeqi | NP_001003395.1, NM_001003395.2 [Q16890-5] NP_001003396.1, NM_001003396.2 [Q16890-2] NP_001003397.1, NM_001003397.2 [Q16890-3] NP_003278.1, NM_003287.3 [Q16890-1] XP_005267179.1, XM_005267122.2 [Q16890-5] XP_016866729.1, XM_017011240.1 [Q16890-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113017, 23 interactors |
IntActi | Q16890, 16 interactors |
MINTi | Q16890 |
STRINGi | 9606.ENSP00000434142 |
PTM databases
iPTMneti | Q16890 |
PhosphoSitePlusi | Q16890 |
Polymorphism and mutation databases
BioMutai | TPD52L1 |
DMDMi | 12585368 |
Proteomic databases
EPDi | Q16890 |
jPOSTi | Q16890 |
MassIVEi | Q16890 |
MaxQBi | Q16890 |
PaxDbi | Q16890 |
PeptideAtlasi | Q16890 |
PRIDEi | Q16890 |
ProteomicsDBi | 28063 61125 [Q16890-1] 61126 [Q16890-2] 61127 [Q16890-3] 61128 [Q16890-4] |
TopDownProteomicsi | Q16890-3 [Q16890-3] |
Protocols and materials databases
Antibodypediai | 32681, 243 antibodies |
DNASUi | 7164 |
Genome annotation databases
Organism-specific databases
CTDi | 7164 |
DisGeNETi | 7164 |
EuPathDBi | HostDB:ENSG00000111907.20 |
GeneCardsi | TPD52L1 |
HGNCi | HGNC:12006, TPD52L1 |
HPAi | ENSG00000111907, Tissue enhanced (adrenal gland, salivary gland) |
MIMi | 604069, gene |
neXtProti | NX_Q16890 |
OpenTargetsi | ENSG00000111907 |
PharmGKBi | PA36687 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4010, Eukaryota |
GeneTreei | ENSGT00940000159202 |
HOGENOMi | CLU_080743_0_0_1 |
InParanoidi | Q16890 |
PhylomeDBi | Q16890 |
TreeFami | TF317562 |
Enzyme and pathway databases
PathwayCommonsi | Q16890 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 7164, 0 hits in 850 CRISPR screens |
ChiTaRSi | TPD52L1, human |
GeneWikii | TPD52L1 |
GenomeRNAii | 7164 |
Pharosi | Q16890, Tbio |
PROi | PR:Q16890 |
RNActi | Q16890, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111907, Expressed in parotid gland and 233 other tissues |
ExpressionAtlasi | Q16890, baseline and differential |
Genevisiblei | Q16890, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007327, TPD52 |
PANTHERi | PTHR19307, PTHR19307, 1 hit |
Pfami | View protein in Pfam PF04201, TPD52, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPD53_HUMAN | |
Accessioni | Q16890Primary (citable) accession number: Q16890 Secondary accession number(s): A8K757 Q9C054 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations