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Entry version 148 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Tumor protein D53

Gene

TPD52L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-432722 Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor protein D53
Short name:
hD53
Alternative name(s):
Tumor protein D52-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPD52L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111907.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12006 TPD52L1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604069 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16890

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7164

Open Targets

More...
OpenTargetsi
ENSG00000111907

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36687

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPD52L1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12585368

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857411 – 204Tumor protein D53Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei133Omega-N-methylarginineCombined sources1
Modified residuei146PhosphothreonineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q16890

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16890

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16890

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16890

PeptideAtlas

More...
PeptideAtlasi
Q16890

PRoteomics IDEntifications database

More...
PRIDEi
Q16890

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61125
61126 [Q16890-2]
61127 [Q16890-3]
61128 [Q16890-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q16890-3 [Q16890-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16890

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16890

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111907 Expressed in 218 organ(s), highest expression level in parotid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16890 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16890 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027915
HPA027916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a homodimer or heterodimer with other members of the family.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113017, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q16890, 14 interactors

Molecular INTeraction database

More...
MINTi
Q16890

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000434142

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16890

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 73Sequence analysisAdd BLAST52

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4010 Eukaryota
ENOG4111M9H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159202

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058643

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16890

Database of Orthologous Groups

More...
OrthoDBi
1225782at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16890

TreeFam database of animal gene trees

More...
TreeFami
TF317562

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007327 TPD52

The PANTHER Classification System

More...
PANTHERi
PTHR19307 PTHR19307, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04201 TPD52, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16890-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI
60 70 80 90 100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH
110 120 130 140 150
ETLSHAGQKA TAAFSNVGTA ISKKFGDMSY SIRHSISMPA MRNSPTFKSF
160 170 180 190 200
EERVETTVTS LKTKVGGTNP NGGSFEEVLS STAHASAQSL AGGSRRTKEE

ELQC
Length:204
Mass (Da):22,449
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B3C336D5C0653C9
GO
Isoform 2 (identifier: Q16890-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-144: NS → RK
     145-204: Missing.

Show »
Length:144
Mass (Da):16,176
Checksum:iA1CEF878A98BAA63
GO
Isoform 3 (identifier: Q16890-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-131: SYS → RRK
     132-204: Missing.

Show »
Length:131
Mass (Da):14,715
Checksum:iACBE38AD88FC4F52
GO
Isoform 4 (identifier: Q16890-4) [UniParc]FASTAAdd to basket
Also known as: +5hD53

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     129-131: SYS → RRK
     132-204: Missing.

Show »
Length:102
Mass (Da):11,721
Checksum:iA2427192E12E4E62
GO
Isoform 5 (identifier: Q16890-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available. Gene prediction based of partial mRNA data.
Show »
Length:175
Mass (Da):19,456
Checksum:i55A40A9DE99E9B00
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNE7J3KNE7_HUMAN
Tumor protein D53
TPD52L1
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPQ1E9PPQ1_HUMAN
Tumor protein D53
TPD52L1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNK6E9PNK6_HUMAN
Tumor protein D53
TPD52L1
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNQ9E9PNQ9_HUMAN
Tumor protein D53
TPD52L1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC98475 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74N → T in BAF84576 (PubMed:14702039).Curated1
Sequence conflicti107G → E in BAF84561 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03456862R → K. Corresponds to variant dbSNP:rs6905231Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0367511 – 29Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_036752129 – 131SYS → RRK in isoform 3 and isoform 4. 3 Publications3
Alternative sequenceiVSP_036753132 – 204Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST73
Alternative sequenceiVSP_036754143 – 144NS → RK in isoform 2. 1 Publication2
Alternative sequenceiVSP_036755145 – 204Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U44427 mRNA Translation: AAB40894.1
U44428 mRNA Translation: AAB40895.1
AF004427 mRNA Translation: AAC98475.1 Different initiation.
AF208012 mRNA Translation: AAG49634.1
AK291866 mRNA Translation: BAF84555.1
AK291872 mRNA Translation: BAF84561.1
AK291887 mRNA Translation: BAF84576.1
AL121938 Genomic DNA No translation available.
AL136128 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48142.1
BC002375 mRNA Translation: AAH02375.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34527.1 [Q16890-2]
CCDS34528.1 [Q16890-3]
CCDS43502.1 [Q16890-5]
CCDS5130.1 [Q16890-1]
CCDS75514.1 [Q16890-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001003395.1, NM_001003395.2 [Q16890-5]
NP_001003396.1, NM_001003396.2 [Q16890-2]
NP_001003397.1, NM_001003397.2 [Q16890-3]
NP_003278.1, NM_003287.3 [Q16890-1]
XP_005267179.1, XM_005267122.2 [Q16890-5]
XP_016866729.1, XM_017011240.1 [Q16890-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.591347

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368388; ENSP00000357373; ENSG00000111907 [Q16890-3]
ENST00000368402; ENSP00000357387; ENSG00000111907 [Q16890-2]
ENST00000392482; ENSP00000376273; ENSG00000111907 [Q16890-4]
ENST00000524679; ENSP00000432787; ENSG00000111907 [Q16890-4]
ENST00000532429; ENSP00000435447; ENSG00000111907 [Q16890-5]
ENST00000534000; ENSP00000434142; ENSG00000111907 [Q16890-1]
ENST00000534199; ENSP00000432590; ENSG00000111907 [Q16890-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7164

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7164

UCSC genome browser

More...
UCSCi
uc003pzu.2 human [Q16890-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44427 mRNA Translation: AAB40894.1
U44428 mRNA Translation: AAB40895.1
AF004427 mRNA Translation: AAC98475.1 Different initiation.
AF208012 mRNA Translation: AAG49634.1
AK291866 mRNA Translation: BAF84555.1
AK291872 mRNA Translation: BAF84561.1
AK291887 mRNA Translation: BAF84576.1
AL121938 Genomic DNA No translation available.
AL136128 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48142.1
BC002375 mRNA Translation: AAH02375.1
CCDSiCCDS34527.1 [Q16890-2]
CCDS34528.1 [Q16890-3]
CCDS43502.1 [Q16890-5]
CCDS5130.1 [Q16890-1]
CCDS75514.1 [Q16890-4]
RefSeqiNP_001003395.1, NM_001003395.2 [Q16890-5]
NP_001003396.1, NM_001003396.2 [Q16890-2]
NP_001003397.1, NM_001003397.2 [Q16890-3]
NP_003278.1, NM_003287.3 [Q16890-1]
XP_005267179.1, XM_005267122.2 [Q16890-5]
XP_016866729.1, XM_017011240.1 [Q16890-4]
UniGeneiHs.591347

3D structure databases

ProteinModelPortaliQ16890
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113017, 21 interactors
IntActiQ16890, 14 interactors
MINTiQ16890
STRINGi9606.ENSP00000434142

PTM databases

iPTMnetiQ16890
PhosphoSitePlusiQ16890

Polymorphism and mutation databases

BioMutaiTPD52L1
DMDMi12585368

Proteomic databases

EPDiQ16890
jPOSTiQ16890
MaxQBiQ16890
PaxDbiQ16890
PeptideAtlasiQ16890
PRIDEiQ16890
ProteomicsDBi61125
61126 [Q16890-2]
61127 [Q16890-3]
61128 [Q16890-4]
TopDownProteomicsiQ16890-3 [Q16890-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7164
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368388; ENSP00000357373; ENSG00000111907 [Q16890-3]
ENST00000368402; ENSP00000357387; ENSG00000111907 [Q16890-2]
ENST00000392482; ENSP00000376273; ENSG00000111907 [Q16890-4]
ENST00000524679; ENSP00000432787; ENSG00000111907 [Q16890-4]
ENST00000532429; ENSP00000435447; ENSG00000111907 [Q16890-5]
ENST00000534000; ENSP00000434142; ENSG00000111907 [Q16890-1]
ENST00000534199; ENSP00000432590; ENSG00000111907 [Q16890-4]
GeneIDi7164
KEGGihsa:7164
UCSCiuc003pzu.2 human [Q16890-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7164
DisGeNETi7164
EuPathDBiHostDB:ENSG00000111907.20

GeneCards: human genes, protein and diseases

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GeneCardsi
TPD52L1
HGNCiHGNC:12006 TPD52L1
HPAiHPA027915
HPA027916
MIMi604069 gene
neXtProtiNX_Q16890
OpenTargetsiENSG00000111907
PharmGKBiPA36687

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4010 Eukaryota
ENOG4111M9H LUCA
GeneTreeiENSGT00940000159202
HOVERGENiHBG058643
InParanoidiQ16890
OrthoDBi1225782at2759
PhylomeDBiQ16890
TreeFamiTF317562

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TPD52L1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TPD52L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7164

Protein Ontology

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PROi
PR:Q16890

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111907 Expressed in 218 organ(s), highest expression level in parotid gland
ExpressionAtlasiQ16890 baseline and differential
GenevisibleiQ16890 HS

Family and domain databases

InterProiView protein in InterPro
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPD53_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16890
Secondary accession number(s): A8K757
, A8K772, A8MUD2, A8MUJ7, A8MW70, F6V707, O43397, Q5TC99, Q5TDQ0, Q9BUQ6, Q9C054
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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