TPD52L1

Functionⁱ

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 9484778
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9484778
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9484778

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G2/M transition of mitotic cell cycle
Source: UniProtKB
Inferred from direct assayⁱ
- 16112108
positive regulation of apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 14761963
positive regulation of JNK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 14761963
positive regulation of MAP kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14761963

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-432722 Golgi Associated Vesicle Biogenesis

Reactomeⁱ

R-HSA-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor protein D53 Short name: hD53 Alternative name(s): Tumor protein D52-like 1
Gene namesⁱ	Name:TPD52L1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111907.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12006 TPD52L1
MIMⁱ	604069 gene
neXtProtⁱ	NX_Q16890

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7164
Open Targets More...OpenTargetsⁱ	ENSG00000111907
PharmGKBⁱ	PA36687

Polymorphism and mutation databases

BioMutaⁱ	TPD52L1
DMDMⁱ	12585368

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000185741	1 – 204	Tumor protein D53Add BLAST		204

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	29	PhosphoserineCombined sources	1
Modified residueⁱ	86	PhosphoserineCombined sources	1
Modified residueⁱ	122	PhosphoserineCombined sources	1
Modified residueⁱ	131	PhosphoserineCombined sources	1
Modified residueⁱ	133	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	146	PhosphothreonineCombined sources	1
Modified residueⁱ	149	PhosphoserineCombined sources	1
Modified residueⁱ	174	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q16890
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16890
PaxDbⁱ	Q16890
PeptideAtlas More...PeptideAtlasⁱ	Q16890
PRIDEⁱ	Q16890
ProteomicsDBⁱ	61125 61126 [Q16890-2] 61127 [Q16890-3] 61128 [Q16890-4]
TopDownProteomicsⁱ	Q16890-3 [Q16890-3]

PTM databases

iPTMnetⁱ	Q16890
PhosphoSitePlusⁱ	Q16890

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000111907 Expressed in 218 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_TPD52L1
ExpressionAtlasⁱ	Q16890 baseline and differential
Genevisibleⁱ	Q16890 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027915 HPA027916

HPAⁱ

HPA027915
HPA027916

Interactionⁱ

Subunit structureⁱ

Forms a homodimer or heterodimer with other members of the family.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-717470,EBI-717470
TPD52	P55327	3	EBI-717470,EBI-782581
Tpd52	Q62393	3	EBI-717470,EBI-782591	From Mus musculus.

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 9484778
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9484778
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9484778

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113017, 20 interactors
IntActⁱ	Q16890, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q16890
STRINGⁱ	9606.ENSP00000434142

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16890
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	22 – 73	Sequence analysisAdd BLAST		52

Sequence similaritiesⁱ

Belongs to the TPD52 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4010 Eukaryota ENOG4111M9H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015988
HOVERGENⁱ	HBG058643
InParanoidⁱ	Q16890
PhylomeDBⁱ	Q16890
TreeFamⁱ	TF317562

Family and domain databases

InterProⁱ	View protein in InterPro IPR007327 TPD52
PANTHERⁱ	PTHR19307 PTHR19307, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04201 TPD52, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q16890-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI 
        60         70         80         90        100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH 
       110        120        130        140        150
ETLSHAGQKA TAAFSNVGTA ISKKFGDMSY SIRHSISMPA MRNSPTFKSF 
       160        170        180        190        200
EERVETTVTS LKTKVGGTNP NGGSFEEVLS STAHASAQSL AGGSRRTKEE 

ELQC

Length:204

Mass (Da):22,449

Last modified:November 1, 1996 - v1

Checksum:ⁱ6B3C336D5C0653C9

GO

Isoform 2 (identifier: Q16890-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
143-144: NS → RK
145-204: Missing.

« Hide

        10         20         30         40         50
MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI 
        60         70         80         90        100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH 
       110        120        130        140 
ETLSHAGQKA TAAFSNVGTA ISKKFGDMSY SIRHSISMPA MRRK

Show »

Length:144

Mass (Da):16,176

Checksum:ⁱA1CEF878A98BAA63

GO

Isoform 3 (identifier: Q16890-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
129-131: SYS → RRK
132-204: Missing.

« Hide

        10         20         30         40         50
MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI 
        60         70         80         90        100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH 
       110        120        130 
ETLSHAGQKA TAAFSNVGTA ISKKFGDMRR K

Show »

Length:131

Mass (Da):14,715

Checksum:ⁱACBE38AD88FC4F52

GO

Isoform 4 (identifier: Q16890-4) [UniParc]FASTA Add to basket

Also known as: +5hD53

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     129-131: SYS → RRK
     132-204: Missing.

« Hide

        10         20         30         40         50
MLSEEEKEEL KAELVQLEDE ITTLRQVLSA KERHLVEIKQ KLGMNLMNEL 
        60         70         80         90        100
KQNFSKSWHD MQTTTAYKKT HETLSHAGQK ATAAFSNVGT AISKKFGDMR 

RK

Show »

Length:102

Mass (Da):11,721

Checksum:ⁱA2427192E12E4E62

GO

Isoform 5 (identifier: Q16890-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-29: Missing.

« Hide

        10         20         30         40         50
MLSEEEKEEL KAELVQLEDE ITTLRQVLSA KERHLVEIKQ KLGMNLMNEL 
        60         70         80         90        100
KQNFSKSWHD MQTTTAYKKT HETLSHAGQK ATAAFSNVGT AISKKFGDMS 
       110        120        130        140        150
YSIRHSISMP AMRNSPTFKS FEERVETTVT SLKTKVGGTN PNGGSFEEVL 
       160        170 
SSTAHASAQS LAGGSRRTKE EELQC

Note: No experimental confirmation available. Gene prediction based of partial mRNA data.

Show »

Length:175

Mass (Da):19,456

Checksum:ⁱ55A40A9DE99E9B00

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KNE7	J3KNE7_HUMAN	Tumor protein D53 Tumor protein D53	TPD52L1	209	Annotation score:
E9PNK6	E9PNK6_HUMAN	Tumor protein D53 Tumor protein D53	TPD52L1	166	Annotation score:
E9PPQ1	E9PPQ1_HUMAN	Tumor protein D53 Tumor protein D53	TPD52L1	191	Annotation score:
E9PNQ9	E9PNQ9_HUMAN	Tumor protein D53 Tumor protein D53	TPD52L1	92	Annotation score:

Sequence cautionⁱ

The sequence AAC98475 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	74	N → T in BAF84576 (PubMed:14702039).Curated		1
Sequence conflictⁱ	107	G → E in BAF84561 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034568	62	R → K. Corresponds to variant dbSNP:rs6905231Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_036751	1 – 29	Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_036752	129 – 131	SYS → RRK in isoform 3 and isoform 4. 3 Publications	3
Alternative sequenceⁱVSP_036753	132 – 204	Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST	73
Alternative sequenceⁱVSP_036754	143 – 144	NS → RK in isoform 2. 1 Publication	2
Alternative sequenceⁱVSP_036755	145 – 204	Missing in isoform 2. 1 PublicationAdd BLAST	60

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44427 mRNA Translation: AAB40894.1 U44428 mRNA Translation: AAB40895.1 AF004427 mRNA Translation: AAC98475.1 Different initiation. AF208012 mRNA Translation: AAG49634.1 AK291866 mRNA Translation: BAF84555.1 AK291872 mRNA Translation: BAF84561.1 AK291887 mRNA Translation: BAF84576.1 AL121938 Genomic DNA No translation available. AL136128 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48142.1 BC002375 mRNA Translation: AAH02375.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34527.1 [Q16890-2] CCDS34528.1 [Q16890-3] CCDS43502.1 [Q16890-5] CCDS5130.1 [Q16890-1] CCDS75514.1 [Q16890-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001003395.1, NM_001003395.2 [Q16890-5] NP_001003396.1, NM_001003396.2 [Q16890-2] NP_001003397.1, NM_001003397.2 [Q16890-3] NP_003278.1, NM_003287.3 [Q16890-1] XP_005267179.1, XM_005267122.2 [Q16890-5] XP_016866729.1, XM_017011240.1 [Q16890-4]
UniGeneⁱ	Hs.591347

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q16890	Tumor protein D52-like 1		PANTR		204	UniRef100_Q16890
Tumor protein D52 like 1		GORGO		204
Uncharacterized protein		PANPA		197
Uncharacterized protein		MACMU		175
Uncharacterized protein		MANLE		175
+2
Q16890-2	Tumor protein D52-like 1		PANTR		144	UniRef100_K7D7F6
Tumor protein D52 like 1		GORGO		144
Uncharacterized protein		PANPA		137
UPI0004F1EF31		HUMAN		115
Q16890-3	Tumor protein D52-like 1		PANTR		131	UniRef100_K7ATA4
Tumor protein D52 like 1		GORGO		131
Uncharacterized protein		PANPA		124
Q16890-4	TPD52L1 isoform 11		PONAB		102	UniRef100_A0A2J8RYY2
Uncharacterized protein		MACMU		102
Uncharacterized protein		COLAP		102
Uncharacterized protein		NOMLE		102
Tumor protein D52 like 1		GORGO		102
+2

Protein	Similar proteins		Species	Score	Length	Source
Q16890	Tumor protein D52-like 1		PANTR		204	UniRef90_Q16890
Tumor protein D52 like 1		GORGO		204
Uncharacterized protein		PANPA		197
Uncharacterized protein		MACMU		175
Uncharacterized protein		MANLE		175
+117
Q16890-2	Tumor protein D53 isoform 3		MACMU		144	UniRef90_I0FMV0
Uncharacterized protein		MACFA		144
Uncharacterized protein		MACNE		144
Tumor protein D52-like 1		PANTR		144
Tumor protein D52 like 1		GORGO		144
+27
Q16890-3	Tumor protein D52-like 1, isoform CRA_a		MOUSE		131	UniRef90_Q3V2G6
TPD52L1 isoform 2		PANTR		131
Tumor protein D53 isoform 4		MACMU		131
Uncharacterized protein		MACFA		131
Uncharacterized protein		MACNE		131
+56
Q16890-4	TPD52L1 isoform 11		PONAB		102	UniRef90_A0A2J8RYY2
Uncharacterized protein		MACMU		102
Uncharacterized protein		COLAP		102
Uncharacterized protein		NOMLE		102
Tumor protein D52 like 1		GORGO		102
+3

Protein	Similar proteins		Species	Score	Length	Source
Q16890	Tumor protein D52-like 1		PANTR		204	UniRef50_Q16890
Tumor protein D52 like 1		GORGO		204
Uncharacterized protein		PANPA		197
Uncharacterized protein		MACMU		175
Uncharacterized protein		MANLE		175
+161
Q16890-2	Tumor protein D53 isoform 3		MACMU		144	UniRef50_I0FMV0
Uncharacterized protein		MACFA		144
Uncharacterized protein		MACNE		144
Uncharacterized protein		CALJA		144
Uncharacterized protein		Cebus capucinus imitator		144
+41
Q16890-3	Tumor protein D52-like 1, isoform CRA_a		MOUSE		131	UniRef50_Q3V2G6
Tumor protein D52-like 1		PANTR		131
Tumor protein D52 like 1		GORGO		131
Uncharacterized protein		PANPA		124
tumor protein D53		ODORO		131
+121
Q16890-4	Tumor protein D54		HUMAN		152	UniRef50_A0A087WZ51
Uncharacterized protein		MACMU		153
Uncharacterized protein		PAPAN		152
Uncharacterized protein		CERAT		152
Uncharacterized protein		RHIRO		152
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44427 mRNA Translation: AAB40894.1 U44428 mRNA Translation: AAB40895.1 AF004427 mRNA Translation: AAC98475.1 Different initiation. AF208012 mRNA Translation: AAG49634.1 AK291866 mRNA Translation: BAF84555.1 AK291872 mRNA Translation: BAF84561.1 AK291887 mRNA Translation: BAF84576.1 AL121938 Genomic DNA No translation available. AL136128 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48142.1 BC002375 mRNA Translation: AAH02375.1
CCDSⁱ	CCDS34527.1 [Q16890-2] CCDS34528.1 [Q16890-3] CCDS43502.1 [Q16890-5] CCDS5130.1 [Q16890-1] CCDS75514.1 [Q16890-4]
RefSeqⁱ	NP_001003395.1, NM_001003395.2 [Q16890-5] NP_001003396.1, NM_001003396.2 [Q16890-2] NP_001003397.1, NM_001003397.2 [Q16890-3] NP_003278.1, NM_003287.3 [Q16890-1] XP_005267179.1, XM_005267122.2 [Q16890-5] XP_016866729.1, XM_017011240.1 [Q16890-4]
UniGeneⁱ	Hs.591347

3D structure databases

ProteinModelPortalⁱ	Q16890
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113017, 20 interactors
IntActⁱ	Q16890, 14 interactors
MINTⁱ	Q16890
STRINGⁱ	9606.ENSP00000434142

PTM databases

iPTMnetⁱ	Q16890
PhosphoSitePlusⁱ	Q16890

Polymorphism and mutation databases

BioMutaⁱ	TPD52L1
DMDMⁱ	12585368

Proteomic databases

EPDⁱ	Q16890
MaxQBⁱ	Q16890
PaxDbⁱ	Q16890
PeptideAtlasⁱ	Q16890
PRIDEⁱ	Q16890
ProteomicsDBⁱ	61125 61126 [Q16890-2] 61127 [Q16890-3] 61128 [Q16890-4]
TopDownProteomicsⁱ	Q16890-3 [Q16890-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7164
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368388; ENSP00000357373; ENSG00000111907 [Q16890-3] ENST00000368402; ENSP00000357387; ENSG00000111907 [Q16890-2] ENST00000392482; ENSP00000376273; ENSG00000111907 [Q16890-4] ENST00000524679; ENSP00000432787; ENSG00000111907 [Q16890-4] ENST00000532429; ENSP00000435447; ENSG00000111907 [Q16890-5] ENST00000534000; ENSP00000434142; ENSG00000111907 [Q16890-1] ENST00000534199; ENSP00000432590; ENSG00000111907 [Q16890-4]
GeneIDⁱ	7164
KEGGⁱ	hsa:7164
UCSCⁱ	uc003pzu.2 human [Q16890-1]

Organism-specific databases

CTDⁱ	7164
DisGeNETⁱ	7164
EuPathDBⁱ	HostDB:ENSG00000111907.20
GeneCardsⁱ	TPD52L1
HGNCⁱ	HGNC:12006 TPD52L1
HPAⁱ	HPA027915 HPA027916
MIMⁱ	604069 gene
neXtProtⁱ	NX_Q16890
OpenTargetsⁱ	ENSG00000111907
PharmGKBⁱ	PA36687
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4010 Eukaryota ENOG4111M9H LUCA
GeneTreeⁱ	ENSGT00390000015988
HOVERGENⁱ	HBG058643
InParanoidⁱ	Q16890
PhylomeDBⁱ	Q16890
TreeFamⁱ	TF317562

Enzyme and pathway databases

Reactomeⁱ	R-HSA-432722 Golgi Associated Vesicle Biogenesis

Reactomeⁱ

R-HSA-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRSⁱ	TPD52L1 human
GeneWikiⁱ	TPD52L1
GenomeRNAiⁱ	7164
Protein Ontology More...PROⁱ	PR:Q16890
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111907 Expressed in 218 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_TPD52L1
ExpressionAtlasⁱ	Q16890 baseline and differential
Genevisibleⁱ	Q16890 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007327 TPD52
PANTHERⁱ	PTHR19307 PTHR19307, 1 hit
Pfamⁱ	View protein in Pfam PF04201 TPD52, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPD53_HUMAN
Accessionⁱ	Q16890Primary (citable) accession number: Q16890 Secondary accession number(s): A8K757 Q9C054
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16890 (TPD53_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Tumor protein D53

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ