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UniProtKB - Q16890 (TPD53_HUMAN)

Entry version 161 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Tumor protein D53

Gene

TPD52L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16890

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-432722, Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor protein D53
Short name:
hD53
Alternative name(s):
Tumor protein D52-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPD52L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12006, TPD52L1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604069, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16890

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111907.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7164

Open Targets

More...OpenTargetsi		ENSG00000111907

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36687

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16890, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TPD52L1

Domain mapping of disease mutations (DMDM)

More...DMDMi		12585368

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857411 – 204Tumor protein D53Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei133Omega-N-methylarginineCombined sources1
Modified residuei146PhosphothreonineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16890

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16890

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16890

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16890

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16890

PeptideAtlas

More...PeptideAtlasi		Q16890

PRoteomics IDEntifications database

More...PRIDEi		Q16890

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		28063
61125 [Q16890-1]
61126 [Q16890-2]
61127 [Q16890-3]
61128 [Q16890-4]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q16890-3 [Q16890-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16890

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16890

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111907, Expressed in parotid gland and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16890, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16890, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111907, Tissue enhanced (adrenal gland, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a homodimer or heterodimer with other members of the family.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113017, 23 interactors

Protein interaction database and analysis system

More...IntActi		Q16890, 16 interactors

Molecular INTeraction database

More...MINTi		Q16890

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000434142

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16890, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 73Sequence analysisAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4010, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159202

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_080743_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16890

Identification of Orthologs from Complete Genome Data

More...OMAi		MVTDVDF

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16890

TreeFam database of animal gene trees

More...TreeFami		TF317562

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007327, TPD52

The PANTHER Classification System

More...PANTHERi		PTHR19307, PTHR19307, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04201, TPD52, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16890-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI 
        60         70         80         90        100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH 
       110        120        130        140        150
ETLSHAGQKA TAAFSNVGTA ISKKFGDMSY SIRHSISMPA MRNSPTFKSF 
       160        170        180        190        200
EERVETTVTS LKTKVGGTNP NGGSFEEVLS STAHASAQSL AGGSRRTKEE 

ELQC
Length:204
Mass (Da):22,449
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B3C336D5C0653C9
GO
Isoform 2 (identifier: Q16890-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-144: NS → RK
     145-204: Missing.

Show »
Length:144
Mass (Da):16,176
Checksum:iA1CEF878A98BAA63
GO
Isoform 3 (identifier: Q16890-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-131: SYS → RRK
     132-204: Missing.

Show »
Length:131
Mass (Da):14,715
Checksum:iACBE38AD88FC4F52
GO
Isoform 4 (identifier: Q16890-4) [UniParc]FASTAAdd to basket
Also known as: +5hD53

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     129-131: SYS → RRK
     132-204: Missing.

Show »
Length:102
Mass (Da):11,721
Checksum:iA2427192E12E4E62
GO
Isoform 5 (identifier: Q16890-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:175
Mass (Da):19,456
Checksum:i55A40A9DE99E9B00
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNK6E9PNK6_HUMAN
Tumor protein D53
TPD52L1
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNE7J3KNE7_HUMAN
Tumor protein D53
TPD52L1
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNQ9E9PNQ9_HUMAN
Tumor protein D53
TPD52L1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPQ1E9PPQ1_HUMAN
Tumor protein D53
TPD52L1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC98475 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74N → T in BAF84576 (PubMed:14702039).Curated1
Sequence conflicti107G → E in BAF84561 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03456862R → K. Corresponds to variant dbSNP:rs6905231Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0367511 – 29Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_036752129 – 131SYS → RRK in isoform 3 and isoform 4. 3 Publications3
Alternative sequenceiVSP_036753132 – 204Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST73
Alternative sequenceiVSP_036754143 – 144NS → RK in isoform 2. 1 Publication2
Alternative sequenceiVSP_036755145 – 204Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U44427 mRNA Translation: AAB40894.1
U44428 mRNA Translation: AAB40895.1
AF004427 mRNA Translation: AAC98475.1 Different initiation.
AF208012 mRNA Translation: AAG49634.1
AK291866 mRNA Translation: BAF84555.1
AK291872 mRNA Translation: BAF84561.1
AK291887 mRNA Translation: BAF84576.1
AL121938 Genomic DNA No translation available.
AL136128 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48142.1
BC002375 mRNA Translation: AAH02375.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34527.1 [Q16890-2]
CCDS34528.1 [Q16890-3]
CCDS43502.1 [Q16890-5]
CCDS5130.1 [Q16890-1]
CCDS75514.1 [Q16890-4]

NCBI Reference Sequences

More...RefSeqi		NP_001003395.1, NM_001003395.2 [Q16890-5]
NP_001003396.1, NM_001003396.2 [Q16890-2]
NP_001003397.1, NM_001003397.2 [Q16890-3]
NP_003278.1, NM_003287.3 [Q16890-1]
XP_005267179.1, XM_005267122.2 [Q16890-5]
XP_016866729.1, XM_017011240.1 [Q16890-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368388; ENSP00000357373; ENSG00000111907 [Q16890-3]
ENST00000368402; ENSP00000357387; ENSG00000111907 [Q16890-2]
ENST00000392482; ENSP00000376273; ENSG00000111907 [Q16890-4]
ENST00000524679; ENSP00000432787; ENSG00000111907 [Q16890-4]
ENST00000532429; ENSP00000435447; ENSG00000111907 [Q16890-5]
ENST00000534000; ENSP00000434142; ENSG00000111907 [Q16890-1]
ENST00000534199; ENSP00000432590; ENSG00000111907 [Q16890-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7164

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7164

UCSC genome browser

More...UCSCi		uc003pzu.2, human [Q16890-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44427 mRNA Translation: AAB40894.1
U44428 mRNA Translation: AAB40895.1
AF004427 mRNA Translation: AAC98475.1 Different initiation.
AF208012 mRNA Translation: AAG49634.1
AK291866 mRNA Translation: BAF84555.1
AK291872 mRNA Translation: BAF84561.1
AK291887 mRNA Translation: BAF84576.1
AL121938 Genomic DNA No translation available.
AL136128 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48142.1
BC002375 mRNA Translation: AAH02375.1
CCDSiCCDS34527.1 [Q16890-2]
CCDS34528.1 [Q16890-3]
CCDS43502.1 [Q16890-5]
CCDS5130.1 [Q16890-1]
CCDS75514.1 [Q16890-4]
RefSeqiNP_001003395.1, NM_001003395.2 [Q16890-5]
NP_001003396.1, NM_001003396.2 [Q16890-2]
NP_001003397.1, NM_001003397.2 [Q16890-3]
NP_003278.1, NM_003287.3 [Q16890-1]
XP_005267179.1, XM_005267122.2 [Q16890-5]
XP_016866729.1, XM_017011240.1 [Q16890-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi113017, 23 interactors
IntActiQ16890, 16 interactors
MINTiQ16890
STRINGi9606.ENSP00000434142

PTM databases

iPTMnetiQ16890
PhosphoSitePlusiQ16890

Genetic variation databases

BioMutaiTPD52L1
DMDMi12585368

Proteomic databases

EPDiQ16890
jPOSTiQ16890
MassIVEiQ16890
MaxQBiQ16890
PaxDbiQ16890
PeptideAtlasiQ16890
PRIDEiQ16890
ProteomicsDBi28063
61125 [Q16890-1]
61126 [Q16890-2]
61127 [Q16890-3]
61128 [Q16890-4]
TopDownProteomicsiQ16890-3 [Q16890-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32681, 249 antibodies

The DNASU plasmid repository

More...DNASUi		7164

Genome annotation databases

EnsembliENST00000368388; ENSP00000357373; ENSG00000111907 [Q16890-3]
ENST00000368402; ENSP00000357387; ENSG00000111907 [Q16890-2]
ENST00000392482; ENSP00000376273; ENSG00000111907 [Q16890-4]
ENST00000524679; ENSP00000432787; ENSG00000111907 [Q16890-4]
ENST00000532429; ENSP00000435447; ENSG00000111907 [Q16890-5]
ENST00000534000; ENSP00000434142; ENSG00000111907 [Q16890-1]
ENST00000534199; ENSP00000432590; ENSG00000111907 [Q16890-4]
GeneIDi7164
KEGGihsa:7164
UCSCiuc003pzu.2, human [Q16890-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7164
DisGeNETi7164

GeneCards: human genes, protein and diseases

More...GeneCardsi		TPD52L1
HGNCiHGNC:12006, TPD52L1
HPAiENSG00000111907, Tissue enhanced (adrenal gland, salivary gland)
MIMi604069, gene
neXtProtiNX_Q16890
OpenTargetsiENSG00000111907
PharmGKBiPA36687
VEuPathDBiHostDB:ENSG00000111907.20

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4010, Eukaryota
GeneTreeiENSGT00940000159202
HOGENOMiCLU_080743_0_0_1
InParanoidiQ16890
OMAiMVTDVDF
PhylomeDBiQ16890
TreeFamiTF317562

Enzyme and pathway databases

PathwayCommonsiQ16890
ReactomeiR-HSA-432722, Golgi Associated Vesicle Biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7164, 3 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TPD52L1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TPD52L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7164
PharosiQ16890, Tbio

Protein Ontology

More...PROi		PR:Q16890
RNActiQ16890, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111907, Expressed in parotid gland and 233 other tissues
ExpressionAtlasiQ16890, baseline and differential
GenevisibleiQ16890, HS

Family and domain databases

InterProiView protein in InterPro
IPR007327, TPD52
PANTHERiPTHR19307, PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201, TPD52, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPD53_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16890
Secondary accession number(s): A8K757
, A8K772, A8MUD2, A8MUJ7, A8MW70, F6V707, O43397, Q5TC99, Q5TDQ0, Q9BUQ6, Q9C054
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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