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Protein

Tumor protein D53

Gene

TPD52L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein D53
Short name:
hD53
Alternative name(s):
Tumor protein D52-like 1
Gene namesi
Name:TPD52L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111907.20
HGNCiHGNC:12006 TPD52L1
MIMi604069 gene
neXtProtiNX_Q16890

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi7164
OpenTargetsiENSG00000111907
PharmGKBiPA36687

Polymorphism and mutation databases

BioMutaiTPD52L1
DMDMi12585368

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857411 – 204Tumor protein D53Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei133Omega-N-methylarginineCombined sources1
Modified residuei146PhosphothreonineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ16890
MaxQBiQ16890
PaxDbiQ16890
PeptideAtlasiQ16890
PRIDEiQ16890
ProteomicsDBi61125
61126 [Q16890-2]
61127 [Q16890-3]
61128 [Q16890-4]
TopDownProteomicsiQ16890-3 [Q16890-3]

PTM databases

iPTMnetiQ16890
PhosphoSitePlusiQ16890

Expressioni

Gene expression databases

BgeeiENSG00000111907 Expressed in 218 organ(s), highest expression level in parotid gland
CleanExiHS_TPD52L1
ExpressionAtlasiQ16890 baseline and differential
GenevisibleiQ16890 HS

Organism-specific databases

HPAiHPA027915
HPA027916

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with other members of the family.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113017, 20 interactors
IntActiQ16890, 14 interactors
MINTiQ16890
STRINGi9606.ENSP00000434142

Structurei

3D structure databases

ProteinModelPortaliQ16890
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili22 – 73Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4010 Eukaryota
ENOG4111M9H LUCA
GeneTreeiENSGT00390000015988
HOVERGENiHBG058643
InParanoidiQ16890
PhylomeDBiQ16890
TreeFamiTF317562

Family and domain databases

InterProiView protein in InterPro
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16890-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI
60 70 80 90 100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH
110 120 130 140 150
ETLSHAGQKA TAAFSNVGTA ISKKFGDMSY SIRHSISMPA MRNSPTFKSF
160 170 180 190 200
EERVETTVTS LKTKVGGTNP NGGSFEEVLS STAHASAQSL AGGSRRTKEE

ELQC
Length:204
Mass (Da):22,449
Last modified:November 1, 1996 - v1
Checksum:i6B3C336D5C0653C9
GO
Isoform 2 (identifier: Q16890-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-144: NS → RK
     145-204: Missing.

Show »
Length:144
Mass (Da):16,176
Checksum:iA1CEF878A98BAA63
GO
Isoform 3 (identifier: Q16890-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-131: SYS → RRK
     132-204: Missing.

Show »
Length:131
Mass (Da):14,715
Checksum:iACBE38AD88FC4F52
GO
Isoform 4 (identifier: Q16890-4) [UniParc]FASTAAdd to basket
Also known as: +5hD53

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     129-131: SYS → RRK
     132-204: Missing.

Show »
Length:102
Mass (Da):11,721
Checksum:iA2427192E12E4E62
GO
Isoform 5 (identifier: Q16890-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available. Gene prediction based of partial mRNA data.
Show »
Length:175
Mass (Da):19,456
Checksum:i55A40A9DE99E9B00
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNE7J3KNE7_HUMAN
Tumor protein D53
TPD52L1
209Annotation score:
E9PNK6E9PNK6_HUMAN
Tumor protein D53
TPD52L1
166Annotation score:
E9PPQ1E9PPQ1_HUMAN
Tumor protein D53
TPD52L1
191Annotation score:
E9PNQ9E9PNQ9_HUMAN
Tumor protein D53
TPD52L1
92Annotation score:

Sequence cautioni

The sequence AAC98475 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74N → T in BAF84576 (PubMed:14702039).Curated1
Sequence conflicti107G → E in BAF84561 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03456862R → K. Corresponds to variant dbSNP:rs6905231Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367511 – 29Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_036752129 – 131SYS → RRK in isoform 3 and isoform 4. 3 Publications3
Alternative sequenceiVSP_036753132 – 204Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST73
Alternative sequenceiVSP_036754143 – 144NS → RK in isoform 2. 1 Publication2
Alternative sequenceiVSP_036755145 – 204Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44427 mRNA Translation: AAB40894.1
U44428 mRNA Translation: AAB40895.1
AF004427 mRNA Translation: AAC98475.1 Different initiation.
AF208012 mRNA Translation: AAG49634.1
AK291866 mRNA Translation: BAF84555.1
AK291872 mRNA Translation: BAF84561.1
AK291887 mRNA Translation: BAF84576.1
AL121938 Genomic DNA No translation available.
AL136128 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48142.1
BC002375 mRNA Translation: AAH02375.1
CCDSiCCDS34527.1 [Q16890-2]
CCDS34528.1 [Q16890-3]
CCDS43502.1 [Q16890-5]
CCDS5130.1 [Q16890-1]
CCDS75514.1 [Q16890-4]
RefSeqiNP_001003395.1, NM_001003395.2 [Q16890-5]
NP_001003396.1, NM_001003396.2 [Q16890-2]
NP_001003397.1, NM_001003397.2 [Q16890-3]
NP_003278.1, NM_003287.3 [Q16890-1]
XP_005267179.1, XM_005267122.2 [Q16890-5]
XP_016866729.1, XM_017011240.1 [Q16890-4]
UniGeneiHs.591347

Genome annotation databases

EnsembliENST00000368388; ENSP00000357373; ENSG00000111907 [Q16890-3]
ENST00000368402; ENSP00000357387; ENSG00000111907 [Q16890-2]
ENST00000392482; ENSP00000376273; ENSG00000111907 [Q16890-4]
ENST00000524679; ENSP00000432787; ENSG00000111907 [Q16890-4]
ENST00000532429; ENSP00000435447; ENSG00000111907 [Q16890-5]
ENST00000534000; ENSP00000434142; ENSG00000111907 [Q16890-1]
ENST00000534199; ENSP00000432590; ENSG00000111907 [Q16890-4]
GeneIDi7164
KEGGihsa:7164
UCSCiuc003pzu.2 human [Q16890-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44427 mRNA Translation: AAB40894.1
U44428 mRNA Translation: AAB40895.1
AF004427 mRNA Translation: AAC98475.1 Different initiation.
AF208012 mRNA Translation: AAG49634.1
AK291866 mRNA Translation: BAF84555.1
AK291872 mRNA Translation: BAF84561.1
AK291887 mRNA Translation: BAF84576.1
AL121938 Genomic DNA No translation available.
AL136128 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48142.1
BC002375 mRNA Translation: AAH02375.1
CCDSiCCDS34527.1 [Q16890-2]
CCDS34528.1 [Q16890-3]
CCDS43502.1 [Q16890-5]
CCDS5130.1 [Q16890-1]
CCDS75514.1 [Q16890-4]
RefSeqiNP_001003395.1, NM_001003395.2 [Q16890-5]
NP_001003396.1, NM_001003396.2 [Q16890-2]
NP_001003397.1, NM_001003397.2 [Q16890-3]
NP_003278.1, NM_003287.3 [Q16890-1]
XP_005267179.1, XM_005267122.2 [Q16890-5]
XP_016866729.1, XM_017011240.1 [Q16890-4]
UniGeneiHs.591347

3D structure databases

ProteinModelPortaliQ16890
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113017, 20 interactors
IntActiQ16890, 14 interactors
MINTiQ16890
STRINGi9606.ENSP00000434142

PTM databases

iPTMnetiQ16890
PhosphoSitePlusiQ16890

Polymorphism and mutation databases

BioMutaiTPD52L1
DMDMi12585368

Proteomic databases

EPDiQ16890
MaxQBiQ16890
PaxDbiQ16890
PeptideAtlasiQ16890
PRIDEiQ16890
ProteomicsDBi61125
61126 [Q16890-2]
61127 [Q16890-3]
61128 [Q16890-4]
TopDownProteomicsiQ16890-3 [Q16890-3]

Protocols and materials databases

DNASUi7164
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368388; ENSP00000357373; ENSG00000111907 [Q16890-3]
ENST00000368402; ENSP00000357387; ENSG00000111907 [Q16890-2]
ENST00000392482; ENSP00000376273; ENSG00000111907 [Q16890-4]
ENST00000524679; ENSP00000432787; ENSG00000111907 [Q16890-4]
ENST00000532429; ENSP00000435447; ENSG00000111907 [Q16890-5]
ENST00000534000; ENSP00000434142; ENSG00000111907 [Q16890-1]
ENST00000534199; ENSP00000432590; ENSG00000111907 [Q16890-4]
GeneIDi7164
KEGGihsa:7164
UCSCiuc003pzu.2 human [Q16890-1]

Organism-specific databases

CTDi7164
DisGeNETi7164
EuPathDBiHostDB:ENSG00000111907.20
GeneCardsiTPD52L1
HGNCiHGNC:12006 TPD52L1
HPAiHPA027915
HPA027916
MIMi604069 gene
neXtProtiNX_Q16890
OpenTargetsiENSG00000111907
PharmGKBiPA36687
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4010 Eukaryota
ENOG4111M9H LUCA
GeneTreeiENSGT00390000015988
HOVERGENiHBG058643
InParanoidiQ16890
PhylomeDBiQ16890
TreeFamiTF317562

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRSiTPD52L1 human
GeneWikiiTPD52L1
GenomeRNAii7164
PROiPR:Q16890
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111907 Expressed in 218 organ(s), highest expression level in parotid gland
CleanExiHS_TPD52L1
ExpressionAtlasiQ16890 baseline and differential
GenevisibleiQ16890 HS

Family and domain databases

InterProiView protein in InterPro
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPD53_HUMAN
AccessioniPrimary (citable) accession number: Q16890
Secondary accession number(s): A8K757
, A8K772, A8MUD2, A8MUJ7, A8MW70, F6V707, O43397, Q5TC99, Q5TDQ0, Q9BUQ6, Q9C054
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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