UGT8

Functionⁱ

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.By similarity

Catalytic activityⁱ

UDP-alpha-D-galactose + N-acylsphingosine = UDP + beta-D-galactosylceramide.By similarity

Pathwayⁱ: galactosylceramide biosynthesis

This protein is involved in the pathway galactosylceramide biosynthesis, which is part of Sphingolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway galactosylceramide biosynthesis and in Sphingolipid metabolism.

GO - Molecular functionⁱ

glucuronosyltransferase activity Source: GO_Central
N-acylsphingosine galactosyltransferase activity Source: Reactome
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
Source: ProtInc
Traceable author statementⁱ
- 8661025

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 8661025
cytoskeleton organization Source: Ensembl
galactosylceramide biosynthetic process Source: UniProtKB-UniPathway
glycosphingolipid metabolic process Source: Reactome
neuron projection morphogenesis Source: Ensembl
paranodal junction assembly Source: Ensembl
peripheral nervous system development
Source: ProtInc
Traceable author statementⁱ
- 8661025
protein localization to paranode region of axon Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Biological process	Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS10812-MONOMER
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism
UniPathwayⁱ	UPA00787

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT1 Glycosyltransferase Family 1

CAZyⁱ

GT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsⁱ	SLP:000001432

SwissLipidsⁱ

SLP:000001432

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC:2.4.1.47By similarity) Alternative name(s): Ceramide UDP-galactosyltransferase Cerebroside synthase UDP-galactose-ceramide galactosyltransferase
Gene namesⁱ	Name:UGT8 Synonyms:CGT, UGT4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174607.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12555 UGT8
MIMⁱ	601291 gene
neXtProtⁱ	NX_Q16880

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	472 – 492	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7368
Open Targets More...OpenTargetsⁱ	ENSG00000174607
PharmGKBⁱ	PA37195

Polymorphism and mutation databases

BioMutaⁱ	UGT8
DMDMⁱ	296434442

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000036064	21 – 541	2-hydroxyacylsphingosine 1-beta-galactosyltransferaseAdd BLAST		521

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	78	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	333	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	442	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q16880
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16880
PaxDbⁱ	Q16880
PeptideAtlas More...PeptideAtlasⁱ	Q16880
PRIDEⁱ	Q16880
ProteomicsDBⁱ	61118

PTM databases

GlyConnectⁱ	980
iPTMnetⁱ	Q16880
PhosphoSitePlusⁱ	Q16880

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000174607 Expressed in 158 organ(s), highest expression level in spinal cord
CleanExⁱ	HS_UGT8
ExpressionAtlasⁱ	Q16880 baseline and differential
Genevisibleⁱ	Q16880 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014405 HPA065785

HPAⁱ

HPA014405
HPA065785

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	113215, 30 interactors
IntActⁱ	Q16880, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q16880
STRINGⁱ	9606.ENSP00000311648

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16880
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1192 Eukaryota COG1819 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118949
HOGENOMⁱ	HOG000220831
HOVERGENⁱ	HBG098341
InParanoidⁱ	Q16880
KEGG Orthology (KO) More...KOⁱ	K04628
OMAⁱ	IAPSNHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06JC
PhylomeDBⁱ	Q16880
TreeFamⁱ	TF315472

Family and domain databases

InterProⁱ	View protein in InterPro IPR002213 UDP_glucos_trans IPR035595 UDP_glycos_trans_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00201 UDPGT, 1 hit
PROSITEⁱ	View protein in PROSITE PS00375 UDPGT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q16880-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKSYTPYFIL LWSAVGIAKA AKIIIVPPIM FESHMYIFKT LASALHERGH 
        60         70         80         90        100
HTVFLLSEGR DIAPSNHYSL QRYPGIFNST TSDAFLQSKM RNIFSGRLTA 
       110        120        130        140        150
IELFDILDHY TKNCDLMVGN HALIQGLKKE KFDLLLVDPN DMCGFVIAHL 
       160        170        180        190        200
LGVKYAVFST GLWYPAEVGA PAPLAYVPEF NSLLTDRMNL LQRMKNTGVY 
       210        220        230        240        250
LISRLGVSFL VLPKYERIMQ KYNLLPEKSM YDLVHGSSLW MLCTDVALEF 
       260        270        280        290        300
PRPTLPNVVY VGGILTKPAS PLPEDLQRWV NGANEHGFVL VSFGAGVKYL 
       310        320        330        340        350
SEDIANKLAG ALGRLPQKVI WRFSGPKPKN LGNNTKLIEW LPQNDLLGHS 
       360        370        380        390        400
KIKAFLSHGG LNSIFETIYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE 
       410        420        430        440        450
WKTVTEKELY EALVKVINNP SYRQRAQKLS EIHKDQPGHP VNRTIYWIDY 
       460        470        480        490        500
IIRHNGAHHL RAAVHQISFC QYFLLDIAFV LLLGAALLYF LLSWVTKFIY 
       510        520        530        540 
RKIKSLWSRN KHSTVNGHYH NGILNGKYKR NGHIKHEKKV K

Length:541

Mass (Da):61,438

Last modified:May 18, 2010 - v2

Checksum:ⁱ02FA965FEC8EB788

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RFW2	D6RFW2_HUMAN		2-hydroxyacylsphingosine 1-beta-gal... 2-hydroxyacylsphingosine 1-beta-galactosyltransferase	UGT8	141	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	99	T → P in AAC51187 (PubMed:9125199).Curated	1
Sequence conflictⁱ	116	L → M in AAC51187 (PubMed:9125199).Curated	1
Sequence conflictⁱ	356	L → V in AAC51187 (PubMed:9125199).Curated	1
Sequence conflictⁱ	379	L → V in AAC51187 (PubMed:9125199).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052466	226	P → L. Corresponds to variant dbSNP:rs4148254Ensembl.		1
Natural variantⁱVAR_052467	368	I → M5 PublicationsCorresponds to variant dbSNP:rs11098261Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30930 mRNA Translation: AAC50565.1 U32370 , U31353, U31461, U31658, U31861 Genomic DNA Translation: AAC50815.1 U62899 mRNA Translation: AAC51187.1 AK127970 mRNA Translation: BAG54609.1 AC122938 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06307.1 BC075069 mRNA Translation: AAH75069.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3705.1
PIRⁱ	JC5423
NCBI Reference Sequences More...RefSeqⁱ	NP_001121646.1, NM_001128174.2 NP_001309041.1, NM_001322112.1 NP_001309042.1, NM_001322113.1 NP_001309043.1, NM_001322114.1 NP_003351.2, NM_003360.4
UniGeneⁱ	Hs.144197

Genome annotation databases

Ensemblⁱ	ENST00000310836; ENSP00000311648; ENSG00000174607 ENST00000394511; ENSP00000378019; ENSG00000174607
GeneIDⁱ	7368
KEGGⁱ	hsa:7368
UCSC genome browser More...UCSCⁱ	uc003ibs.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16880	2-hydroxyacylsphingosine 1-beta-galactosyltransferase (Fragment)		HUMAN		141	UniRef100_Q16880

Protein	Similar proteins		Species	Score	Length	Source
Q16880	2-hydroxyacylsphingosine 1-beta-galactosyltransferase		MOUSE		541	UniRef90_Q16880
2-hydroxyacylsphingosine 1-beta-galactosyltransferase		RAT		541
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (Fragment)		HUMAN		141
Uncharacterized protein		PIG		556
Uncharacterized protein		RHIBE		542
+129

Protein	Similar proteins		Species	Score	Length	Source
Q16880	2-hydroxyacylsphingosine 1-beta-galactosyltransferase		RAT		541	UniRef50_Q16880
2-hydroxyacylsphingosine 1-beta-galactosyltransferase		MOUSE		541
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (Fragment)		HUMAN		141
Uncharacterized protein		PIG		556
Uncharacterized protein		RHIBE		542
+144

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - GTase

2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30930 mRNA Translation: AAC50565.1 U32370 , U31353, U31461, U31658, U31861 Genomic DNA Translation: AAC50815.1 U62899 mRNA Translation: AAC51187.1 AK127970 mRNA Translation: BAG54609.1 AC122938 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06307.1 BC075069 mRNA Translation: AAH75069.1
CCDSⁱ	CCDS3705.1
PIRⁱ	JC5423
RefSeqⁱ	NP_001121646.1, NM_001128174.2 NP_001309041.1, NM_001322112.1 NP_001309042.1, NM_001322113.1 NP_001309043.1, NM_001322114.1 NP_003351.2, NM_003360.4
UniGeneⁱ	Hs.144197

3D structure databases

ProteinModelPortalⁱ	Q16880
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113215, 30 interactors
IntActⁱ	Q16880, 4 interactors
MINTⁱ	Q16880
STRINGⁱ	9606.ENSP00000311648

Chemistry databases

SwissLipidsⁱ	SLP:000001432

SwissLipidsⁱ

SLP:000001432

Protein family/group databases

CAZyⁱ	GT1 Glycosyltransferase Family 1

CAZyⁱ

GT1 Glycosyltransferase Family 1

PTM databases

GlyConnectⁱ	980
iPTMnetⁱ	Q16880
PhosphoSitePlusⁱ	Q16880

Polymorphism and mutation databases

BioMutaⁱ	UGT8
DMDMⁱ	296434442

Proteomic databases

EPDⁱ	Q16880
MaxQBⁱ	Q16880
PaxDbⁱ	Q16880
PeptideAtlasⁱ	Q16880
PRIDEⁱ	Q16880
ProteomicsDBⁱ	61118

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000310836; ENSP00000311648; ENSG00000174607 ENST00000394511; ENSP00000378019; ENSG00000174607
GeneIDⁱ	7368
KEGGⁱ	hsa:7368
UCSCⁱ	uc003ibs.3 human

Organism-specific databases

CTDⁱ	7368
DisGeNETⁱ	7368
EuPathDBⁱ	HostDB:ENSG00000174607.10
GeneCardsⁱ	UGT8
HGNCⁱ	HGNC:12555 UGT8
HPAⁱ	HPA014405 HPA065785
MIMⁱ	601291 gene
neXtProtⁱ	NX_Q16880
OpenTargetsⁱ	ENSG00000174607
PharmGKBⁱ	PA37195
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1192 Eukaryota COG1819 LUCA
GeneTreeⁱ	ENSGT00760000118949
HOGENOMⁱ	HOG000220831
HOVERGENⁱ	HBG098341
InParanoidⁱ	Q16880
KOⁱ	K04628
OMAⁱ	IAPSNHY
OrthoDBⁱ	EOG091G06JC
PhylomeDBⁱ	Q16880
TreeFamⁱ	TF315472

Enzyme and pathway databases

UniPathwayⁱ	UPA00787
BioCycⁱ	MetaCyc:HS10812-MONOMER
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism

Miscellaneous databases

GeneWikiⁱ	UGT8
GenomeRNAiⁱ	7368
Protein Ontology More...PROⁱ	PR:Q16880
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174607 Expressed in 158 organ(s), highest expression level in spinal cord
CleanExⁱ	HS_UGT8
ExpressionAtlasⁱ	Q16880 baseline and differential
Genevisibleⁱ	Q16880 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002213 UDP_glucos_trans IPR035595 UDP_glycos_trans_CS
Pfamⁱ	View protein in Pfam PF00201 UDPGT, 1 hit
PROSITEⁱ	View protein in PROSITE PS00375 UDPGT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CGT_HUMAN
Accessionⁱ	Q16880Primary (citable) accession number: Q16880 Secondary accession number(s): B3KXU7, O00196
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 18, 2010
	Last modified:	October 10, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16880 (CGT_HUMAN)

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2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: galactosylceramide biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: galactosylceramide biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ