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Entry version 158 (08 May 2019)
Sequence version 2 (27 Sep 2005)
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Protein

Cysteine dioxygenase type 1

Gene

CDO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+Note: Binds 1 Fe2+ cation per subunit. Zn2+ can be used to a much lesser extent.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: taurine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes hypotaurine from L-cysteine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Cysteine dioxygenase type 1 (CDO1)
  2. Cysteine sulfinic acid decarboxylase (CSAD)
This subpathway is part of the pathway taurine biosynthesis, which is itself part of Organosulfur biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes hypotaurine from L-cysteine, the pathway taurine biosynthesis and in Organosulfur biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi86Iron; via tele nitrogen; catalytic1 Publication1
Metal bindingi88Iron; via tele nitrogen; catalytic1 Publication1
Metal bindingi140Iron; via tele nitrogen; catalytic1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS05299-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.13.11.20 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1614558 Degradation of cysteine and homocysteine

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q16878

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16878

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00012;UER00537

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine dioxygenase type 1 (EC:1.13.11.20)
Alternative name(s):
Cysteine dioxygenase type I
Short name:
CDO
Short name:
CDO-I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1795 CDO1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603943 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16878

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60R → Q: Reduces enzyme activity by 70%. Reduces iron and zinc incorporation by 50%. 1
Mutagenesisi93C → S: Reduces enzyme activity and iron incorporation by 50%. Zinc incorporation increased by 20%. 1
Mutagenesisi157Y → F: Almost total loss of enzyme activity and iron incorporation. Reduces zinc incorporation by 20%. 1
Mutagenesisi164C → S: Reduces enzyme activity by 20%. Little effect on iron incorporation. No effect on zinc incorporation. 1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1036

Open Targets

More...
OpenTargetsi
ENSG00000129596

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26327

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00151 L-Cysteine
DB00157 NADH

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
76800649

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002066061 – 200Cysteine dioxygenase type 1Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.1 Publication

Keywords - PTMi

Thioether bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16878

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16878

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q16878

PeptideAtlas

More...
PeptideAtlasi
Q16878

PRoteomics IDEntifications database

More...
PRIDEi
Q16878

ProteomicsDB human proteome resource

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ProteomicsDBi
61117

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16878

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16878

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129596 Expressed in 206 organ(s), highest expression level in tendon of biceps brachii

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q16878 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA036573
HPA057503

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107468, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q16878, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000250535

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IC1X-ray2.70A1-200[»]
6BGFX-ray2.25A2-200[»]
6BGMX-ray2.21A2-200[»]
6BPSX-ray2.10A2-200[»]
6BPTX-ray2.40A2-200[»]
6BPUX-ray1.80A2-200[»]
6BPVX-ray1.95A2-200[»]
6BPWX-ray2.43A2-200[»]
6BPXX-ray2.15A2-200[»]
6CDHX-ray1.82A2-200[»]
6CDNX-ray2.06A2-200[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16878

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q16878

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4064 Eukaryota
ENOG410XQM4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000018226

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000177818

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16878

KEGG Orthology (KO)

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KOi
K00456

Identification of Orthologs from Complete Genome Data

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OMAi
TETRYAF

Database of Orthologous Groups

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OrthoDBi
1516232at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q16878

TreeFam database of animal gene trees

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TreeFami
TF105636

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010300 CDO_1
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12918 PTHR12918, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05995 CDO_I, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51182 SSF51182, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q16878-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY
60 70 80 90 100
AKFDQYRYTR NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG
110 120 130 140 150
NLKETLFAWP DKKSNEMVKK SERVLRENQC AYINDSIGLH RVENISHTEP
160 170 180 190 200
AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT FHSKFGIRTP NATSGSLENN
Length:200
Mass (Da):22,972
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4EF87221D05C14D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137I → V in AAH24241 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02353645T → I2 PublicationsCorresponds to variant dbSNP:rs1042867Ensembl.1
Natural variantiVAR_036170143E → Q in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z31357 mRNA Translation: CAA83234.1
Z23010 mRNA Translation: CAA80552.1
D85782 Genomic DNA Translation: BAA12873.1
D85777 mRNA Translation: BAA12872.1
AK314231 mRNA Translation: BAG36901.1
U80055, U60232, U78979 Genomic DNA Translation: AAB58352.1
CR536540 mRNA Translation: CAG38777.1
CH471086 Genomic DNA Translation: EAW48957.1
BC024241 mRNA Translation: AAH24241.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4121.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50192

NCBI Reference Sequences

More...
RefSeqi
NP_001310494.1, NM_001323565.1
NP_001310495.1, NM_001323566.1
NP_001310496.1, NM_001323567.1
NP_001792.2, NM_001801.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000250535; ENSP00000250535; ENSG00000129596

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1036

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1036

UCSC genome browser

More...
UCSCi
uc003krg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31357 mRNA Translation: CAA83234.1
Z23010 mRNA Translation: CAA80552.1
D85782 Genomic DNA Translation: BAA12873.1
D85777 mRNA Translation: BAA12872.1
AK314231 mRNA Translation: BAG36901.1
U80055, U60232, U78979 Genomic DNA Translation: AAB58352.1
CR536540 mRNA Translation: CAG38777.1
CH471086 Genomic DNA Translation: EAW48957.1
BC024241 mRNA Translation: AAH24241.1
CCDSiCCDS4121.1
PIRiS50192
RefSeqiNP_001310494.1, NM_001323565.1
NP_001310495.1, NM_001323566.1
NP_001310496.1, NM_001323567.1
NP_001792.2, NM_001801.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IC1X-ray2.70A1-200[»]
6BGFX-ray2.25A2-200[»]
6BGMX-ray2.21A2-200[»]
6BPSX-ray2.10A2-200[»]
6BPTX-ray2.40A2-200[»]
6BPUX-ray1.80A2-200[»]
6BPVX-ray1.95A2-200[»]
6BPWX-ray2.43A2-200[»]
6BPXX-ray2.15A2-200[»]
6CDHX-ray1.82A2-200[»]
6CDNX-ray2.06A2-200[»]
SMRiQ16878
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107468, 10 interactors
IntActiQ16878, 2 interactors
STRINGi9606.ENSP00000250535

Chemistry databases

DrugBankiDB00151 L-Cysteine
DB00157 NADH

PTM databases

iPTMnetiQ16878
PhosphoSitePlusiQ16878

Polymorphism and mutation databases

BioMutaiCDO1
DMDMi76800649

Proteomic databases

EPDiQ16878
jPOSTiQ16878
PaxDbiQ16878
PeptideAtlasiQ16878
PRIDEiQ16878
ProteomicsDBi61117

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1036
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250535; ENSP00000250535; ENSG00000129596
GeneIDi1036
KEGGihsa:1036
UCSCiuc003krg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1036
DisGeNETi1036

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDO1
HGNCiHGNC:1795 CDO1
HPAiHPA036573
HPA057503
MIMi603943 gene
neXtProtiNX_Q16878
OpenTargetsiENSG00000129596
PharmGKBiPA26327

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiKOG4064 Eukaryota
ENOG410XQM4 LUCA
GeneTreeiENSGT00390000018226
HOGENOMiHOG000177818
InParanoidiQ16878
KOiK00456
OMAiTETRYAF
OrthoDBi1516232at2759
PhylomeDBiQ16878
TreeFamiTF105636

Enzyme and pathway databases

UniPathwayi
UPA00012;UER00537

BioCyciMetaCyc:HS05299-MONOMER
BRENDAi1.13.11.20 2681
ReactomeiR-HSA-1614558 Degradation of cysteine and homocysteine
SignaLinkiQ16878
SIGNORiQ16878

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CDO1 human
EvolutionaryTraceiQ16878

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1036

Protein Ontology

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PROi
PR:Q16878

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000129596 Expressed in 206 organ(s), highest expression level in tendon of biceps brachii
GenevisibleiQ16878 HS

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR010300 CDO_1
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR12918 PTHR12918, 1 hit
PfamiView protein in Pfam
PF05995 CDO_I, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDO1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16878
Secondary accession number(s): B2RAK4
, P78513, Q6FHZ8, Q8TB64
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2005
Last modified: May 8, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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