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Entry version 181 (17 Jun 2020)
Sequence version 2 (01 Nov 1998)
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Protein
Submitted name:

Cytochrome P450 21-hydroxylase

Gene

CYP21A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cytochrome P450 21-hydroxylaseImported
Submitted name:
Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_bImported
Submitted name:
DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B))Imported
Submitted name:
Steroid 21-hydroxylaseImported
Submitted name:
cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP21A2Imported
Synonyms:CYP21BImported, P450-CYP21BImported
ORF Names:hCG_1999926Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000231852.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2600 CYP21A2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000231852

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27096

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61113

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000231852 Expressed in left adrenal gland and 82 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0156 Eukaryota
COG2124 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158338

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001570_22_0_1

KEGG Orthology (KO)

More...
KOi
K00513

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNADEFR

Database of Orthologous Groups

More...
OrthoDBi
702827at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105095

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00463 EP450I
PR00385 P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q16874-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLGLLLLL PLLAGARLLW NWWKLRSLHL PPLAPGFLHL LQPDLPIYLL
60 70 80 90 100
GLTQKFGPIY RLHLGLQDVV VLNSKRTIEE AMVKKWADFA GRPEPLTYKL
110 120 130 140 150
VSRNYPDLSL GDYSLLWKAH KKLTRSALLL GIRDSMEPVV EQLTQEFCER
160 170 180 190 200
MRAQPGTPVA IEEEFSLLTC SIICYLTFGD KIKDDNLMPA YYKCIQEVLK
210 220 230 240 250
TWSHWSIQIV DVIPFLRFFP NPGLRRLKQA IEKRDHIVEM QLRQHKESLV
260 270 280 290 300
AGQWRDMMDY MLQGVAQPSM EEGSGQLLEG HVHMAAVDLL IGGTETTANT
310 320 330 340 350
LSWAVVFLLH HPEIQQRLQE ELDHELGPGA SSSRVPYKDR ARLPLLNATI
360 370 380 390 400
AEVLRLRPVV PLALPHRTTR PSSISGYDIP EGTVIIPNLQ GAHLDETVWE
410 420 430 440 450
RPHEFWPDRF LEPGKNSRAL AFGCGARVCL GEPLARLELF VVLTRLLQAF
460 470 480 490
TLLPSGDALP SLQPLPHCSV ILKMQPFQVR LQPRGMGAHS PGQSQ
Length:495
Mass (Da):56,001
Last modified:November 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE5C4EE9D3A0851C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P08686CP21A_HUMAN
Steroid 21-hydroxylase
CYP21A2 CYP21, CYP21B
494Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JJF2A0A0G2JJF2_HUMAN
Steroid 21-hydroxylase
CYP21A2
464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EN87E7EN87_HUMAN
Steroid 21-hydroxylase
CYP21A2
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERT7E7ERT7_HUMAN
Steroid 21-hydroxylase
CYP21A2
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVC0E7EVC0_HUMAN
Steroid 21-hydroxylase
CYP21A2
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBR4F8WBR4_HUMAN
Steroid 21-hydroxylase
CYP21A2
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL645922 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
AL929593 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
AF019413 Genomic DNA Translation: AAB67982.1
GQ222278 Genomic DNA Translation: ACT35404.1
GQ222283 Genomic DNA Translation: ACT35409.1
GQ222289 Genomic DNA Translation: ACT35415.1
GQ222295 Genomic DNA Translation: ACT35421.1
GQ222297 Genomic DNA Translation: ACT35423.1
GQ222312 Genomic DNA Translation: ACT35438.1
GQ222319 Genomic DNA Translation: ACT35445.1
GQ222320 Genomic DNA Translation: ACT35446.1
GQ222321 Genomic DNA Translation: ACT35447.1
GQ222323 Genomic DNA Translation: ACT35449.1
GQ222327 Genomic DNA Translation: ACT35453.1
GQ222334 Genomic DNA Translation: ACT35460.1
GQ222340 Genomic DNA Translation: ACT35466.1
JN034391 Genomic DNA Translation: AFK10114.1
JN034393 Genomic DNA Translation: AFK10116.1
JN034394 Genomic DNA Translation: AFK10117.1
JN034395 Genomic DNA Translation: AFK10118.1
JN034396 Genomic DNA Translation: AFK10119.1
JN034397 Genomic DNA Translation: AFK10120.1
JN034398 Genomic DNA Translation: AFK10121.1
JN034401 Genomic DNA Translation: AFK10124.1
JN034402 Genomic DNA Translation: AFK10125.1
JN034403 Genomic DNA Translation: AFK10126.1
JN034410 Genomic DNA Translation: AFK10133.1
JN034411 Genomic DNA Translation: AFK10134.1
KC493622 Genomic DNA Translation: AHA59281.1
KU302772 Genomic DNA Translation: APT40591.1
KU302773 Genomic DNA Translation: APT40592.1
AK314651 mRNA Translation: BAG37212.1
AL049547 Genomic DNA Translation: CAB89301.1
CH471081 Genomic DNA Translation: EAX03571.1

NCBI Reference Sequences

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RefSeqi
NP_000491.4, NM_000500.7

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383322; ENSP00000372812; ENSG00000206338
ENST00000448478; ENSP00000416598; ENSG00000232414
ENST00000456152; ENSP00000394942; ENSG00000233151
ENST00000644719; ENSP00000496625; ENSG00000231852

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1589

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1589

UCSC genome browser

More...
UCSCi
uc003nze.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645922 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
AL929593 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
AF019413 Genomic DNA Translation: AAB67982.1
GQ222278 Genomic DNA Translation: ACT35404.1
GQ222283 Genomic DNA Translation: ACT35409.1
GQ222289 Genomic DNA Translation: ACT35415.1
GQ222295 Genomic DNA Translation: ACT35421.1
GQ222297 Genomic DNA Translation: ACT35423.1
GQ222312 Genomic DNA Translation: ACT35438.1
GQ222319 Genomic DNA Translation: ACT35445.1
GQ222320 Genomic DNA Translation: ACT35446.1
GQ222321 Genomic DNA Translation: ACT35447.1
GQ222323 Genomic DNA Translation: ACT35449.1
GQ222327 Genomic DNA Translation: ACT35453.1
GQ222334 Genomic DNA Translation: ACT35460.1
GQ222340 Genomic DNA Translation: ACT35466.1
JN034391 Genomic DNA Translation: AFK10114.1
JN034393 Genomic DNA Translation: AFK10116.1
JN034394 Genomic DNA Translation: AFK10117.1
JN034395 Genomic DNA Translation: AFK10118.1
JN034396 Genomic DNA Translation: AFK10119.1
JN034397 Genomic DNA Translation: AFK10120.1
JN034398 Genomic DNA Translation: AFK10121.1
JN034401 Genomic DNA Translation: AFK10124.1
JN034402 Genomic DNA Translation: AFK10125.1
JN034403 Genomic DNA Translation: AFK10126.1
JN034410 Genomic DNA Translation: AFK10133.1
JN034411 Genomic DNA Translation: AFK10134.1
KC493622 Genomic DNA Translation: AHA59281.1
KU302772 Genomic DNA Translation: APT40591.1
KU302773 Genomic DNA Translation: APT40592.1
AK314651 mRNA Translation: BAG37212.1
AL049547 Genomic DNA Translation: CAB89301.1
CH471081 Genomic DNA Translation: EAX03571.1
RefSeqiNP_000491.4, NM_000500.7

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VBUX-ray3.31A/B/C30-495[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Proteomic databases

ProteomicsDBi61113

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53182 312 antibodies

Genome annotation databases

EnsembliENST00000383322; ENSP00000372812; ENSG00000206338
ENST00000448478; ENSP00000416598; ENSG00000232414
ENST00000456152; ENSP00000394942; ENSG00000233151
ENST00000644719; ENSP00000496625; ENSG00000231852
GeneIDi1589
KEGGihsa:1589
UCSCiuc003nze.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1589
EuPathDBiHostDB:ENSG00000231852.6
HGNCiHGNC:2600 CYP21A2
OpenTargetsiENSG00000231852
PharmGKBiPA27096

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00940000158338
HOGENOMiCLU_001570_22_0_1
KOiK00513
OMAiPNADEFR
OrthoDBi702827at2759
TreeFamiTF105095

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1589 2 hits in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYP21A2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1589

Gene expression databases

BgeeiENSG00000231852 Expressed in left adrenal gland and 82 other tissues

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ16874_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16874
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1998
Last modified: June 17, 2020
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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