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UniProtKB - Q16873 (LTC4S_HUMAN)

Entry version 184 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Leukotriene C4 synthase

Gene

LTC4S

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:7937884, PubMed:27791009, PubMed:27365393, PubMed:9153254, PubMed:23409838). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by MK886.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 19 sec(-1) with glutathione as substrate (PubMed:27365393). kcat is 105 sec(-1) with leukotriene A4 as substrate (PubMed:27365393).1 Publication
  1. KM=70 µM for glutathione1 Publication
  2. KM=300 µM for glutathione1 Publication
  3. KM=30 µM for leukotriene A42 Publications
  4. KM=70.5 µM for 13S,14S-epoxy- 4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid1 Publication
  5. KM=76 µM for leukotriene A41 Publication
  1. Vmax=70.5 mmol/min/mg enzyme with 13S,14S-epoxy- 4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid as substrate1 Publication
  2. Vmax=6.7 mmol/min/mg enzyme with leukotriene A4 as substrate1 Publication

pH dependencei

Optimum pH is 8.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: leukotriene C4 biosynthesis

This protein is involved in the pathway leukotriene C4 biosynthesis, which is part of Lipid metabolism.Curated
View all proteins of this organism that are known to be involved in the pathway leukotriene C4 biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei30Glutathione3 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei31Proton donor1 Publication1
Active sitei104Proton acceptor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Transferase
Biological processLeukotriene biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS08566-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.4.1.20, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16873

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2142688, Synthesis of 5-eicosatetraenoic acids
R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142700, Synthesis of Lipoxins (LX)
R-HSA-9026762, Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
R-HSA-9026766, Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q16873

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q16873

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q16873

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00879

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001452

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukotriene C4 synthase (EC:4.4.1.205 Publications)
Short name:
LTC4 synthase
Alternative name(s):
Glutathione S-transferase LTC4Curated (EC:2.5.1.-1 Publication)
Leukotriene-C(4) synthase
Leukotriene-C4 synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LTC4S
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6719, LTC4S

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		246530, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16873

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000213316.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6Cytoplasmic3 Publications6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27Helical3 PublicationsAdd BLAST21
Topological domaini28 – 48Lumenal3 PublicationsAdd BLAST21
Transmembranei49 – 69Helical3 PublicationsAdd BLAST21
Topological domaini70 – 73Cytoplasmic3 Publications4
Transmembranei74 – 94Helical3 PublicationsAdd BLAST21
Topological domaini95 – 104Lumenal3 Publications10
Transmembranei105 – 124Helical3 PublicationsAdd BLAST20
Topological domaini125 – 150Cytoplasmic3 PublicationsAdd BLAST26

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi36S → E: Reduced leukotriene-C4 synthase activity by nearly 80%. 1 Publication1
Mutagenesisi40T → A: Leukotriene-C4 synthaseactivity is reduced by 30%. 1 Publication1
Mutagenesisi51R → T or I: Loss of leukotriene-C4 synthase activity. 1 Publication1
Mutagenesisi55N → A: Does not affect leukotriene-C4 synthase activity but substantially increased KM for GSH. 1 Publication1
Mutagenesisi59Y → F: Does not affect leukotriene-C4 synthase activity but substantially increased KM for GSH. 1 Publication1
Mutagenesisi93Y → F: Reduces Leukotriene-C4 synthase activity and increases the optimum for pH-dependent activity. 1 Publication1
Mutagenesisi97Y → F: Does not affect leukotriene-C4 synthase activity but substantially increased KM for GSH. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4056

MalaCards human disease database

More...MalaCardsi		LTC4S

Open Targets

More...OpenTargetsi		ENSG00000213316

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA235

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16873, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1743183

Drug and drug target database

More...DrugBanki		DB00972, Azelastine
DB00143, Glutathione

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1391

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LTC4S

Domain mapping of disease mutations (DMDM)

More...DMDMi		2833283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002177481 – 150Leukotriene C4 synthaseAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36Phosphoserine; by RPS6KB11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16873

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16873

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16873

PeptideAtlas

More...PeptideAtlasi		Q16873

PRoteomics IDEntifications database

More...PRIDEi		Q16873

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61112

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16873

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16873

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000213316, Expressed in testis and 108 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16873, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16873, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000213316, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:17632548, PubMed:17632546).

Interacts with ALOX5AP and ALOX5 (PubMed:19233132).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110234, 20 interactors

Database of interacting proteins

More...DIPi		DIP-48473N

Protein interaction database and analysis system

More...IntActi		Q16873, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000292596

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q16873

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16873, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16873

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q16873

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 55Glutathione binding1 Publication5
Regioni58 – 59Glutathione binding1 Publication2
Regioni93 – 97Glutathione binding1 Publication5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RZYY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_110291_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16873

Identification of Orthologs from Complete Genome Data

More...OMAi		IFRAQAN

Database of Orthologous Groups

More...OrthoDBi		1609516at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16873

TreeFam database of animal gene trees

More...TreeFami		TF105328

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.550, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001446, 5_LipOase_AP
IPR018295, FLAP/GST2/LTC4S_CS
IPR023352, MAPEG-like_dom_sf
IPR001129, Membr-assoc_MAPEG

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01124, MAPEG, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00488, 5LPOXGNASEAP

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF161084, SSF161084, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01297, FLAP_GST2_LTC4S, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q16873-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDEVALLAA VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERVY 
        60         70         80         90        100
RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLVYLFAR LRYFQGYARS 
       110        120        130        140        150
AQLRLAPLYA SARALWLLVA LAALGLLAHF LPAALRAALL GRLRTLLPWA
Length:150
Mass (Da):16,567
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04E269B475063037
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YF10A0A286YF10_HUMAN
Leukotriene C4 synthase
LTC4S
104Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCC3B5MCC3_HUMAN
Leukotriene C4 synthase
LTC4S
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJA1D6RJA1_HUMAN
Leukotriene C4 synthase
LTC4S
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21Y → G AA sequence (PubMed:8446623).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042736142R → Q1 PublicationCorresponds to variant dbSNP:rs11541078Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U09353 mRNA Translation: AAA20467.1
U11552 mRNA Translation: AAA50555.1
U50136 Genomic DNA Translation: AAC50476.1
U62025 Genomic DNA Translation: AAB06723.1
BC029498 mRNA Translation: AAH29498.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34316.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38595
JC5398

NCBI Reference Sequences

More...RefSeqi		NP_665874.1, NM_145867.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292596; ENSP00000292596; ENSG00000213316
ENST00000639087; ENSP00000492334; ENSG00000283887

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4056

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4056

UCSC genome browser

More...UCSCi		uc003mko.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09353 mRNA Translation: AAA20467.1
U11552 mRNA Translation: AAA50555.1
U50136 Genomic DNA Translation: AAC50476.1
U62025 Genomic DNA Translation: AAB06723.1
BC029498 mRNA Translation: AAH29498.1
CCDSiCCDS34316.1
PIRiI38595
JC5398
RefSeqiNP_665874.1, NM_145867.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PNOX-ray3.30A/B/C/D/E/F/G/H/I/J/K/L1-150[»]
2UUHX-ray2.15A2-150[»]
2UUIX-ray2.00A2-150[»]
3B29X-ray3.20A1-150[»]
3HKKX-ray2.90A2-150[»]
3LEOX-ray2.10A2-150[»]
3PCVX-ray1.90A1-150[»]
4BPMX-ray2.08A131-150[»]
4J7TX-ray3.20A2-150[»]
4J7YX-ray2.90A2-150[»]
4JC7X-ray2.70A2-150[»]
4JCZX-ray2.75A2-150[»]
4JRZX-ray2.40A2-150[»]
4WABX-ray2.70A130-150[»]
5HV9X-ray3.00A2-150[»]
6R7DX-ray2.35A/B/C/D/E/F/G/H/I/J/K/L2-150[»]
SMRiQ16873
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110234, 20 interactors
DIPiDIP-48473N
IntActiQ16873, 9 interactors
STRINGi9606.ENSP00000292596

Chemistry databases

BindingDBiQ16873
ChEMBLiCHEMBL1743183
DrugBankiDB00972, Azelastine
DB00143, Glutathione
GuidetoPHARMACOLOGYi1391
SwissLipidsiSLP:000001452

PTM databases

iPTMnetiQ16873
PhosphoSitePlusiQ16873

Genetic variation databases

BioMutaiLTC4S
DMDMi2833283

Proteomic databases

jPOSTiQ16873
MassIVEiQ16873
PaxDbiQ16873
PeptideAtlasiQ16873
PRIDEiQ16873
ProteomicsDBi61112

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17732, 103 antibodies

The DNASU plasmid repository

More...DNASUi		4056

Genome annotation databases

EnsembliENST00000292596; ENSP00000292596; ENSG00000213316
ENST00000639087; ENSP00000492334; ENSG00000283887
GeneIDi4056
KEGGihsa:4056
UCSCiuc003mko.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4056
DisGeNETi4056

GeneCards: human genes, protein and diseases

More...GeneCardsi		LTC4S
HGNCiHGNC:6719, LTC4S
HPAiENSG00000213316, Tissue enhanced (blood)
MalaCardsiLTC4S
MIMi246530, gene
neXtProtiNX_Q16873
OpenTargetsiENSG00000213316
PharmGKBiPA235
VEuPathDBiHostDB:ENSG00000213316.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RZYY, Eukaryota
GeneTreeiENSGT00940000160738
HOGENOMiCLU_110291_3_0_1
InParanoidiQ16873
OMAiIFRAQAN
OrthoDBi1609516at2759
PhylomeDBiQ16873
TreeFamiTF105328

Enzyme and pathway databases

UniPathwayiUPA00879
BioCyciMetaCyc:HS08566-MONOMER
BRENDAi4.4.1.20, 2681
PathwayCommonsiQ16873
ReactomeiR-HSA-2142688, Synthesis of 5-eicosatetraenoic acids
R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142700, Synthesis of Lipoxins (LX)
R-HSA-9026762, Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
R-HSA-9026766, Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
SABIO-RKiQ16873
SignaLinkiQ16873
SIGNORiQ16873

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4056, 1 hit in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LTC4S, human
EvolutionaryTraceiQ16873

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Leukotriene_C4_synthase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4056
PharosiQ16873, Tchem

Protein Ontology

More...PROi		PR:Q16873
RNActiQ16873, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000213316, Expressed in testis and 108 other tissues
ExpressionAtlasiQ16873, baseline and differential
GenevisibleiQ16873, HS

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR001446, 5_LipOase_AP
IPR018295, FLAP/GST2/LTC4S_CS
IPR023352, MAPEG-like_dom_sf
IPR001129, Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124, MAPEG, 1 hit
PRINTSiPR00488, 5LPOXGNASEAP
SUPFAMiSSF161084, SSF161084, 1 hit
PROSITEiView protein in PROSITE
PS01297, FLAP_GST2_LTC4S, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTC4S_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16873
Secondary accession number(s): Q8N6P0, Q9UC73, Q9UD18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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