UniProtKB - Q16864 (VATF_HUMAN)
Protein
V-type proton ATPase subunit F
Gene
ATP6V1F
Organism
Homo sapiens (Human)
Status
Functioni
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATPase-coupled ion transmembrane transporter activity Source: GO_Central
- proton transmembrane transporter activity Source: UniProtKB
- proton-transporting ATPase activity, rotational mechanism Source: InterPro
GO - Biological processi
- insulin receptor signaling pathway Source: Reactome
- ion transmembrane transport Source: Reactome
- phagosome acidification Source: Reactome
- proton transmembrane transport Source: UniProtKB
- transferrin transport Source: Reactome
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS05192-MONOMER |
PathwayCommonsi | Q16864 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-77387, Insulin receptor recycling R-HSA-917977, Transferrin endocytosis and recycling R-HSA-9639288, Amino acids regulate mTORC1 R-HSA-983712, Ion channel transport |
Protein family/group databases
TCDBi | 3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit FShort name: V-ATPase subunit F Alternative name(s): V-ATPase 14 kDa subunit Vacuolar proton pump subunit F |
Gene namesi | Name:ATP6V1F Synonyms:ATP6S14, VATF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16832, ATP6V1F |
MIMi | 607160, gene |
neXtProti | NX_Q16864 |
VEuPathDBi | HostDB:ENSG00000128524.4 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- membrane Source: UniProtKB
- proton-transporting two-sector ATPase complex Source: UniProtKB
- proton-transporting V-type ATPase, V1 domain Source: InterPro
- vacuolar proton-transporting V-type ATPase complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9296 |
OpenTargetsi | ENSG00000128524 |
PharmGKBi | PA38421 |
Miscellaneous databases
Pharosi | Q16864, Tbio |
Chemistry databases
DrugBanki | DB01133, Tiludronic acid |
Genetic variation databases
BioMutai | ATP6V1F |
DMDMi | 126302612 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144799 | 1 – 119 | V-type proton ATPase subunit FAdd BLAST | 119 |
Proteomic databases
EPDi | Q16864 |
jPOSTi | Q16864 |
MassIVEi | Q16864 |
MaxQBi | Q16864 |
PeptideAtlasi | Q16864 |
PRIDEi | Q16864 |
ProteomicsDBi | 61111 [Q16864-1] 8219 |
TopDownProteomicsi | Q16864-1 [Q16864-1] Q16864-2 [Q16864-2] |
PTM databases
iPTMneti | Q16864 |
MetOSitei | Q16864 |
PhosphoSitePlusi | Q16864 |
Expressioni
Gene expression databases
Bgeei | ENSG00000128524, Expressed in muscle tissue and 134 other tissues |
ExpressionAtlasi | Q16864, baseline and differential |
Genevisiblei | Q16864, HS |
Organism-specific databases
HPAi | ENSG00000128524, Low tissue specificity |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Binary interactionsi
Q16864
With | #Exp. | IntAct |
---|---|---|
ATP6V1D [Q9Y5K8] | 3 | EBI-714690,EBI-2684998 |
Protein-protein interaction databases
BioGRIDi | 114710, 73 interactors |
IntActi | Q16864, 23 interactors |
Miscellaneous databases
RNActi | Q16864, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the V-ATPase F subunit family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000013208 |
HOGENOMi | CLU_135754_0_0_1 |
InParanoidi | Q16864 |
OMAi | QNVAEMI |
OrthoDBi | 1483558at2759 |
PhylomeDBi | Q16864 |
TreeFami | TF300080 |
Family and domain databases
Gene3Di | 3.40.50.10580, 1 hit |
InterProi | View protein in InterPro IPR008218, ATPase_V1-cplx_f_g_su IPR005772, ATPase_V1-cplx_fsu_euk IPR036906, ATPase_V1_fsu_sf |
Pfami | View protein in Pfam PF01990, ATP-synt_F, 1 hit |
PIRSFi | PIRSF015945, ATPase_V1_F_euk, 1 hit |
SUPFAMi | SSF159468, SSF159468, 1 hit |
TIGRFAMsi | TIGR01101, V_ATP_synt_F, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q16864-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED
60 70 80 90 100
TFRQFLNRDD IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA
110
AKDSILRRAR GMFTAEDLR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | I → T in BAA08392 (PubMed:8581736).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048348 | 24 | G → V. Corresponds to variant dbSNP:rs10958Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045952 | 52 | F → FRSLGSLPGSVVEANPNQRD PPLWDEIDS in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D49400 mRNA Translation: BAA08392.1 CR456896 mRNA Translation: CAG33177.1 AC025594 Genomic DNA No translation available. BC104230 mRNA Translation: AAI04231.1 BC104231 mRNA Translation: AAI04232.1 BC107854 mRNA Translation: AAI07855.1 BU956696 mRNA No translation available. |
CCDSi | CCDS56511.1 [Q16864-2] CCDS5807.1 [Q16864-1] |
PIRi | JC4193 |
RefSeqi | NP_001185838.1, NM_001198909.1 [Q16864-2] NP_004222.2, NM_004231.3 [Q16864-1] |
Genome annotation databases
Ensembli | ENST00000249289; ENSP00000249289; ENSG00000128524 [Q16864-1] ENST00000492758; ENSP00000417378; ENSG00000128524 [Q16864-2] |
GeneIDi | 9296 |
KEGGi | hsa:9296 |
UCSCi | uc003voc.3, human [Q16864-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D49400 mRNA Translation: BAA08392.1 CR456896 mRNA Translation: CAG33177.1 AC025594 Genomic DNA No translation available. BC104230 mRNA Translation: AAI04231.1 BC104231 mRNA Translation: AAI04232.1 BC107854 mRNA Translation: AAI07855.1 BU956696 mRNA No translation available. |
CCDSi | CCDS56511.1 [Q16864-2] CCDS5807.1 [Q16864-1] |
PIRi | JC4193 |
RefSeqi | NP_001185838.1, NM_001198909.1 [Q16864-2] NP_004222.2, NM_004231.3 [Q16864-1] |
3D structure databases
SMRi | Q16864 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114710, 73 interactors |
IntActi | Q16864, 23 interactors |
Chemistry databases
DrugBanki | DB01133, Tiludronic acid |
Protein family/group databases
TCDBi | 3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
PTM databases
iPTMneti | Q16864 |
MetOSitei | Q16864 |
PhosphoSitePlusi | Q16864 |
Genetic variation databases
BioMutai | ATP6V1F |
DMDMi | 126302612 |
Proteomic databases
EPDi | Q16864 |
jPOSTi | Q16864 |
MassIVEi | Q16864 |
MaxQBi | Q16864 |
PeptideAtlasi | Q16864 |
PRIDEi | Q16864 |
ProteomicsDBi | 61111 [Q16864-1] 8219 |
TopDownProteomicsi | Q16864-1 [Q16864-1] Q16864-2 [Q16864-2] |
Protocols and materials databases
Antibodypediai | 4025, 191 antibodies |
Genome annotation databases
Ensembli | ENST00000249289; ENSP00000249289; ENSG00000128524 [Q16864-1] ENST00000492758; ENSP00000417378; ENSG00000128524 [Q16864-2] |
GeneIDi | 9296 |
KEGGi | hsa:9296 |
UCSCi | uc003voc.3, human [Q16864-1] |
Organism-specific databases
CTDi | 9296 |
DisGeNETi | 9296 |
GeneCardsi | ATP6V1F |
HGNCi | HGNC:16832, ATP6V1F |
HPAi | ENSG00000128524, Low tissue specificity |
MIMi | 607160, gene |
neXtProti | NX_Q16864 |
OpenTargetsi | ENSG00000128524 |
PharmGKBi | PA38421 |
VEuPathDBi | HostDB:ENSG00000128524.4 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000013208 |
HOGENOMi | CLU_135754_0_0_1 |
InParanoidi | Q16864 |
OMAi | QNVAEMI |
OrthoDBi | 1483558at2759 |
PhylomeDBi | Q16864 |
TreeFami | TF300080 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS05192-MONOMER |
PathwayCommonsi | Q16864 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-77387, Insulin receptor recycling R-HSA-917977, Transferrin endocytosis and recycling R-HSA-9639288, Amino acids regulate mTORC1 R-HSA-983712, Ion channel transport |
Miscellaneous databases
BioGRID-ORCSi | 9296, 611 hits in 878 CRISPR screens |
ChiTaRSi | ATP6V1F, human |
GeneWikii | ATP6V1F |
GenomeRNAii | 9296 |
Pharosi | Q16864, Tbio |
PROi | PR:Q16864 |
RNActi | Q16864, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128524, Expressed in muscle tissue and 134 other tissues |
ExpressionAtlasi | Q16864, baseline and differential |
Genevisiblei | Q16864, HS |
Family and domain databases
Gene3Di | 3.40.50.10580, 1 hit |
InterProi | View protein in InterPro IPR008218, ATPase_V1-cplx_f_g_su IPR005772, ATPase_V1-cplx_fsu_euk IPR036906, ATPase_V1_fsu_sf |
Pfami | View protein in Pfam PF01990, ATP-synt_F, 1 hit |
PIRSFi | PIRSF015945, ATPase_V1_F_euk, 1 hit |
SUPFAMi | SSF159468, SSF159468, 1 hit |
TIGRFAMsi | TIGR01101, V_ATP_synt_F, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VATF_HUMAN | |
Accessioni | Q16864Primary (citable) accession number: Q16864 Secondary accession number(s): C9J2K4, Q6IBA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants