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Protein

V-type proton ATPase subunit F

Gene

ATP6V1F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS05192-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit F
Short name:
V-ATPase subunit F
Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F
Gene namesi
Name:ATP6V1F
Synonyms:ATP6S14, VATF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128524.4
HGNCiHGNC:16832 ATP6V1F
MIMi607160 gene
neXtProtiNX_Q16864

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9296
OpenTargetsiENSG00000128524
PharmGKBiPA38421

Polymorphism and mutation databases

BioMutaiATP6V1F
DMDMi126302612

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447991 – 119V-type proton ATPase subunit FAdd BLAST119

Proteomic databases

EPDiQ16864
MaxQBiQ16864
PeptideAtlasiQ16864
PRIDEiQ16864
ProteomicsDBi61111
TopDownProteomicsiQ16864-1 [Q16864-1]
Q16864-2 [Q16864-2]

PTM databases

iPTMnetiQ16864
PhosphoSitePlusiQ16864

Expressioni

Gene expression databases

BgeeiENSG00000128524 Expressed in 112 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_ATP6V1F
ExpressionAtlasiQ16864 baseline and differential
GenevisibleiQ16864 HS

Organism-specific databases

HPAiCAB009529
HPA048700
HPA062011

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi114710, 58 interactors
IntActiQ16864, 14 interactors

Structurei

3D structure databases

ProteinModelPortaliQ16864
SMRiQ16864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase F subunit family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013208
HOGENOMiHOG000056545
HOVERGENiHBG004488
InParanoidiQ16864
KOiK02151
OMAiQNVAEMI
OrthoDBiEOG091G0ZUA
PhylomeDBiQ16864
TreeFamiTF300080

Family and domain databases

Gene3Di3.40.50.10580, 1 hit
InterProiView protein in InterPro
IPR008218 ATPase_V1-cplx_f_g_su
IPR005772 ATPase_V1-cplx_fsu_euk
IPR036906 ATPase_V1_fsu_sf
PfamiView protein in Pfam
PF01990 ATP-synt_F, 1 hit
PIRSFiPIRSF015945 ATPase_V1_F_euk, 1 hit
SUPFAMiSSF159468 SSF159468, 1 hit
TIGRFAMsiTIGR01101 V_ATP_synt_F, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED
60 70 80 90 100
TFRQFLNRDD IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA
110
AKDSILRRAR GMFTAEDLR
Length:119
Mass (Da):13,370
Last modified:February 20, 2007 - v2
Checksum:i9FE5A8BD249A85FA
GO
Isoform 2 (identifier: Q16864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: F → FRSLGSLPGSVVEANPNQRDPPLWDEIDS

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,402
Checksum:i964BE12671E7C4DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8I → T in BAA08392 (PubMed:8581736).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04834824G → V. Corresponds to variant dbSNP:rs10958Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04595252F → FRSLGSLPGSVVEANPNQRD PPLWDEIDS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49400 mRNA Translation: BAA08392.1
CR456896 mRNA Translation: CAG33177.1
AC025594 Genomic DNA No translation available.
BC104230 mRNA Translation: AAI04231.1
BC104231 mRNA Translation: AAI04232.1
BC107854 mRNA Translation: AAI07855.1
BU956696 mRNA No translation available.
CCDSiCCDS56511.1 [Q16864-2]
CCDS5807.1 [Q16864-1]
PIRiJC4193
RefSeqiNP_001185838.1, NM_001198909.1 [Q16864-2]
NP_004222.2, NM_004231.3 [Q16864-1]
UniGeneiHs.78089

Genome annotation databases

EnsembliENST00000249289; ENSP00000249289; ENSG00000128524 [Q16864-1]
ENST00000492758; ENSP00000417378; ENSG00000128524 [Q16864-2]
GeneIDi9296
KEGGihsa:9296
UCSCiuc003voc.3 human [Q16864-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49400 mRNA Translation: BAA08392.1
CR456896 mRNA Translation: CAG33177.1
AC025594 Genomic DNA No translation available.
BC104230 mRNA Translation: AAI04231.1
BC104231 mRNA Translation: AAI04232.1
BC107854 mRNA Translation: AAI07855.1
BU956696 mRNA No translation available.
CCDSiCCDS56511.1 [Q16864-2]
CCDS5807.1 [Q16864-1]
PIRiJC4193
RefSeqiNP_001185838.1, NM_001198909.1 [Q16864-2]
NP_004222.2, NM_004231.3 [Q16864-1]
UniGeneiHs.78089

3D structure databases

ProteinModelPortaliQ16864
SMRiQ16864
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114710, 58 interactors
IntActiQ16864, 14 interactors

Protein family/group databases

TCDBi3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiQ16864
PhosphoSitePlusiQ16864

Polymorphism and mutation databases

BioMutaiATP6V1F
DMDMi126302612

Proteomic databases

EPDiQ16864
MaxQBiQ16864
PeptideAtlasiQ16864
PRIDEiQ16864
ProteomicsDBi61111
TopDownProteomicsiQ16864-1 [Q16864-1]
Q16864-2 [Q16864-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249289; ENSP00000249289; ENSG00000128524 [Q16864-1]
ENST00000492758; ENSP00000417378; ENSG00000128524 [Q16864-2]
GeneIDi9296
KEGGihsa:9296
UCSCiuc003voc.3 human [Q16864-1]

Organism-specific databases

CTDi9296
DisGeNETi9296
EuPathDBiHostDB:ENSG00000128524.4
GeneCardsiATP6V1F
HGNCiHGNC:16832 ATP6V1F
HPAiCAB009529
HPA048700
HPA062011
MIMi607160 gene
neXtProtiNX_Q16864
OpenTargetsiENSG00000128524
PharmGKBiPA38421
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000013208
HOGENOMiHOG000056545
HOVERGENiHBG004488
InParanoidiQ16864
KOiK02151
OMAiQNVAEMI
OrthoDBiEOG091G0ZUA
PhylomeDBiQ16864
TreeFamiTF300080

Enzyme and pathway databases

BioCyciMetaCyc:HS05192-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Miscellaneous databases

GeneWikiiATP6V1F
GenomeRNAii9296
PROiPR:Q16864
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128524 Expressed in 112 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_ATP6V1F
ExpressionAtlasiQ16864 baseline and differential
GenevisibleiQ16864 HS

Family and domain databases

Gene3Di3.40.50.10580, 1 hit
InterProiView protein in InterPro
IPR008218 ATPase_V1-cplx_f_g_su
IPR005772 ATPase_V1-cplx_fsu_euk
IPR036906 ATPase_V1_fsu_sf
PfamiView protein in Pfam
PF01990 ATP-synt_F, 1 hit
PIRSFiPIRSF015945 ATPase_V1_F_euk, 1 hit
SUPFAMiSSF159468 SSF159468, 1 hit
TIGRFAMsiTIGR01101 V_ATP_synt_F, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVATF_HUMAN
AccessioniPrimary (citable) accession number: Q16864
Secondary accession number(s): C9J2K4, Q6IBA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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