ATP6V1F

Functionⁱ

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functionⁱ

ATPase activity, uncoupled
Source: UniProtKB
Non-traceable author statementⁱ
- 8581736
ATPase coupled ion transmembrane transporter activity Source: GO_Central
proton transmembrane transporter activity
Source: UniProtKB
Non-traceable author statementⁱ
- 8581736
proton-transporting ATPase activity, rotational mechanism Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP hydrolysis coupled proton transport Source: InterPro
insulin receptor signaling pathway Source: Reactome
ion transmembrane transport Source: Reactome
proton transmembrane transport
Source: UniProtKB
Non-traceable author statementⁱ
- 8581736
transferrin transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Hydrogen ion transport, Ion transport, Transport

Biological process

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05192-MONOMER
Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport

Protein family/group databases

TCDBⁱ	3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

TCDBⁱ

3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: V-type proton ATPase subunit F Short name: V-ATPase subunit F Alternative name(s): V-ATPase 14 kDa subunit Vacuolar proton pump subunit F
Gene namesⁱ	Name:ATP6V1F Synonyms:ATP6S14, VATF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128524.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16832 ATP6V1F
MIMⁱ	607160 gene
neXtProtⁱ	NX_Q16864

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9296
Open Targets More...OpenTargetsⁱ	ENSG00000128524
PharmGKBⁱ	PA38421

Polymorphism and mutation databases

BioMutaⁱ	ATP6V1F
DMDMⁱ	126302612

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144799	1 – 119	V-type proton ATPase subunit FAdd BLAST		119

Proteomic databases

EPDⁱ	Q16864
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16864
PeptideAtlas More...PeptideAtlasⁱ	Q16864
PRIDEⁱ	Q16864
ProteomicsDBⁱ	61111
TopDownProteomicsⁱ	Q16864-1 [Q16864-1] Q16864-2 [Q16864-2]

PTM databases

iPTMnetⁱ	Q16864
PhosphoSitePlusⁱ	Q16864

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000128524 Expressed in 112 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_ATP6V1F
ExpressionAtlasⁱ	Q16864 baseline and differential
Genevisibleⁱ	Q16864 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009529 HPA048700 HPA062011

HPAⁱ

CAB009529
HPA048700
HPA062011

Interactionⁱ

Subunit structureⁱ

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridⁱ	114710, 58 interactors
IntActⁱ	Q16864, 14 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16864
SMRⁱ	Q16864
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the V-ATPase F subunit family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013208
HOGENOMⁱ	HOG000056545
HOVERGENⁱ	HBG004488
InParanoidⁱ	Q16864
KEGG Orthology (KO) More...KOⁱ	K02151
OMAⁱ	QNVAEMI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZUA
PhylomeDBⁱ	Q16864
TreeFamⁱ	TF300080

Family and domain databases

Gene3Dⁱ	3.40.50.10580, 1 hit
InterProⁱ	View protein in InterPro IPR008218 ATPase_V1-cplx_f_g_su IPR005772 ATPase_V1-cplx_fsu_euk IPR036906 ATPase_V1_fsu_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01990 ATP-synt_F, 1 hit
PIRSFⁱ	PIRSF015945 ATPase_V1_F_euk, 1 hit
SUPFAMⁱ	SSF159468 SSF159468, 1 hit
TIGRFAMsⁱ	TIGR01101 V_ATP_synt_F, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q16864-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED 
        60         70         80         90        100
TFRQFLNRDD IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA 
       110 
AKDSILRRAR GMFTAEDLR

Length:119

Mass (Da):13,370

Last modified:February 20, 2007 - v2

Checksum:ⁱ9FE5A8BD249A85FA

GO

Isoform 2 (identifier: Q16864-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
52-52: F → FRSLGSLPGSVVEANPNQRDPPLWDEIDS

« Hide

        10         20         30         40         50
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED 
        60         70         80         90        100
TFRSLGSLPG SVVEANPNQR DPPLWDEIDS RQFLNRDDIG IILINQYIAE 
       110        120        130        140 
MVRHALDAHQ QSIPAVLEIP SKEHPYDAAK DSILRRARGM FTAEDLR

Note: No experimental confirmation available.

Show »

Length:147

Mass (Da):16,402

Checksum:ⁱ964BE12671E7C4DA

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	8	I → T in BAA08392 (PubMed:8581736).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048348	24	G → V. Corresponds to variant dbSNP:rs10958Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045952	52	F → FRSLGSLPGSVVEANPNQRD PPLWDEIDS in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D49400 mRNA Translation: BAA08392.1 CR456896 mRNA Translation: CAG33177.1 AC025594 Genomic DNA No translation available. BC104230 mRNA Translation: AAI04231.1 BC104231 mRNA Translation: AAI04232.1 BC107854 mRNA Translation: AAI07855.1 BU956696 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56511.1 [Q16864-2] CCDS5807.1 [Q16864-1]
PIRⁱ	JC4193
NCBI Reference Sequences More...RefSeqⁱ	NP_001185838.1, NM_001198909.1 [Q16864-2] NP_004222.2, NM_004231.3 [Q16864-1]
UniGeneⁱ	Hs.78089

Genome annotation databases

Ensemblⁱ	ENST00000249289; ENSP00000249289; ENSG00000128524 [Q16864-1] ENST00000492758; ENSP00000417378; ENSG00000128524 [Q16864-2]
GeneIDⁱ	9296
KEGGⁱ	hsa:9296
UCSC genome browser More...UCSCⁱ	uc003voc.3 human [Q16864-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q16864	V-type proton ATPase subunit F		HUMAN		119	UniRef100_Q16864
V-type proton ATPase subunit F		PANTR		119
V-type proton ATPase subunit F		PANPA		119
V-type proton ATPase subunit F		CERAT		119
V-type proton ATPase subunit F		MANLE		119
+2
Q16864-2	V-type proton ATPase subunit F		GORGO		147	UniRef100_G3RTM3

Protein	Similar proteins		Species	Score	Length	Source
Q16864	V-type proton ATPase subunit F		HUMAN		119	UniRef90_Q16864
V-type proton ATPase subunit F		PANTR		119
V-type proton ATPase subunit F		PANPA		119
V-type proton ATPase subunit F		CERAT		119
V-type proton ATPase subunit F		MANLE		119
+4
Q16864-2	V-type proton ATPase subunit F		GORGO		147	UniRef90_G3RTM3
V-type proton ATPase subunit F		PANTR		147
V-type proton ATPase subunit F		SAIBB		147
V-type proton ATPase subunit F		MACMU		147
V-type proton ATPase subunit F		Cebus capucinus imitator		147
+9

Protein	Similar proteins		Species	Score	Length	Source
Q16864	V-type proton ATPase subunit F		HUMAN		119	UniRef50_Q16864
V-type proton ATPase subunit F		PANTR		119
V-type proton ATPase subunit F		PANPA		119
V-type proton ATPase subunit F		CERAT		119
V-type proton ATPase subunit F		MANLE		119
+27
Q16864-2	V-type proton ATPase subunit F		GORGO		147	UniRef50_G3RTM3
V-type proton ATPase subunit F		AOTNA		147
V-type proton ATPase subunit F		PANPA		147
V-type proton ATPase subunit F		PONAB		147
V-type proton ATPase subunit F		NOMLE		147
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D49400 mRNA Translation: BAA08392.1 CR456896 mRNA Translation: CAG33177.1 AC025594 Genomic DNA No translation available. BC104230 mRNA Translation: AAI04231.1 BC104231 mRNA Translation: AAI04232.1 BC107854 mRNA Translation: AAI07855.1 BU956696 mRNA No translation available.
CCDSⁱ	CCDS56511.1 [Q16864-2] CCDS5807.1 [Q16864-1]
PIRⁱ	JC4193
RefSeqⁱ	NP_001185838.1, NM_001198909.1 [Q16864-2] NP_004222.2, NM_004231.3 [Q16864-1]
UniGeneⁱ	Hs.78089

3D structure databases

ProteinModelPortalⁱ	Q16864
SMRⁱ	Q16864
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114710, 58 interactors
IntActⁱ	Q16864, 14 interactors

Protein family/group databases

TCDBⁱ	3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

TCDBⁱ

3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetⁱ	Q16864
PhosphoSitePlusⁱ	Q16864

Polymorphism and mutation databases

BioMutaⁱ	ATP6V1F
DMDMⁱ	126302612

Proteomic databases

EPDⁱ	Q16864
MaxQBⁱ	Q16864
PeptideAtlasⁱ	Q16864
PRIDEⁱ	Q16864
ProteomicsDBⁱ	61111
TopDownProteomicsⁱ	Q16864-1 [Q16864-1] Q16864-2 [Q16864-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000249289; ENSP00000249289; ENSG00000128524 [Q16864-1] ENST00000492758; ENSP00000417378; ENSG00000128524 [Q16864-2]
GeneIDⁱ	9296
KEGGⁱ	hsa:9296
UCSCⁱ	uc003voc.3 human [Q16864-1]

Organism-specific databases

CTDⁱ	9296
DisGeNETⁱ	9296
EuPathDBⁱ	HostDB:ENSG00000128524.4
GeneCardsⁱ	ATP6V1F
HGNCⁱ	HGNC:16832 ATP6V1F
HPAⁱ	CAB009529 HPA048700 HPA062011
MIMⁱ	607160 gene
neXtProtⁱ	NX_Q16864
OpenTargetsⁱ	ENSG00000128524
PharmGKBⁱ	PA38421
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000013208
HOGENOMⁱ	HOG000056545
HOVERGENⁱ	HBG004488
InParanoidⁱ	Q16864
KOⁱ	K02151
OMAⁱ	QNVAEMI
OrthoDBⁱ	EOG091G0ZUA
PhylomeDBⁱ	Q16864
TreeFamⁱ	TF300080

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05192-MONOMER
Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport

Miscellaneous databases

GeneWikiⁱ	ATP6V1F
GenomeRNAiⁱ	9296
Protein Ontology More...PROⁱ	PR:Q16864
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128524 Expressed in 112 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_ATP6V1F
ExpressionAtlasⁱ	Q16864 baseline and differential
Genevisibleⁱ	Q16864 HS

Family and domain databases

Gene3Dⁱ	3.40.50.10580, 1 hit
InterProⁱ	View protein in InterPro IPR008218 ATPase_V1-cplx_f_g_su IPR005772 ATPase_V1-cplx_fsu_euk IPR036906 ATPase_V1_fsu_sf
Pfamⁱ	View protein in Pfam PF01990 ATP-synt_F, 1 hit
PIRSFⁱ	PIRSF015945 ATPase_V1_F_euk, 1 hit
SUPFAMⁱ	SSF159468 SSF159468, 1 hit
TIGRFAMsⁱ	TIGR01101 V_ATP_synt_F, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VATF_HUMAN
Accessionⁱ	Q16864Primary (citable) accession number: Q16864 Secondary accession number(s): C9J2K4, Q6IBA8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	February 20, 2007
	Last modified:	September 12, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16864 (VATF_HUMAN)

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V-type proton ATPase subunit F

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ