UniProtKB - Q16853 (AOC3_HUMAN)
Protein
Membrane primary amine oxidase
Gene
AOC3
Organism
Homo sapiens (Human)
Status
Functioni
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.4 Publications
Catalytic activityi
- EC:1.4.3.211 Publication
Cofactori
Protein has several cofactor binding sites:- Cu cation1 PublicationNote: Binds 1 copper ion per subunit.1 Publication
- Ca2+1 PublicationNote: Binds 2 calcium ions per subunit.1 Publication
- L-topaquinone1 PublicationNote: Contains 1 topaquinone per subunit.1 Publication
Kineticsi
- KM=1.94 mM for 2-phenylethylamine1 Publication
- KM=0.67 mM for methylamine1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 386 | Proton acceptorBy similarity | 1 | |
Active sitei | 471 | Schiff-base intermediate with substrate; via topaquinoneCombined sources | 1 | |
Metal bindingi | 520 | Copper; via tele nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 522 | Copper; via tele nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 529 | Calcium 1Combined sources | 1 | |
Metal bindingi | 530 | Calcium 1; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 531 | Calcium 1Combined sources | 1 | |
Metal bindingi | 572 | Calcium 2Combined sources | 1 | |
Metal bindingi | 638 | Calcium 2Combined sources | 1 | |
Metal bindingi | 641 | Calcium 2Combined sources | 1 | |
Metal bindingi | 663 | Calcium 2; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 665 | Calcium 2Combined sources | 1 | |
Metal bindingi | 667 | Calcium 2Combined sources | 1 | |
Metal bindingi | 673 | Calcium 1Combined sources | 1 | |
Metal bindingi | 674 | Calcium 1; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 684 | Copper; via pros nitrogenCombined sources1 Publication | 1 |
GO - Molecular functioni
- aliphatic-amine oxidase activity Source: UniProtKB-EC
- aminoacetone:oxygen oxidoreductase(deaminating) activity Source: UniProtKB-EC
- calcium ion binding Source: UniProtKB
- copper ion binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- phenethylamine:oxygen oxidoreductase (deaminating) activity Source: UniProtKB-EC
- primary amine oxidase activity Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- quinone binding Source: UniProtKB
- tryptamine:oxygen oxidoreductase (deaminating) activity Source: UniProtKB-EC
GO - Biological processi
- amine metabolic process Source: UniProtKB
- cell adhesion Source: UniProtKB
- inflammatory response Source: UniProtKB
- negative regulation of primary amine oxidase activity Source: UniProtKB
- response to antibiotic Source: UniProtKB
- xenobiotic metabolic process Source: Reactome
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cell adhesion |
Ligand | Calcium, Copper, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.4.3.21, 2681 |
PathwayCommonsi | Q16853 |
Reactomei | R-HSA-211945, Phase I - Functionalization of compounds |
SABIO-RKi | Q16853 |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane primary amine oxidase (EC:1.4.3.211 Publication)Alternative name(s): Copper amine oxidase HPAO Semicarbazide-sensitive amine oxidase Short name: SSAO Vascular adhesion protein 1 Short name: VAP-1 |
Gene namesi | Name:AOC3 Synonyms:VAP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000131471.6 |
HGNCi | HGNC:550, AOC3 |
MIMi | 603735, gene |
neXtProti | NX_Q16853 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: CACAO
Endosome
- early endosome Source: CACAO
Golgi apparatus
- Golgi apparatus Source: CACAO
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB
- microvillus Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 5 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 6 – 26 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 27 – 763 | ExtracellularSequence analysisAdd BLAST | 737 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 211 | M → V: Increased activity towards 2-phenylethylamine, and decreased activity towards methylamine; when associated with N-394 and G-469. 1 Publication | 1 | |
Mutagenesisi | 394 | Y → N: Increased activity towards 2-phenylethylamine, and decreased activity towards methylamine; when associated with V-211 and G-469. 1 Publication | 1 | |
Mutagenesisi | 469 | L → G: Increased activity towards 2-phenylethylamine, and decreased activity towards methylamine; when associated with V-211 and N-394. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8639 |
OpenTargetsi | ENSG00000131471 |
PharmGKBi | PA24840 |
Miscellaneous databases
Pharosi | Q16853, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3437 |
DrugBanki | DB04334, 6-hydroxydopa quinone DB01275, Hydralazine DB00780, Phenelzine |
DrugCentrali | Q16853 |
GuidetoPHARMACOLOGYi | 2767 |
Polymorphism and mutation databases
BioMutai | AOC3 |
DMDMi | 2501336 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064102 | 1 – 763 | Membrane primary amine oxidaseAdd BLAST | 763 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Disulfide bondi | 198 ↔ 199 | 1 Publication | ||
Glycosylationi | 212 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Glycosylationi | 294 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Disulfide bondi | 404 ↔ 430 | By similarity | ||
Modified residuei | 471 | 2',4',5'-topaquinoneCombined sources | 1 | |
Glycosylationi | 592 | N-linked (GlcNAc...) (complex) asparagineCombined sources4 Publications | 1 | |
Glycosylationi | 618 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 | |
Glycosylationi | 666 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 | |
Disulfide bondi | 734 ↔ 741 | 1 Publication | ||
Disulfide bondi | 748 | Interchain1 Publication |
Post-translational modificationi
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.1 Publication
N- and O-glycosylated.4 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, TPQProteomic databases
jPOSTi | Q16853 |
MassIVEi | Q16853 |
PaxDbi | Q16853 |
PeptideAtlasi | Q16853 |
PRIDEi | Q16853 |
ProteomicsDBi | 61105 [Q16853-1] |
PTM databases
GlyConnecti | 1502, 9 N-Linked glycans (4 sites) |
GlyGeni | Q16853, 8 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q16853 |
PhosphoSitePlusi | Q16853 |
Expressioni
Tissue specificityi
Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.3 Publications
Inductioni
Up-regulated during in vitro adipocyte differentiation.1 Publication
Gene expression databases
Bgeei | ENSG00000131471, Expressed in adipose tissue and 219 other tissues |
ExpressionAtlasi | Q16853, baseline and differential |
Genevisiblei | Q16853, HS |
Organism-specific databases
HPAi | ENSG00000131471, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; disulfide-linked. Can heterodimerize with isoform 2 leading to reduced surface expression.
Forms a heterodimer with AOC2.
3 PublicationsBinary interactionsi
Hide detailsQ16853
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114192, 34 interactors |
IntActi | Q16853, 18 interactors |
STRINGi | 9606.ENSP00000312326 |
Chemistry databases
BindingDBi | Q16853 |
Miscellaneous databases
RNActi | Q16853, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q16853 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16853 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 384 – 394 | Substrate bindingCombined sourcesAdd BLAST | 11 | |
Regioni | 468 – 473 | Substrate bindingBy similarity | 6 |
Sequence similaritiesi
Belongs to the copper/topaquinone oxidase family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1186, Eukaryota |
GeneTreei | ENSGT00950000183207 |
HOGENOMi | CLU_015739_1_0_1 |
InParanoidi | Q16853 |
OMAi | ITFKADF |
OrthoDBi | 1320015at2759 |
PhylomeDBi | Q16853 |
TreeFami | TF314750 |
Family and domain databases
Gene3Di | 2.70.98.20, 1 hit |
InterProi | View protein in InterPro IPR000269, Cu_amine_oxidase IPR015798, Cu_amine_oxidase_C IPR036460, Cu_amine_oxidase_C_sf IPR016182, Cu_amine_oxidase_N-reg IPR015800, Cu_amine_oxidase_N2 IPR015802, Cu_amine_oxidase_N3 |
PANTHERi | PTHR10638, PTHR10638, 1 hit |
Pfami | View protein in Pfam PF01179, Cu_amine_oxid, 1 hit PF02727, Cu_amine_oxidN2, 1 hit PF02728, Cu_amine_oxidN3, 1 hit |
PRINTSi | PR00766, CUDAOXIDASE |
SUPFAMi | SSF49998, SSF49998, 1 hit SSF54416, SSF54416, 2 hits |
PROSITEi | View protein in PROSITE PS01164, COPPER_AMINE_OXID_1, 1 hit PS01165, COPPER_AMINE_OXID_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q16853-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNQKTILVLL ILAVITIFAL VCVLLVGRGG DGGEPSQLPH CPSVSPSAQP
60 70 80 90 100
WTHPGQSQLF ADLSREELTA VMRFLTQRLG PGLVDAAQAR PSDNCVFSVE
110 120 130 140 150
LQLPPKAAAL AHLDRGSPPP AREALAIVFF GRQPQPNVSE LVVGPLPHPS
160 170 180 190 200
YMRDVTVERH GGPLPYHRRP VLFQEYLDID QMIFNRELPQ ASGLLHHCCF
210 220 230 240 250
YKHRGRNLVT MTTAPRGLQS GDRATWFGLY YNISGAGFFL HHVGLELLVN
260 270 280 290 300
HKALDPARWT IQKVFYQGRY YDSLAQLEAQ FEAGLVNVVL IPDNGTGGSW
310 320 330 340 350
SLKSPVPPGP APPLQFYPQG PRFSVQGSRV ASSLWTFSFG LGAFSGPRIF
360 370 380 390 400
DVRFQGERLV YEISLQEALA IYGGNSPAAM TTRYVDGGFG MGKYTTPLTR
410 420 430 440 450
GVDCPYLATY VDWHFLLESQ APKTIRDAFC VFEQNQGLPL RRHHSDLYSH
460 470 480 490 500
YFGGLAETVL VVRSMSTLLN YDYVWDTVFH PSGAIEIRFY ATGYISSAFL
510 520 530 540 550
FGATGKYGNQ VSEHTLGTVH THSAHFKVDL DVAGLENWVW AEDMVFVPMA
560 570 580 590 600
VPWSPEHQLQ RLQVTRKLLE MEEQAAFLVG SATPRYLYLA SNHSNKWGHP
610 620 630 640 650
RGYRIQMLSF AGEPLPQNSS MARGFSWERY QLAVTQRKEE EPSSSSVFNQ
660 670 680 690 700
NDPWAPTVDF SDFINNETIA GKDLVAWVTA GFLHIPHAED IPNTVTVGNG
710 720 730 740 750
VGFFLRPYNF FDEDPSFYSA DSIYFRGDQD AGACEVNPLA CLPQAAACAP
760
DLPAFSHGGF SHN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EIK5 | K7EIK5_HUMAN | Amine oxidase | AOC3 | 144 | Annotation score: | ||
K7EL47 | K7EL47_HUMAN | Amine oxidase | AOC3 | 152 | Annotation score: | ||
K7EQZ5 | K7EQZ5_HUMAN | Amine oxidase | AOC3 | 112 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025035 | 5 | T → R1 PublicationCorresponds to variant dbSNP:rs33954211Ensembl. | 1 | |
Natural variantiVAR_052603 | 78 | R → Q. Corresponds to variant dbSNP:rs402680Ensembl. | 1 | |
Natural variantiVAR_025027 | 167 | H → Y1 PublicationCorresponds to variant dbSNP:rs2228470Ensembl. | 1 | |
Natural variantiVAR_052604 | 171 | V → M. Corresponds to variant dbSNP:rs408038Ensembl. | 1 | |
Natural variantiVAR_052605 | 203 | H → R. Corresponds to variant dbSNP:rs630079Ensembl. | 1 | |
Natural variantiVAR_012064 | 317 | Y → H. Corresponds to variant dbSNP:rs438287Ensembl. | 1 | |
Natural variantiVAR_024343 | 329 | R → Q. Corresponds to variant dbSNP:rs2229595EnsemblClinVar. | 1 | |
Natural variantiVAR_025028 | 371 | I → T1 PublicationCorresponds to variant dbSNP:rs35097308EnsemblClinVar. | 1 | |
Natural variantiVAR_025029 | 408 | A → S1 PublicationCorresponds to variant dbSNP:rs35643019Ensembl. | 1 | |
Natural variantiVAR_025030 | 426 | R → H1 PublicationCorresponds to variant dbSNP:rs33986943Ensembl. | 1 | |
Natural variantiVAR_025031 | 441 | R → W1 PublicationCorresponds to variant dbSNP:rs2229596EnsemblClinVar. | 1 | |
Natural variantiVAR_025032 | 582 | A → T1 PublicationCorresponds to variant dbSNP:rs34987927EnsemblClinVar. | 1 | |
Natural variantiVAR_025033 | 700 | G → S1 PublicationCorresponds to variant dbSNP:rs477207Ensembl. | 1 | |
Natural variantiVAR_025034 | 749 | A → V1 PublicationCorresponds to variant dbSNP:rs34012919Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055201 | 1 – 543 | Missing in isoform 3. 1 PublicationAdd BLAST | 543 | |
Alternative sequenceiVSP_053751 | 630 – 634 | YQLAV → IWWPG in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_053752 | 635 – 763 | Missing in isoform 2. 1 PublicationAdd BLAST | 129 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39447 mRNA Translation: AAC50919.1 AF067406 mRNA Translation: AAC25170.1 AB050502 Genomic DNA Translation: BAB18866.1 JX020506 mRNA Translation: AGB67480.1 AK025727 mRNA No translation available. AK315129 mRNA Translation: BAG37582.1 DQ143944 Genomic DNA Translation: AAZ38716.1 AC016889 Genomic DNA No translation available. BC050549 mRNA Translation: AAH50549.1 |
CCDSi | CCDS11444.1 [Q16853-1] CCDS62198.1 [Q16853-3] CCDS74071.1 [Q16853-2] |
PIRi | JC5234 |
RefSeqi | NP_001264660.1, NM_001277731.1 [Q16853-2] NP_001264661.1, NM_001277732.1 [Q16853-3] NP_003725.1, NM_003734.3 [Q16853-1] |
Genome annotation databases
Ensembli | ENST00000308423; ENSP00000312326; ENSG00000131471 [Q16853-1] ENST00000591562; ENSP00000468632; ENSG00000131471 [Q16853-3] ENST00000613571; ENSP00000484312; ENSG00000131471 [Q16853-2] ENST00000617500; ENSP00000477686; ENSG00000131471 [Q16853-3] |
GeneIDi | 8639 |
KEGGi | hsa:8639 |
UCSCi | uc002ibv.6, human [Q16853-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39447 mRNA Translation: AAC50919.1 AF067406 mRNA Translation: AAC25170.1 AB050502 Genomic DNA Translation: BAB18866.1 JX020506 mRNA Translation: AGB67480.1 AK025727 mRNA No translation available. AK315129 mRNA Translation: BAG37582.1 DQ143944 Genomic DNA Translation: AAZ38716.1 AC016889 Genomic DNA No translation available. BC050549 mRNA Translation: AAH50549.1 |
CCDSi | CCDS11444.1 [Q16853-1] CCDS62198.1 [Q16853-3] CCDS74071.1 [Q16853-2] |
PIRi | JC5234 |
RefSeqi | NP_001264660.1, NM_001277731.1 [Q16853-2] NP_001264661.1, NM_001277732.1 [Q16853-3] NP_003725.1, NM_003734.3 [Q16853-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PU4 | X-ray | 3.20 | A/B | 1-763 | [»] | |
1US1 | X-ray | 2.90 | A/B | 1-763 | [»] | |
2C10 | X-ray | 2.50 | A/B/C/D | 29-763 | [»] | |
2C11 | X-ray | 2.90 | A/B/C/D | 29-763 | [»] | |
2Y73 | X-ray | 2.60 | A/B | 1-763 | [»] | |
2Y74 | X-ray | 2.95 | A/B | 1-763 | [»] | |
3ALA | X-ray | 2.90 | A/B/C/D/E/F/G | 33-763 | [»] | |
4BTW | X-ray | 2.80 | A/B | 27-763 | [»] | |
4BTX | X-ray | 2.78 | A/B | 27-763 | [»] | |
4BTY | X-ray | 3.10 | A/B | 27-763 | [»] | |
SMRi | Q16853 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114192, 34 interactors |
IntActi | Q16853, 18 interactors |
STRINGi | 9606.ENSP00000312326 |
Chemistry databases
BindingDBi | Q16853 |
ChEMBLi | CHEMBL3437 |
DrugBanki | DB04334, 6-hydroxydopa quinone DB01275, Hydralazine DB00780, Phenelzine |
DrugCentrali | Q16853 |
GuidetoPHARMACOLOGYi | 2767 |
PTM databases
GlyConnecti | 1502, 9 N-Linked glycans (4 sites) |
GlyGeni | Q16853, 8 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q16853 |
PhosphoSitePlusi | Q16853 |
Polymorphism and mutation databases
BioMutai | AOC3 |
DMDMi | 2501336 |
Proteomic databases
jPOSTi | Q16853 |
MassIVEi | Q16853 |
PaxDbi | Q16853 |
PeptideAtlasi | Q16853 |
PRIDEi | Q16853 |
ProteomicsDBi | 61105 [Q16853-1] |
Protocols and materials databases
ABCDi | Q16853, 8 sequenced antibodies |
Antibodypediai | 611, 419 antibodies |
Genome annotation databases
Ensembli | ENST00000308423; ENSP00000312326; ENSG00000131471 [Q16853-1] ENST00000591562; ENSP00000468632; ENSG00000131471 [Q16853-3] ENST00000613571; ENSP00000484312; ENSG00000131471 [Q16853-2] ENST00000617500; ENSP00000477686; ENSG00000131471 [Q16853-3] |
GeneIDi | 8639 |
KEGGi | hsa:8639 |
UCSCi | uc002ibv.6, human [Q16853-1] |
Organism-specific databases
CTDi | 8639 |
DisGeNETi | 8639 |
EuPathDBi | HostDB:ENSG00000131471.6 |
GeneCardsi | AOC3 |
HGNCi | HGNC:550, AOC3 |
HPAi | ENSG00000131471, Low tissue specificity |
MIMi | 603735, gene |
neXtProti | NX_Q16853 |
OpenTargetsi | ENSG00000131471 |
PharmGKBi | PA24840 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1186, Eukaryota |
GeneTreei | ENSGT00950000183207 |
HOGENOMi | CLU_015739_1_0_1 |
InParanoidi | Q16853 |
OMAi | ITFKADF |
OrthoDBi | 1320015at2759 |
PhylomeDBi | Q16853 |
TreeFami | TF314750 |
Enzyme and pathway databases
BRENDAi | 1.4.3.21, 2681 |
PathwayCommonsi | Q16853 |
Reactomei | R-HSA-211945, Phase I - Functionalization of compounds |
SABIO-RKi | Q16853 |
Miscellaneous databases
BioGRID-ORCSi | 8639, 3 hits in 840 CRISPR screens |
ChiTaRSi | AOC3, human |
EvolutionaryTracei | Q16853 |
GeneWikii | AOC3 |
GenomeRNAii | 8639 |
Pharosi | Q16853, Tchem |
PROi | PR:Q16853 |
RNActi | Q16853, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131471, Expressed in adipose tissue and 219 other tissues |
ExpressionAtlasi | Q16853, baseline and differential |
Genevisiblei | Q16853, HS |
Family and domain databases
Gene3Di | 2.70.98.20, 1 hit |
InterProi | View protein in InterPro IPR000269, Cu_amine_oxidase IPR015798, Cu_amine_oxidase_C IPR036460, Cu_amine_oxidase_C_sf IPR016182, Cu_amine_oxidase_N-reg IPR015800, Cu_amine_oxidase_N2 IPR015802, Cu_amine_oxidase_N3 |
PANTHERi | PTHR10638, PTHR10638, 1 hit |
Pfami | View protein in Pfam PF01179, Cu_amine_oxid, 1 hit PF02727, Cu_amine_oxidN2, 1 hit PF02728, Cu_amine_oxidN3, 1 hit |
PRINTSi | PR00766, CUDAOXIDASE |
SUPFAMi | SSF49998, SSF49998, 1 hit SSF54416, SSF54416, 2 hits |
PROSITEi | View protein in PROSITE PS01164, COPPER_AMINE_OXID_1, 1 hit PS01165, COPPER_AMINE_OXID_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AOC3_HUMAN | |
Accessioni | Q16853Primary (citable) accession number: Q16853 Secondary accession number(s): B2RCI5 Q45F94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 200 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations