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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Caution

The human genome was initially thought to contain 2 genes for UTP--glucose-1-phosphate uridylyltransferase: UGP1 and UGP2. However, the sequence defined as UGP1 (PubMed:8354390) probably does not exist and corresponds to UGP2.1 Publication

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127MagnesiumBy similarity1
Binding sitei127UTPBy similarity1
Binding sitei190UTPBy similarity1
Binding sitei222UTP; via amide nitrogenBy similarity1
Binding sitei223SubstrateCombined sources1 Publication1
Metal bindingi253MagnesiumBy similarity1
Binding sitei253UTPBy similarity1
Binding sitei330SubstrateCombined sources1 Publication1
Active sitei396By similarity1
Binding sitei396UTPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS10006-MONOMER
BRENDAi2.7.7.9 2681
ReactomeiR-HSA-173599 Formation of the active cofactor, UDP-glucuronate
R-HSA-3322077 Glycogen synthesis
SABIO-RKiQ16851

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP2
Synonyms:UGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000169764.14
HGNCiHGNC:12527 UGP2
MIMi191750 gene
191760 gene
neXtProtiNX_Q16851

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi123C → S: No significant loss of activity. 1 Publication1
Mutagenesisi218W → S: No significant loss of activity. 1 Publication1
Mutagenesisi266H → R: No significant loss of activity. 1 Publication1
Mutagenesisi333W → S: Loss of activity; possibly due to folding defect. 1 Publication1
Mutagenesisi389R → H: No significant loss of activity. 1 Publication1
Mutagenesisi391R → H: Loss of activity; possibly due to folding defect. 1 Publication1
Mutagenesisi422R → H: No significant loss of activity. 1 Publication1
Mutagenesisi445R → H: No significant loss of activity. 1 Publication1
Mutagenesisi502 – 503NL → PE: Abolishes oligomerization and significantly increases enzymatic activity. 1 Publication2

Organism-specific databases

DisGeNETi7360
OpenTargetsiENSG00000169764
PharmGKBiPA37172

Polymorphism and mutation databases

BioMutaiUGP2
DMDMi59803098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857521 – 508UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST508
Isoform 2 (identifier: Q16851-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei426PhosphothreonineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei438N6-acetyllysineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Isoform 2 (identifier: Q16851-2)
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ16851
MaxQBiQ16851
PaxDbiQ16851
PeptideAtlasiQ16851
PRIDEiQ16851
ProteomicsDBi61103
61104 [Q16851-2]

2D gel databases

REPRODUCTION-2DPAGEiIPI00395676
UCD-2DPAGEiQ16851

PTM databases

iPTMnetiQ16851
PhosphoSitePlusiQ16851
SwissPalmiQ16851

Expressioni

Gene expression databases

BgeeiENSG00000169764 Expressed in 234 organ(s), highest expression level in adipose tissue
CleanExiHS_UGP2
ExpressionAtlasiQ16851 baseline and differential
GenevisibleiQ16851 HS

Organism-specific databases

HPAiHPA034696
HPA034697
HPA064836

Interactioni

Subunit structurei

Homooctamer.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113207, 58 interactors
IntActiQ16851, 8 interactors
STRINGi9606.ENSP00000338703

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16851
SMRiQ16851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116UTP bindingBy similarity4
Regioni115 – 116Substrate bindingCombined sources1 Publication2
Regioni251 – 253Substrate bindingCombined sources1 Publication3
Regioni457 – 508OligomerizationAdd BLAST52
Regioni502 – 503Critical for end-to-end subunit interaction2

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiKOG2638 Eukaryota
COG4284 LUCA
GeneTreeiENSGT00390000003174
HOGENOMiHOG000113618
HOVERGENiHBG055396
InParanoidiQ16851
KOiK00963
PhylomeDBiQ16851
TreeFamiTF300567

Family and domain databases

CDDicd00897 UGPase_euk, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR002618 UDPGP_fam
IPR016267 UDPGP_trans
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
PIRSFiPIRSF000806 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16851-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTASSHEFEH
60 70 80 90 100
TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN
110 120 130 140 150
ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN
160 170 180 190 200
KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES
210 220 230 240 250
LLPVAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI GEGKEYIFVS
260 270 280 290 300
NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG
310 320 330 340 350
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM
360 370 380 390 400
EIIVNAKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD
410 420 430 440 450
LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP
460 470 480 490 500
DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS

GNLRILDH
Length:508
Mass (Da):56,940
Last modified:January 23, 2007 - v5
Checksum:i60E54806807AB470
GO
Isoform 2 (identifier: Q16851-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:497
Mass (Da):55,677
Checksum:i2B3FD9731E371E47
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUC7E7EUC7_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
517Annotation score:
A0A087WYS1A0A087WYS1_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
508Annotation score:
C9JWG0C9JWG0_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
150Annotation score:
C9JQU9C9JQU9_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
175Annotation score:
C9JNZ1C9JNZ1_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
212Annotation score:
C9JUW1C9JUW1_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
135Annotation score:
C9JVG3C9JVG3_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
170Annotation score:
C9JTZ5C9JTZ5_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
104Annotation score:
F2Z3H1F2Z3H1_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
76Annotation score:
C9J3M0C9J3M0_HUMAN
UTP--glucose-1-phosphate uridylyltr...
UGP2
38Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25R → L (PubMed:8354390).Curated1
Sequence conflicti44S → T (PubMed:8354390).Curated1
Sequence conflicti48F → Y (PubMed:8354390).Curated1
Sequence conflicti62F → Y (PubMed:8354390).Curated1
Sequence conflicti152T → S (PubMed:8354390).Curated1
Sequence conflicti202L → R (PubMed:8354390).Curated1
Sequence conflicti202L → R in AAB05640 (PubMed:8631325).Curated1
Sequence conflicti210Y → S (PubMed:8354390).Curated1
Sequence conflicti214N → S (PubMed:8354390).Curated1
Sequence conflicti240 – 241IG → LE (PubMed:8354390).Curated2
Sequence conflicti356A → P (PubMed:8354390).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033042268M → I2 PublicationsCorresponds to variant dbSNP:rs1130982Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0128341 – 11Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27460 mRNA Translation: AAB05640.1
BC000173 mRNA Translation: AAH00173.2
BC002954 mRNA Translation: AAH02954.1
BC047004 mRNA Translation: AAH47004.1
CCDSiCCDS1875.1 [Q16851-1]
CCDS42690.1 [Q16851-2]
PIRiS35692
RefSeqiNP_001001521.1, NM_001001521.1 [Q16851-2]
NP_006750.3, NM_006759.3 [Q16851-1]
XP_005264594.1, XM_005264537.2 [Q16851-2]
XP_005264595.1, XM_005264538.1 [Q16851-2]
UniGeneiHs.516217

Genome annotation databases

EnsembliENST00000337130; ENSP00000338703; ENSG00000169764 [Q16851-1]
ENST00000394417; ENSP00000377939; ENSG00000169764 [Q16851-2]
ENST00000467648; ENSP00000420793; ENSG00000169764 [Q16851-2]
GeneIDi7360
KEGGihsa:7360
UCSCiuc002scl.4 human [Q16851-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27460 mRNA Translation: AAB05640.1
BC000173 mRNA Translation: AAH00173.2
BC002954 mRNA Translation: AAH02954.1
BC047004 mRNA Translation: AAH47004.1
CCDSiCCDS1875.1 [Q16851-1]
CCDS42690.1 [Q16851-2]
PIRiS35692
RefSeqiNP_001001521.1, NM_001001521.1 [Q16851-2]
NP_006750.3, NM_006759.3 [Q16851-1]
XP_005264594.1, XM_005264537.2 [Q16851-2]
XP_005264595.1, XM_005264538.1 [Q16851-2]
UniGeneiHs.516217

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R2WX-ray3.60A/B/C/D1-508[»]
3R3IX-ray3.57A/B/C/D1-508[»]
4R7PX-ray3.35A/B/C/D2-508[»]
ProteinModelPortaliQ16851
SMRiQ16851
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113207, 58 interactors
IntActiQ16851, 8 interactors
STRINGi9606.ENSP00000338703

PTM databases

iPTMnetiQ16851
PhosphoSitePlusiQ16851
SwissPalmiQ16851

Polymorphism and mutation databases

BioMutaiUGP2
DMDMi59803098

2D gel databases

REPRODUCTION-2DPAGEiIPI00395676
UCD-2DPAGEiQ16851

Proteomic databases

EPDiQ16851
MaxQBiQ16851
PaxDbiQ16851
PeptideAtlasiQ16851
PRIDEiQ16851
ProteomicsDBi61103
61104 [Q16851-2]

Protocols and materials databases

DNASUi7360
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337130; ENSP00000338703; ENSG00000169764 [Q16851-1]
ENST00000394417; ENSP00000377939; ENSG00000169764 [Q16851-2]
ENST00000467648; ENSP00000420793; ENSG00000169764 [Q16851-2]
GeneIDi7360
KEGGihsa:7360
UCSCiuc002scl.4 human [Q16851-1]

Organism-specific databases

CTDi7360
DisGeNETi7360
EuPathDBiHostDB:ENSG00000169764.14
GeneCardsiUGP2
HGNCiHGNC:12527 UGP2
HPAiHPA034696
HPA034697
HPA064836
MIMi191750 gene
191760 gene
neXtProtiNX_Q16851
OpenTargetsiENSG00000169764
PharmGKBiPA37172
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2638 Eukaryota
COG4284 LUCA
GeneTreeiENSGT00390000003174
HOGENOMiHOG000113618
HOVERGENiHBG055396
InParanoidiQ16851
KOiK00963
PhylomeDBiQ16851
TreeFamiTF300567

Enzyme and pathway databases

BioCyciMetaCyc:HS10006-MONOMER
BRENDAi2.7.7.9 2681
ReactomeiR-HSA-173599 Formation of the active cofactor, UDP-glucuronate
R-HSA-3322077 Glycogen synthesis
SABIO-RKiQ16851

Miscellaneous databases

ChiTaRSiUGP2 human
GenomeRNAii7360
PROiPR:Q16851
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169764 Expressed in 234 organ(s), highest expression level in adipose tissue
CleanExiHS_UGP2
ExpressionAtlasiQ16851 baseline and differential
GenevisibleiQ16851 HS

Family and domain databases

CDDicd00897 UGPase_euk, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR002618 UDPGP_fam
IPR016267 UDPGP_trans
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
PIRSFiPIRSF000806 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUGPA_HUMAN
AccessioniPrimary (citable) accession number: Q16851
Secondary accession number(s): Q07131
, Q0P6K2, Q86Y81, Q9BU15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 163 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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