CYP51A1

Functionⁱ

Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.2 Publications

Catalytic activityⁱ

A 14-alpha-methylsteroid + 3 [reduced NADPH--hemoprotein reductase] + 3 O₂ = a Delta(14)-steroid + formate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H₂O.2 Publications

Cofactorⁱ

heme1 Publication

Pathwayⁱ: zymosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes zymosterol from lanosterol.1 Publication
Proteins known to be involved in the 6 steps of the subpathway in this organism are:

Lanosterol 14-alpha demethylase (CYP51A1)
no protein annotated in this organism
Methylsterol monooxygenase 1 (MSMO1)
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)
3-keto-steroid reductase (HSD17B7)
no protein annotated in this organism

This subpathway is part of the pathway zymosterol biosynthesis, which is itself part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol, the pathway zymosterol biosynthesis and in Steroid biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	449	Iron (heme axial ligand)1 Publication		1

GO - Molecular functionⁱ

heme binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20149798
iron ion binding Source: InterPro
sterol 14-demethylase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20149798

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cholesterol biosynthetic process Source: Reactome
cholesterol biosynthetic process via 24,25-dihydrolanosterol
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxidation-reduction process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cholesterol biosynthetic process Source: Reactome
steroid biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20149798
sterol biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sterol metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Biological process	Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00076-MONOMER
BRENDAⁱ	1.14.13.70 2681
Reactomeⁱ	R-HSA-191273 Cholesterol biosynthesis R-HSA-211976 Endogenous sterols R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
UniPathwayⁱ	UPA00770;UER00754

Chemistry databases

SwissLipidsⁱ	SLP:000001162

SwissLipidsⁱ

SLP:000001162

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lanosterol 14-alpha demethylase (EC:1.14.14.1542 Publications) Short name: LDM Alternative name(s): CYPLI Cytochrome P450 51A1 Cytochrome P450-14DM Short name: Cytochrome P45014DM Cytochrome P450LI Sterol 14-alpha demethylase
Gene namesⁱ	Name:CYP51A1 Synonyms:CYP51
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000001630.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2649 CYP51A1
MIMⁱ	601637 gene
neXtProtⁱ	NX_Q16850

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	24 – 44	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1595
Open Targets More...OpenTargetsⁱ	ENSG00000001630
PharmGKBⁱ	PA27123

Chemistry databases

ChEMBLⁱ	CHEMBL3849
Drug and drug target database More...DrugBankⁱ	DB01167 Itraconazole DB01026 Ketoconazole DB00916 Metronidazole DB01045 Rifampicin DB01153 Sertaconazole DB01007 Tioconazole
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1374

Polymorphism and mutation databases

DMDMⁱ	3915660

DMDMⁱ

3915660

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051998	1 – 503	Lanosterol 14-alpha demethylaseAdd BLAST		503

Proteomic databases

EPDⁱ	Q16850
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16850
PaxDbⁱ	Q16850
PeptideAtlas More...PeptideAtlasⁱ	Q16850
PRIDEⁱ	Q16850
ProteomicsDBⁱ	61101 61102 [Q16850-2]

PTM databases

iPTMnetⁱ	Q16850
PhosphoSitePlusⁱ	Q16850
SwissPalmⁱ	Q16850

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000001630 Expressed in 98 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_CYP51A1
ExpressionAtlasⁱ	Q16850 baseline and differential
Genevisibleⁱ	Q16850 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041325 HPA043508

HPAⁱ

HPA041325
HPA043508

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107967, 41 interactors
IntActⁱ	Q16850, 7 interactors
STRINGⁱ	9606.ENSP00000003100

Chemistry databases

BindingDBⁱ

Q16850

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	69 – 73	Combined sources	5
Helixⁱ	74 – 79	Combined sources	6
Helixⁱ	81 – 92	Combined sources	12
Beta strandⁱ	94 – 100	Combined sources	7
Beta strandⁱ	103 – 108	Combined sources	6
Helixⁱ	111 – 119	Combined sources	9
Turnⁱ	122 – 124	Combined sources	3
Beta strandⁱ	125 – 127	Combined sources	3
Helixⁱ	128 – 139	Combined sources	12
Helixⁱ	144 – 146	Combined sources	3
Helixⁱ	149 – 162	Combined sources	14
Helixⁱ	165 – 184	Combined sources	20
Beta strandⁱ	188 – 193	Combined sources	6
Helixⁱ	194 – 211	Combined sources	18
Helixⁱ	213 – 217	Combined sources	5
Helixⁱ	221 – 231	Combined sources	11
Helixⁱ	236 – 240	Combined sources	5
Helixⁱ	248 – 273	Combined sources	26
Helixⁱ	281 – 287	Combined sources	7
Helixⁱ	298 – 329	Combined sources	32
Helixⁱ	331 – 345	Combined sources	15
Helixⁱ	354 – 357	Combined sources	4
Helixⁱ	361 – 373	Combined sources	13
Beta strandⁱ	380 – 386	Combined sources	7
Beta strandⁱ	388 – 390	Combined sources	3
Beta strandⁱ	393 – 395	Combined sources	3
Beta strandⁱ	400 – 403	Combined sources	4
Helixⁱ	405 – 408	Combined sources	4
Turnⁱ	412 – 414	Combined sources	3
Turnⁱ	416 – 419	Combined sources	4
Helixⁱ	423 – 427	Combined sources	5
Helixⁱ	431 – 434	Combined sources	4
Beta strandⁱ	435 – 438	Combined sources	4
Helixⁱ	445 – 447	Combined sources	3
Helixⁱ	452 – 469	Combined sources	18
Beta strandⁱ	470 – 473	Combined sources	4
Beta strandⁱ	475 – 477	Combined sources	3
Beta strandⁱ	486 – 488	Combined sources	3
Beta strandⁱ	490 – 493	Combined sources	4
Beta strandⁱ	495 – 500	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16850
SMRⁱ	Q16850
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q16850

EvolutionaryTraceⁱ

Q16850

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0684 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000151026
HOVERGENⁱ	HBG051102
InParanoidⁱ	Q16850
KEGG Orthology (KO) More...KOⁱ	K05917
PhylomeDBⁱ	Q16850
TreeFamⁱ	TF105091

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002403 Cyt_P450_E_grp-IV IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00465 EP450IV PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q16850-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLGLLQAG GSVLGQAMEK VTGGNLLSML LIACAFTLSL VYLIRLAAGH 
        60         70         80         90        100
LVQLPAGVKS PPYIFSPIPF LGHAIAFGKS PIEFLENAYE KYGPVFSFTM 
       110        120        130        140        150
VGKTFTYLLG SDAAALLFNS KNEDLNAEDV YSRLTTPVFG KGVAYDVPNP 
       160        170        180        190        200
VFLEQKKMLK SGLNIAHFKQ HVSIIEKETK EYFESWGESG EKNVFEALSE 
       210        220        230        240        250
LIILTASHCL HGKEIRSQLN EKVAQLYADL DGGFSHAAWL LPGWLPLPSF 
       260        270        280        290        300
RRRDRAHREI KDIFYKAIQK RRQSQEKIDD ILQTLLDATY KDGRPLTDDE 
       310        320        330        340        350
VAGMLIGLLL AGQHTSSTTS AWMGFFLARD KTLQKKCYLE QKTVCGENLP 
       360        370        380        390        400
PLTYDQLKDL NLLDRCIKET LRLRPPIMIM MRMARTPQTV AGYTIPPGHQ 
       410        420        430        440        450
VCVSPTVNQR LKDSWVERLD FNPDRYLQDN PASGEKFAYV PFGAGRHRCI 
       460        470        480        490        500
GENFAYVQIK TIWSTMLRLY EFDLIDGYFP TVNYTTMIHT PENPVIRYKR 

RSK

Length:503

Mass (Da):56,806

Last modified:December 15, 1998 - v3

Checksum:ⁱ4FCEC147FB4DED86

GO

Isoform 2 (identifier: Q16850-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-99: Missing.

« Hide

        10         20         30         40         50
MVGKTFTYLL GSDAAALLFN SKNEDLNAED VYSRLTTPVF GKGVAYDVPN 
        60         70         80         90        100
PVFLEQKKML KSGLNIAHFK QHVSIIEKET KEYFESWGES GEKNVFEALS 
       110        120        130        140        150
ELIILTASHC LHGKEIRSQL NEKVAQLYAD LDGGFSHAAW LLPGWLPLPS 
       160        170        180        190        200
FRRRDRAHRE IKDIFYKAIQ KRRQSQEKID DILQTLLDAT YKDGRPLTDD 
       210        220        230        240        250
EVAGMLIGLL LAGQHTSSTT SAWMGFFLAR DKTLQKKCYL EQKTVCGENL 
       260        270        280        290        300
PPLTYDQLKD LNLLDRCIKE TLRLRPPIMI MMRMARTPQT VAGYTIPPGH 
       310        320        330        340        350
QVCVSPTVNQ RLKDSWVERL DFNPDRYLQD NPASGEKFAY VPFGAGRHRC 
       360        370        380        390        400
IGENFAYVQI KTIWSTMLRL YEFDLIDGYF PTVNYTTMIH TPENPVIRYK 

RRSK

Note: No experimental confirmation available.

Show »

Length:404

Mass (Da):46,312

Checksum:ⁱ2D5198C9B55ED478

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DFL7	A0A0C4DFL7_HUMAN	Lanosterol 14-alpha demethylase Lanosterol 14-alpha demethylase	CYP51A1	509	Annotation score:
H7C0D0	H7C0D0_HUMAN	Lanosterol 14-alpha demethylase Lanosterol 14-alpha demethylase	CYP51A1	222	Annotation score:
C9IYR8	C9IYR8_HUMAN	Lanosterol 14-alpha demethylase Lanosterol 14-alpha demethylase	CYP51A1	30	Annotation score:

Sequence cautionⁱ

The sequence AAB39951 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAB46356 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH32322 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAA09512 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAG36881 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence EAL24154 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence EAW76858 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	270	K → E in BAG36881 (PubMed:14702039).Curated	1
Sequence conflictⁱ	272	R → T in AAC50951 (PubMed:8975714).Curated	1
Sequence conflictⁱ	368	K → R in AAC50951 (PubMed:8975714).Curated	1
Sequence conflictⁱ	377	I → V in AAH32322 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023470	13	V → A. Corresponds to variant dbSNP:rs2229188Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037413	1 – 99	Missing in isoform 2. 1 PublicationAdd BLAST		99

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U23942 mRNA Translation: AAB39951.1 Different initiation. D55653 mRNA Translation: BAA09512.1 Different initiation. U51692 U51691 Genomic DNA Translation: AAC50951.1 AK314205 mRNA Translation: BAG36881.1 Different initiation. AK295932 mRNA Translation: BAG58717.1 AC000120 Genomic DNA Translation: AAB46356.1 Different initiation. CH236949 Genomic DNA Translation: EAL24154.1 Different initiation. CH471091 Genomic DNA Translation: EAW76858.1 Different initiation. CH471091 Genomic DNA Translation: EAW76859.1 BC032322 mRNA Translation: AAH32322.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55123.1 [Q16850-2]
PIRⁱ	JC4759 S68855
NCBI Reference Sequences More...RefSeqⁱ	NP_000777.1, NM_000786.3 NP_001139624.1, NM_001146152.1 [Q16850-2]
UniGeneⁱ	Hs.417077

Genome annotation databases

Ensemblⁱ	ENST00000450723; ENSP00000406757; ENSG00000001630 [Q16850-2]
GeneIDⁱ	1595
KEGGⁱ	hsa:1595
UCSC genome browser More...UCSCⁱ	uc003ulm.5 human [Q16850-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16850	Lanosterol 14-alpha demethylase		HUMAN		509	UniRef100_Q16850
Isoform 2 of Lanosterol 14-alpha demethylase		HUMAN		404
UPI0007E2A972		HUMAN		443

Protein	Similar proteins		Species	Score	Length	Source
Q16850	Lanosterol 14-alpha demethylase		MOUSE		503	UniRef90_Q16850
Lanosterol 14-alpha demethylase		PIG		503
Lanosterol 14-alpha demethylase		RAT		503
Lanosterol 14-alpha demethylase		PONAB		503
Lanosterol 14-alpha demethylase		MACFA		503
+161

Protein	Similar proteins		Species	Score	Length	Source
Q16850	Lanosterol 14-alpha demethylase		PONAB		503	UniRef50_Q16850
Lanosterol 14-alpha demethylase		RAT		503
Lanosterol 14-alpha demethylase		PIG		503
Lanosterol 14-alpha demethylase		MOUSE		503
Lanosterol 14-alpha demethylase		MACFA		503
+423

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U23942 mRNA Translation: AAB39951.1 Different initiation. D55653 mRNA Translation: BAA09512.1 Different initiation. U51692 U51691 Genomic DNA Translation: AAC50951.1 AK314205 mRNA Translation: BAG36881.1 Different initiation. AK295932 mRNA Translation: BAG58717.1 AC000120 Genomic DNA Translation: AAB46356.1 Different initiation. CH236949 Genomic DNA Translation: EAL24154.1 Different initiation. CH471091 Genomic DNA Translation: EAW76858.1 Different initiation. CH471091 Genomic DNA Translation: EAW76859.1 BC032322 mRNA Translation: AAH32322.1 Different initiation.
CCDSⁱ	CCDS55123.1 [Q16850-2]
PIRⁱ	JC4759 S68855
RefSeqⁱ	NP_000777.1, NM_000786.3 NP_001139624.1, NM_001146152.1 [Q16850-2]
UniGeneⁱ	Hs.417077

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3JUS	X-ray	2.90	A/B	54-502	[»]
	3JUV	X-ray	3.12	A	54-502	[»]
	3LD6	X-ray	2.80	A/B	54-502	[»]
	4UHI	X-ray	2.04	A/B/C/D	61-503	[»]
	4UHL	X-ray	2.50	A/B/C/D/E/F/G/H	61-503	[»]
ProteinModelPortalⁱ	Q16850
SMRⁱ	Q16850
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107967, 41 interactors
IntActⁱ	Q16850, 7 interactors
STRINGⁱ	9606.ENSP00000003100

Chemistry databases

BindingDBⁱ	Q16850
ChEMBLⁱ	CHEMBL3849
DrugBankⁱ	DB01167 Itraconazole DB01026 Ketoconazole DB00916 Metronidazole DB01045 Rifampicin DB01153 Sertaconazole DB01007 Tioconazole
GuidetoPHARMACOLOGYⁱ	1374
SwissLipidsⁱ	SLP:000001162

PTM databases

iPTMnetⁱ	Q16850
PhosphoSitePlusⁱ	Q16850
SwissPalmⁱ	Q16850

Polymorphism and mutation databases

DMDMⁱ	3915660

DMDMⁱ

3915660

Proteomic databases

EPDⁱ	Q16850
MaxQBⁱ	Q16850
PaxDbⁱ	Q16850
PeptideAtlasⁱ	Q16850
PRIDEⁱ	Q16850
ProteomicsDBⁱ	61101 61102 [Q16850-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1595
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000450723; ENSP00000406757; ENSG00000001630 [Q16850-2]
GeneIDⁱ	1595
KEGGⁱ	hsa:1595
UCSCⁱ	uc003ulm.5 human [Q16850-1]

Organism-specific databases

CTDⁱ	1595
DisGeNETⁱ	1595
EuPathDBⁱ	HostDB:ENSG00000001630.15
GeneCardsⁱ	CYP51A1
HGNCⁱ	HGNC:2649 CYP51A1
HPAⁱ	HPA041325 HPA043508
MIMⁱ	601637 gene
neXtProtⁱ	NX_Q16850
OpenTargetsⁱ	ENSG00000001630
PharmGKBⁱ	PA27123
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0684 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00930000151026
HOVERGENⁱ	HBG051102
InParanoidⁱ	Q16850
KOⁱ	K05917
PhylomeDBⁱ	Q16850
TreeFamⁱ	TF105091

Enzyme and pathway databases

UniPathwayⁱ	UPA00770;UER00754
BioCycⁱ	MetaCyc:HS00076-MONOMER
BRENDAⁱ	1.14.13.70 2681
Reactomeⁱ	R-HSA-191273 Cholesterol biosynthesis R-HSA-211976 Endogenous sterols R-HSA-2426168 Activation of gene expression by SREBF (SREBP)

Miscellaneous databases

ChiTaRSⁱ	CYP51A1 human
EvolutionaryTraceⁱ	Q16850
GenomeRNAiⁱ	1595
Protein Ontology More...PROⁱ	PR:Q16850
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000001630 Expressed in 98 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_CYP51A1
ExpressionAtlasⁱ	Q16850 baseline and differential
Genevisibleⁱ	Q16850 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002403 Cyt_P450_E_grp-IV IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00465 EP450IV PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP51A_HUMAN
Accessionⁱ	Q16850Primary (citable) accession number: Q16850 Secondary accession number(s): A4D1F8 Q99868
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	December 15, 1998
	Last modified:	November 7, 2018
	This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16850 (CP51A_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Lanosterol 14-alpha demethylase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: zymosterol biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: zymosterol biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ