UniProtKB - Q16836 (HCDH_HUMAN)
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
HADH
Functioni
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361).
Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity).
By similarity3 PublicationsCatalytic activityi
- EC:1.1.1.353 Publications
Kineticsi
- KM=34.5 µM for acetoacetyl-CoA at pH 5.01 Publication
- KM=45.0 µM for acetoacetyl-CoA at pH 6.01 Publication
- KM=18.7 µM for acetoacetyl-CoA at pH 7.01 Publication
- KM=13.8 µM for acetoacetyl-CoA at pH 8.01 Publication
- KM=11.9 µM for acetoacetyl-CoA1 Publication
- KM=24.2 µM for NADH1 Publication
- Vmax=281 µmol/min/mg enzyme with acetoacetyl-CoA as substrate at PH 5.01 Publication
- Vmax=448 µmol/min/mg enzyme with acetoacetyl-CoA as substrate at PH 6.01 Publication
- Vmax=459 µmol/min/mg enzyme with acetoacetyl-CoA as substrate at PH 6.01 Publication
- Vmax=205 µmol/min/mg enzyme with acetoacetyl-CoA as substrate at PH 8.01 Publication
pH dependencei
: fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.2 PublicationsView all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 57 | NAD2 Publications | 1 | |
Binding sitei | 73 | Coenzyme A1 Publication | 1 | |
Binding sitei | 80 | Coenzyme A1 Publication | 1 | |
Binding sitei | 122 | NAD2 Publications | 1 | |
Binding sitei | 127 | NAD2 Publications | 1 | |
Binding sitei | 149 | Coenzyme A1 Publication | 1 | |
Binding sitei | 149 | NAD2 Publications | 1 | |
Sitei | 170 | Important for catalytic activityCurated | 1 | |
Binding sitei | 173 | NAD2 Publications | 1 | |
Binding sitei | 305 | NAD2 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 39 | NAD2 Publications | 6 |
GO - Molecular functioni
- 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB
- identical protein binding Source: UniProtKB
- NAD+ binding Source: UniProtKB
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- fatty acid beta-oxidation Source: UniProtKB
- negative regulation of insulin secretion Source: Ensembl
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- regulation of insulin secretion Source: UniProtKB
- response to activity Source: Ensembl
- response to insulin Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
Keywordsi
Molecular function | Oxidoreductase, Transferase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | NAD |
Enzyme and pathway databases
BRENDAi | 1.1.1.35, 2681 |
PathwayCommonsi | Q16836 |
Reactomei | R-HSA-77310, Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77346, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77348, Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77350, Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77352, Beta oxidation of butanoyl-CoA to acetyl-CoA |
SABIO-RKi | Q16836 |
SignaLinki | Q16836 |
UniPathwayi | UPA00659 |
Chemistry databases
SwissLipidsi | SLP:000001250 |
Names & Taxonomyi
Protein namesi | Recommended name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (EC:1.1.1.353 Publications)Short name: HCDH Alternative name(s): Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase Short-chain 3-hydroxyacyl-CoA dehydrogenase1 Publication |
Gene namesi | Name:HADH Synonyms:HAD1 Publication, HAD11 Publication, HADHSC, SCHAD1 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4799, HADH |
MIMi | 601609, gene |
neXtProti | NX_Q16836 |
VEuPathDBi | HostDB:ENSG00000138796 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 1 Publication
Mitochondrion
- mitochondrial matrix Source: Reactome
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: LIFEdb
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
3-alpha-hydroxyacyl-CoA dehydrogenase deficiency (HADH deficiency)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024079 | 40 | A → T in HADH deficiency. 1 PublicationCorresponds to variant dbSNP:rs137853101EnsemblClinVar. | 1 | |
Natural variantiVAR_024080 | 57 | D → E in HADH deficiency. 1 PublicationCorresponds to variant dbSNP:rs137853102EnsemblClinVar. | 1 |
Familial hyperinsulinemic hypoglycemia 4 (HHF4)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024081 | 258 | P → L in HHF4; loss of 3-hydroxyacyl-CoA dehydrogenase activity. 1 PublicationCorresponds to variant dbSNP:rs137853103EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 3033 |
GeneReviewsi | HADH |
MalaCardsi | HADH |
MIMi | 231530, phenotype 609975, phenotype |
OpenTargetsi | ENSG00000138796 |
Orphaneti | 71212, Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency |
PharmGKBi | PA29173 |
Miscellaneous databases
Pharosi | Q16836, Tbio |
Chemistry databases
DrugBanki | DB03612, 3-Hydroxybutyryl-Coenzyme A DB03059, Acetoacetyl-CoA DB00157, NADH DB09568, Omega-3-carboxylic acids |
Genetic variation databases
BioMutai | HADH |
DMDMi | 311033442 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 12 | Mitochondrion1 PublicationAdd BLAST | 12 | |
ChainiPRO_0000007406 | 13 – 314 | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialAdd BLAST | 302 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 80 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 81 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 81 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 87 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 87 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 125 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 127 | N6-(2-hydroxyisobutyryl)lysine1 Publication | 1 | |
Modified residuei | 136 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 136 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 179 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 185 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 185 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 192 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 192 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 202 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 202 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 206 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 212 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 212 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 241 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 241 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 312 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 312 | N6-succinyllysine; alternateBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, HydroxylationProteomic databases
EPDi | Q16836 |
jPOSTi | Q16836 |
MassIVEi | Q16836 |
MaxQBi | Q16836 |
PeptideAtlasi | Q16836 |
PRIDEi | Q16836 |
ProteomicsDBi | 61096 [Q16836-1] 61097 [Q16836-2] |
TopDownProteomicsi | Q16836-1 [Q16836-1] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00298406 |
UCD-2DPAGEi | Q16836 |
PTM databases
GlyGeni | Q16836, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q16836 |
PhosphoSitePlusi | Q16836 |
SwissPalmi | Q16836 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000138796, Expressed in parietal pleura and 246 other tissues |
ExpressionAtlasi | Q16836, baseline and differential |
Genevisiblei | Q16836, HS |
Organism-specific databases
HPAi | ENSG00000138796, Tissue enhanced (tongue) |
Interactioni
Subunit structurei
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109283, 94 interactors |
IntActi | Q16836, 12 interactors |
MINTi | Q16836 |
STRINGi | 9606.ENSP00000474560 |
Miscellaneous databases
RNActi | Q16836, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q16836 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16836 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2304, Eukaryota |
GeneTreei | ENSGT00940000159984 |
HOGENOMi | CLU_009834_2_0_1 |
InParanoidi | Q16836 |
OMAi | MAHPMGP |
OrthoDBi | 938257at2759 |
PhylomeDBi | Q16836 |
TreeFami | TF300886 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR022694, 3-OHacyl-CoA_DH IPR006180, 3-OHacyl-CoA_DH_CS IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit |
PIRSFi | PIRSF000105, HCDH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00067, 3HCDH, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFVTRQFMR SVSSSSTASA SAKKIIVKHV TVIGGGLMGA GIAQVAAATG
60 70 80 90 100
HTVVLVDQTE DILAKSKKGI EESLRKVAKK KFAENLKAGD EFVEKTLSTI
110 120 130 140 150
ATSTDAASVV HSTDLVVEAI VENLKVKNEL FKRLDKFAAE HTIFASNTSS
160 170 180 190 200
LQITSIANAT TRQDRFAGLH FFNPVPVMKL VEVIKTPMTS QKTFESLVDF
210 220 230 240 250
SKALGKHPVS CKDTPGFIVN RLLVPYLMEA IRLYERGDAS KEDIDTAMKL
260 270 280 290 300
GAGYPMGPFE LLDYVGLDTT KFIVDGWHEM DAENPLHQPS PSLNKLVAEN
310
KFGKKTGEGF YKYK
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSE2 | A0A0A0MSE2_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 317 | Annotation score: | ||
A0A0D9SFP2 | A0A0D9SFP2_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 318 | Annotation score: | ||
A0A1W2PNM1 | A0A1W2PNM1_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 267 | Annotation score: | ||
E9PF18 | E9PF18_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 390 | Annotation score: | ||
A0A1W2PQV5 | A0A1W2PQV5_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 245 | Annotation score: | ||
A0A1W2PQ78 | A0A1W2PQ78_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 176 | Annotation score: | ||
A0A1W2PP40 | A0A1W2PP40_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 145 | Annotation score: | ||
A0A1W2PQC2 | A0A1W2PQC2_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 165 | Annotation score: | ||
A0A1W2PRT2 | A0A1W2PRT2_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 183 | Annotation score: | ||
A0A1W2PQ55 | A0A1W2PQ55_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 100 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q16836-2) | |||||
Sequence conflicti | 41 | L → P in AAB58153 (Ref. 2) Curated | 1 | ||
Sequence conflicti | 56 | R → H in AAB58153 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024079 | 40 | A → T in HADH deficiency. 1 PublicationCorresponds to variant dbSNP:rs137853101EnsemblClinVar. | 1 | |
Natural variantiVAR_024080 | 57 | D → E in HADH deficiency. 1 PublicationCorresponds to variant dbSNP:rs137853102EnsemblClinVar. | 1 | |
Natural variantiVAR_083648 | 57 | D → G Found in a patient with Reye-like syndrome. Does not affect 3-hydroxyacyl-CoA dehydrogenase activity. Increases KM value for NADH. Does not affect dimerization. 1 Publication | 1 | |
Natural variantiVAR_026764 | 86 | L → P4 PublicationsCorresponds to variant dbSNP:rs4956145EnsemblClinVar. | 1 | |
Natural variantiVAR_055701 | 152 | Q → H1 PublicationCorresponds to variant dbSNP:rs1051519EnsemblClinVar. | 1 | |
Natural variantiVAR_083649 | 226 | Y → H Found in a patient with Reye-like syndrome; loss of 3-hydroxyacyl-CoA dehydrogenase activity. Does not affect dimerization. 1 PublicationCorresponds to variant dbSNP:rs146036912EnsemblClinVar. | 1 | |
Natural variantiVAR_024081 | 258 | P → L in HHF4; loss of 3-hydroxyacyl-CoA dehydrogenase activity. 1 PublicationCorresponds to variant dbSNP:rs137853103EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016551 | 1 | M → MGRAGLEAPPPPCGVTGTPG ARGLQGRVGPRPQSLAFRGC LPRASSLPGSPRCRRRCHTM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_016552 | 236 | R → RDFQTCGDSNSGLGFSLK in isoform 2 and isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X96752 mRNA Translation: CAA65528.1 AF001902 mRNA Translation: AAB54008.1 AF001903 mRNA Translation: AAB54009.1 AF001904 Genomic DNA Translation: AAB58153.1 AF095703 Genomic DNA Translation: AAD13581.1 AC114733 Genomic DNA Translation: AAY41050.1 AC118062 Genomic DNA No translation available. BC000306 mRNA Translation: AAH00306.1 |
CCDSi | CCDS3678.1 [Q16836-1] CCDS54790.1 [Q16836-3] |
PIRi | JC4879 |
RefSeqi | NP_001171634.2, NM_001184705.2 [Q16836-3] NP_005318.3, NM_005327.4 [Q16836-1] |
Genome annotation databases
Ensembli | ENST00000309522; ENSP00000312288; ENSG00000138796 ENST00000603302; ENSP00000474560; ENSG00000138796 [Q16836-3] |
GeneIDi | 3033 |
KEGGi | hsa:3033 |
MANE-Selecti | ENST00000309522.8; ENSP00000312288.4; NM_005327.7; NP_005318.6 |
UCSCi | uc003hyq.4, human [Q16836-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X96752 mRNA Translation: CAA65528.1 AF001902 mRNA Translation: AAB54008.1 AF001903 mRNA Translation: AAB54009.1 AF001904 Genomic DNA Translation: AAB58153.1 AF095703 Genomic DNA Translation: AAD13581.1 AC114733 Genomic DNA Translation: AAY41050.1 AC118062 Genomic DNA No translation available. BC000306 mRNA Translation: AAH00306.1 |
CCDSi | CCDS3678.1 [Q16836-1] CCDS54790.1 [Q16836-3] |
PIRi | JC4879 |
RefSeqi | NP_001171634.2, NM_001184705.2 [Q16836-3] NP_005318.3, NM_005327.4 [Q16836-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F0Y | X-ray | 1.80 | A/B | 13-314 | [»] | |
1F12 | X-ray | 2.40 | A/B | 13-314 | [»] | |
1F14 | X-ray | 2.30 | A/B | 13-314 | [»] | |
1F17 | X-ray | 2.30 | A/B | 13-314 | [»] | |
1IL0 | X-ray | 2.20 | A/B | 13-314 | [»] | |
1LSJ | X-ray | 2.50 | A/B | 13-314 | [»] | |
1LSO | X-ray | 2.60 | A/B | 13-314 | [»] | |
1M75 | X-ray | 2.30 | A/B | 13-314 | [»] | |
1M76 | X-ray | 2.15 | A/B | 13-314 | [»] | |
2HDH | X-ray | 2.20 | A/B | 24-314 | [»] | |
3HAD | X-ray | 2.00 | A/B | 13-314 | [»] | |
3RQS | X-ray | 2.00 | A/B | 1-314 | [»] | |
SMRi | Q16836 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109283, 94 interactors |
IntActi | Q16836, 12 interactors |
MINTi | Q16836 |
STRINGi | 9606.ENSP00000474560 |
Chemistry databases
DrugBanki | DB03612, 3-Hydroxybutyryl-Coenzyme A DB03059, Acetoacetyl-CoA DB00157, NADH DB09568, Omega-3-carboxylic acids |
SwissLipidsi | SLP:000001250 |
PTM databases
GlyGeni | Q16836, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q16836 |
PhosphoSitePlusi | Q16836 |
SwissPalmi | Q16836 |
Genetic variation databases
BioMutai | HADH |
DMDMi | 311033442 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00298406 |
UCD-2DPAGEi | Q16836 |
Proteomic databases
EPDi | Q16836 |
jPOSTi | Q16836 |
MassIVEi | Q16836 |
MaxQBi | Q16836 |
PeptideAtlasi | Q16836 |
PRIDEi | Q16836 |
ProteomicsDBi | 61096 [Q16836-1] 61097 [Q16836-2] |
TopDownProteomicsi | Q16836-1 [Q16836-1] |
Protocols and materials databases
Antibodypediai | 26260, 554 antibodies from 34 providers |
DNASUi | 3033 |
Genome annotation databases
Ensembli | ENST00000309522; ENSP00000312288; ENSG00000138796 ENST00000603302; ENSP00000474560; ENSG00000138796 [Q16836-3] |
GeneIDi | 3033 |
KEGGi | hsa:3033 |
MANE-Selecti | ENST00000309522.8; ENSP00000312288.4; NM_005327.7; NP_005318.6 |
UCSCi | uc003hyq.4, human [Q16836-1] |
Organism-specific databases
CTDi | 3033 |
DisGeNETi | 3033 |
GeneCardsi | HADH |
GeneReviewsi | HADH |
HGNCi | HGNC:4799, HADH |
HPAi | ENSG00000138796, Tissue enhanced (tongue) |
MalaCardsi | HADH |
MIMi | 231530, phenotype 601609, gene 609975, phenotype |
neXtProti | NX_Q16836 |
OpenTargetsi | ENSG00000138796 |
Orphaneti | 71212, Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency |
PharmGKBi | PA29173 |
VEuPathDBi | HostDB:ENSG00000138796 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2304, Eukaryota |
GeneTreei | ENSGT00940000159984 |
HOGENOMi | CLU_009834_2_0_1 |
InParanoidi | Q16836 |
OMAi | MAHPMGP |
OrthoDBi | 938257at2759 |
PhylomeDBi | Q16836 |
TreeFami | TF300886 |
Enzyme and pathway databases
UniPathwayi | UPA00659 |
BRENDAi | 1.1.1.35, 2681 |
PathwayCommonsi | Q16836 |
Reactomei | R-HSA-77310, Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77346, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77348, Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77350, Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77352, Beta oxidation of butanoyl-CoA to acetyl-CoA |
SABIO-RKi | Q16836 |
SignaLinki | Q16836 |
Miscellaneous databases
BioGRID-ORCSi | 3033, 11 hits in 1055 CRISPR screens |
ChiTaRSi | HADH, human |
EvolutionaryTracei | Q16836 |
GeneWikii | Hydroxyacyl-Coenzyme_A_dehydrogenase |
GenomeRNAii | 3033 |
Pharosi | Q16836, Tbio |
PROi | PR:Q16836 |
RNActi | Q16836, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138796, Expressed in parietal pleura and 246 other tissues |
ExpressionAtlasi | Q16836, baseline and differential |
Genevisiblei | Q16836, HS |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR022694, 3-OHacyl-CoA_DH IPR006180, 3-OHacyl-CoA_DH_CS IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit |
PIRSFi | PIRSF000105, HCDH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00067, 3HCDH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HCDH_HUMAN | |
Accessioni | Q16836Primary (citable) accession number: Q16836 Secondary accession number(s): J3KQ17 Q4W5B4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 23, 2022 | |
This is version 217 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families