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Protein

Uridine phosphorylase 1

Gene

UPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.Curated1 Publication

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.1 Publication

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes uracil from uridine (phosphorylase route).Curated
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine phosphorylase 1 (UPP1), Uridine phosphorylase (UPP2), Uridine phosphorylase (UPP2), Uridine phosphorylase 2 (UPP2)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes uracil from uridine (phosphorylase route), the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94PhosphateCombined sources1 Publication1
Binding sitei217Substrate2 Publications1
Binding sitei219Substrate2 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS00053-MONOMER
BRENDAi2.4.2.3 2681
ReactomeiR-HSA-73614 Pyrimidine salvage
R-HSA-73621 Pyrimidine catabolism
SABIO-RKiQ16831
SignaLinkiQ16831
UniPathwayiUPA00574; UER00633

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase 1 (EC:2.4.2.31 Publication)
Short name:
UPase 1
Short name:
UrdPase 1
Gene namesi
Name:UPP1
Synonyms:UP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000183696.13
HGNCiHGNC:12576 UPP1
MIMi191730 gene
neXtProtiNX_Q16831

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7378
OpenTargetsiENSG00000183696
PharmGKBiPA365

Chemistry databases

ChEMBLiCHEMBL4811
DrugBankiDB00544 Fluorouracil
DB05041 RP101

Polymorphism and mutation databases

BioMutaiUPP1
DMDMi2494059

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000631911 – 310Uridine phosphorylase 1Add BLAST310

Proteomic databases

EPDiQ16831
MaxQBiQ16831
PaxDbiQ16831
PeptideAtlasiQ16831
PRIDEiQ16831
ProteomicsDBi61093
61094 [Q16831-2]

PTM databases

iPTMnetiQ16831
PhosphoSitePlusiQ16831

Expressioni

Inductioni

By vitamin D3 and a mixture of inflammatory cytokines: TNF, IL1/interleukin-1 and IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiENSG00000183696
CleanExiHS_UPP1
ExpressionAtlasiQ16831 baseline and differential
GenevisibleiQ16831 HS

Organism-specific databases

HPAiHPA054040
HPA055394

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi113224, 19 interactors
IntActiQ16831, 3 interactors
STRINGi9606.ENSP00000330032

Chemistry databases

BindingDBiQ16831

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 28Combined sources3
Turni35 – 38Combined sources4
Turni41 – 43Combined sources3
Helixi46 – 50Combined sources5
Beta strandi55 – 60Combined sources6
Helixi62 – 76Combined sources15
Beta strandi81 – 83Combined sources3
Turni88 – 91Combined sources4
Beta strandi97 – 100Combined sources4
Beta strandi103 – 107Combined sources5
Helixi112 – 128Combined sources17
Beta strandi135 – 147Combined sources13
Beta strandi152 – 159Combined sources8
Beta strandi165 – 171Combined sources7
Beta strandi174 – 179Combined sources6
Helixi184 – 197Combined sources14
Beta strandi202 – 209Combined sources8
Helixi215 – 217Combined sources3
Beta strandi222 – 224Combined sources3
Helixi229 – 241Combined sources13
Beta strandi244 – 250Combined sources7
Helixi251 – 260Combined sources10
Beta strandi264 – 274Combined sources11
Helixi275 – 277Combined sources3
Helixi285 – 292Combined sources8
Helixi294 – 306Combined sources13

3D structure databases

ProteinModelPortaliQ16831
SMRiQ16831
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16831

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 141Phosphate bindingCombined sources1 Publication4

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Phylogenomic databases

eggNOGiKOG3728 Eukaryota
COG2820 LUCA
GeneTreeiENSGT00390000004400
HOGENOMiHOG000231747
HOVERGENiHBG047725
InParanoidiQ16831
KOiK00757
OMAiNPCLKCL
OrthoDBiEOG091G0EIO
PhylomeDBiQ16831
TreeFamiTF314310

Family and domain databases

InterProiView protein in InterPro
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR010059 Uridine_phosphorylase_euk
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01719 euk_UDPppase, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16831-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF
60 70 80 90 100
GDVKFVCVGG SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV
110 120 130 140 150
GPVLSVSHGM GIPSISIMLH ELIKLLYYAR CSNVTIIRIG TSGGIGLEPG
160 170 180 190 200
TVVITEQAVD TCFKAEFEQI VLGKRVIRKT DLNKKLVQEL LLCSAELSEF
210 220 230 240 250
TTVVGNTMCT LDFYEGQGRL DGALCSYTEK DKQAYLEAAY AAGVRNIEME
260 270 280 290 300
SSVFAAMCSA CGLQAAVVCV TLLNRLEGDQ ISSPRNVLSE YQQRPQRLVS
310
YFIKKKLSKA
Length:310
Mass (Da):33,934
Last modified:November 1, 1997 - v1
Checksum:i110CF678561E53F3
GO
Isoform 2 (identifier: Q16831-2) [UniParc]FASTAAdd to basket
Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     15-36: NDCPVRLLNPNIAKMKEDILYH → KSGARHCGHNRAGSGYLLQGRV
     37-310: Missing.

Note: Inactive.
Show »
Length:36
Mass (Da):3,694
Checksum:i5D38DC6FA1548616
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00127915 – 36NDCPV…DILYH → KSGARHCGHNRAGSGYLLQG RV in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_00128037 – 310Missing in isoform 2. 1 PublicationAdd BLAST274

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90858 mRNA Translation: CAA62369.1
X90858 mRNA Translation: CAA62370.1
BT006699 mRNA Translation: AAP35345.1
CH471128 Genomic DNA Translation: EAW60994.1
CH471128 Genomic DNA Translation: EAW60995.1
BC001405 mRNA Translation: AAH01405.1
BC007348 mRNA Translation: AAH07348.1
BC053592 mRNA Translation: AAH53592.1 Sequence problems.
CCDSiCCDS5507.1 [Q16831-1]
PIRiJC4343
RefSeqiNP_001274355.1, NM_001287426.1 [Q16831-1]
NP_001274357.1, NM_001287428.1
NP_001274358.1, NM_001287429.1
NP_001274359.1, NM_001287430.1
NP_003355.1, NM_003364.3 [Q16831-1]
XP_011513814.1, XM_011515512.2 [Q16831-1]
UniGeneiHs.488240

Genome annotation databases

EnsembliENST00000331803; ENSP00000330032; ENSG00000183696 [Q16831-1]
ENST00000395560; ENSP00000378927; ENSG00000183696 [Q16831-2]
ENST00000395564; ENSP00000378931; ENSG00000183696 [Q16831-1]
ENST00000417464; ENSP00000413611; ENSG00000183696 [Q16831-2]
ENST00000457596; ENSP00000408899; ENSG00000183696 [Q16831-2]
GeneIDi7378
KEGGihsa:7378
UCSCiuc003tok.5 human [Q16831-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUPP1_HUMAN
AccessioniPrimary (citable) accession number: Q16831
Secondary accession number(s): D3DVM4, Q15362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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