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Entry version 167 (07 Oct 2020)
Sequence version 4 (28 Jun 2011)
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Protein

Dual specificity protein phosphatase 7

Gene

DUSP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).By similarity1 Publication

Caution

An out-of-frame translation product, PYST2SB, has been experimentally demonstrated to be formed from the alternative promoter. The expression of the in-frame product has not yet been shown.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly inhibited by sodium orthovanadate.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6.82 mM for p-nitrophenyl phosphate1 Publication
  2. KM=0.76 mM for p-nitrophenyl phosphate (in the presence of MAPK1)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei331Phosphocysteine intermediatePROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protein phosphatase

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q16829

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-112409, RAF-independent MAPK1/3 activation
    R-HSA-202670, ERKs are inactivated
    R-HSA-5675221, Negative regulation of MAPK pathway

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q16829

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 7Imported (EC:3.1.3.161 Publication, EC:3.1.3.481 Publication)
    Alternative name(s):
    Dual specificity protein phosphatase PYST21 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DUSP7Imported
    Synonyms:PYST21 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000164086.9

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:3073, DUSP7

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602749, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q16829

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1849

    Open Targets

    More...
    OpenTargetsi
    ENSG00000164086

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA27530

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q16829, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    DUSP7

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    338817906

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000948071 – 419Dual specificity protein phosphatase 7Add BLAST419

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q16829

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q16829

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q16829

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q16829

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q16829

    PeptideAtlas

    More...
    PeptideAtlasi
    Q16829

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q16829

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    61091 [Q16829-1]
    61092 [Q16829-2]

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q16829-2 [Q16829-2]

    PTM databases

    DEPOD human dephosphorylation database

    More...
    DEPODi
    DUSP7

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q16829

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q16829

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Strongly expressed in liver (PubMed:8670865). Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells (PubMed:14576828).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000164086, Expressed in squamous epithelium and 245 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q16829, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q16829, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000164086, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with MAPK1/ERK2; the interaction enhances DUSP7 phosphatase activity.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    108182, 64 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q16829, 17 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q16829

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000417183

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q16829, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1419
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q16829

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 187RhodanesePROSITE-ProRule annotationAdd BLAST120
    Domaini244 – 387Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST144

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni331 – 337Substrate bindingCombined sources1 Publication7

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi192 – 240Ser-richPROSITE-ProRule annotationAdd BLAST49

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1717, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157262

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_027074_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q16829

    KEGG Orthology (KO)

    More...
    KOi
    K04459

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DPAGHQG

    Database of Orthologous Groups

    More...
    OrthoDBi
    911920at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q16829

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105122

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.250.10, 1 hit
    3.90.190.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000340, Dual-sp_phosphatase_cat-dom
    IPR008343, MKP
    IPR029021, Prot-tyrosine_phosphatase-like
    IPR001763, Rhodanese-like_dom
    IPR036873, Rhodanese-like_dom_sf
    IPR000387, TYR_PHOSPHATASE_dom
    IPR020422, TYR_PHOSPHATASE_DUAL_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00782, DSPc, 1 hit
    PF00581, Rhodanese, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000939, MAPK_Ptase, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01764, MAPKPHPHTASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00195, DSPc, 1 hit
    SM00450, RHOD, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52799, SSF52799, 1 hit
    SSF52821, SSF52821, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50206, RHODANESE_3, 1 hit
    PS50056, TYR_PHOSPHATASE_2, 1 hit
    PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q16829-1) [UniParc]FASTAAdd to basket
    Also known as: PYST2-L

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKNQLRGPPA RAHMSTSGAA AAGGTRAGSE PGAGSGSGAG TGAGAATGAG
    60 70 80 90 100
    AMPCKSAEWL QEELEARGGA SLLLLDCRPH ELFESSHIET AINLAIPGLM
    110 120 130 140 150
    LRRLRKGNLP IRSIIPNHAD KERFATRCKA ATVLLYDEAT AEWQPEPGAP
    160 170 180 190 200
    ASVLGLLLQK LRDDGCQAYY LQGGFNKFQT EYSEHCETNV DSSSSPSSSP
    210 220 230 240 250
    PTSVLGLGGL RISSDCSDGE SDRELPSSAT ESDGSPVPSS QPAFPVQILP
    260 270 280 290 300
    YLYLGCAKDS TNLDVLGKYG IKYILNVTPN LPNAFEHGGE FTYKQIPISD
    310 320 330 340 350
    HWSQNLSQFF PEAISFIDEA RSKKCGVLVH CLAGISRSVT VTVAYLMQKM
    360 370 380 390 400
    NLSLNDAYDF VKRKKSNISP NFNFMGQLLD FERTLGLSSP CDNHASSEQL
    410
    YFSTPTNHNL FPLNTLEST
    Length:419
    Mass (Da):44,957
    Last modified:June 28, 2011 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i434467AC16A3F8BA
    GO
    Isoform 2 (identifier: Q16829-2) [UniParc]FASTAAdd to basket
    Also known as: PYST2-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.

    Show »
    Length:368
    Mass (Da):40,551
    Checksum:i097023C27EBC341C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H7C4Z0H7C4Z0_HUMAN
    Protein-tyrosine-phosphatase
    DUSP7
    275Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87 – 90HIET → THRD no nucleotide entry (PubMed:9788880).Curated4

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051752235S → N. Corresponds to variant dbSNP:rs34821455Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0128221 – 51Missing in isoform 2. 1 PublicationAdd BLAST51

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF508727 mRNA Translation: AAM77606.1
    AF508728 mRNA No translation available.
    AC115284 Genomic DNA No translation available.
    AL556300 mRNA No translation available.
    BC019107 mRNA Translation: AAH19107.2
    BC104880 mRNA Translation: AAI04881.1
    BC104882 mRNA Translation: AAI04883.1
    X93921 mRNA Translation: CAA63814.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS33766.2 [Q16829-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001938.2, NM_001947.3 [Q16829-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000495880; ENSP00000417183; ENSG00000164086 [Q16829-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1849

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:1849

    UCSC genome browser

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    UCSCi
    uc003dct.4, human [Q16829-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF508727 mRNA Translation: AAM77606.1
    AF508728 mRNA No translation available.
    AC115284 Genomic DNA No translation available.
    AL556300 mRNA No translation available.
    BC019107 mRNA Translation: AAH19107.2
    BC104880 mRNA Translation: AAI04881.1
    BC104882 mRNA Translation: AAI04883.1
    X93921 mRNA Translation: CAA63814.1
    CCDSiCCDS33766.2 [Q16829-1]
    RefSeqiNP_001938.2, NM_001947.3 [Q16829-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4Y2EX-ray1.67A/B/C/D240-388[»]
    SMRiQ16829
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi108182, 64 interactors
    IntActiQ16829, 17 interactors
    MINTiQ16829
    STRINGi9606.ENSP00000417183

    PTM databases

    DEPODiDUSP7
    iPTMnetiQ16829
    PhosphoSitePlusiQ16829

    Polymorphism and mutation databases

    BioMutaiDUSP7
    DMDMi338817906

    Proteomic databases

    EPDiQ16829
    jPOSTiQ16829
    MassIVEiQ16829
    MaxQBiQ16829
    PaxDbiQ16829
    PeptideAtlasiQ16829
    PRIDEiQ16829
    ProteomicsDBi61091 [Q16829-1]
    61092 [Q16829-2]
    TopDownProteomicsiQ16829-2 [Q16829-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    31149, 172 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    1849

    Genome annotation databases

    EnsembliENST00000495880; ENSP00000417183; ENSG00000164086 [Q16829-1]
    GeneIDi1849
    KEGGihsa:1849
    UCSCiuc003dct.4, human [Q16829-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1849
    DisGeNETi1849
    EuPathDBiHostDB:ENSG00000164086.9

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    DUSP7
    HGNCiHGNC:3073, DUSP7
    HPAiENSG00000164086, Low tissue specificity
    MIMi602749, gene
    neXtProtiNX_Q16829
    OpenTargetsiENSG00000164086
    PharmGKBiPA27530

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1717, Eukaryota
    GeneTreeiENSGT00940000157262
    HOGENOMiCLU_027074_0_0_1
    InParanoidiQ16829
    KOiK04459
    OMAiDPAGHQG
    OrthoDBi911920at2759
    PhylomeDBiQ16829
    TreeFamiTF105122

    Enzyme and pathway databases

    PathwayCommonsiQ16829
    ReactomeiR-HSA-112409, RAF-independent MAPK1/3 activation
    R-HSA-202670, ERKs are inactivated
    R-HSA-5675221, Negative regulation of MAPK pathway
    SIGNORiQ16829

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    1849, 9 hits in 872 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    DUSP7, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    DUSP7

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    1849
    PharosiQ16829, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q16829
    RNActiQ16829, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000164086, Expressed in squamous epithelium and 245 other tissues
    ExpressionAtlasiQ16829, baseline and differential
    GenevisibleiQ16829, HS

    Family and domain databases

    Gene3Di3.40.250.10, 1 hit
    3.90.190.10, 1 hit
    InterProiView protein in InterPro
    IPR000340, Dual-sp_phosphatase_cat-dom
    IPR008343, MKP
    IPR029021, Prot-tyrosine_phosphatase-like
    IPR001763, Rhodanese-like_dom
    IPR036873, Rhodanese-like_dom_sf
    IPR000387, TYR_PHOSPHATASE_dom
    IPR020422, TYR_PHOSPHATASE_DUAL_dom
    PfamiView protein in Pfam
    PF00782, DSPc, 1 hit
    PF00581, Rhodanese, 1 hit
    PIRSFiPIRSF000939, MAPK_Ptase, 1 hit
    PRINTSiPR01764, MAPKPHPHTASE
    SMARTiView protein in SMART
    SM00195, DSPc, 1 hit
    SM00450, RHOD, 1 hit
    SUPFAMiSSF52799, SSF52799, 1 hit
    SSF52821, SSF52821, 1 hit
    PROSITEiView protein in PROSITE
    PS50206, RHODANESE_3, 1 hit
    PS50056, TYR_PHOSPHATASE_2, 1 hit
    PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUS7_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16829
    Secondary accession number(s): Q2M3J7, Q8NFJ0
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 28, 2011
    Last modified: October 7, 2020
    This is version 167 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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