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Protein

Receptor-type tyrosine-protein phosphatase O

Gene

PTPRO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1102SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1136Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1180SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-9034015 Signaling by NTRK3 (TRKC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase O (EC:3.1.3.48)
Short name:
R-PTP-O
Alternative name(s):
Glomerular epithelial protein 1
Protein tyrosine phosphatase U2
Short name:
PTP-U2
Short name:
PTPase U2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRO
Synonyms:GLEPP1, PTPU2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000151490.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9678 PTPRO

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600579 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16827

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 822ExtracellularSequence analysisAdd BLAST793
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei823 – 843HelicalSequence analysisAdd BLAST21
Topological domaini844 – 1216CytoplasmicSequence analysisAdd BLAST373

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nephrotic syndrome 6 (NPHS6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.
See also OMIM:614196

Organism-specific databases

DisGeNET

More...
DisGeNETi
5800

MalaCards human disease database

More...
MalaCardsi
PTPRO
MIMi614196 phenotype

Open Targets

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OpenTargetsi
ENSG00000151490

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93214 Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation
93217 Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
93213 Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
93216 Familial idiopathic steroid-resistant nephrotic syndrome with minimal changes

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34023

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPRO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002545830 – 1216Receptor-type tyrosine-protein phosphatase OAdd BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi490N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi700N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi712N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi733N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei865PhosphoserineBy similarity1
Modified residuei1210PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16827

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q16827

PeptideAtlas

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PeptideAtlasi
Q16827

PRoteomics IDEntifications database

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PRIDEi
Q16827

ProteomicsDB human proteome resource

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ProteomicsDBi
61085
61086 [Q16827-2]
61087 [Q16827-3]
61088 [Q16827-4]

PTM databases

DEPOD human dephosphorylation database

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DEPODi
Q16827

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q16827

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q16827

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Glomerulus of kidney. Also detected in brain, lung and placenta.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By various differentiation-inducing agents.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151490 Expressed in 155 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

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CleanExi
HS_PTPRO

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16827 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16827 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA034525

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (phosphorylated form) with FYN and GRB2.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111764, 82 interactors

Protein interaction database and analysis system

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IntActi
Q16827, 36 interactors

Molecular INTeraction database

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MINTi
Q16827

STRING: functional protein association networks

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STRINGi
9606.ENSP00000281171

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q16827

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16827

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q16827

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 124Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST75
Domaini142 – 211Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST70
Domaini246 – 306Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST61
Domaini329 – 425Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini435 – 531Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST97
Domaini532 – 628Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST97
Domaini631 – 724Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST94
Domaini725 – 817Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST93
Domaini938 – 1195Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1136 – 1142Substrate bindingBy similarity7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0791 Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154814

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115792

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053969

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16827

KEGG Orthology (KO)

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KOi
K18035

Identification of Orthologs from Complete Genome Data

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OMAi
YFNPSTM

Database of Orthologous Groups

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OrthoDBi
EOG091G00JF

Database for complete collections of gene phylogenies

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PhylomeDBi
Q16827

TreeFam database of animal gene trees

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TreeFami
TF351926

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 3 hits
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF00102 Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 4 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16827-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHLPTGIHG ARRLLPLLWL FVLFKNATAF HVTVQDDNNI VVSLEASDVI
60 70 80 90 100
SPASVYVVKI TGESKNYFFE FEEFNSTLPP PVIFKASYHG LYYIITLVVV
110 120 130 140 150
NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
TRVNISYWEG KDFRTMLYKD FFKGKTVFNH WLPGMCYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVEYSG VSHEPKQHRT APYPPQNISV RIVNLNKNNW EEQSGNFPEE
260 270 280 290 300
SFMRSQDTIG KEKLFHFTEE TPEIPSGNIS SGWPDFNSSD YETTSQPYWW
310 320 330 340 350
DSASAAPESE DEFVSVLPME YENNSTLSET EKSTSGSFSF FPVQMILTWL
360 370 380 390 400
PPKPPTAFDG FHIHIEREEN FTEYLMVDEE AHEFVAELKE PGKYKLSVTT
410 420 430 440 450
FSSSGSCETR KSQSAKSLSF YISPSGEWIE ELTEKPQHVS VHVLSSTTAL
460 470 480 490 500
MSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN SSKPIIENLV
510 520 530 540 550
PGAQYQVVIY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP LGPTAVVLSW
560 570 580 590 600
TRPYLGVFRK YVVEMFYFNP ATMTSEWTTY YEIAATVSLT ASVRIANLLP
610 620 630 640 650
AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS
660 670 680 690 700
WTYGDDTTDL SHSRMLHWMV VAEGKKKIKK SVTRNVMTAI LSLPPGDIYN
710 720 730 740 750
LSVTACTERG SNTSMLRLVK LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD
760 770 780 790 800
FFEVFCQQVG SSQKTKLQEP VAVSSHVVTI SSLLPATAYN CSVTSFSHDS
810 820 830 840 850
PSVPTFIAVS TMVTEMNPNV VVISVLAILS TLLIGLLLVT LIILRKKHLQ
860 870 880 890 900
MARECGAGTF VNFASLERDG KLPYNWRRSI FAFLTLLPSC LWTDYLLAFY
910 920 930 940 950
INPWSKNGLK KRKLTNPVQL DDFDAYIKDM AKDSDYKFSL QFEELKLIGL
960 970 980 990 1000
DIPHFAADLP LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA DYINANYIPG
1010 1020 1030 1040 1050
YNSPQEYIAT QGPLPETRND FWKMVLQQKS QIIVMLTQCN EKRRVKCDHY
1060 1070 1080 1090 1100
WPFTEEPIAY GDITVEMISE EEQDDWACRH FRINYADEMQ DVMHFNYTAW
1110 1120 1130 1140 1150
PDHGVPTANA AESILQFVHM VRQQATKSKG PMIIHCSAGV GRTGTFIALD
1160 1170 1180 1190 1200
RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWMKKK
1210
QQFCISDVIY ENVSKS
Length:1,216
Mass (Da):138,344
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC902B48D1A73BFE1
GO
Isoform 2 (identifier: Q16827-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-903: Missing.

Show »
Length:1,188
Mass (Da):134,941
Checksum:iC27FCA3BDFA0D1EF
GO
Isoform 3 (identifier: Q16827-3) [UniParc]FASTAAdd to basket
Also known as: PTPROt

The sequence of this isoform differs from the canonical sequence as follows:
     1-811: Missing.

Note: Predominantly expressed in B-lymphoid tissues.
Show »
Length:405
Mass (Da):47,163
Checksum:iD7BED5FFF7312782
GO
Isoform 4 (identifier: Q16827-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-811: Missing.
     876-903: Missing.

Show »
Length:377
Mass (Da):43,760
Checksum:i42E10120DBF2D1EF
GO
Isoform 5 (identifier: Q16827-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     594-597: RIAN → VIFP
     598-1216: Missing.

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):67,672
Checksum:iC0B2674199E893AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YH60H0YH60_HUMAN
Receptor-type tyrosine-protein phos...
PTPRO
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH11H0YH11_HUMAN
Receptor-type tyrosine-protein phos...
PTPRO
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159E → G in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti159E → G in AAA82892 (PubMed:7665166).Curated1
Sequence conflicti196S → C in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti205L → V in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti314V → F in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti441V → F in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti672A → T in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti698I → T in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti705A → T in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti753E → K in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti756 – 758CQQ → FQH in CAA88425 (PubMed:7753550).Curated3
Sequence conflicti775S → P in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti790N → S in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti861 – 863VNF → ANC in CAA88425 (PubMed:7753550).Curated3
Sequence conflicti876W → C in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti876W → C in AAA82892 (PubMed:7665166).Curated1
Sequence conflicti896L → P in CAA88425 (PubMed:7753550).Curated1
Sequence conflicti896L → P in AAA82892 (PubMed:7665166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0431361 – 811Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST811
Alternative sequenceiVSP_054481594 – 597RIAN → VIFP in isoform 5. 1 Publication4
Alternative sequenceiVSP_054482598 – 1216Missing in isoform 5. 1 PublicationAdd BLAST619
Alternative sequenceiVSP_035586876 – 903Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z48541 mRNA Translation: CAA88425.1
U20489 mRNA Translation: AAA82892.1
AF187043 mRNA Translation: AAF04086.1
AF187044 mRNA Translation: AAF04087.1
AK290982 mRNA Translation: BAF83671.1
AC007542 Genomic DNA No translation available.
AC022334 Genomic DNA No translation available.
AC092183 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96349.1
CH471094 Genomic DNA Translation: EAW96350.1
CH471094 Genomic DNA Translation: EAW96351.1
BC035960 mRNA Translation: AAH35960.1
BC126201 mRNA Translation: AAI26202.1
BC126203 mRNA Translation: AAI26204.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44837.1 [Q16827-3]
CCDS53754.1 [Q16827-4]
CCDS8674.1 [Q16827-2]
CCDS8675.1 [Q16827-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A57064
S60613

NCBI Reference Sequences

More...
RefSeqi
NP_002839.1, NM_002848.3 [Q16827-2]
NP_109592.1, NM_030667.2 [Q16827-1]
NP_109593.1, NM_030668.2 [Q16827-4]
NP_109594.1, NM_030669.2 [Q16827-3]
NP_109595.1, NM_030670.2 [Q16827-4]
NP_109596.1, NM_030671.2 [Q16827-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.160871

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281171; ENSP00000281171; ENSG00000151490 [Q16827-1]
ENST00000348962; ENSP00000343434; ENSG00000151490 [Q16827-2]
ENST00000442921; ENSP00000404188; ENSG00000151490 [Q16827-3]
ENST00000445537; ENSP00000393449; ENSG00000151490 [Q16827-3]
ENST00000542557; ENSP00000437571; ENSG00000151490 [Q16827-4]
ENST00000543886; ENSP00000444173; ENSG00000151490 [Q16827-5]
ENST00000544244; ENSP00000439234; ENSG00000151490 [Q16827-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5800

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5800

UCSC genome browser

More...
UCSCi
uc001rcu.3 human [Q16827-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48541 mRNA Translation: CAA88425.1
U20489 mRNA Translation: AAA82892.1
AF187043 mRNA Translation: AAF04086.1
AF187044 mRNA Translation: AAF04087.1
AK290982 mRNA Translation: BAF83671.1
AC007542 Genomic DNA No translation available.
AC022334 Genomic DNA No translation available.
AC092183 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96349.1
CH471094 Genomic DNA Translation: EAW96350.1
CH471094 Genomic DNA Translation: EAW96351.1
BC035960 mRNA Translation: AAH35960.1
BC126201 mRNA Translation: AAI26202.1
BC126203 mRNA Translation: AAI26204.1
CCDSiCCDS44837.1 [Q16827-3]
CCDS53754.1 [Q16827-4]
CCDS8674.1 [Q16827-2]
CCDS8675.1 [Q16827-1]
PIRiA57064
S60613
RefSeqiNP_002839.1, NM_002848.3 [Q16827-2]
NP_109592.1, NM_030667.2 [Q16827-1]
NP_109593.1, NM_030668.2 [Q16827-4]
NP_109594.1, NM_030669.2 [Q16827-3]
NP_109595.1, NM_030670.2 [Q16827-4]
NP_109596.1, NM_030671.2 [Q16827-3]
UniGeneiHs.160871

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G59X-ray2.19A/B914-1200[»]
2GJTX-ray2.15A/B916-1208[»]
ProteinModelPortaliQ16827
SMRiQ16827
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111764, 82 interactors
IntActiQ16827, 36 interactors
MINTiQ16827
STRINGi9606.ENSP00000281171

PTM databases

DEPODiQ16827
iPTMnetiQ16827
PhosphoSitePlusiQ16827

Polymorphism and mutation databases

BioMutaiPTPRO
DMDMi209572663

Proteomic databases

MaxQBiQ16827
PaxDbiQ16827
PeptideAtlasiQ16827
PRIDEiQ16827
ProteomicsDBi61085
61086 [Q16827-2]
61087 [Q16827-3]
61088 [Q16827-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5800
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281171; ENSP00000281171; ENSG00000151490 [Q16827-1]
ENST00000348962; ENSP00000343434; ENSG00000151490 [Q16827-2]
ENST00000442921; ENSP00000404188; ENSG00000151490 [Q16827-3]
ENST00000445537; ENSP00000393449; ENSG00000151490 [Q16827-3]
ENST00000542557; ENSP00000437571; ENSG00000151490 [Q16827-4]
ENST00000543886; ENSP00000444173; ENSG00000151490 [Q16827-5]
ENST00000544244; ENSP00000439234; ENSG00000151490 [Q16827-4]
GeneIDi5800
KEGGihsa:5800
UCSCiuc001rcu.3 human [Q16827-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5800
DisGeNETi5800
EuPathDBiHostDB:ENSG00000151490.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPRO
HGNCiHGNC:9678 PTPRO
HPAiHPA034525
MalaCardsiPTPRO
MIMi600579 gene
614196 phenotype
neXtProtiNX_Q16827
OpenTargetsiENSG00000151490
Orphaneti93214 Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation
93217 Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
93213 Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
93216 Familial idiopathic steroid-resistant nephrotic syndrome with minimal changes
PharmGKBiPA34023

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0791 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000154814
HOGENOMiHOG000115792
HOVERGENiHBG053969
InParanoidiQ16827
KOiK18035
OMAiYFNPSTM
OrthoDBiEOG091G00JF
PhylomeDBiQ16827
TreeFamiTF351926

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-9034015 Signaling by NTRK3 (TRKC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPRO human
EvolutionaryTraceiQ16827

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PTPRO

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5800

Protein Ontology

More...
PROi
PR:Q16827

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151490 Expressed in 155 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_PTPRO
ExpressionAtlasiQ16827 baseline and differential
GenevisibleiQ16827 HS

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 3 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16827
Secondary accession number(s): A0AV39
, Q13101, Q8IYG3, Q9UBF0, Q9UBT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 14, 2008
Last modified: December 5, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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