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Entry version 175 (12 Aug 2020)
Sequence version 2 (02 Mar 2010)
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Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

PTPN21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1067SubstrateSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1108Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1152SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q16825

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16825

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase D1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPN21
Synonyms:PTPD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000070778.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9651, PTPN21

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603271, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16825

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11099

Open Targets

More...
OpenTargetsi
ENSG00000070778

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33994

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16825, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPN21

Domain mapping of disease mutations (DMDM)

More...
DMDMi
290457654

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194391 – 1174Tyrosine-protein phosphatase non-receptor type 21Add BLAST1174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei577PhosphoserineBy similarity1
Modified residuei589PhosphoserineBy similarity1
Modified residuei590PhosphoserineBy similarity1
Modified residuei637PhosphoserineCombined sources1
Modified residuei673PhosphoserineBy similarity1
Modified residuei710PhosphoserineBy similarity1
Modified residuei711PhosphoserineBy similarity1
Modified residuei797PhosphoserineBy similarity1
Modified residuei799PhosphoserineBy similarity1
Modified residuei804PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16825

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16825

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16825

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16825

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16825

PeptideAtlas

More...
PeptideAtlasi
Q16825

PRoteomics IDEntifications database

More...
PRIDEi
Q16825

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61084

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
PTPN21

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16825

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16825

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000070778, Expressed in upper lobe of lung and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16825, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16825, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000070778, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116280, 65 interactors

Protein interaction database and analysis system

More...
IntActi
Q16825, 33 interactors

Molecular INTeraction database

More...
MINTi
Q16825

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000452414

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16825

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q16825, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16825

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 308FERMPROSITE-ProRule annotationAdd BLAST286
Domaini896 – 1167Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1108 – 1114Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi340 – 343Poly-Pro4
Compositional biasi565 – 574Poly-Pro10
Compositional biasi712 – 717Poly-Glu6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0792, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155613

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006456_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16825

KEGG Orthology (KO)

More...
KOi
K18025

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEQHMER

Database of Orthologous Groups

More...
OrthoDBi
144506at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16825

TreeFam database of animal gene trees

More...
TreeFami
TF315900

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd13188, FERM_C_PTPN14_PTPN21, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR014392, PTP_non-rcpt_14/21
IPR000242, PTPase_domain
IPR041782, PTPN14/21_FERM_C
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF00102, Y_phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000934, Tyr-Ptase_nr14, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935, BAND41
PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit
SM00194, PTPc, 1 hit
SM00404, PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF52799, SSF52799, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q16825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE
60 70 80 90 100
AVAQRLELRE VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK YALEPTVYFG
110 120 130 140 150
VVFYVPSVSQ LQQEITRYQY YLQLKKDILE GSIPCTLEQA IQLAGLAVQA
160 170 180 190 200
DFGDFDQYES QDFLQKFALF PVGWLQDEKV LEEATQKVAL LHQKYRGLTA
210 220 230 240 250
PDAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLEG IFVKHKNGRH
260 270 280 290 300
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYIWRLCVAR
310 320 330 340 350
HKFYRLNQCN LQTQTVTVNP IRRRSSSRMS LPKPQPYVMP PPPQLHYNGH
360 370 380 390 400
YTEPYASSQD NLFVPNQNGY YCHSQTSLDR AQIDLNGRIR NGSVYSAHST
410 420 430 440 450
NSLNNPQPYL QPSPMSSNPS ITGSDVMRPD YLPSHRHSAV IPPSYRPTPD
460 470 480 490 500
YETVMKQLNR GLVHAERQSH SLRNLNIGSS YAYSRPAALV YSQPEIREHA
510 520 530 540 550
QLPSPAAAHC PFSLSYSFHS PSPYPYPAER RPVVGAVSVP ELTNAQLQAQ
560 570 580 590 600
DYPSPNIMRT QVYRPPPPYP PPRPANSTPD LSRHLYISSS NPDLITRRVH
610 620 630 640 650
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA QLHKRNSIEV AGLSHGLEGL
660 670 680 690 700
RLKERTLSAS AAEVAPRAVS VGSQPSVFTE RTQREGPEEA EGLRYGHKKS
710 720 730 740 750
LSDATMLIHS SEEEEDEDFE EESGARAPPA RAREPRPGLA QDPPGCPRVL
760 770 780 790 800
LAGPLHILEP KAHVPDAEKR MMDSSPVRTT AEAQRPWRDG LLMPSMSESD
810 820 830 840 850
LTTSGRYRAR RDSLKKRPVS DLLSGKKNIV EGLPPLGGMK KTRVDAKKIG
860 870 880 890 900
PLKLAALNGL SLSRVPLPDE GKEVATRATN DERCKILEQR LEQGMVFTEY
910 920 930 940 950
ERILKKRLVD GECSTARLPE NAERNRFQDV LPYDDVRVEL VPTKENNTGY
960 970 980 990 1000
INASHIKVSV SGIEWDYIAT QGPLQNTCQD FWQMVWEQGI AIIAMVTAEE
1010 1020 1030 1040 1050
EGGREKSFRY WPRLGSRHNT VTYGRFKITT RFRTDSGCYA TTGLKMKHLL
1060 1070 1080 1090 1100
TGQERTVWHL QYTDWPEHGC PEDLKGFLSY LEEIQSVRRH TNSTSDPQSP
1110 1120 1130 1140 1150
NPPLLVHCSA GVGRTGVVIL SEIMIACLEH NEVLDIPRVL DMLRQQRMML
1160 1170
VQTLCQYTFV YRVLIQFLKS SRLI
Length:1,174
Mass (Da):133,281
Last modified:March 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B746C824578F117
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJ59H0YJ59_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN21
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3S6G3V3S6_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN21
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1Q9G3V1Q9_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN21
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060341385L → F1 PublicationCorresponds to variant dbSNP:rs2401751Ensembl.1
Natural variantiVAR_055539906K → N. Corresponds to variant dbSNP:rs12879993Ensembl.1
Natural variantiVAR_060342936V → A1 PublicationCorresponds to variant dbSNP:rs2274736Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X79510 mRNA Translation: CAA56042.1
AL162171 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9884.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38140

NCBI Reference Sequences

More...
RefSeqi
NP_008970.2, NM_007039.3
XP_005267344.1, XM_005267287.2
XP_011534669.1, XM_011536367.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328736; ENSP00000330276; ENSG00000070778
ENST00000556564; ENSP00000452414; ENSG00000070778

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11099

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11099

UCSC genome browser

More...
UCSCi
uc001xwv.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79510 mRNA Translation: CAA56042.1
AL162171 Genomic DNA No translation available.
CCDSiCCDS9884.1
PIRiI38140
RefSeqiNP_008970.2, NM_007039.3
XP_005267344.1, XM_005267287.2
XP_011534669.1, XM_011536367.2

3D structure databases

SMRiQ16825
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116280, 65 interactors
IntActiQ16825, 33 interactors
MINTiQ16825
STRINGi9606.ENSP00000452414

Chemistry databases

BindingDBiQ16825

PTM databases

DEPODiPTPN21
iPTMnetiQ16825
PhosphoSitePlusiQ16825

Polymorphism and mutation databases

BioMutaiPTPN21
DMDMi290457654

Proteomic databases

EPDiQ16825
jPOSTiQ16825
MassIVEiQ16825
MaxQBiQ16825
PaxDbiQ16825
PeptideAtlasiQ16825
PRIDEiQ16825
ProteomicsDBi61084

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
26302, 132 antibodies

The DNASU plasmid repository

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DNASUi
11099

Genome annotation databases

EnsembliENST00000328736; ENSP00000330276; ENSG00000070778
ENST00000556564; ENSP00000452414; ENSG00000070778
GeneIDi11099
KEGGihsa:11099
UCSCiuc001xwv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11099
DisGeNETi11099
EuPathDBiHostDB:ENSG00000070778.12

GeneCards: human genes, protein and diseases

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GeneCardsi
PTPN21
HGNCiHGNC:9651, PTPN21
HPAiENSG00000070778, Low tissue specificity
MIMi603271, gene
neXtProtiNX_Q16825
OpenTargetsiENSG00000070778
PharmGKBiPA33994

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0792, Eukaryota
GeneTreeiENSGT00940000155613
HOGENOMiCLU_006456_1_0_1
InParanoidiQ16825
KOiK18025
OMAiLEQHMER
OrthoDBi144506at2759
PhylomeDBiQ16825
TreeFamiTF315900

Enzyme and pathway databases

BRENDAi3.1.3.48, 2681
PathwayCommonsiQ16825
SIGNORiQ16825

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11099, 4 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PTPN21, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PTPN21

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11099
PharosiQ16825, Tbio

Protein Ontology

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PROi
PR:Q16825
RNActiQ16825, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000070778, Expressed in upper lobe of lung and 213 other tissues
ExpressionAtlasiQ16825, baseline and differential
GenevisibleiQ16825, HS

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13188, FERM_C_PTPN14_PTPN21, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR014392, PTP_non-rcpt_14/21
IPR000242, PTPase_domain
IPR041782, PTPN14/21_FERM_C
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF00102, Y_phosphatase, 1 hit
PIRSFiPIRSF000934, Tyr-Ptase_nr14, 1 hit
PRINTSiPR00935, BAND41
PR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit
SM00194, PTPc, 1 hit
SM00404, PTPc_motif, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF52799, SSF52799, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTN21_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16825
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 2, 2010
Last modified: August 12, 2020
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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