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Protein

Protein phosphatase 1 regulatory subunit 3A

Gene

PPP1R3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCarbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16821

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM21 Carbohydrate-Binding Module Family 21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3A
Alternative name(s):
Protein phosphatase 1 glycogen-associated regulatory subunit
Protein phosphatase type-1 glycogen targeting subunit
Short name:
RG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R3A
Synonyms:PP1G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000154415.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9291 PPP1R3A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600917 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16821

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1078 – 1098HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125853
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019699931A → E in NIDDM. 1 PublicationCorresponds to variant dbSNP:rs35449651EnsemblClinVar.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5506

MalaCards human disease database

More...
MalaCardsi
PPP1R3A
MIMi125853 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000154415

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33651

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R3A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
298286906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000715001 – 1122Protein phosphatase 1 regulatory subunit 3AAdd BLAST1122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei38Phosphoserine; by GSK3By similarity1
Modified residuei42Phosphoserine; by GSK3By similarity1
Modified residuei46Phosphoserine; by PKA and ISPKBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei56PhosphothreonineBy similarity1
Modified residuei65Phosphoserine; by PKABy similarity1
Modified residuei844PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16821

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16821

PeptideAtlas

More...
PeptideAtlasi
Q16821

PRoteomics IDEntifications database

More...
PRIDEi
Q16821

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61080
61081 [Q16821-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16821

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16821

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skeletal muscle and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154415 Expressed in 58 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

CleanEx database of gene expression profiles

More...
CleanExi
HS_PPP1R3A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16821 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16821 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111499, 45 interactors

Protein interaction database and analysis system

More...
IntActi
Q16821, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000284601

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16821

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16821

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 230CBM21PROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi62 – 65PP1-binding motif4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3986 Eukaryota
ENOG4111FT1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157682

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053657

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16821

KEGG Orthology (KO)

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KOi
K07189

Identification of Orthologs from Complete Genome Data

More...
OMAi
LFTCQET

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00OC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16821

TreeFam database of animal gene trees

More...
TreeFami
TF105537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2440, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03370 CBM_21, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51159 CBM21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16821-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPSEVPSQI SKDNFLEVPN LSDSLCEDEE VTFQPGFSPQ PSRRGSDSSE
60 70 80 90 100
DIYLDTPSSG TRRVSFADSF GFNLVSVKEF DCWELPSAST TFDLGTDIFH
110 120 130 140 150
TEEYVLAPLF DLPSSKEDLM QQLQIQKAIL ESTESLLGST SIKGIIRVLN
160 170 180 190 200
VSFEKLVYVR MSLDDWQTHY DILAEYVPNS CDGETDQFSF KIVLVPPYQK
210 220 230 240 250
DGSKVEFCIR YETSVGTFWS NNNGTNYTFI CQKKEQEPEP VKPWKEVPNR
260 270 280 290 300
QIKGCLKVKS SKEESSVTSE ENNFENPKNT DTYIPTIICS HEDKEDLEAS
310 320 330 340 350
NRNVKDVNRE HDEHNEKELE LMINQHLIRT RSTASRDERN TFSTDPVNFP
360 370 380 390 400
NKAEGLEKKQ IHGEICTDLF QRSLSPSSSA ESSVKGDFYC NEKYSSGDDC
410 420 430 440 450
THQPSEETTS NMGEIKPSLG DTSSDELVQL HTGSKEVLDD NANPAHGNGT
460 470 480 490 500
VQIPCPSSDQ LMAGNLNKKH EGGAKNIEVK DLGCLRRDFH SDTSACLKES
510 520 530 540 550
TEEGSSKEDY YGNGKDDEEQ RIYLGVNEKQ RKNFQTILHD QERKMGNPKI
560 570 580 590 600
SVAGIGASNR DLATLLSEHT AIPTRAITAD VSHSPRTNLS WEEAVLTPEH
610 620 630 640 650
HHLTSEGSAL GGITGQVCSS RTGNVLRNDY LFQVEEKSGG INSEDQDNSP
660 670 680 690 700
QHKQSWNVLE SQGKSRENKT NITEHIKGQT DCEDVWGKRD NTRSLKATTE
710 720 730 740 750
ELFTCQETVC CELSSLADHG ITEKAEAGTA YIIKTTSEST PESMSAREKA
760 770 780 790 800
IIAKLPQETA RSDRPIEVKE TAFDPHEGRN DDSHYTLCQR DTVGVIYDND
810 820 830 840 850
FEKESRLGIC NVRVDEMEKE ETMSMYNPRK THDREKCGTG NITSVEESSW
860 870 880 890 900
VITEYQKATS KLDLQLGMLP TDKTVFSENR DLRQVQELSK KTDSDAIVHS
910 920 930 940 950
AFNSDTNRAP QNSSPFSKHH TEISVSTNEQ AIAVENAVTT MASQPISTKS
960 970 980 990 1000
ENICNSTREI QGIEKHPYPE SKPEEVSRSS GIVTSGSRKE RCIGQIFQTE
1010 1020 1030 1040 1050
EYSVEKSLGP MILINKPLEN MEEARHENEG LVSSGQSLYT SGEKESDSSA
1060 1070 1080 1090 1100
STSLPVEESQ AQGNESLFSK YTNSKIPYFL LFLIFLITVY HYDLMIGLTF
1110 1120
YVLSLSWLSW EEGRQKESVK KK
Length:1,122
Mass (Da):125,767
Last modified:June 15, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFACB2CEA7C00E75B
GO
Isoform 2 (identifier: Q16821-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-74: GTRRVSFADSFGFNL → ERTRAGACKTMERSS
     75-1122: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:74
Mass (Da):8,187
Checksum:i16A09845C8C8273A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZB3C9JZB3_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R3A
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS07492 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02792945G → S. Corresponds to variant dbSNP:rs8192687EnsemblClinVar.1
Natural variantiVAR_027930231C → Y. Corresponds to variant dbSNP:rs7801819Ensembl.1
Natural variantiVAR_027931451V → M4 PublicationsCorresponds to variant dbSNP:rs2974942Ensembl.1
Natural variantiVAR_027932476N → K4 PublicationsCorresponds to variant dbSNP:rs2974944Ensembl.1
Natural variantiVAR_036287554G → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_057128627R → K. Corresponds to variant dbSNP:rs35067467EnsemblClinVar.1
Natural variantiVAR_027933748E → K. Corresponds to variant dbSNP:rs4304271Ensembl.1
Natural variantiVAR_027934882L → H4 PublicationsCorresponds to variant dbSNP:rs2974938Ensembl.1
Natural variantiVAR_019697883R → S1 PublicationCorresponds to variant dbSNP:rs1800000EnsemblClinVar.1
Natural variantiVAR_019698905D → Y Common polymorphism; can be associated with insulin resistance. 2 PublicationsCorresponds to variant dbSNP:rs1799999EnsemblClinVar.1
Natural variantiVAR_019699931A → E in NIDDM. 1 PublicationCorresponds to variant dbSNP:rs35449651EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01158560 – 74GTRRV…FGFNL → ERTRAGACKTMERSS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_01158675 – 1122Missing in isoform 2. 1 PublicationAdd BLAST1048

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF024578, AF024576, AF024577 Genomic DNA Translation: AAB94596.1
AF024579 mRNA Translation: AAB94597.1
AC092465 Genomic DNA Translation: AAS07492.1 Sequence problems.
AC093598 Genomic DNA Translation: AAP22361.1
CH236947 Genomic DNA Translation: EAL24370.1
BC126451 mRNA Translation: AAI26452.1
BC126453 mRNA Translation: AAI26454.1
X78578 mRNA Translation: CAA55316.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5759.1 [Q16821-1]

Protein sequence database of the Protein Information Resource

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PIRi
I38127

NCBI Reference Sequences

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RefSeqi
NP_002702.2, NM_002711.3 [Q16821-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.458309

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000284601; ENSP00000284601; ENSG00000154415 [Q16821-1]
ENST00000284602; ENSP00000284602; ENSG00000154415 [Q16821-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5506

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5506

UCSC genome browser

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UCSCi
uc010ljy.2 human [Q16821-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024578, AF024576, AF024577 Genomic DNA Translation: AAB94596.1
AF024579 mRNA Translation: AAB94597.1
AC092465 Genomic DNA Translation: AAS07492.1 Sequence problems.
AC093598 Genomic DNA Translation: AAP22361.1
CH236947 Genomic DNA Translation: EAL24370.1
BC126451 mRNA Translation: AAI26452.1
BC126453 mRNA Translation: AAI26454.1
X78578 mRNA Translation: CAA55316.1
CCDSiCCDS5759.1 [Q16821-1]
PIRiI38127
RefSeqiNP_002702.2, NM_002711.3 [Q16821-1]
UniGeneiHs.458309

3D structure databases

ProteinModelPortaliQ16821
SMRiQ16821
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111499, 45 interactors
IntActiQ16821, 2 interactors
STRINGi9606.ENSP00000284601

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

PTM databases

iPTMnetiQ16821
PhosphoSitePlusiQ16821

Polymorphism and mutation databases

BioMutaiPPP1R3A
DMDMi298286906

Proteomic databases

EPDiQ16821
PaxDbiQ16821
PeptideAtlasiQ16821
PRIDEiQ16821
ProteomicsDBi61080
61081 [Q16821-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5506
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284601; ENSP00000284601; ENSG00000154415 [Q16821-1]
ENST00000284602; ENSP00000284602; ENSG00000154415 [Q16821-2]
GeneIDi5506
KEGGihsa:5506
UCSCiuc010ljy.2 human [Q16821-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5506
DisGeNETi5506
EuPathDBiHostDB:ENSG00000154415.7

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP1R3A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0033522
HGNCiHGNC:9291 PPP1R3A
MalaCardsiPPP1R3A
MIMi125853 phenotype
600917 gene
neXtProtiNX_Q16821
OpenTargetsiENSG00000154415
PharmGKBiPA33651

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00940000157682
HOVERGENiHBG053657
InParanoidiQ16821
KOiK07189
OMAiLFTCQET
OrthoDBiEOG091G00OC
PhylomeDBiQ16821
TreeFamiTF105537

Enzyme and pathway databases

SIGNORiQ16821

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP1R3A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PPP1R3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5506

Protein Ontology

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PROi
PR:Q16821

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154415 Expressed in 58 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_PPP1R3A
ExpressionAtlasiQ16821 baseline and differential
GenevisibleiQ16821 HS

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPR3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16821
Secondary accession number(s): A0AVQ2
, A4D0T6, O43476, Q75LN8, Q7KYM8, Q86UI6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 15, 2010
Last modified: December 5, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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