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Entry version 182 (13 Feb 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Meprin A subunit alpha

Gene

MEP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues. EC:3.4.24.18

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by several hydroxamate compounds, the most potent inhibitor is actinonin.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=110 µM for GRP1 Publication
  2. KM=18.0 µM for PTH 12-341 Publication
  3. KM=33.9 µM for secretin1 Publication
  4. KM=41.3 µM for substance P1 Publication
  5. KM=56.5 µM for LHRH1 Publication
  6. KM=73.2 µM for orcokinin1 Publication
  7. KM=292 µM for alpha-MSH1 Publication
  8. KM=125 µM for bradykinin1 Publication
  9. KM=200 µM for gastrin1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi155Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei156PROSITE-ProRule annotation1
    Metal bindingi159Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
    Metal bindingi165Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • metalloendopeptidase activity Source: GO_Central
    • zinc ion binding Source: InterPro

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.24.18 2681

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    Q16819

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q16819

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M12.002

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Meprin A subunit alpha (EC:3.4.24.18)
    Alternative name(s):
    Endopeptidase-2
    N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
    PABA peptide hydrolase
    PPH alpha
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:MEP1A
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000112818.9

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:7015 MEP1A

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600388 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q16819

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini66 – 712ExtracellularSequence analysisAdd BLAST647
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei713 – 740HelicalSequence analysisAdd BLAST28
    Topological domaini741 – 746CytoplasmicSequence analysis6

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    4224

    Open Targets

    More...
    OpenTargetsi
    ENSG00000112818

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA30749

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    MEP1A

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    205830902

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002887722 – 65By similarityAdd BLAST44
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002887866 – 746Meprin A subunit alphaAdd BLAST681

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi107 ↔ 259PROSITE-ProRule annotation
    Disulfide bondi128 ↔ 147PROSITE-ProRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi269 ↔ 431PROSITE-ProRule annotation
    Disulfide bondi277InterchainPROSITE-ProRule annotation
    Disulfide bondi308InterchainPROSITE-ProRule annotation
    Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi539N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi674 ↔ 685PROSITE-ProRule annotation
    Disulfide bondi679 ↔ 694PROSITE-ProRule annotation
    Disulfide bondi696 ↔ 709PROSITE-ProRule annotation

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q16819

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q16819

    PeptideAtlas

    More...
    PeptideAtlasi
    Q16819

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q16819

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    61078

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q16819

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q16819

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000112818 Expressed in 52 organ(s), highest expression level in jejunal mucosa

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q16819 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q16819 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB025163
    HPA029416

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity (By similarity).By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    MMP9P147802EBI-8153734,EBI-1382326

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    110387, 12 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q16819

    Protein interaction database and analysis system

    More...
    IntActi
    Q16819, 1 interactor

    Molecular INTeraction database

    More...
    MINTi
    Q16819

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000230588

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q16819

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q16819

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 260Peptidase M12APROSITE-ProRule annotationAdd BLAST195
    Domaini264 – 433MAMPROSITE-ProRule annotationAdd BLAST170
    Domaini434 – 593MATHPROSITE-ProRule annotationAdd BLAST160
    Domaini670 – 710EGF-likePROSITE-ProRule annotationAdd BLAST41

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3714 Eukaryota
    ENOG410ZPX7 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000164139

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG052457

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q16819

    KEGG Orthology (KO)

    More...
    KOi
    K01395

    Database of Orthologous Groups

    More...
    OrthoDBi
    241999at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q16819

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315280

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06263 MAM, 1 hit
    cd04282 ZnMc_meprin, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.210.10, 1 hit
    3.40.390.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013320 ConA-like_dom_sf
    IPR000742 EGF-like_dom
    IPR000998 MAM_dom
    IPR002083 MATH/TRAF_dom
    IPR008294 Meprin
    IPR034301 Meprin_alpha
    IPR024079 MetalloPept_cat_dom_sf
    IPR001506 Peptidase_M12A
    IPR006026 Peptidase_Metallo
    IPR008974 TRAF-like
    IPR034038 ZnMP_meprin

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR44155 PTHR44155, 1 hit
    PTHR44155:SF4 PTHR44155:SF4, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01400 Astacin, 1 hit
    PF00008 EGF, 1 hit
    PF00629 MAM, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF001196 Meprin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00480 ASTACIN
    PR00020 MAMDOMAIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00137 MAM, 1 hit
    SM00061 MATH, 1 hit
    SM00235 ZnMc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49599 SSF49599, 1 hit
    SSF49899 SSF49899, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51864 ASTACIN, 1 hit
    PS50026 EGF_3, 1 hit
    PS00740 MAM_1, 1 hit
    PS50060 MAM_2, 1 hit
    PS50144 MATH, 1 hit
    PS00142 ZINC_PROTEASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q16819-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAWIRSTCIL FFTLLFAHIA AVPIKYLPEE NVHDADFGEQ KDISEINLAA
    60 70 80 90 100
    GLDLFQGDIL LQKSRNGLRD PNTRWTFPIP YILADNLGLN AKGAILYAFE
    110 120 130 140 150
    MFRLKSCVDF KPYEGESSYI IFQQFDGCWS EVGDQHVGQN ISIGQGCAYK
    160 170 180 190 200
    AIIEHEILHA LGFYHEQSRT DRDDYVNIWW DQILSGYQHN FDTYDDSLIT
    210 220 230 240 250
    DLNTPYDYES LMHYQPFSFN KNASVPTITA KIPEFNSIIG QRLDFSAIDL
    260 270 280 290 300
    ERLNRMYNCT TTHTLLDHCT FEKANICGMI QGTRDDTDWA HQDSAQAGEV
    310 320 330 340 350
    DHTLLGQCTG AGYFMQFSTS SGSAEEAALL ESRILYPKRK QQCLQFFYKM
    360 370 380 390 400
    TGSPSDRLVV WVRRDDSTGN VRKLVKVQTF QGDDDHNWKI AHVVLKEEQK
    410 420 430 440 450
    FRYLFQGTKG DPQNSTGGIY LDDITLTETP CPTGVWTVRN FSQVLENTSK
    460 470 480 490 500
    GDKLQSPRFY NSEGYGFGVT LYPNSRESSG YLRLAFHVCS GENDAILEWP
    510 520 530 540 550
    VENRQVIITI LDQEPDVRNR MSSSMVFTTS KSHTSPAIND TVIWDRPSRV
    560 570 580 590 600
    GTYHTDCNCF RSIDLGWSGF ISHQMLKRRS FLKNDDLIIF VDFEDITHLS
    610 620 630 640 650
    QTEVPTKGKR LSPQGLILQG QEQQVSEEGS GKAMLEEALP VSLSQGQPSR
    660 670 680 690 700
    QKRSVENTGP LEDHNWPQYF RDPCDPNPCQ NDGICVNVKG MASCRCISGH
    710 720 730 740
    AFFYTGERCQ AVQVHGSVLG MVIGGTAGVI FLTFSIIAIL SQRPRK
    Length:746
    Mass (Da):84,419
    Last modified:July 22, 2008 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5F0812F2850F958
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B7ZL91B7ZL91_HUMAN
    Meprin A subunit
    MEP1A
    774Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26Y → H in AAA21338 (Ref. 1) Curated1
    Sequence conflicti162G → V in AAL85339 (Ref. 2) Curated1
    Sequence conflicti306G → E in BAF98731 (PubMed:14702039).Curated1
    Sequence conflicti426L → P in BAF98731 (PubMed:14702039).Curated1
    Sequence conflicti518R → Q in BAG37669 (PubMed:14702039).Curated1
    Sequence conflicti546R → S in BAF98731 (PubMed:14702039).Curated1
    Sequence conflicti638A → V in BAF98731 (PubMed:14702039).Curated1
    Sequence conflicti711 – 713AVQ → SAE in AAA21338 (Ref. 1) Curated3
    Sequence conflicti711 – 713AVQ → SAE no nucleotide entry (PubMed:8262185).Curated3

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020056469V → L2 PublicationsCorresponds to variant dbSNP:rs2274658Ensembl.1
    Natural variantiVAR_033492476R → G1 PublicationCorresponds to variant dbSNP:rs12197930Ensembl.1
    Natural variantiVAR_051583606T → S2 PublicationsCorresponds to variant dbSNP:rs2297020Ensembl.1
    Natural variantiVAR_021846634M → V. Corresponds to variant dbSNP:rs2297019Ensembl.1
    Natural variantiVAR_033493726T → M1 PublicationCorresponds to variant dbSNP:rs1804211Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M82962 mRNA Translation: AAA21338.1
    AF478685 mRNA Translation: AAL85339.1
    AK290282 mRNA Translation: BAF82971.1
    AK315246 mRNA Translation: BAG37669.1
    AK315840 mRNA Translation: BAF98731.1
    AL161618 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX04306.1
    BC131714 mRNA Translation: AAI31715.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4918.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S60193 HYHUMA

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_005579.2, NM_005588.2

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.179704

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000230588; ENSP00000230588; ENSG00000112818

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4224

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:4224

    UCSC genome browser

    More...
    UCSCi
    uc010jzh.2 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M82962 mRNA Translation: AAA21338.1
    AF478685 mRNA Translation: AAL85339.1
    AK290282 mRNA Translation: BAF82971.1
    AK315246 mRNA Translation: BAG37669.1
    AK315840 mRNA Translation: BAF98731.1
    AL161618 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX04306.1
    BC131714 mRNA Translation: AAI31715.1
    CCDSiCCDS4918.1
    PIRiS60193 HYHUMA
    RefSeqiNP_005579.2, NM_005588.2
    UniGeneiHs.179704

    3D structure databases

    ProteinModelPortaliQ16819
    SMRiQ16819
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi110387, 12 interactors
    CORUMiQ16819
    IntActiQ16819, 1 interactor
    MINTiQ16819
    STRINGi9606.ENSP00000230588

    Protein family/group databases

    MEROPSiM12.002

    PTM databases

    iPTMnetiQ16819
    PhosphoSitePlusiQ16819

    Polymorphism and mutation databases

    BioMutaiMEP1A
    DMDMi205830902

    Proteomic databases

    jPOSTiQ16819
    PaxDbiQ16819
    PeptideAtlasiQ16819
    PRIDEiQ16819
    ProteomicsDBi61078

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000230588; ENSP00000230588; ENSG00000112818
    GeneIDi4224
    KEGGihsa:4224
    UCSCiuc010jzh.2 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4224
    DisGeNETi4224
    EuPathDBiHostDB:ENSG00000112818.9

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    MEP1A

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0032798
    HGNCiHGNC:7015 MEP1A
    HPAiCAB025163
    HPA029416
    MIMi600388 gene
    neXtProtiNX_Q16819
    OpenTargetsiENSG00000112818
    PharmGKBiPA30749

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3714 Eukaryota
    ENOG410ZPX7 LUCA
    GeneTreeiENSGT00940000164139
    HOVERGENiHBG052457
    InParanoidiQ16819
    KOiK01395
    OrthoDBi241999at2759
    PhylomeDBiQ16819
    TreeFamiTF315280

    Enzyme and pathway databases

    BRENDAi3.4.24.18 2681
    SignaLinkiQ16819
    SIGNORiQ16819

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    MEP1A

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    4224

    Protein Ontology

    More...
    PROi
    PR:Q16819

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000112818 Expressed in 52 organ(s), highest expression level in jejunal mucosa
    ExpressionAtlasiQ16819 baseline and differential
    GenevisibleiQ16819 HS

    Family and domain databases

    CDDicd06263 MAM, 1 hit
    cd04282 ZnMc_meprin, 1 hit
    Gene3Di2.60.210.10, 1 hit
    3.40.390.10, 1 hit
    InterProiView protein in InterPro
    IPR013320 ConA-like_dom_sf
    IPR000742 EGF-like_dom
    IPR000998 MAM_dom
    IPR002083 MATH/TRAF_dom
    IPR008294 Meprin
    IPR034301 Meprin_alpha
    IPR024079 MetalloPept_cat_dom_sf
    IPR001506 Peptidase_M12A
    IPR006026 Peptidase_Metallo
    IPR008974 TRAF-like
    IPR034038 ZnMP_meprin
    PANTHERiPTHR44155 PTHR44155, 1 hit
    PTHR44155:SF4 PTHR44155:SF4, 1 hit
    PfamiView protein in Pfam
    PF01400 Astacin, 1 hit
    PF00008 EGF, 1 hit
    PF00629 MAM, 1 hit
    PIRSFiPIRSF001196 Meprin, 1 hit
    PRINTSiPR00480 ASTACIN
    PR00020 MAMDOMAIN
    SMARTiView protein in SMART
    SM00137 MAM, 1 hit
    SM00061 MATH, 1 hit
    SM00235 ZnMc, 1 hit
    SUPFAMiSSF49599 SSF49599, 1 hit
    SSF49899 SSF49899, 1 hit
    PROSITEiView protein in PROSITE
    PS51864 ASTACIN, 1 hit
    PS50026 EGF_3, 1 hit
    PS00740 MAM_1, 1 hit
    PS50060 MAM_2, 1 hit
    PS50144 MATH, 1 hit
    PS00142 ZINC_PROTEASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEP1A_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16819
    Secondary accession number(s): A2RRM4
    , B0AZP9, B2RCS2, Q8TDC9, Q9H1R1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 22, 2008
    Last modified: February 13, 2019
    This is version 182 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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