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Entry version 154 (31 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Reticulon-1

Gene

RTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.102.1.9 the reticulon (reticulon) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reticulon-1
Alternative name(s):
Neuroendocrine-specific protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTN1
Synonyms:NSP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10467 RTN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600865 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16799

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei603 – 623HelicalSequence analysisAdd BLAST21
Transmembranei705 – 725HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6252

Open Targets

More...
OpenTargetsi
ENSG00000139970

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34880

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RTN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643733

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001681581 – 776Reticulon-1Add BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei327PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei352PhosphoserineBy similarity1
Modified residuei487PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoforms RTN1-A and RTN1-B are phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16799

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16799

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16799

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16799

PeptideAtlas

More...
PeptideAtlasi
Q16799

PRoteomics IDEntifications database

More...
PRIDEi
Q16799

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61074 [Q16799-1]
61075 [Q16799-2]
61076 [Q16799-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16799

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16799

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q16799

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139970 Expressed in 206 organ(s), highest expression level in Brodmann (1909) area 23

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16799 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16799 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002745
HPA040945
HPA044249

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NDRG1 (PubMed:15922294). Isoform RTN1-A: interacts with TMEM33 (PubMed:25612671). Isoform RTN1-C: interacts with UGCG; regulates the ceramide glucosyltransferase activity of UGCG (PubMed:12873973).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005603EBI-10180131,EBI-727004

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112165, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q16799, 13 interactors

Molecular INTeraction database

More...
MINTi
Q16799

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000267484

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16799

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini589 – 776ReticulonPROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi609 – 612Poly-Leu4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1792 Eukaryota
ENOG410XPKH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000134444

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16799

KEGG Orthology (KO)

More...
KOi
K20721

Identification of Orthologs from Complete Genome Data

More...
OMAi
SRMNREN

Database of Orthologous Groups

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OrthoDBi
244299at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q16799

TreeFam database of animal gene trees

More...
TreeFami
TF105431

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003388 Reticulon

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02453 Reticulon, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50845 RETICULON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform RTN1-A (identifier: Q16799-1) [UniParc]FASTAAdd to basket
Also known as: NSP-A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPGDPQDE LLPLAGPGSQ WLRHRGEGEN EAVTPKGATP APQAGEPSPG
60 70 80 90 100
LGARAREAAS REAGSGPARQ SPVAMETAST GVAGVSSAMD HTFSTTSKDG
110 120 130 140 150
EGSCYTSLIS DICYPPQEDS TYFTGILQKE NGHVTISESP EELGTPGPSL
160 170 180 190 200
PDVPGIESRG LFSSDSGIEM TPAESTEVNK ILADPLDQMK AEAYKYIDIT
210 220 230 240 250
RPEEVKHQEQ HHPELEDKDL DFKNKDTDIS IKPEGVREPD KPAPVEGKII
260 270 280 290 300
KDHLLEESTF APYIDDLSEE QRRAPQITTP VKITLTEIEP SVETTTQEKT
310 320 330 340 350
PEKQDICLKP SPDTVPTVTV SEPEDDSPGS ITPPSSGTEP SAAESQGKGS
360 370 380 390 400
ISEDELITAI KEAKGLSYET AENPRPVGQL ADRPEVKARS GPPTIPSPLD
410 420 430 440 450
HEASSAESGD SEIELVSEDP MAAEDALPSG YVSFGHVGGP PPSPASPSIQ
460 470 480 490 500
YSILREEREA ELDSELIIES CDASSASEES PKREQDSPPM KPSALDAIRE
510 520 530 540 550
ETGVRAEERA PSRRGLAEPG SFLDYPSTEP QPGPELPPGD GALEPETPML
560 570 580 590 600
PRKPEEDSSS NQSPAATKGP GPLGPGAPPP LLFLNKQKAI DLLYWRDIKQ
610 620 630 640 650
TGIVFGSFLL LLFSLTQFSV VSVVAYLALA ALSATISFRI YKSVLQAVQK
660 670 680 690 700
TDEGHPFKAY LELEITLSQE QIQKYTDCLQ FYVNSTLKEL RRLFLVQDLV
710 720 730 740 750
DSLKFAVLMW LLTYVGALFN GLTLLLMAVV SMFTLPVVYV KHQAQIDQYL
760 770
GLVRTHINAV VAKIQAKIPG AKRHAE
Length:776
Mass (Da):83,618
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA5B6232353096FE
GO
Isoform RTN1-B (identifier: Q16799-2) [UniParc]FASTAAdd to basket
Also known as: NSP-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.

Show »
Length:356
Mass (Da):38,950
Checksum:iBE8956BC59FB6F08
GO
Isoform RTN1-C (identifier: Q16799-3) [UniParc]FASTAAdd to basket
Also known as: NSP-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-568: Missing.
     569-588: GPGPLGPGAPPPLLFLNKQK → MQATADSTKMDCVWSNWKSQ

Show »
Length:208
Mass (Da):23,576
Checksum:i49C5668130635E17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q2NKQ5Q2NKQ5_HUMAN
Reticulon
RTN1
702Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MT72A8MT72_HUMAN
Reticulon
RTN1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053630247G → E. Corresponds to variant dbSNP:rs35645652Ensembl.1
Natural variantiVAR_053631357I → V. Corresponds to variant dbSNP:rs35707243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0056451 – 568Missing in isoform RTN1-C. 2 PublicationsAdd BLAST568
Alternative sequenceiVSP_0056441 – 420Missing in isoform RTN1-B. 1 PublicationAdd BLAST420
Alternative sequenceiVSP_005646569 – 588GPGPL…LNKQK → MQATADSTKMDCVWSNWKSQ in isoform RTN1-C. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L10333 mRNA Translation: AAA59950.1
L10334 mRNA Translation: AAA59951.1
L10335 mRNA Translation: AAA59952.1
CH471061 Genomic DNA Translation: EAW80762.1
BC090862 mRNA Translation: AAH90862.1
BC000314 mRNA Translation: AAH00314.2
BC003003 mRNA Translation: AAH03003.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9740.1 [Q16799-1]
CCDS9741.1 [Q16799-3]

Protein sequence database of the Protein Information Resource

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PIRi
A46583
I60904

NCBI Reference Sequences

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RefSeqi
NP_066959.1, NM_021136.2 [Q16799-1]
NP_996734.1, NM_206852.2 [Q16799-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267484; ENSP00000267484; ENSG00000139970 [Q16799-1]
ENST00000342503; ENSP00000340716; ENSG00000139970 [Q16799-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6252

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6252

UCSC genome browser

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UCSCi
uc001xek.3 human [Q16799-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10333 mRNA Translation: AAA59950.1
L10334 mRNA Translation: AAA59951.1
L10335 mRNA Translation: AAA59952.1
CH471061 Genomic DNA Translation: EAW80762.1
BC090862 mRNA Translation: AAH90862.1
BC000314 mRNA Translation: AAH00314.2
BC003003 mRNA Translation: AAH03003.2
CCDSiCCDS9740.1 [Q16799-1]
CCDS9741.1 [Q16799-3]
PIRiA46583
I60904
RefSeqiNP_066959.1, NM_021136.2 [Q16799-1]
NP_996734.1, NM_206852.2 [Q16799-3]

3D structure databases

SMRiQ16799
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112165, 30 interactors
IntActiQ16799, 13 interactors
MINTiQ16799
STRINGi9606.ENSP00000267484

Protein family/group databases

TCDBi8.A.102.1.9 the reticulon (reticulon) family

PTM databases

iPTMnetiQ16799
PhosphoSitePlusiQ16799
SwissPalmiQ16799

Polymorphism and mutation databases

BioMutaiRTN1
DMDMi12643733

Proteomic databases

EPDiQ16799
jPOSTiQ16799
MaxQBiQ16799
PaxDbiQ16799
PeptideAtlasiQ16799
PRIDEiQ16799
ProteomicsDBi61074 [Q16799-1]
61075 [Q16799-2]
61076 [Q16799-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267484; ENSP00000267484; ENSG00000139970 [Q16799-1]
ENST00000342503; ENSP00000340716; ENSG00000139970 [Q16799-3]
GeneIDi6252
KEGGihsa:6252
UCSCiuc001xek.3 human [Q16799-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6252
DisGeNETi6252

GeneCards: human genes, protein and diseases

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GeneCardsi
RTN1
HGNCiHGNC:10467 RTN1
HPAiCAB002745
HPA040945
HPA044249
MIMi600865 gene
neXtProtiNX_Q16799
OpenTargetsiENSG00000139970
PharmGKBiPA34880

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA
GeneTreeiENSGT00940000155077
HOGENOMiHOG000134444
InParanoidiQ16799
KOiK20721
OMAiSRMNREN
OrthoDBi244299at2759
PhylomeDBiQ16799
TreeFamiTF105431

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RTN1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RTN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6252

Protein Ontology

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PROi
PR:Q16799

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000139970 Expressed in 206 organ(s), highest expression level in Brodmann (1909) area 23
ExpressionAtlasiQ16799 baseline and differential
GenevisibleiQ16799 HS

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16799
Secondary accession number(s): Q16800
, Q16801, Q5BKZ4, Q9BQ59
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 31, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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