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Protein

Hydroxyacylglutathione hydrolase, mitochondrial

Gene

HAGH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

Caution

Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 2 Zn2+ ions per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: methylglyoxal degradation

This protein is involved in step 2 of the subpathway that synthesizes (R)-lactate from methylglyoxal.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Lactoylglutathione lyase (HEL-S-74), Lactoylglutathione lyase (GLO1), Lactoylglutathione lyase (GLO1)
  2. Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)
This subpathway is part of the pathway methylglyoxal degradation, which is itself part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi102Zinc 1; via tele nitrogen1 Publication1
Metal bindingi104Zinc 1; via pros nitrogen1 Publication1
Metal bindingi106Zinc 21 Publication1
Metal bindingi107Zinc 2; via tele nitrogen1 Publication1
Metal bindingi158Zinc 1; via tele nitrogen1 Publication1
Metal bindingi182Zinc 11 Publication1
Metal bindingi182Zinc 21 Publication1
Metal bindingi221Zinc 2; via tele nitrogen1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hydroxyacylglutathione hydrolase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.2.6 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70268 Pyruvate metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q16775

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00619;UER00676

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydroxyacylglutathione hydrolase, mitochondrial1 Publication (EC:3.1.2.6)
Alternative name(s):
Glyoxalase II
Short name:
Glx II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HAGH
Synonyms:GLO2, HAGH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000063854.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4805 HAGH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138760 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16775

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3029

MalaCards human disease database

More...
MalaCardsi
HAGH
MIMi138760 gene+phenotype

Open Targets

More...
OpenTargetsi
ENSG00000063854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29179

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2261

Drug and drug target database

More...
DrugBanki
DB00143 Glutathione
DB03889 S-(N-Hydroxy-N-Bromophenylcarbamoyl)Glutathione

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HAGH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
257051015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 13MitochondrionSequence analysisAdd BLAST13
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000019234214 – 308Hydroxyacylglutathione hydrolase, mitochondrialAdd BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei116N6-acetyllysineBy similarity1
Modified residuei229N6-acetyllysine; alternateCombined sources1
Modified residuei229N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16775

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16775

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16775

PeptideAtlas

More...
PeptideAtlasi
Q16775

PRoteomics IDEntifications database

More...
PRIDEi
Q16775

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61064
61065 [Q16775-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16775

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16775

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000063854 Expressed in 227 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_HAGH

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16775 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16775 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043041
HPA061143

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-3905342,EBI-750109

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109279, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q16775, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380514

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16775

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q16775

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16775

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16775

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni191 – 193Substrate binding1 Publication3
Regioni221 – 223Substrate binding1 Publication3
Regioni297 – 300Substrate binding1 Publication4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0813 Eukaryota
COG0491 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159176

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000058041

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001152

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16775

KEGG Orthology (KO)

More...
KOi
K01069

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYIWLLQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0E58

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16775

TreeFam database of animal gene trees

More...
TreeFami
TF105273

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07723 hydroxyacylglutathione_hydrola, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.15.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01374 Glyoxalase_2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035680 Clx_II_MBL
IPR032282 HAGH_C
IPR017782 Hydroxyacylglutathione_Hdrlase
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16123 HAGH_C, 1 hit
PF00753 Lactamase_B, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005457 Glx, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00849 Lactamase_B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56281 SSF56281, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03413 GSH_gloB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16775-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVGRGLLGR RSLAALGAAC ARRGLGPALL GVFCHTDLRK NLTVDEGTMK
60 70 80 90 100
VEVLPALTDN YMYLVIDDET KEAAIVDPVQ PQKVVDAARK HGVKLTTVLT
110 120 130 140 150
THHHWDHAGG NEKLVKLESG LKVYGGDDRI GALTHKITHL STLQVGSLNV
160 170 180 190 200
KCLATPCHTS GHICYFVSKP GGSEPPAVFT GDTLFVAGCG KFYEGTADEM
210 220 230 240 250
CKALLEVLGR LPPDTRVYCG HEYTINNLKF ARHVEPGNAA IREKLAWAKE
260 270 280 290 300
KYSIGEPTVP STLAEEFTYN PFMRVREKTV QQHAGETDPV TTMRAVRREK

DQFKMPRD
Length:308
Mass (Da):33,806
Last modified:September 1, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64E5C214B6EC61CB
GO
Isoform 2 (identifier: Q16775-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Note: Produced by alternative splicing. Also produced by alternative initiation at Met-49 of isoform 1.
Show »
Length:260
Mass (Da):28,860
Checksum:i4C3DEC87FB27A1D2
GO
Isoform 3 (identifier: Q16775-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-236: GSLNVKCLAT...NLKFARHVEP → TPCLWLAAGS...WQRSLPTTPS
     237-308: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):25,455
Checksum:i25A00E2EAD5E9A15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPQ4H3BPQ4_HUMAN
Hydroxyacylglutathione hydrolase, m...
HAGH
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPK3H3BPK3_HUMAN
Hydroxyacylglutathione hydrolase, m...
HAGH
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQW8H3BQW8_HUMAN
Hydroxyacylglutathione hydrolase, m...
HAGH
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV79H3BV79_HUMAN
Hydroxyacylglutathione hydrolase, m...
HAGH
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00840 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA62483 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67D → G in BAG60445 (PubMed:14702039).Curated1
Sequence conflicti121L → P in BAG61219 (PubMed:14702039).Curated1
Sequence conflicti202K → E in BAF82844 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0379291 – 48Missing in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_055199146 – 236GSLNV…RHVEP → TPCLWLAAGSSMKGLRMRCV KLCWRSWAGSPRTQESTVAT STPSTTSSLHATWSPAMPPS GRSWPGPRRSTASGSPQCHP PWQRSLPTTPS in isoform 3. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_055200237 – 308Missing in isoform 3. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK290155 mRNA Translation: BAF82844.1
AK298174 mRNA Translation: BAG60445.1
AK299173 mRNA Translation: BAG61219.1
AE006639 Genomic DNA Translation: AAK61294.1
AC012180 Genomic DNA No translation available.
BC000840 mRNA Translation: AAH00840.1 Different initiation.
BC002627 mRNA Translation: AAH02627.2
X90999 mRNA Translation: CAA62483.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS10447.2 [Q16775-1]
CCDS32366.1 [Q16775-2]
CCDS66900.1 [Q16775-3]

NCBI Reference Sequences

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RefSeqi
NP_001035517.1, NM_001040427.1 [Q16775-2]
NP_001273178.1, NM_001286249.1 [Q16775-3]
NP_005317.2, NM_005326.4 [Q16775-1]
XP_011520772.1, XM_011522470.2 [Q16775-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.157394

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000397353; ENSP00000380511; ENSG00000063854 [Q16775-2]
ENST00000397356; ENSP00000380514; ENSG00000063854 [Q16775-1]
ENST00000455446; ENSP00000406552; ENSG00000063854 [Q16775-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3029

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3029

UCSC genome browser

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UCSCi
uc002cmz.4 human [Q16775-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290155 mRNA Translation: BAF82844.1
AK298174 mRNA Translation: BAG60445.1
AK299173 mRNA Translation: BAG61219.1
AE006639 Genomic DNA Translation: AAK61294.1
AC012180 Genomic DNA No translation available.
BC000840 mRNA Translation: AAH00840.1 Different initiation.
BC002627 mRNA Translation: AAH02627.2
X90999 mRNA Translation: CAA62483.1 Different initiation.
CCDSiCCDS10447.2 [Q16775-1]
CCDS32366.1 [Q16775-2]
CCDS66900.1 [Q16775-3]
RefSeqiNP_001035517.1, NM_001040427.1 [Q16775-2]
NP_001273178.1, NM_001286249.1 [Q16775-3]
NP_005317.2, NM_005326.4 [Q16775-1]
XP_011520772.1, XM_011522470.2 [Q16775-3]
UniGeneiHs.157394

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QH3X-ray1.90A/B49-308[»]
1QH5X-ray1.45A/B49-308[»]
2F50model-A64-225[»]
ProteinModelPortaliQ16775
SMRiQ16775
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109279, 10 interactors
IntActiQ16775, 25 interactors
STRINGi9606.ENSP00000380514

Chemistry databases

BindingDBiQ16775
ChEMBLiCHEMBL2261
DrugBankiDB00143 Glutathione
DB03889 S-(N-Hydroxy-N-Bromophenylcarbamoyl)Glutathione

PTM databases

iPTMnetiQ16775
PhosphoSitePlusiQ16775

Polymorphism and mutation databases

BioMutaiHAGH
DMDMi257051015

Proteomic databases

EPDiQ16775
MaxQBiQ16775
PaxDbiQ16775
PeptideAtlasiQ16775
PRIDEiQ16775
ProteomicsDBi61064
61065 [Q16775-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3029
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397353; ENSP00000380511; ENSG00000063854 [Q16775-2]
ENST00000397356; ENSP00000380514; ENSG00000063854 [Q16775-1]
ENST00000455446; ENSP00000406552; ENSG00000063854 [Q16775-3]
GeneIDi3029
KEGGihsa:3029
UCSCiuc002cmz.4 human [Q16775-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3029
DisGeNETi3029
EuPathDBiHostDB:ENSG00000063854.12

GeneCards: human genes, protein and diseases

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GeneCardsi
HAGH
HGNCiHGNC:4805 HAGH
HPAiHPA043041
HPA061143
MalaCardsiHAGH
MIMi138760 gene+phenotype
neXtProtiNX_Q16775
OpenTargetsiENSG00000063854
PharmGKBiPA29179

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0813 Eukaryota
COG0491 LUCA
GeneTreeiENSGT00940000159176
HOGENOMiHOG000058041
HOVERGENiHBG001152
InParanoidiQ16775
KOiK01069
OMAiNYIWLLQ
OrthoDBiEOG091G0E58
PhylomeDBiQ16775
TreeFamiTF105273

Enzyme and pathway databases

UniPathwayi
UPA00619;UER00676

BRENDAi3.1.2.6 2681
ReactomeiR-HSA-70268 Pyruvate metabolism
SABIO-RKiQ16775

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HAGH human
EvolutionaryTraceiQ16775

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HAGH

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3029

Protein Ontology

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PROi
PR:Q16775

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000063854 Expressed in 227 organ(s), highest expression level in right lobe of liver
CleanExiHS_HAGH
ExpressionAtlasiQ16775 baseline and differential
GenevisibleiQ16775 HS

Family and domain databases

CDDicd07723 hydroxyacylglutathione_hydrola, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01374 Glyoxalase_2, 1 hit
InterProiView protein in InterPro
IPR035680 Clx_II_MBL
IPR032282 HAGH_C
IPR017782 Hydroxyacylglutathione_Hdrlase
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF16123 HAGH_C, 1 hit
PF00753 Lactamase_B, 1 hit
PIRSFiPIRSF005457 Glx, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR03413 GSH_gloB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16775
Secondary accession number(s): A8K290
, B4DP33, B4DRA7, E7EN93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 1, 2009
Last modified: December 5, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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