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Entry version 172 (12 Aug 2020)
Sequence version 2 (23 Jan 2007)
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Protein

Guanylate kinase

Gene

GUK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664).By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Up-regulated by RD3.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 58.5 sec(-1) with GMP as substrate.1 Publication
  1. KM=20.7 µM for GMP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei44By similarity1
    Active sitei137By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei137ATPBy similarity1
    Active sitei148By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi14 – 19ATPBy similarity6
    Nucleotide bindingi37 – 51Substrate bindingBy similarityAdd BLAST15
    Nucleotide bindingi171 – 172ATPBy similarity2

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS07104-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.4.8, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q16774

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2161541, Abacavir metabolism
    R-HSA-499943, Interconversion of nucleotide di- and triphosphates

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q16774

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Guanylate kinase (EC:2.7.4.81 Publication)
    Alternative name(s):
    GMP kinase
    Guanylate kinase 1Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:GUK11 PublicationImported
    Synonyms:GMK, GMPK1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000143774.16

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:4693, GUK1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    139270, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q16774

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2S → L: Increases in Kcat with GMP as substrate. 1 Publication1
    Mutagenesisi3G → A: Increases in Kcat with GMP as substrate. 1 Publication1
    Mutagenesisi25L → P: Leads to aggregation. Increases in Kcat with GMP as substrate. 1 Publication1
    Mutagenesisi91V → M: Increases in Kcat with GMP as substrate. 1 Publication1
    Mutagenesisi96R → H: Increases in Kcat with GMP as substrate. 1 Publication1
    Mutagenesisi116R → Q: Increases in Kcat with GMP as substrate. 1 Publication1
    Mutagenesisi121S → F: Increases in Kcat with GMP as substrate. 1 Publication1
    Mutagenesisi186S → Y: Increases in Kcat with GMP as substrate. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    2987

    Open Targets

    More...
    OpenTargetsi
    ENSG00000143774

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA29072

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q16774, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4989

    Drug and drug target database

    More...
    DrugBanki
    DB00787, Acyclovir
    DB01972, Guanosine-5'-Monophosphate
    DB00577, Valaciclovir

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    GUK1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    2497498

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001706512 – 197Guanylate kinaseAdd BLAST196

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q16774

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q16774

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q16774

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q16774

    PeptideAtlas

    More...
    PeptideAtlasi
    Q16774

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q16774

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    3255
    61062 [Q16774-1]
    61063 [Q16774-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q16774

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    Q16774

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q16774

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000143774, Expressed in prefrontal cortex and 241 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q16774, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q16774, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000143774, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer (PubMed:31201273).

    Interacts with RD3 (PubMed:29515371).

    2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    109242, 46 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q16774, 8 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000355689

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q16774, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1197
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q16774

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 186Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST183

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the guanylate kinase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0707, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155815

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_001715_0_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q16774

    KEGG Orthology (KO)

    More...
    KOi
    K00942

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q16774

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314473

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR008145, GK/Ca_channel_bsu
    IPR008144, Guanylate_kin-like_dom
    IPR017665, Guanylate_kinase
    IPR020590, Guanylate_kinase_CS
    IPR027417, P-loop_NTPase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00625, Guanylate_kin, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00072, GuKc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540, SSF52540, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR03263, guanyl_kin, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00856, GUANYLATE_KINASE_1, 1 hit
    PS50052, GUANYLATE_KINASE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q16774-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSGPRPVVLS GPSGAGKSTL LKRLLQEHSG IFGFSVSHTT RNPRPGEENG
    60 70 80 90 100
    KDYYFVTREV MQRDIAAGDF IEHAEFSGNL YGTSKVAVQA VQAMNRICVL
    110 120 130 140 150
    DVDLQGVRNI KATDLRPIYI SVQPPSLHVL EQRLRQRNTE TEESLVKRLA
    160 170 180 190
    AAQADMESSK EPGLFDVVII NDSLDQAYAE LKEALSEEIK KAQRTGA
    Length:197
    Mass (Da):21,726
    Last modified:January 23, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC49573212A0DA825
    GO
    Isoform 2 (identifier: Q16774-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLRRPLAGLAAAALGRAPPDGM

    Show »
    Length:218
    Mass (Da):23,782
    Checksum:i6972858284006BB2
    GO
    Isoform 3 (identifier: Q16774-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLRRPLAGLAAAALGRAPPDGM
         159-197: SKEPGLFDVV...EIKKAQRTGA → RNQESSKDRR...CCPCGWNILG

    Show »
    Length:241
    Mass (Da):26,596
    Checksum:i418604D9B391F864
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B1ANH0B1ANH0_HUMAN
    Guanylate kinase
    GUK1
    217Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B1ANG9B1ANG9_HUMAN
    Guanylate kinase
    GUK1
    235Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B1ANH2B1ANH2_HUMAN
    Guanylate kinase
    GUK1
    253Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B1ANH6B1ANH6_HUMAN
    Guanylate kinase
    GUK1
    242Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B1ANH5B1ANH5_HUMAN
    Guanylate kinase
    GUK1
    199Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B1ANH3B1ANH3_HUMAN
    Guanylate kinase
    GUK1
    272Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0437781M → MLRRPLAGLAAAALGRAPPD GM in isoform 2 and isoform 3. 1 Publication1
    Alternative sequenceiVSP_047372159 – 197SKEPG…QRTGA → RNQESSKDRRLRLAVCSRHP GPIQDQGSSIEPPPWQAIRQ LCALGQHVEWRRCCPCGWNI LG in isoform 3. CuratedAdd BLAST39

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L76200 mRNA Translation: AAC37598.1
    U66895 mRNA Translation: AAC50659.1
    AK303845 mRNA Translation: BAG64788.1
    AL359510 Genomic DNA No translation available.
    CH471098 Genomic DNA Translation: EAW69856.1
    BC006249 mRNA Translation: AAH06249.1
    BC009914 mRNA Translation: AAH09914.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1568.1 [Q16774-1]
    CCDS53481.1 [Q16774-2]
    CCDS55689.1 [Q16774-3]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S68864

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000849.1, NM_000858.5 [Q16774-1]
    NP_001152862.1, NM_001159390.1 [Q16774-2]
    NP_001152863.1, NM_001159391.1 [Q16774-1]
    NP_001229768.1, NM_001242839.1 [Q16774-1]
    NP_001229769.1, NM_001242840.1 [Q16774-3]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000312726; ENSP00000317659; ENSG00000143774 [Q16774-1]
    ENST00000366716; ENSP00000355677; ENSG00000143774 [Q16774-1]
    ENST00000366718; ENSP00000355679; ENSG00000143774 [Q16774-1]
    ENST00000366726; ENSP00000355687; ENSG00000143774 [Q16774-1]
    ENST00000366728; ENSP00000355689; ENSG00000143774 [Q16774-3]
    ENST00000366730; ENSP00000355691; ENSG00000143774 [Q16774-1]
    ENST00000391865; ENSP00000375738; ENSG00000143774 [Q16774-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2987

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:2987

    UCSC genome browser

    More...
    UCSCi
    uc001hsi.4, human [Q16774-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L76200 mRNA Translation: AAC37598.1
    U66895 mRNA Translation: AAC50659.1
    AK303845 mRNA Translation: BAG64788.1
    AL359510 Genomic DNA No translation available.
    CH471098 Genomic DNA Translation: EAW69856.1
    BC006249 mRNA Translation: AAH06249.1
    BC009914 mRNA Translation: AAH09914.1
    CCDSiCCDS1568.1 [Q16774-1]
    CCDS53481.1 [Q16774-2]
    CCDS55689.1 [Q16774-3]
    PIRiS68864
    RefSeqiNP_000849.1, NM_000858.5 [Q16774-1]
    NP_001152862.1, NM_001159390.1 [Q16774-2]
    NP_001152863.1, NM_001159391.1 [Q16774-1]
    NP_001229768.1, NM_001242839.1 [Q16774-1]
    NP_001229769.1, NM_001242840.1 [Q16774-3]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6NUINMR-A1-197[»]
    SMRiQ16774
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi109242, 46 interactors
    IntActiQ16774, 8 interactors
    STRINGi9606.ENSP00000355689

    Chemistry databases

    ChEMBLiCHEMBL4989
    DrugBankiDB00787, Acyclovir
    DB01972, Guanosine-5'-Monophosphate
    DB00577, Valaciclovir

    PTM databases

    iPTMnetiQ16774
    MetOSiteiQ16774
    PhosphoSitePlusiQ16774

    Polymorphism and mutation databases

    BioMutaiGUK1
    DMDMi2497498

    Proteomic databases

    EPDiQ16774
    jPOSTiQ16774
    MassIVEiQ16774
    PaxDbiQ16774
    PeptideAtlasiQ16774
    PRIDEiQ16774
    ProteomicsDBi3255
    61062 [Q16774-1]
    61063 [Q16774-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    34661, 215 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    2987

    Genome annotation databases

    EnsembliENST00000312726; ENSP00000317659; ENSG00000143774 [Q16774-1]
    ENST00000366716; ENSP00000355677; ENSG00000143774 [Q16774-1]
    ENST00000366718; ENSP00000355679; ENSG00000143774 [Q16774-1]
    ENST00000366726; ENSP00000355687; ENSG00000143774 [Q16774-1]
    ENST00000366728; ENSP00000355689; ENSG00000143774 [Q16774-3]
    ENST00000366730; ENSP00000355691; ENSG00000143774 [Q16774-1]
    ENST00000391865; ENSP00000375738; ENSG00000143774 [Q16774-2]
    GeneIDi2987
    KEGGihsa:2987
    UCSCiuc001hsi.4, human [Q16774-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    2987
    DisGeNETi2987
    EuPathDBiHostDB:ENSG00000143774.16

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    GUK1
    HGNCiHGNC:4693, GUK1
    HPAiENSG00000143774, Low tissue specificity
    MIMi139270, gene
    neXtProtiNX_Q16774
    OpenTargetsiENSG00000143774
    PharmGKBiPA29072

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0707, Eukaryota
    GeneTreeiENSGT00940000155815
    HOGENOMiCLU_001715_0_2_1
    InParanoidiQ16774
    KOiK00942
    PhylomeDBiQ16774
    TreeFamiTF314473

    Enzyme and pathway databases

    BioCyciMetaCyc:HS07104-MONOMER
    BRENDAi2.7.4.8, 2681
    PathwayCommonsiQ16774
    ReactomeiR-HSA-2161541, Abacavir metabolism
    R-HSA-499943, Interconversion of nucleotide di- and triphosphates
    SABIO-RKiQ16774

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    2987, 686 hits in 871 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    GUK1, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    GUK1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    2987
    PharosiQ16774, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q16774
    RNActiQ16774, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000143774, Expressed in prefrontal cortex and 241 other tissues
    ExpressionAtlasiQ16774, baseline and differential
    GenevisibleiQ16774, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR008145, GK/Ca_channel_bsu
    IPR008144, Guanylate_kin-like_dom
    IPR017665, Guanylate_kinase
    IPR020590, Guanylate_kinase_CS
    IPR027417, P-loop_NTPase
    PfamiView protein in Pfam
    PF00625, Guanylate_kin, 1 hit
    SMARTiView protein in SMART
    SM00072, GuKc, 1 hit
    SUPFAMiSSF52540, SSF52540, 1 hit
    TIGRFAMsiTIGR03263, guanyl_kin, 1 hit
    PROSITEiView protein in PROSITE
    PS00856, GUANYLATE_KINASE_1, 1 hit
    PS50052, GUANYLATE_KINASE_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKGUA_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16774
    Secondary accession number(s): B1ANH1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: August 12, 2020
    This is version 172 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
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