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Entry version 164 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Kynurenine--oxoglutarate transaminase 1

Gene

KYAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate2 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by tryptophan, indole-3-pyruvic acid, 3-indolepropionic acid, DL-indole-3-lactic acid, indole-3-acetic acid (IAC) and Tris.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes kynurenate from L-kynurenine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Kynurenine--oxoglutarate transaminase 1 (KYAT1)
  2. no protein annotated in this organism
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes kynurenate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36Substrate; via amide nitrogen1
Binding sitei185Substrate1
Binding sitei398Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferase, Lyase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS10240-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.6.1.7 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70614 Amino acid synthesis and interconversion (transamination)
R-HSA-71182 Phenylalanine and tyrosine catabolism
R-HSA-71240 Tryptophan catabolism

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00334;UER00726

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase 1 (EC:2.6.1.7)
Alternative name(s):
Cysteine-S-conjugate beta-lyase (EC:4.4.1.13)
Glutamine transaminase K
Short name:
GTK
Glutamine--phenylpyruvate transaminase (EC:2.6.1.64)
Kynurenine aminotransferase 1Imported
Kynurenine aminotransferase I
Short name:
KATI
Kynurenine--oxoglutarate transaminase I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KYAT1Imported
Synonyms:CCBL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1564 KYAT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600547 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q16773

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
883

Open Targets

More...
OpenTargetsi
ENSG00000171097

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26138

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3962

Drug and drug target database

More...
DrugBanki
DB07950 1H-INDOL-3-YLACETIC ACID
DB02556 D-Phenylalanine
DB00130 L-Glutamine
DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate
DB00114 Pyridoxal Phosphate
DB02142 Pyridoxamine-5'-Phosphate

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1445

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KYAT1

Domain mapping of disease mutations (DMDM)

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DMDMi
46396284

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001239421 – 422Kynurenine--oxoglutarate transaminase 1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei247N6-(pyridoxal phosphate)lysine1

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q16773

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16773

MaxQB - The MaxQuant DataBase

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MaxQBi
Q16773

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16773

PeptideAtlas

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PeptideAtlasi
Q16773

PRoteomics IDEntifications database

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PRIDEi
Q16773

ProteomicsDB human proteome resource

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ProteomicsDBi
61059
61060 [Q16773-2]
61061 [Q16773-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16773

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16773

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000171097 Expressed in 158 organ(s), highest expression level in metanephric glomerulus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16773 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q16773 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA021176
HPA021177
HPA027736

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107326, 11 interactors

Protein interaction database and analysis system

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IntActi
Q16773, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000399415

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q16773

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1422
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W7LX-ray2.00A1-422[»]
1W7MX-ray2.70A1-422[»]
1W7NX-ray2.90A1-422[»]
3FVSX-ray1.50A/B1-422[»]
3FVUX-ray1.55A/B1-422[»]
3FVXX-ray1.50A/B1-422[»]
4WLHX-ray1.28A/B1-422[»]
4WLJX-ray1.54A/B1-422[»]
4WP0X-ray3.00A/B/C/D1-422[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16773

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16773

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0257 Eukaryota
COG0436 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158797

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16773

KEGG Orthology (KO)

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KOi
K00816

Database of Orthologous Groups

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OrthoDBi
683031at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q16773

TreeFam database of animal gene trees

More...
TreeFami
TF105482

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004839 Aminotransferase_I/II
IPR034614 KAT_I
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major

The PANTHER Classification System

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PANTHERi
PTHR43807:SF14 PTHR43807:SF14, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00155 Aminotran_1_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53383 SSF53383, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16773-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKQLQARRL DGIDYNPWVE FVKLASEHDV VNLGQGFPDF PPPDFAVEAF
60 70 80 90 100
QHAVSGDFML NQYTKTFGYP PLTKILASFF GELLGQEIDP LRNVLVTVGG
110 120 130 140 150
YGALFTAFQA LVDEGDEVII IEPFFDCYEP MTMMAGGRPV FVSLKPGPIQ
160 170 180 190 200
NGELGSSSNW QLDPMELAGK FTSRTKALVL NTPNNPLGKV FSREELELVA
210 220 230 240 250
SLCQQHDVVC ITDEVYQWMV YDGHQHISIA SLPGMWERTL TIGSAGKTFS
260 270 280 290 300
ATGWKVGWVL GPDHIMKHLR TVHQNSVFHC PTQSQAAVAE SFEREQLLFR
310 320 330 340 350
QPSSYFVQFP QAMQRCRDHM IRSLQSVGLK PIIPQGSYFL ITDISDFKRK
360 370 380 390 400
MPDLPGAVDE PYDRRFVKWM IKNKGLVAIP VSIFYSVPHQ KHFDHYIRFC
410 420
FVKDEATLQA MDEKLRKWKV EL
Length:422
Mass (Da):47,875
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAEF2F5E77A9B55A
GO
Isoform 2 (identifier: Q16773-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-117: Missing.

Show »
Length:372
Mass (Da):42,550
Checksum:iAAD732B1797B180C
GO
Isoform 3 (identifier: Q16773-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-250: ASLPGMWERTLTIGSAGKTFS → VSAAVLFGLGQPASLACGNGP
     251-422: Missing.

Show »
Length:250
Mass (Da):27,420
Checksum:iB431352A3ECB8B8B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z4W5B7Z4W5_HUMAN
Cysteine conjugate-beta lyase cytop...
KYAT1 CCBL1, hCG_30593
516Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T276Q5T276_HUMAN
Kynurenine--oxoglutarate transamina...
KYAT1
184Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T278Q5T278_HUMAN
Kynurenine--oxoglutarate transamina...
KYAT1
251Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T277Q5T277_HUMAN
Kynurenine--oxoglutarate transamina...
KYAT1
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti422L → LWP in AAH33685 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00987568 – 117Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_009876230 – 250ASLPG…GKTFS → VSAAVLFGLGQPASLACGNG P in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_009877251 – 422Missing in isoform 3. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X82224 mRNA Translation: CAA57702.1
AL441992 Genomic DNA No translation available.
BC021262 mRNA Translation: AAH21262.1
BC033685 mRNA Translation: AAH33685.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43884.1 [Q16773-1]
CCDS48038.1 [Q16773-2]

Protein sequence database of the Protein Information Resource

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PIRi
S69001 S52790

NCBI Reference Sequences

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RefSeqi
NP_001116143.1, NM_001122671.1 [Q16773-1]
NP_001116144.1, NM_001122672.1 [Q16773-2]
NP_004050.3, NM_004059.4 [Q16773-1]
XP_011517470.1, XM_011519168.1 [Q16773-1]
XP_011517471.1, XM_011519169.1 [Q16773-1]
XP_011517472.1, XM_011519170.2 [Q16773-1]
XP_016870754.1, XM_017015265.1 [Q16773-1]
XP_016870755.1, XM_017015266.1
XP_016870756.1, XM_017015267.1 [Q16773-1]
XP_016870757.1, XM_017015268.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000302586; ENSP00000302227; ENSG00000171097 [Q16773-1]
ENST00000320665; ENSP00000317342; ENSG00000171097 [Q16773-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
883

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:883

UCSC genome browser

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UCSCi
uc004bwh.5 human [Q16773-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82224 mRNA Translation: CAA57702.1
AL441992 Genomic DNA No translation available.
BC021262 mRNA Translation: AAH21262.1
BC033685 mRNA Translation: AAH33685.1
CCDSiCCDS43884.1 [Q16773-1]
CCDS48038.1 [Q16773-2]
PIRiS69001 S52790
RefSeqiNP_001116143.1, NM_001122671.1 [Q16773-1]
NP_001116144.1, NM_001122672.1 [Q16773-2]
NP_004050.3, NM_004059.4 [Q16773-1]
XP_011517470.1, XM_011519168.1 [Q16773-1]
XP_011517471.1, XM_011519169.1 [Q16773-1]
XP_011517472.1, XM_011519170.2 [Q16773-1]
XP_016870754.1, XM_017015265.1 [Q16773-1]
XP_016870755.1, XM_017015266.1
XP_016870756.1, XM_017015267.1 [Q16773-1]
XP_016870757.1, XM_017015268.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W7LX-ray2.00A1-422[»]
1W7MX-ray2.70A1-422[»]
1W7NX-ray2.90A1-422[»]
3FVSX-ray1.50A/B1-422[»]
3FVUX-ray1.55A/B1-422[»]
3FVXX-ray1.50A/B1-422[»]
4WLHX-ray1.28A/B1-422[»]
4WLJX-ray1.54A/B1-422[»]
4WP0X-ray3.00A/B/C/D1-422[»]
SMRiQ16773
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107326, 11 interactors
IntActiQ16773, 2 interactors
STRINGi9606.ENSP00000399415

Chemistry databases

BindingDBiQ16773
ChEMBLiCHEMBL3962
DrugBankiDB07950 1H-INDOL-3-YLACETIC ACID
DB02556 D-Phenylalanine
DB00130 L-Glutamine
DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate
DB00114 Pyridoxal Phosphate
DB02142 Pyridoxamine-5'-Phosphate
GuidetoPHARMACOLOGYi1445

PTM databases

iPTMnetiQ16773
PhosphoSitePlusiQ16773

Polymorphism and mutation databases

BioMutaiKYAT1
DMDMi46396284

Proteomic databases

EPDiQ16773
jPOSTiQ16773
MaxQBiQ16773
PaxDbiQ16773
PeptideAtlasiQ16773
PRIDEiQ16773
ProteomicsDBi61059
61060 [Q16773-2]
61061 [Q16773-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302586; ENSP00000302227; ENSG00000171097 [Q16773-1]
ENST00000320665; ENSP00000317342; ENSG00000171097 [Q16773-2]
GeneIDi883
KEGGihsa:883
UCSCiuc004bwh.5 human [Q16773-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
883
DisGeNETi883

GeneCards: human genes, protein and diseases

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GeneCardsi
KYAT1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0008439
HGNCiHGNC:1564 KYAT1
HPAiHPA021176
HPA021177
HPA027736
MIMi600547 gene
neXtProtiNX_Q16773
OpenTargetsiENSG00000171097
PharmGKBiPA26138

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0257 Eukaryota
COG0436 LUCA
GeneTreeiENSGT00940000158797
InParanoidiQ16773
KOiK00816
OrthoDBi683031at2759
PhylomeDBiQ16773
TreeFamiTF105482

Enzyme and pathway databases

UniPathwayi
UPA00334;UER00726

BioCyciMetaCyc:HS10240-MONOMER
BRENDAi2.6.1.7 2681
ReactomeiR-HSA-70614 Amino acid synthesis and interconversion (transamination)
R-HSA-71182 Phenylalanine and tyrosine catabolism
R-HSA-71240 Tryptophan catabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KYAT1 human
EvolutionaryTraceiQ16773

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CCBL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
883

Protein Ontology

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PROi
PR:Q16773

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171097 Expressed in 158 organ(s), highest expression level in metanephric glomerulus
ExpressionAtlasiQ16773 baseline and differential
GenevisibleiQ16773 HS

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR034614 KAT_I
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43807:SF14 PTHR43807:SF14, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16773
Secondary accession number(s): Q5T275, Q8N191
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
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