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Entry version 166 (07 Oct 2020)
Sequence version 1 (01 Nov 1997)
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Protein

Glutaminyl-peptide cyclotransferase

Gene

QPCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.3 Publications

Caution

It is unclear whether this protein requires a metal cofactor for catalysis. It was originally proposed to be a Zn2+-dependent metalloenzyme based on structural similarities to bacterial aminopeptidases and the observation that it can bind Zn2+ ions, typically in a 1:1 stoichiometry (PubMed:18072935, PubMed:21288892). However, a recent study suggests a Zn2+-independent catalytic mechanism (By similarity).By similarityCurated2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi159ZincCombined sources4 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei201Proton acceptor1 Publication1
Metal bindingi202ZincCombined sources4 Publications1
Active sitei248Proton acceptor1 Publication1
Metal bindingi330ZincCombined sources4 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03941-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.2.5, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q16769

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695, Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M28.974

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutaminyl-peptide cyclotransferase (EC:2.3.2.5)
Alternative name(s):
Glutaminyl cyclase
Short name:
QC
Short name:
sQC
Glutaminyl-tRNA cyclotransferase
Glutamyl cyclase
Short name:
EC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:QPCT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115828.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9753, QPCT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607065, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16769

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi144K → A: Lowers activity by approximately 40%. 1 Publication1
Mutagenesisi146F → A: Lowers activity by approximately 30%. 1 Publication1
Mutagenesisi160S → A: Reduces activity by about 50%. 1 Publication1
Mutagenesisi160S → G: Reduces activity by 96%. 1 Publication1
Mutagenesisi201E → D: Reduces activity by about 98%. 2 Publications1
Mutagenesisi201E → L or Q: Abolishes activity. 2 Publications1
Mutagenesisi207W → L: Greatly lowers activity. 1 Publication1
Mutagenesisi248D → A: Reduces activity by 99%. 2 Publications1
Mutagenesisi248D → Q: Abolishes activity. 2 Publications1
Mutagenesisi304Q → L: Lowers activity by approximately 35%. 1 Publication1
Mutagenesisi305D → A, E or L: Abolishes activity. 2 Publications1
Mutagenesisi305D → N: Reduces activity by 99%. 2 Publications1
Mutagenesisi319H → L: Reduces activity by 87%. 1 Publication1
Mutagenesisi325F → A: Greatly lowers activity. 1 Publication1
Mutagenesisi329W → A: Abolishes activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
25797

Open Targets

More...
OpenTargetsi
ENSG00000115828

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34095

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16769, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4508

Drug and drug target database

More...
DrugBanki
DB04581, 1-benzylimidazole
DB04636, Glutamine t-butyl ester
DB04622, N-acetylhistamine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2411

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
QPCT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2498824

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002219529 – 361Glutaminyl-peptide cyclotransferaseAdd BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi49N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi139 ↔ 1641 Publication
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1301

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16769

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16769

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16769

PeptideAtlas

More...
PeptideAtlasi
Q16769

PRoteomics IDEntifications database

More...
PRIDEi
Q16769

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61056 [Q16769-1]
61057 [Q16769-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q16769-2 [Q16769-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q16769, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16769

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16769

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115828, Expressed in bone marrow and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16769, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16769, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000115828, Tissue enhanced (adrenal gland, blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117329, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q16769, 19 interactors

Molecular INTeraction database

More...
MINTi
Q16769

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344829

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16769

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q16769, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16769

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16769

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3946, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_045003_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16769

KEGG Orthology (KO)

More...
KOi
K00683

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTFDDNE

Database of Orthologous Groups

More...
OrthoDBi
1257754at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16769

TreeFam database of animal gene trees

More...
TreeFami
TF315071

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03880, M28_QC_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037457, M28_QC
IPR007484, Peptidase_M28

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04389, Peptidase_M28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16769-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGGRHRRVV GTLHLLLLVA ALPWASRGVS PSASAWPEEK NYHQPAILNS
60 70 80 90 100
SALRQIAEGT SISEMWQNDL QPLLIERYPG SPGSYAARQH IMQRIQRLQA
110 120 130 140 150
DWVLEIDTFL SQTPYGYRSF SNIISTLNPT AKRHLVLACH YDSKYFSHWN
160 170 180 190 200
NRVFVGATDS AVPCAMMLEL ARALDKKLLS LKTVSDSKPD LSLQLIFFDG
210 220 230 240 250
EEAFLHWSPQ DSLYGSRHLA AKMASTPHPP GARGTSQLHG MDLLVLLDLI
260 270 280 290 300
GAPNPTFPNF FPNSARWFER LQAIEHELHE LGLLKDHSLE GRYFQNYSYG
310 320 330 340 350
GVIQDDHIPF LRRGVPVLHL IPSPFPEVWH TMDDNEENLD ESTIDNLNKI
360
LQVFVLEYLH L
Length:361
Mass (Da):40,877
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32C26041BCF5ED75
GO
Isoform 2 (identifier: Q16769-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-89: Missing.

Show »
Length:312
Mass (Da):35,421
Checksum:i21EF984B639F5DEE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCZ9B5MCZ9_HUMAN
Glutaminyl-peptide cyclotransferase
QPCT
284Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JS14C9JS14_HUMAN
Glutaminyl-peptide cyclotransferase
QPCT
117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IUD5A0A3B3IUD5_HUMAN
Glutaminyl-peptide cyclotransferase
QPCT
137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05395654R → W Lowers activity by approximately 30%. 1 PublicationCorresponds to variant dbSNP:rs2255991Ensembl.1
Natural variantiVAR_00556971Q → R. Corresponds to variant dbSNP:rs895245310Ensembl.1
Natural variantiVAR_053957360H → P1 PublicationCorresponds to variant dbSNP:rs4670696Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03848741 – 89Missing in isoform 2. CuratedAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X71125 mRNA Translation: CAA50438.1
X67731 mRNA Translation: CAA47961.1
AK290605 mRNA Translation: BAF83294.1
AC007391 Genomic DNA Translation: AAY14804.1
CH471053 Genomic DNA Translation: EAX00392.1
CH471053 Genomic DNA Translation: EAX00394.1
CH471053 Genomic DNA Translation: EAX00396.1
BC036721 mRNA Translation: AAH36721.1
BC047756 mRNA Translation: AAH47756.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1790.1 [Q16769-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I37421

NCBI Reference Sequences

More...
RefSeqi
NP_036545.1, NM_012413.3 [Q16769-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338415; ENSP00000344829; ENSG00000115828 [Q16769-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25797

UCSC genome browser

More...
UCSCi
uc002rqg.4, human [Q16769-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71125 mRNA Translation: CAA50438.1
X67731 mRNA Translation: CAA47961.1
AK290605 mRNA Translation: BAF83294.1
AC007391 Genomic DNA Translation: AAY14804.1
CH471053 Genomic DNA Translation: EAX00392.1
CH471053 Genomic DNA Translation: EAX00394.1
CH471053 Genomic DNA Translation: EAX00396.1
BC036721 mRNA Translation: AAH36721.1
BC047756 mRNA Translation: AAH47756.1
CCDSiCCDS1790.1 [Q16769-1]
PIRiI37421
RefSeqiNP_036545.1, NM_012413.3 [Q16769-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MOImodel-A1-361[»]
2AFMX-ray1.66A/B33-361[»]
2AFOX-ray2.35A/B33-361[»]
2AFSX-ray2.22A/B33-361[»]
2AFUX-ray2.22A/B33-361[»]
2AFWX-ray1.56A/B33-361[»]
2AFXX-ray1.64A/B33-361[»]
2AFZX-ray1.68A/B33-361[»]
2ZEDX-ray1.70A/B33-361[»]
2ZEEX-ray1.99A/B33-361[»]
2ZEFX-ray1.67A/B33-361[»]
2ZEGX-ray2.08A/B33-361[»]
2ZEHX-ray1.80A/B33-361[»]
2ZELX-ray1.97A/B33-361[»]
2ZEMX-ray2.18A/B33-361[»]
2ZENX-ray1.78A/B33-361[»]
2ZEOX-ray1.66A/B33-361[»]
2ZEPX-ray2.10A/B33-361[»]
3PBBX-ray1.95A/B33-361[»]
3PBEX-ray1.95A/B33-361[»]
3SI0X-ray2.10A38-361[»]
4YU9X-ray2.10A/B/C33-361[»]
4YWYX-ray1.95A/B/C1-361[»]
6GBXX-ray1.72A/B/C33-361[»]
6YI1X-ray1.92A/B35-361[»]
6YJYX-ray1.67A/B35-361[»]
SMRiQ16769
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117329, 26 interactors
IntActiQ16769, 19 interactors
MINTiQ16769
STRINGi9606.ENSP00000344829

Chemistry databases

BindingDBiQ16769
ChEMBLiCHEMBL4508
DrugBankiDB04581, 1-benzylimidazole
DB04636, Glutamine t-butyl ester
DB04622, N-acetylhistamine
GuidetoPHARMACOLOGYi2411

Protein family/group databases

MEROPSiM28.974

PTM databases

GlyGeniQ16769, 2 sites
iPTMnetiQ16769
PhosphoSitePlusiQ16769

Polymorphism and mutation databases

BioMutaiQPCT
DMDMi2498824

Proteomic databases

CPTACiCPTAC-1301
jPOSTiQ16769
MassIVEiQ16769
PaxDbiQ16769
PeptideAtlasiQ16769
PRIDEiQ16769
ProteomicsDBi61056 [Q16769-1]
61057 [Q16769-2]
TopDownProteomicsiQ16769-2 [Q16769-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1981, 214 antibodies

The DNASU plasmid repository

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DNASUi
25797

Genome annotation databases

EnsembliENST00000338415; ENSP00000344829; ENSG00000115828 [Q16769-1]
GeneIDi25797
KEGGihsa:25797
UCSCiuc002rqg.4, human [Q16769-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25797
DisGeNETi25797
EuPathDBiHostDB:ENSG00000115828.15

GeneCards: human genes, protein and diseases

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GeneCardsi
QPCT
HGNCiHGNC:9753, QPCT
HPAiENSG00000115828, Tissue enhanced (adrenal gland, blood)
MIMi607065, gene
neXtProtiNX_Q16769
OpenTargetsiENSG00000115828
PharmGKBiPA34095

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3946, Eukaryota
GeneTreeiENSGT00390000003107
HOGENOMiCLU_045003_1_0_1
InParanoidiQ16769
KOiK00683
OMAiHTFDDNE
OrthoDBi1257754at2759
PhylomeDBiQ16769
TreeFamiTF315071

Enzyme and pathway databases

BioCyciMetaCyc:HS03941-MONOMER
BRENDAi2.3.2.5, 2681
PathwayCommonsiQ16769
ReactomeiR-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
25797, 4 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
QPCT, human
EvolutionaryTraceiQ16769

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
QPCT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25797
PharosiQ16769, Tchem

Protein Ontology

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PROi
PR:Q16769
RNActiQ16769, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115828, Expressed in bone marrow and 216 other tissues
ExpressionAtlasiQ16769, baseline and differential
GenevisibleiQ16769, HS

Family and domain databases

CDDicd03880, M28_QC_like, 1 hit
InterProiView protein in InterPro
IPR037457, M28_QC
IPR007484, Peptidase_M28
PfamiView protein in Pfam
PF04389, Peptidase_M28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQPCT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16769
Secondary accession number(s): Q16770, Q3KRG6, Q53TR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 7, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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