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Protein

Thiosulfate sulfurtransferase

Gene

TST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.By similarity2 Publications

Catalytic activityi

Thiosulfate + cyanide = sulfite + thiocyanate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei187SubstrateBy similarity1
Active sitei248Cysteine persulfide intermediatePROSITE-ProRule annotation1
Binding sitei250SubstrateBy similarity1

GO - Molecular functioni

  • 5S rRNA binding Source: UniProtKB
  • thiosulfate sulfurtransferase activity Source: Reactome

GO - Biological processi

  • cyanate catabolic process Source: ProtInc
  • epithelial cell differentiation Source: UniProtKB
  • rRNA import into mitochondrion Source: UniProtKB
  • rRNA transport Source: UniProtKB
  • sulfur amino acid catabolic process Source: Reactome

Keywordsi

Molecular functionRNA-binding, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS05179-MONOMER
ReactomeiR-HSA-1614517 Sulfide oxidation to sulfate
R-HSA-1614558 Degradation of cysteine and homocysteine

Names & Taxonomyi

Protein namesi
Recommended name:
Thiosulfate sulfurtransferase (EC:2.8.1.1)
Alternative name(s):
Rhodanese
Gene namesi
Name:TST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128311.13
HGNCiHGNC:12388 TST
MIMi180370 gene
neXtProtiNX_Q16762

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi7263
OpenTargetsiENSG00000128311
PharmGKBiPA37055

Chemistry databases

DrugBankiDB02761 S-Mercaptocysteine
DB09499 Sodium thiosulfate

Polymorphism and mutation databases

BioMutaiTST
DMDMi3122965

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001393952 – 297Thiosulfate sulfurtransferaseAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14N6-acetyllysine; alternateCombined sources1
Modified residuei14N6-succinyllysine; alternateBy similarity1
Glycosylationi35O-linked (GlcNAc) serineBy similarity1
Modified residuei38PhosphoserineBy similarity1
Modified residuei136N6-acetyllysine; alternateBy similarity1
Modified residuei136N6-succinyllysine; alternateBy similarity1
Modified residuei163N6-acetyllysineBy similarity1
Modified residuei175N6-acetyllysine; alternateBy similarity1
Modified residuei175N6-succinyllysine; alternateBy similarity1
Modified residuei224N6-acetyllysine; alternateBy similarity1
Modified residuei224N6-succinyllysine; alternateBy similarity1
Modified residuei236N6-acetyllysineBy similarity1
Modified residuei237N6-acetyllysine; alternateBy similarity1
Modified residuei237N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ16762
MaxQBiQ16762
PaxDbiQ16762
PeptideAtlasiQ16762
PRIDEiQ16762
ProteomicsDBi61054

2D gel databases

REPRODUCTION-2DPAGEiIPI00216293

PTM databases

iPTMnetiQ16762
PhosphoSitePlusiQ16762
SwissPalmiQ16762

Expressioni

Gene expression databases

BgeeiENSG00000128311 Expressed in 218 organ(s), highest expression level in colonic mucosa
CleanExiHS_TST
ExpressionAtlasiQ16762 baseline and differential
GenevisibleiQ16762 HS

Organism-specific databases

HPAiCAB009546
HPA003044
HPA003643

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi113114, 13 interactors
IntActiQ16762, 4 interactors
MINTiQ16762
STRINGi9606.ENSP00000249042

Structurei

3D structure databases

ProteinModelPortaliQ16762
SMRiQ16762
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 143Rhodanese 1PROSITE-ProRule annotationAdd BLAST119
Domaini173 – 288Rhodanese 2PROSITE-ProRule annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni144 – 159HingeAdd BLAST16

Domaini

Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1529 Eukaryota
COG2897 LUCA
GeneTreeiENSGT00510000046773
HOGENOMiHOG000157237
HOVERGENiHBG002345
InParanoidiQ16762
KOiK01011
OMAiAARVYWT
OrthoDBiEOG091G0X2Q
PhylomeDBiQ16762
TreeFamiTF315133

Family and domain databases

Gene3Di3.40.250.10, 2 hits
InterProiView protein in InterPro
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR001307 Thiosulphate_STrfase_CS
PfamiView protein in Pfam
PF00581 Rhodanese, 2 hits
SMARTiView protein in SMART
SM00450 RHOD, 2 hits
SUPFAMiSSF52821 SSF52821, 2 hits
PROSITEiView protein in PROSITE
PS00380 RHODANESE_1, 1 hit
PS00683 RHODANESE_2, 1 hit
PS50206 RHODANESE_3, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q16762-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVHQVLYRAL VSTKWLAESI RTGKLGPGLR VLDASWYSPG TREARKEYLE
60 70 80 90 100
RHVPGASFFD IEECRDTASP YEMMLPSEAG FAEYVGRLGI SNHTHVVVYD
110 120 130 140 150
GEHLGSFYAP RVWWMFRVFG HRTVSVLNGG FRNWLKEGHP VTSEPSRPEP
160 170 180 190 200
AVFKATLDRS LLKTYEQVLE NLESKRFQLV DSRSQGRFLG TEPEPDAVGL
210 220 230 240 250
DSGHIRGAVN MPFMDFLTED GFEKGPEELR ALFQTKKVDL SQPLIATCRK
260 270 280 290
GVTACHVALA AYLCGKPDVA VYDGSWSEWF RRAPPESRVS QGKSEKA
Length:297
Mass (Da):33,429
Last modified:January 23, 2007 - v4
Checksum:iBDAE6EE4E47A5650
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AH48B1AH48_HUMAN
Thiosulfate sulfurtransferase
TST
124Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051799102E → D1 PublicationCorresponds to variant dbSNP:rs35156365Ensembl.1
Natural variantiVAR_051800228E → G. Corresponds to variant dbSNP:rs1049270Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87292 mRNA Translation: BAA13327.1
CR456598 mRNA Translation: CAG30484.1
CR456998 mRNA Translation: CAG33279.1
AK091874 mRNA Translation: BAG52433.1
Z73420 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60132.1
BC010148 mRNA Translation: AAH10148.1
CCDSiCCDS13938.1
PIRiJC5286
RefSeqiNP_001257412.1, NM_001270483.1
NP_003303.2, NM_003312.5
UniGeneiHs.474783

Genome annotation databases

EnsembliENST00000249042; ENSP00000249042; ENSG00000128311
ENST00000403892; ENSP00000385828; ENSG00000128311
ENST00000622841; ENSP00000478739; ENSG00000128311
GeneIDi7263
KEGGihsa:7263
UCSCiuc003aqg.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87292 mRNA Translation: BAA13327.1
CR456598 mRNA Translation: CAG30484.1
CR456998 mRNA Translation: CAG33279.1
AK091874 mRNA Translation: BAG52433.1
Z73420 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60132.1
BC010148 mRNA Translation: AAH10148.1
CCDSiCCDS13938.1
PIRiJC5286
RefSeqiNP_001257412.1, NM_001270483.1
NP_003303.2, NM_003312.5
UniGeneiHs.474783

3D structure databases

ProteinModelPortaliQ16762
SMRiQ16762
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113114, 13 interactors
IntActiQ16762, 4 interactors
MINTiQ16762
STRINGi9606.ENSP00000249042

Chemistry databases

DrugBankiDB02761 S-Mercaptocysteine
DB09499 Sodium thiosulfate

PTM databases

iPTMnetiQ16762
PhosphoSitePlusiQ16762
SwissPalmiQ16762

Polymorphism and mutation databases

BioMutaiTST
DMDMi3122965

2D gel databases

REPRODUCTION-2DPAGEiIPI00216293

Proteomic databases

EPDiQ16762
MaxQBiQ16762
PaxDbiQ16762
PeptideAtlasiQ16762
PRIDEiQ16762
ProteomicsDBi61054

Protocols and materials databases

DNASUi7263
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249042; ENSP00000249042; ENSG00000128311
ENST00000403892; ENSP00000385828; ENSG00000128311
ENST00000622841; ENSP00000478739; ENSG00000128311
GeneIDi7263
KEGGihsa:7263
UCSCiuc003aqg.5 human

Organism-specific databases

CTDi7263
DisGeNETi7263
EuPathDBiHostDB:ENSG00000128311.13
GeneCardsiTST
HGNCiHGNC:12388 TST
HPAiCAB009546
HPA003044
HPA003643
MIMi180370 gene
neXtProtiNX_Q16762
OpenTargetsiENSG00000128311
PharmGKBiPA37055
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1529 Eukaryota
COG2897 LUCA
GeneTreeiENSGT00510000046773
HOGENOMiHOG000157237
HOVERGENiHBG002345
InParanoidiQ16762
KOiK01011
OMAiAARVYWT
OrthoDBiEOG091G0X2Q
PhylomeDBiQ16762
TreeFamiTF315133

Enzyme and pathway databases

BioCyciMetaCyc:HS05179-MONOMER
ReactomeiR-HSA-1614517 Sulfide oxidation to sulfate
R-HSA-1614558 Degradation of cysteine and homocysteine

Miscellaneous databases

ChiTaRSiTST human
GeneWikiiTST_(gene)
GenomeRNAii7263
PROiPR:Q16762
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128311 Expressed in 218 organ(s), highest expression level in colonic mucosa
CleanExiHS_TST
ExpressionAtlasiQ16762 baseline and differential
GenevisibleiQ16762 HS

Family and domain databases

Gene3Di3.40.250.10, 2 hits
InterProiView protein in InterPro
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR001307 Thiosulphate_STrfase_CS
PfamiView protein in Pfam
PF00581 Rhodanese, 2 hits
SMARTiView protein in SMART
SM00450 RHOD, 2 hits
SUPFAMiSSF52821 SSF52821, 2 hits
PROSITEiView protein in PROSITE
PS00380 RHODANESE_1, 1 hit
PS00683 RHODANESE_2, 1 hit
PS50206 RHODANESE_3, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTHTR_HUMAN
AccessioniPrimary (citable) accession number: Q16762
Secondary accession number(s): B3KRM1, Q6IB06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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